Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• potential of oleic acid (OLA), the protonated form of sodium oleate (SO), to enhance membrane fluidity in specific lipid bilayer models, including dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC), as well as in complex biological systems such as the human skin barrier [9][10][11

• depicted in Figure 5 provide a comprehensive analysis of the interaction dynamics between OLA and the AUR peptide with a model lipid bilayer composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (POPG). These simulations

• the lipid bilayer, reinforcing the observed differences in their membrane integration and potential membrane modulation effects. The distance plots in Figure 5c,d demonstrate the separation between the center of mass of the POPC and POPG components and the interacting molecules over time. For OLA, a

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• ]. Liposomes Liposomes are another type of DDS that has been extensively investigated over the years [87][88][89]. The structure of a liposome contains a lipid bilayer surrounding an aqueous core, which offers advantages in encapsulating both hydrophobic and hydrophilic substances [90]. The additional

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• ]. Although this nanostructured system is a promising carrier, further in vitro and in vivo studies are necessary to evaluate such improvements for curc or other leishmanicidal drugs. Nanoliposomes Nanoliposomes are nanoscale lipid bilayer vesicles mainly composed of phospholipids. These systems (small

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• , a natural inhibitor of neutral magnesium-dependent sphingomyelinase, a key enzyme in sphingomyelin breakdown. This enzyme is essential because sphingomyelin is crucial in forming the outer leaflet of the tegumental lipid bilayer membrane in Schistosoma mansoni [43]. Araújo et al. [84] verified the

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• it to the outer leaflet of the lipid bilayer [49]. Trypanosoma brucei predominant membrane protein variant surface glycoprotein (VSG), which is involved in parasite host immune system evasion, is anchored by a GPI that requires myristate for its synthesis. Analogs of myristate have shown toxicity

• indicated that the specificity of fatty acid incorporation depends on chain length [52]. The lipid in our formulation is an ester of fatty acids that could hypothetically interrupt the anchoring of mucin to the lipid bilayer in T. cruzi, thus rendering the parasites non-viable. However, further studies are

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• physicochemical properties (polar headgroup, linker region, and type and length of hydrophobic domain), PEG amount, PEG lipid alkyl length, as well as the physicochemical properties of the LNPs (zeta potential, pKa value, and structure and conformation of the lipid bilayer) will result in improved targeting

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• ]. Contrarily, nanoparticles composed of a lipid bilayer with cores of different crosslinking extent showed higher uptake of softer particles in MCF-7 cells, which was thought to be due to a melting process of particles with the cell membrane that consumed less energy than endocytosis [8]. Regarding the in vivo

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• high amounts of ethanol that can carry both hydrophilic and lipophilic drug molecules. They are also highly deformable and reach deep skin layers [18][19]. ETHs are similar to the lipid bilayer composition of cells in the epidermis, due to the presence of phospholipids in their structure, and thus

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• intensifies the biophysical effects of the US waves [41]. This leads to transient permeabilization of cell membranes through the formation of transient pores and/or defects in the lipid bilayer, and finally, the diffusion of surrounding molecules into the cytosol [74]. Cavitation events triggered by MBs

Fusion of purple membranes triggered by immobilization on carbon nanomembranes

• René Riedel,
• Natalie Frese,
• Fang Yang,
• Martin Wortmann,
• Raphael Dalpke,
• Daniel Rhinow,
• Norbert Hampp and
• Armin Gölzhäuser

Beilstein J. Nanotechnol. 2021, 12, 93–101, doi:10.3762/bjnano.12.8

• CNM and a c-His PM. The c-His PM consists of BR (purple) with a lipid bilayer between the BR molecules. The chemical structure shows the linker used to build a complex between NTA CNM and c-His PM. (b) Fluorescence microscopy of NTA-functionalized NBPT CNMs incubated with a fluorescent protein

Bio-imaging with the helium-ion microscope: A review

• Matthias Schmidt,
• James M. Byrne and
• Ilari J. Maasilta

Beilstein J. Nanotechnol. 2021, 12, 1–23, doi:10.3762/bjnano.12.1

• visualization of the shape of membrane nanodomains, including lipid rafts and caveolae.” It was concluded that the pits result from the sample preparation since “the cell fixation with OsO4 cross-links the lipid bilayer outside the nanodomains while the lipid bilayer inside the nanodomains is removed by the

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• and, secondly, angiopep-2 increased the accumulation of nanoparticles in glioma cells thanks to recognition of the LRP1 on the glioma cells surface. Lipid-based nanoparticles Liposomes: Liposomes are well-known and well-studied nanocarrier systems. They are composed of a lipid bilayer surrounding a

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

• Valentina Francia,
• Daphne Montizaan and
• Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

• Section 2.1. Recently, computer simulations and in vitro studies of nanoparticle–membrane interactions have shown that the surface of nanomaterials can in itself induce several changes at the plasma membrane, by determining sol–gel transitions in the lipid bilayer and impairing lipid lateral diffusion

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

Molecular architectonics of DNA for functional nanoarchitectures

• Debasis Ghosh,
• Lakshmi P. Datta and
• Thimmaiah Govindaraju

Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11

• ligated by DNA via direct amidation, and the covalent attachment allowed the insertion of an array of porphyrin segments along the nucleotide sequence. Recently, a transmembrane lipid bilayer nanopore comprised of folded DNA became the center of attraction by mimicking natural protein pores. Howorka and

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

• Mohammad A. Obeid,
• Ibrahim Khadra,
• Abdullah Albaloushi,
• Margaret Mullin,
• Hanin Alyamani and
• Valerie A. Ferro

Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177

• . 11%, while niosomes prepared using T85 at 3:1 FRR resulted in an EE of ca. 60%. The increase in FRR from 1:1 to 3:1 resulted in a significant (p < 0.05) increase in the EE values for both formulations. Niosomes exhibit a lipid bilayer structure encapsulating an aqueous compartment. Hydrophilic

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• there [15]. These nanocapsules were anchored on the surface of mesoporous silica nanoparticles (MSN) coated with a lipid bilayer (protocells) enhancing their penetration into 3D tumoral tissue models, which yielded a significant enhancement of the therapeutic efficacy of these nanodevices (Figure 1) [16

Wafer-scale bioactive substrate patterning by chemical lift-off lithography

• Chong-You Chen,
• Chang-Ming Wang,
• Hsiang-Hua Li,
• Hong-Hseng Chan and
• Wei-Ssu Liao

Beilstein J. Nanotechnol. 2018, 9, 311–320, doi:10.3762/bjnano.9.31

• reproduction, and high resolution control. Conventional strategies to fabricate bioactive substrates rely on the creation of different local molecular environments that are suitable for subsequent biological species attachment. For example, the supported lipid bilayer system has been widely used for many

Surface-enhanced Raman scattering of self-assembled thiol monolayers and supported lipid membranes on thin anodic porous alumina

• Marco Salerno,
• Amirreza Shayganpour,
• Barbara Salis and
• Silvia Dante

Beilstein J. Nanotechnol. 2017, 8, 74–81, doi:10.3762/bjnano.8.8

• ), and then with phospholipid vesicles of different composition to form a supported lipid bilayer (SLB). At each step, the SERS substrate functionality was assessed, demonstrating acceptable enhancement (≥100×). The chemisorption of thiols during the first step and the formation of SLB from the vesicles

On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles

• Claudia Messerschmidt,
• Daniel Hofmann,
• Anja Kroeger,
• Katharina Landfester,
• Volker Mailänder and
• Ingo Lieberwirth

Beilstein J. Nanotechnol. 2016, 7, 1296–1311, doi:10.3762/bjnano.7.121

• assume that this large area coverage hinders the final vesicle pinch-off from the cell membrane. The additional silica layer on the cell membrane prevents the intimate membrane–membrane contact necessary for the coalescence of the membrane lipid bilayer at the point of pinch-off. Furthermore, the

• higher compared to the cell membrane. Nonetheless, it is remarkable that quite a little difference in NP size results in completely different uptake morphologies. From molecular dynamics simulations of two curvature imprinting particles on a lipid bilayer membrane we learn, that the membrane mediates

Reconstitution of the membrane protein OmpF into biomimetic block copolymer–phospholipid hybrid membranes

• Matthias Bieligmeyer,
• Franjo Artukovic,
• Stephan Nussberger,
• Thomas Hirth,
• Thomas Schiestel and
• Michaela Müller

Beilstein J. Nanotechnol. 2016, 7, 881–892, doi:10.3762/bjnano.7.80

• more and more interest, as the properties of such assemblies can be steadily varied between the characteristics of a lipid bilayer and that of synthetic polymer membranes. By simply mixing lipids and amphiphilic polymers, a plethora of possible chemical and mechanical characteristics of polymeric

• a circular aperture with a diameter of 400 µm in the partitioning wall of a custom-built black lipid bilayer Teflon chamber. The volume of each compartment, separated by the partionining wall, was 5 mL [67]. PIPEO/DPhPC in chloroform (10 µL) was applied around the aperture of the chamber and allowed

Single pyrimidine discrimination during voltage-driven translocation of osmylated oligodeoxynucleotides via the α-hemolysin nanopore

• Yun Ding and
• Anastassia Kanavarioti

Beilstein J. Nanotechnol. 2016, 7, 91–101, doi:10.3762/bjnano.7.11

• , University of Utah. The KCl solution was used as the electrolyte to fill the solution reservoir and the GNM capillary. A voltage was applied across the GNM between two Ag/AgCl electrodes placed inside and outside of the capillary. A lipid bilayer was deposited across the GNM orifice as indicated by a

• resistance increase from ca. 10 MΩ (associated with the open GNM) to ca. 100 GΩ. A pressure of 20 to 40 mmHg was applied to the inside of the GNM capillary using a syringe, allowing the lipid bilayer to be functional for the protein channel reconstitution. Next, 0.2 µL of α-HL monomer solution at 1 mg/mL was

Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state

• Florian G. Strobl,
• Florian Seitz,
• Christoph Westerhausen,
• Armin Reller,
• Adriano A. Torrano,
• Christoph Bräuchle,
• Achim Wixforth and
• Matthias F. Schneider

Beilstein J. Nanotechnol. 2014, 5, 2468–2478, doi:10.3762/bjnano.5.256

• particle and the membrane. As shown in [33], the interaction between a neutral (i.e., zwitterionic) lipid bilayer and negatively charged silica surface is repulsive in pure water but attractive in phosphate buffered saline. The authors also give a plausible theoretical explanation for this finding by

Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes

• Marcela Elisabeta Barbinta-Patrascu,
• Stefan Marian Iordache,
• Ana Maria Iordache,
• Nicoleta Badea and
• Camelia Ungureanu

Beilstein J. Nanotechnol. 2014, 5, 2316–2325, doi:10.3762/bjnano.5.240

• biomimetic membranes (above 41 °C) exhibits low anisotropy and high fluorescence emission intensity due to an increase in the lipid bilayer mobility and hence the chlorophyll has the possibility to move and to minimize the energy transfer leading to fluorescence quenching. In the gel phase of the artificial