On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• , protein targeting, the prediction of coated-NP drug release systems [41][42][43][44][45][46][47][48][49], multitarget networks of neuroprotective compounds for a theoretical study of new asymmetric 1,2-rasagiline carbamates [50], a TOPS-MODE model of multiplexing neuroprotective effects of drugs, an

• coworkers. These researchers employed this database to create advanced predictive models known as multitarget or multiplexing QSAR. These models are designed to forecast both the potential neurotoxicity and neuroprotective effects of drugs across various experimental setups, including multiple assays, drug

Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators

• Leonid S. Revin,
• Dmitry A. Pimanov,
• Alexander V. Chiginev,
• Anton V. Blagodatkin,
• Viktor O. Zbrozhek,
• Andrey V. Samartsev,
• Anastasia N. Orlova,
• Dmitry V. Masterov,
• Alexey E. Parafin,
• Victoria Yu. Safonova,
• Anna V. Gordeeva,
• Andrey L. Pankratov,
• Leonid S. Kuzmin,
• Anatolie S. Sidorenko,
• Silvia Masi and
• Paolo de Bernardis

Beilstein J. Nanotechnol. 2024, 15, 26–36, doi:10.3762/bjnano.15.3

• operating since 2012, and work on the BICEP Array was started in 2018. The BICEP Array is planned to observe the polarized microwave sky at 30/40, 95, 150, and 220/270 GHz. It is stated that the 220/270 GHz channel will have more than 20000 detectors. It will use radio frequency (RF) multiplexing with

• microwave superconducting quantum interference device (SQUID) readout if transition-edge sensors (TESs) detectors are installed. Otherwise, on-wafer RF multiplexing may be used with thermal kinetic inductance detectors [2]. The LSPE mission [3] is a project of the Italian Space Agency aimed at studying the

• detectors are to be installed into waveguide horns, which is a standard way to form the needed radiation pattern for the antenna. The main channel has 162 detectors, and each of the auxiliary channels has 82 detectors. It is intended to use SQUID readout [9][10] with frequency multiplexing for this mission

SERS performance of GaN/Ag substrates fabricated by Ag coating of GaN platforms

• Magdalena A. Zając,
• Bogusław Budner,
• Malwina Liszewska,
• Bartosz Bartosewicz,
• Łukasz Gutowski,
• Jan L. Weyher and
• Bartłomiej J. Jankiewicz

Beilstein J. Nanotechnol. 2023, 14, 552–564, doi:10.3762/bjnano.14.46

• : GaN/Ag; magnetron sputtering; nanofabrication; pulsed laser deposition; SERS substrates; surface-enhanced Raman spectroscopy (SERS); Introduction Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive and specific technique with multiplexing capabilities [1][2][3][4]. It is considered for

Numerical modeling of a multi-frequency receiving system based on an array of dipole antennas for LSPE-SWIPE

• Alexander V. Chiginev,
• Anton V. Blagodatkin,
• Dmitrii A. Pimanov,
• Ekaterina A. Matrozova,
• Anna V. Gordeeva,
• Andrey L. Pankratov and
• Leonid S. Kuzmin

Beilstein J. Nanotechnol. 2022, 13, 865–872, doi:10.3762/bjnano.13.77

• . To use this mode, the CEBs must be connected in parallel. Superconducting quantum interference devices (SQUIDs) with multiplexing [11] will also be used for readout. Therefore, to match this readout system, the arrays of dipole antennas and CEBs connected in parallel should have a resistance value of

Zinc oxide nanostructures for fluorescence and Raman signal enhancement: a review

• Ioana Marica,
• Fran Nekvapil,
• Maria Ștefan,
• Cosmin Farcău and
• Alexandra Falamaș

Beilstein J. Nanotechnol. 2022, 13, 472–490, doi:10.3762/bjnano.13.40

• broad range of wavelengths. This multiplexing property was investigated for ZnO nanoflower (NF) and nanorod arrays by [114]. Different Alexa Fluor (AF) dyes were used and the results showed a significant enhancement of their fluorescence over the entire visual spectral range (400–840 nm). Specifically

