Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation

• Braham Dutt Arya,
• Sandeep Mittal,
• Prachi Joshi,
• Alok Kumar Pandey,
• Jaime E. Ramirez-Vick,
• Govind Gupta and
• Surinder P. Singh

Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24

• ; nanoconjugates; SQSTM1/p62; Introduction Despite of advances in basic and clinical research, an increased mortality rate is seen worldwide in cancer-associated deaths [1]. The heterogeneous and complex tumor microenvironment along with intrinsic and/or acquired drug resistance mechanisms, such as increased drug

• . The cells were seeded onto 96-well and 12-well plates, and onto 75 cm2 culture flasks, depending on the experiment, and were grown overnight. Then, fresh medium with varying concentrations (1–100 μg/mL) of GO–Chl nanoconjugates was added to the cells and incubated for a time period, which depended on

• the specific experiment. Each group contained four technical replicates and three biological replicates for each experiment. In each assay cells without nanoconjugates were used as a control. Transmission electron microscopy analysis The A549 cells (2 × 105 cells/mL/well in 6-well plates) were exposed

Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35

• molecule–polymer nanoconjugates consisting of C60 molecules and polydiacetylene nanowires at designated locations on a solid surface (Figure 2). First, diacetylene monomers were self-assembled on the solid substrate. Then, polydiacetylene nanowires were formed by chain polymerization between the monomer

• more unified materials science. Completion of materials science by nanoarchitectonics will be accelerated with the aid of computer science and technology. History and outline of the nanoarchitectonics concept. Fabrication of molecule–polymer nanoconjugates consisting of C60 molecules and

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

• Gennady L. Burygin,
• Polina I. Abronina,
• Nikita M. Podvalnyy,
• Sergey A. Staroverov,
• Leonid O. Kononov and
• Lev A. Dykman

Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39

• ], which enables the exchange of citrate ligands with amines. The amine-capped GNPs are stable enough to be used as targeting agents for drug-delivery applications [75], as antigens for the generation of antibodies [77], or as antimicrobial agents [78]. These nanoconjugates are nontoxic, effectively

• peptides/proteins). A low-molecular-mass glycan (hapten) alone, i.e., without carrier, cannot induce a cellular immune response and a possible specific immune response induced by the unconjugated hapten would be minimal and hardly detected. Fallarini et al. [113] showed that the nanoconjugates are taken up

Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

• Alina M. Ermakova,
• Julia E. Morozova,
• Yana V. Shalaeva,
• Victor V. Syakaev,
• Aidar T. Gubaidullin,
• Alexandra D. Voloshina,
• Vladimir V. Zobov,
• Irek R. Nizameev,
• Olga B. Bazanova,
• Igor S. Antipin and
• Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195

• a non-toxic amphiphilic calixresorcinarene capable to form nanoconjugates for drug encapsulation, tetraundecylcalixresorcinarene functionalized by methoxy poly(ethylene glycol) chains has been synthesized. The macrocycle obtained is characterized by low hemotoxicity. In aqueous solution it forms

Comparison of four methods for the biofunctionalization of gold nanorods by the introduction of sulfhydryl groups to antibodies

• Xuefeng Wang,
• Zhong Mei,
• Yanyan Wang and
• Liang Tang

Beilstein J. Nanotechnol. 2017, 8, 372–380, doi:10.3762/bjnano.8.39

• cationic surfactant bilayer [17][24], because of the replacement of CTAB by thiolated anti-IgG [17][25]. Anti-IgG were detected in thiolation and nanoconjugates with GNRs, but not in free GNRs, by gel electrophoresis followed by Coomassie brilliant blue staining (Figure S1, Supporting Information File 1

The role of morphology and coupling of gold nanoparticles in optical breakdown during picosecond pulse exposures

• Yevgeniy R. Davletshin and
• J. Carl Kumaradas

Beilstein J. Nanotechnol. 2016, 7, 869–880, doi:10.3762/bjnano.7.79

• spectroscopy [20][21], cell nanosurgery [19], drug release [62][63], fabrication of functional gold-antibody nanoconjugates [64] and imaging [65]. Schematic of the model geometry for a nanosphere trimer. The model contains three concentric domains. The most outer domain (grey) represents a combination of a

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

• Yue Zhang and
• Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

• ., blood–brain barrier, blood–gas barrier and blood–testis barrier). Plain nanoconjugates and nanosized vehicles are widely utilized as drug delivery tools to cross the blood–brain barrier [43]. Moreover, the translocation of gold nanoparticles through the air–blood barrier was found after a treatment with

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• carbon nanotubes-dendrimers nanoconjugates on DPPC monolayers [29]. The presence of such types of adducts did not significantly affect the properties of lipid monolayers. In conclusion, the effect of the free drug and drug attached to the potential carrier on the properties of model thiolipid monolayer

Current state of laser synthesis of metal and alloy nanoparticles as ligand-free reference materials for nano-toxicological assays

• Christoph Rehbock,
• Jurij Jakobi,
• Lisa Gamrad,
• Selina van der Meer,
• Daniela Tiedemann,
• Ulrike Taylor,
• Wilfried Kues,
• Detlef Rath and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2014, 5, 1523–1541, doi:10.3762/bjnano.5.165

• oligonucleotides [52][86], peptides [87] and proteins [68], species native to biological systems and hence omnipresent in toxicity assays. However, in situ conjugation always entails the risk that nanoconjugates are destroyed by post irradiation [88][89][90], leading to pyrolysis products with unpredictable side

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

• Paula M. Castillo,
• Mario de la Mata,
• Maria F. Casula,
• José A. Sánchez-Alcázar and
• Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

• of lactone) is retained in both USM[CPT] and USM-PEG[CPT] spectra, indicating that the chemical integrity of CPT in nanoconjugates is not affected during the formulation process. As chemical integrity of CPT is related to its biological activity, the formulations were tested in a biological setting