Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• cells. In vitro anti-inflammatory effects were evaluated by measuring nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-1β production in the same cells. The RVT-PLHNPs exhibited stronger antioxidant and anti-inflammatory activities than the free RVT solution. Apigenin Apigenin (APN

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• ]. Recent studies have also shown that ALN has a direct anti-inflammatory effect on endothelial cells. It reduces LPS-induced activation in terms of expression of cell adhesion molecules to leukocytes and increases the production of nitric oxide, reducing platelet activation [12]. According to the

• software (National Institutes of Health). NO production The nitric oxide production in HUVECs was measured by the determination of nitrite, a stable and non-volatile breakdown product of the NO released, in the incubation medium employing the spectrometric Griess reaction [12]. Briefly, cells were seeded

• caused mitochondrial membrane hyperpolarization (nanoARC(ALN) = nanoARC-Chol(ALN) > HSPC-Chol(ALN)), the same as void nanoARC (Figure 6B). (iii) Only HSPC-Chol(ALN) caused a significant reduction in ATP content (Figure 6C). After ALN-loaded nanovesicles were endocytosed by HUVECs, no increase in nitric

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• -, peroxidase (POD)-, glucose oxidase (GOx)-, and nitric oxide synthase (NOS)-like activities. More interestingly, both in vitro and in vivo experiments demonstrated that the nanocomposite spray can be activated by the diabetic foot ulcer microenvironment to accelerate diabetic wound healing through decreasing

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• hypertrophy and parasite load, chronic inflammation, fibrosis, and the levels and activities of cardiopathogenic biomarker enzymes and cytokines/chemokines (IL-1β, TNF-α, IL-6, and CCL5), matrix metalloproteinases (MMP-2 and MMP-9), and inducible enzymes (cyclooxygenase and nitric oxide synthase) implicated

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• of action of this drug against leishmaniasis. Curc inhibits the activation of nuclear factor-κB (NFκB); the production of TNFα, IFNγ, and nitric oxide; and gene expression of inducible nitric oxide synthase (iNOS) [49][51]. These pro-inflammatory factors are related to the parasitic infection of

• indicators, without evidence of nitric oxide or TNFα production [95]. In this perspective, NLCs have been a nanoscale platform with promising results aimed at encapsulating anti-leishmanial drugs. This encourages further studies to better understand how NLCs might affect the mechanisms of action of curc when

Nanomaterials for photocatalysis and applications in environmental remediation and renewable energy

• Viet Van Pham and
• Wee-Jun Ong

Beilstein J. Nanotechnol. 2023, 14, 722–724, doi:10.3762/bjnano.14.58

• fuels generates harmful emissions to the environment, such as carbon dioxide (CO2), methane (CH4), nitrous oxide (N2O), nitric oxide and nitrogen dioxide (together termed NOx), and fluorinated gases (e.g., hydrofluorocarbons, perfluorocarbons, and sulfur hexafluoride) which are currently considered

Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles

• Magdalena Lasak and
• Karol Ciepluch

Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28

• cells, the inner lining of blood vessels controls the two-way transport of molecules and ions circulating in the blood and protects the inner tissue environment from harmful and dangerous substances [1][2][3][4]. The endothelium secretes vasodilation factors (e.g., nitric oxide and prostacyclin) and

Rapid fabrication of MgO@g-C₃N₄ heterojunctions for photocatalytic nitric oxide removal

• Minh-Thuan Pham,
• Duyen P. H. Tran,
• Xuan-Thanh Bui and
• Sheng-Jie You

Beilstein J. Nanotechnol. 2022, 13, 1141–1154, doi:10.3762/bjnano.13.96

• Christian University, Taoyuan 32023, Taiwan Faculty of Environment and Natural Resources, Ho Chi Minh City University of Technology (HCMUT), VNU-HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 700000, Viet Nam 10.3762/bjnano.13.96 Abstract Nitric oxide (NO) is an air pollutant impacting the

• simple way to synthesize photocatalytic heterojunction materials with high reusability and the potential of heterojunction photocatalysts in the field of environmental remediation. Keywords: g-C3N4; MgO; nitric oxide; photocatalyst; visible light; Introduction The rapid development of industrialization

Tin dioxide nanomaterial-based photocatalysts for nitrogen oxide oxidation: a review

