Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• required to produce nanoemulsions with a uniform particle size and incorporated a co-surfactant to enhance the stability of the nanoformulation. A straightforward method was proposed, involving the dilution of the preformulation in an ophthalmic vehicle, followed by homogenization through ultrasonication

• efficacy and safety for ocular administration. Keywords: eye drops; micelles; low-energy method; ophthalmic vehicle; sample dilution; stability; Introduction Dry eye disease (DED) is a multifactorial condition affecting the ocular surface, characterized by changes in tear fluid composition and/or

• conducted to determine (1) the appropriate amounts of surfactant in the pre-emulsions, (2) the nanoformulation prepared in an ophthalmic vehicle (OV), and (3) its stabilization with a co-surfactant. The formulations prepared in the OV were sterilized using a polyethersulfone (PES) membrane filter (0.22 μm