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• 3D imaging by exploiting several spectral lines. Fourier/Hadamard transform techniques allow frequency–space multiplexing for faster measurement, where spatial information is recovered through Hadamard encoding and quadrature detection. Hyperpolarization is a novel functional medical imaging

Correlation of surface-enhanced Raman scattering (SERS) with the surface density of gold nanoparticles: evaluation of the critical number of SERS tags for a detectable signal

• Vincenzo Amendola

Beilstein J. Nanotechnol. 2019, 10, 1016–1023, doi:10.3762/bjnano.10.102

• narrowness of the Raman bands allows multiplexing analysis by associating Raman reporters with different, non-overlapping peaks, which serve as a spectroscopic fingerprint that can be associated with different analytes [18][29][30]. Additional favorable features of SERS tags are their photostability, namely

Experimental study of an evanescent-field biosensor based on 1D photonic bandgap structures

• Jad Sabek,
• Francisco Javier Díaz-Fernández,
• Luis Torrijos-Morán,
• Zeneida Díaz-Betancor,
• Ángel Maquieira,
• María-José Bañuls,
• Elena Pinilla-Cienfuegos and
• Jaime García-Rupérez

Beilstein J. Nanotechnol. 2019, 10, 967–974, doi:10.3762/bjnano.10.97

• , due to the various advantages it provides, e.g., high sensitivity, miniaturization, high multiplexing level, fast response, need for very low sample and reagent volumes and the compatibility to complementary metal-oxide semiconductor (CMOS) fabrication [3]. Chip-integrated photonic biosensors have

Commercial polycarbonate track-etched membranes as substrates for low-cost optical sensors

• Paula Martínez-Pérez and
• Jaime García-Rupérez

Beilstein J. Nanotechnol. 2019, 10, 677–683, doi:10.3762/bjnano.10.67

• type, sensors can be classified into several categories. Among all of them, optical sensors stand out because they exhibit a high sensitivity, the capability of multiplexing and direct real-time detection, miniaturization possibilities, immunity to electromagnetic interference and cost-effectiveness [1

Metal–dielectric hybrid nanoantennas for efficient frequency conversion at the anapole mode

• Valerio F. Gili,
• Lavinia Ghirardini,
• Davide Rocco,
• Giuseppe Marino,
• Ivan Favero,
• Iännis Roland,
• Giovanni Pellegrini,
• Lamberto Duò,
• Marco Finazzi,
• Luca Carletti,
• Andrea Locatelli,
• Aristide Lemaître,
• Dragomir Neshev,
• Costantino De Angelis,
• Giuseppe Leo and
• Michele Celebrano

Beilstein J. Nanotechnol. 2018, 9, 2306–2314, doi:10.3762/bjnano.9.215

• properties of molecules at liquid–liquid interfaces [7]. The ability to downscale nonlinear optical processes, such as SHG, in extremely confined spatial regions opens many fascinating opportunities in light manipulation and multiplexing [8] as well as in optical sensing and spectroscopy [9][10]. Yet, to

• nanostructures. The possibility to effectively enhance SHG using the anapole mode field distribution boosted by a plasmonic nanoantenna opens up new avenues for nonlinear sensing, spectroscopy as well as frequency down-conversion and nonlinear multiplexing at the nanoscale [8]. Experimental Sample fabrication

A variable probe pitch micro-Hall effect method

• Maria-Louise Witthøft,
• Frederik W. Østerberg,
• Janusz Bogdanowicz,
• Rong Lin,
• Henrik H. Henrichsen,
• Ole Hansen and
• Dirch H. Petersen