• Viet Van Pham,
• Hong-Huy Tran,
• Thao Kim Truong and
• Thi Minh Cao

Beilstein J. Nanotechnol. 2022, 13, 96–113, doi:10.3762/bjnano.13.7

• photocatalyst for efficient nitric oxide oxidation under visible light”, pages 655–661, Copyright (2018), with permission from Elsevier. This content is not subject to CC BY 4.0. Gaussian fit of PL spectra with inserted images of sample color of SnO2 (a) and SnO2−x (b); and proposed schematic model for

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• (caspase-9, caspase-3, and PARP) [139]. Nitric oxide has been reported to promote resistance to photodynamic therapy in cancer cells, possibly due to its vasodilation effects. It activates MMP-9 and downregulates TIMP-1, allowing CUR to contribute to reduce the resistance to photodynamic therapy by

• inhibiting nitric oxide in cancer cells [14]. Dev et al. [142] reported that CUR-loaded BSA nanoparticles (6 µM) exposed to blue LED light inhibited the growth of glioblastoma stem cells better than F-CUR, which was attributed to an improved sustained intracellular release of CUR. Curcumin-loaded PLGA [poly

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• concentration supports this conclusion [202]. Dong and colleagues prepared plasma MBs by mixing plasma gas and surfactant using an emulsification process. These MBs released the loaded drug and also generated active free radicals (including nitric oxide and hydrogen peroxide) in response to US irradiation [205

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

• Matías Guerrero Correa,
• Fernanda B. Martínez,
• Cristian Patiño Vidal,
• Camilo Streitt,
• Juan Escrig and
• Carol Lopez de Dicastillo

Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129

• increase their efficiency. Bactericidal properties of nitric-oxide-releasing Si NPs against P. aeruginosa, E. coli, S. aureus, S. epidermis, and Candida albicans were studied and the results indicated an increased antimicrobial effectiveness due to a greater amount of nitric oxide released by the Si NPs

Free-radical gases on two-dimensional transition-metal disulfides (XS₂, X = Mo/W): robust half-metallicity for efficient nitrogen oxide sensors

• Chunmei Zhang,
• Yalong Jiao,
• Fengxian Ma,
• Sri Kasi Matta,
• Steven Bottle and
• Aijun Du

Beilstein J. Nanotechnol. 2018, 9, 1641–1646, doi:10.3762/bjnano.9.156

• results also suggest XS2 (X = Mo, W) nanosheets can act as promising nanoscale NO sensors. Keywords: free radical; half-metallicity; nitric oxide (NO); sensors; spin-polarized; Introduction Nitrogen oxide (NOx) gases, one of the most common groups of air pollutants, are known as one culprit of acid rain

A review of carbon-based and non-carbon-based catalyst supports for the selective catalytic reduction of nitric oxide

• Shahreen Binti Izwan Anthonysamy,
• Syahidah Binti Afandi,
• Mehrnoush Khavarian and
• Abdul Rahman Bin Mohamed

Beilstein J. Nanotechnol. 2018, 9, 740–761, doi:10.3762/bjnano.9.68

• catalyst supports for nitric oxide (NO) removal through selective catalytic reduction (SCR) with ammonia are examined in this review. A number of carbon-based materials, such as carbon nanotubes (CNTs), activated carbon (AC), and graphene (GR) and non-carbon-based materials, such as Zeolite Socony Mobil–5

• of the SCR-NH3 catalyst are suggested. Keywords: carbon-based catalyst support; Eley–Riedeal mechanism; Langmuir–Hinshelwood mechanism; nitric oxide; non-carbon-based catalyst support; selective catalytic reduction; Review Introduction Nowadays, air pollution has become a major environmental

• active sites to readily react with NO. The synergetic effect of the metal cations present is important to increase the catalytic activity in the SCR of NO. Catalyst preparation The success of nitric oxide removal in a SCR reaction depends entirely on catalyst stability and activity [28]. The synthesis

Development of an advanced diagnostic concept for intestinal inflammation: molecular visualisation of nitric oxide in macrophages by functional poly(lactic-co-glycolic acid) microspheres

• Kathleen Lange,
• Christian Lautenschläger,
• Maria Wallert,
• Stefan Lorkowski,
• Andreas Stallmach and
• Alexander Schiller

Beilstein J. Nanotechnol. 2017, 8, 1637–1641, doi:10.3762/bjnano.8.163

• Schiller University Jena, Institute for Inorganic and Analytical Chemistry, Humboldtstr. 8, 07743 Jena, Germany 10.3762/bjnano.8.163 Abstract We here describe a new approach to visualise nitric oxide (NO) in living macrophages by fluorescent NO-sensitive microspheres based on poly(lactic-co-glycolic acid

