Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• 6000, Bulgaria 10.3762/bjnano.14.85 Abstract Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have in

• might exist, independent of CD163 and also Hb. Keywords: CD163; HBOC; hemoglobin-based oxygen carriers; monocytes; phagocytosis; Introduction Blood transfusions save lives every day and have become an indispensable part of clinical practice in modern medicine. However, there have always been numerous

• relatively simple and inexpensive to produce, can be stored for a long time and administered universally, is safe to use, and has few to none adverse drug effects. One approach associated with great hopes are hemoglobin-based oxygen carriers (HBOCs). Initially, however, serious side effects were encountered

Bacterial safety study of the production process of hemoglobin-based oxygen carriers

• Axel Steffen,
• Yu Xiong,
• Radostina Georgieva,
• Ulrich Kalus and
• Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

• attracted particular attention in the last years. Many of the different approaches are using hemoglobin as a starting material to produce hemoglobin-based oxygen carriers (HBOC). Thus, hemoglobin from human and animal (especially bovine) sources or recombinant hemoglobin is used, which can then be