Beilstein J. Nanotechnol. 2018, 9, 2032–2039, doi:10.3762/bjnano.9.192

• sample by multiplexing several sets of four electrodes on a M7PP. These sets are called sub-probes and can be chosen with different electrode pitch. In this case, three equidistant sub-probes are used and named with reference to the index number of the four electrodes constituting the sub-probe, “1357

• configurations A, A’, B and B’ used in the experiments. The three sub-probes on an M7PP used for multiplexing during measurements; a) 1357 (20 μm pitch), b) 1234 and c) 4567 (10 μm pitch). The electrode pins used in a given sub-probe are marked with green. The sample itself is highlighted in blue. The direction

Electromigrated electrical optical antennas for transducing electrons and photons at the nanoscale

• Arindam Dasgupta,
• Mickaël Buret,
• Nicolas Cazier,
• Marie-Maxime Mennemanteuil,
• Reinaldo Chacon,
• Kamal Hammani,
• Jean-Claude Weeber,
• Juan Arocas,
• Laurent Markey,
• Gérard Colas des Francs,
• Alexander Uskov,
• Igor Smetanin and
• Alexandre Bouhelier

Beilstein J. Nanotechnol. 2018, 9, 1964–1976, doi:10.3762/bjnano.9.187

• transmission line with broadband spectral characteristics. This asset may help at increasing the bandwidth via wavelength-division multiplexing. Integrated broadband sources are also utilized in photonic sensing chips [57] or to command non-classical secondary photon sources [58]. There is thus a demand for

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

• Nagamalai Vasimalai,
• Vânia Vilas-Boas,
• Juan Gallo,
• María de Fátima Cerqueira,
• Mario Menéndez-Miranda,
• José Manuel Costa-Fernández,
• Lorena Diéguez,
• Begoña Espiña and
• María Teresa Fernández-Argüelles

Beilstein J. Nanotechnol. 2018, 9, 530–544, doi:10.3762/bjnano.9.51

• , multiplexing capabilities, cost-effectiveness and ease of use [1]. Although inorganic semiconductor quantum dots are the most widely studied fluorescent nanoparticles in bioimaging, biosensing and drug delivery applications, carbon-based ultra-small nanoparticles including carbon quantum dots (C-dots) and

Phospholipid arrays on porous polymer coatings generated by micro-contact spotting

• Sylwia Sekula-Neuner,
• Monica de Freitas,
• Lea-Marie Tröster,
• Tobias Jochum,
• Pavel A. Levkin,
• Michael Hirtz and
• Harald Fuchs

Beilstein J. Nanotechnol. 2017, 8, 715–722, doi:10.3762/bjnano.8.75

• -EDMA (Figure 4, graph). Conclusion We present a novel platform for binding studies of functional molecules based on lipid arrays embedded in a nanoporous hydrophilic polymer substrate. The microcontact spotting approach used to pattern the functional lipid inks into arrays allows for the multiplexing

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

• Claudia Koch,
• Fabian J. Eber,
• Carlos Azucena,
• Alexander Förste,
• Stefan Walheim,
• Thomas Schimmel,
• Alexander M. Bittner,
• Holger Jeske,
• Hartmut Gliemann,
• Sabine Eiben,
• Fania C. Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54

• for [SA]-GOx/[SA]-HRP in Figure 8A), which is of special interest for the construction of enzyme cascade reactions, but also for multiplexing in advanced diagnostic approaches. Finally, adsorptive deposition of densely packed rod layers and three-dimensional assemblies was achieved for different TMV

Mismatch detection in DNA monolayers by atomic force microscopy and electrochemical impedance spectroscopy

• Maryse D. Nkoua Ngavouka,
• Pietro Capaldo,
• Elena Ambrosetti,
• Giacinto Scoles,
• Loredana Casalis and
• Pietro Parisse

Beilstein J. Nanotechnol. 2016, 7, 220–227, doi:10.3762/bjnano.7.20

• microscopy [18][19], colorimetric assays [20], Raman spectroscopy [21]. However, all these state-of-the-art technologies are limited in multiplexing implementation, mutation discrimination and/or sample throughput. Therefore the field is still open for an optimization of strategies to overcome the current