• ; intestinal inflammation; microparticle; molecular imaging; nitric oxide; Introduction Inflammation and malignancies are fundamental aspects of many human diseases. Nitric oxide (NO) has been proposed to be an important mediator of inflammation and carcinogenesis. Chronic inflammation, as found in

• inflammatory bowel diseases, seems to be maintained by high levels of nitric oxide (NO) due to an abnormal immune response against endogenous flora and luminal antigens in genetically susceptible individuals. High levels of NO become noxious to mucosal tissue. As NO levels even correlate with severity of

NO gas sensing at room temperature using single titanium oxide nanodot sensors created by atomic force microscopy nanolithography

• Li-Yang Hong and
• Heh-Nan Lin

Beilstein J. Nanotechnol. 2016, 7, 1044–1051, doi:10.3762/bjnano.7.97

• chemisorbed oxygen ions (O2−(ads)) and nitric oxide ions (NO−(ads)) prior to UV irradiation, which are shown in Figure 7a and Figure 7b. The chemical reactions for NO are described by [20][38]: Without UV illumination, the chemisorbed ions are too stable to be removed by pumping. Under UV illumination, the

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

• Bin Song,
• Yanli Zhang,
• Jia Liu,
• Xiaoli Feng,
• Ting Zhou and
• Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

• . This was accompanied by elevated levels of ROS, MDA, constitutive nitric oxide synthase (cNOS), induced nitric oxide synthase (iNOS), and nitric oxide (NO), and inhibited activities of SOD, CAT, ascorbate peroxidase (APX), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), and AChE

The role of low-energy electrons in focused electron beam induced deposition: four case studies of representative precursors

• Rachel M. Thorman,
• Ragesh Kumar T. P.,
• D. Howard Fairbrother and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2015, 6, 1904–1926, doi:10.3762/bjnano.6.194

Manipulation of isolated brain nerve terminals by an external magnetic field using D-mannose-coated γ-Fe₂O₃ nano-sized particles and assessment of their effects on glutamate transport

• Tatiana Borisova,
• Natalia Krisanova,
• Arsenii Borуsov,
• Roman Sivko,
• Ludmila Ostapchenko,
• Michal Babic and
• Daniel Horak

Beilstein J. Nanotechnol. 2014, 5, 778–788, doi:10.3762/bjnano.5.90

• higher Ti contents in the hippocampus region. This lead to oxidative stress in the brain of exposed mice, an increase in the activity of catalase, and the excessive release of glutamic acid and nitric oxide [29]. In this study, neurotoxic effects of D-mannose-coated γ-Fe2O3 nanoparticles have been

Nanostructure sensitization of transition metal oxides for visible-light photocatalysis

• Hongjun Chen and
• Lianzhou Wang

Beilstein J. Nanotechnol. 2014, 5, 696–710, doi:10.3762/bjnano.5.82

• nitric oxide in air under visible light irradiation [28]. The same configuration of CdS photosensitized TiO2 was also used for the photocatalytic oxidation of ethanol vapour [29] and for the production of hydrogen from aqueous H2S solution under visible light [30]. In addition to TiO2 nanocrystals, 1D

The oriented and patterned growth of fluorescent metal–organic frameworks onto functionalized surfaces

• Jinliang Zhuang,
• Jasmin Friedel and
• Andreas Terfort

Beilstein J. Nanotechnol. 2012, 3, 570–578, doi:10.3762/bjnano.3.66

• MOFs have attracted great attention for sensing purposes, but also for bioimaging and biomedical applications, such as nitric oxide (NO) storage and drug delivery [9]. Several strategies have been developed to obtain control over the size and morphology of the MOF crystals, such as microwave heating

Defects in oxide surfaces studied by atomic force and scanning tunneling microscopy

• Thomas König,
• Georg H. Simon,
• Lars Heinke,
• Leonid Lichtenstein and
• Markus Heyde

Beilstein J. Nanotechnol. 2011, 2, 1–14, doi:10.3762/bjnano.2.1

• different atoms and metal clusters. Furthermore, a particular chemical activity at the APDBs has been experimentally verified. For instance, nitric oxide decomposition on thin film aluminum oxide preferentially takes place at the APDBs [52]. It has been predicted by means of DFT calculations [47] that