• mismatched sequences. From the analysis of hybridization kinetics we distinguished the presence of single or multiple mismatches and their relative position. Both nanoarrays and EIS devices hold the premises for parallelization, multiplexing and low-volume analysis, making them amenable for point-of-care

• mismatches after precise annealing steps, as the ones used in current melting-based SNPs assays [30][31]. The novelty of our assay resides in the possibility of reducing the dimensions of the spots (below 1 μm2) and to work multiplexing in small volumes. The use of locked nucleic acids or enzyme-based

Growth and morphological analysis of segmented AuAg alloy nanowires created by pulsed electrodeposition in ion-track etched membranes

• Ina Schubert,
• Loic Burr,
• Christina Trautmann and
• Maria Eugenia Toimil-Molares

Beilstein J. Nanotechnol. 2015, 6, 1272–1280, doi:10.3762/bjnano.6.131

• microscopy [37] and fluorescence spectroscopy for bioanalysis, such as biological multiplexing [7]. Finally, by etching one elemental type of segments in metallic barcoded wires, small gaps separating the unetched (remaining) segments are being created [38][39][40], which could find applications as hot spots

Spin annihilations of and spin sifters for transverse electric and transverse magnetic waves in co- and counter-rotations

• Hyoung-In Lee and
• Jinsik Mok

Beilstein J. Nanotechnol. 2014, 5, 1887–1898, doi:10.3762/bjnano.5.199

• study is motivated in part to better understand multiplexing in wireless communications, which employs photons carrying varying angular momenta. In particular, we examine both transverse electric (TE) and transverse magnetic (TM) waves in either co-rotations or counter-rotations. To this goal, we

• momentum; multiplexing; nanoparticle; orbital; Poynting; spin; trajectory; Introduction Electromagnetic (EM) waves are now fairly well understood at least in terms of angular momentum (AM) and Poynting vector (PV). For instance, the AM of spin-one photons is divisible into the spin and orbital parts [1][2

• motivated to better understand multiplexing of EM waves in the area of wireless communications [15], which is among numerous applications of photon AM. Beams that carry different angular momenta are multiplexed, transported, and then recovered. The communication capacity is thus enhanced, although there

Molecular biology approaches in bioadhesion research

• Marcelo Rodrigues,
• Birgit Lengerer,
• Thomas Ostermann and
• Peter Ladurner

Beilstein J. Nanotechnol. 2014, 5, 983–993, doi:10.3762/bjnano.5.112

• performed [24][25]. Size range selection is performed (about 200 bp) followed by a PCR based amplification step before the library is subjected to next generation (NGS) sequencing. After the raw reads are obtained, bioinformatic data analysis including de-multiplexing, artefact removal and error correction

Porous polymer coatings as substrates for the formation of high-fidelity micropatterns by quill-like pens

• Michael Hirtz,
• Marcus Lyon,
• Wenqian Feng,
• Andrea E. Holmes,
• Harald Fuchs and
• Pavel A. Levkin

Beilstein J. Nanotechnol. 2013, 4, 377–384, doi:10.3762/bjnano.4.44

• minute. However, technically the writing speed can be increased by the use of cantilever arrays, with the added option of intrinsic multiplexing [10]. Comparison of substrates First, we compared four different substrate systems (i.e., plain paper, nylon membrane, nitrocellulose, and a HEMA porous polymer

Magnetic nanoparticles for biomedical NMR-based diagnostics

• Huilin Shao,
• Tae-Jong Yoon,
• Monty Liong,
• Ralph Weissleder and
• Hakho Lee

Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17

• a low cell count (~1000 cells per sample), parallel DMR measurements could be performed rapidly [53]. As a universal labeling approach, BOND-2 simplifies the preparation of the targeted MNPs for multiplexing and amplifies nanoparticle binding to cells. Using the μNMR device with a solenoidal coil