Structure-dependent thermochromism of PAZO thin films: theory and experiment

• Georgi Mateev,
• Dean Dimov,
• Nataliya Berberova-Buhova,
• Nikoleta Kircheva,
• Todor Dudev,
• Ludmila Nikolova,
• Elena Stoykova,
• Keehoon Hong,
• Dimana Nazarova,
• Silvia Angelova and
• Lian Nedelchev

Beilstein J. Nanotechnol. 2026, 17, 186–199, doi:10.3762/bjnano.17.12

• or meta-GGA functionals are desirable for geometry optimization, but considering a polymer with a realistic length would make the calculation too long and, therefore, expensive. On the other hand, the properties of the material (polymer), including crystallinity, density and solubility, are

• , therefore, long-range correction is the best strategy for enhancing the accuracy of the Kohn–Sham method in the calculations of weakly bonded systems [28]. The computations were performed with the 6-31G(d,p) basis set for all atoms [29][30]. The geometry optimization of each structure was followed by

Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• synthesis routes, and minimized toxicity. Moreover, digital twins contribute a real-time, iterative layer of validation and optimization, enabling researchers to virtually explore a variety of scenarios – from nanoparticle–protein interactions to environmental dispersion without ever having to synthesize

• and optimization of functionality, safety, and sustainability across the entire life cycle of a material, from design and production to use and disposal. Realizing this vision requires more than FAIR data principles alone; it necessitates harmonized data sheets for key toxicological and

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• incomplete uptake, are suitable adjustments in the incubation time, temperature, and NL concentration, as well as pH and ion concentrations. Optimization of these factors is essential for accurate identification of transport mechanisms, like diffusion or receptor-mediated endocytosis, also reflecting the

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• protein corona formation under physiological conditions [63]. These findings highlight the importance of surface characterization by AFM in the development and optimization of nanoparticles. 3.4 Fourier-transform infrared spectroscopy assays The FTIR spectra obtained for the formulations showed the

Geometry-controlled engineering of the low-temperature proximity effect in normal metal–superconductor junctions

• Munisa A. Tomayeva,
• Vyacheslav D. Neverov,
• Andrey V. Krasavin,
• Alexei Vagov and
• Mihail D. Croitoru

Beilstein J. Nanotechnol. 2025, 16, 2265–2273, doi:10.3762/bjnano.16.155

• interface governs the transparency of the clean NS junction and thus influences the proximity effect. These results deepen our understanding of how geometry and the proximity effect interact, which is important for the design and optimization of superconducting hybrid devices. Keywords: Bogoliubov–de

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• μg/mL in food), they emphasized performing an optimization study to reach a lower acceptable LOD for the regulatory standard [77]. Kumudha et al. characterized the HPLC peak of extracts of VB12 obtained from the green microalgae Chlorella vulgaris using MS/MS, selected ion recording, and multiple

• nanosphere lithography on a glass slide. It greatly improved the conversion of near-NIR light to UV light, achieving a notable increase in UV light intensity (i.e., six times higher at 344 nm) when stimulated with a NIR light at 980 nm using a low power density of about 13 W/cm2. The process optimization was

Electromagnetic study of a split-ring resonator metamaterial with cold-electron bolometers

• Ekaterina A. Matrozova,
• Alexander V. Chiginev,
• Leonid S. Revin and
• Andrey L. Pankratov

Beilstein J. Nanotechnol. 2025, 16, 2199–2206, doi:10.3762/bjnano.16.152

• the dynamic range and complicating the optimization of noise-equivalent power (NEP). There have been proposals to integrate multiple sensing elements directly into the structure of a log-periodic antenna [28][29][30]. While promising, such designs face significant challenges in implementation. The

• challenging to realize within the constrained geometry of a single-feed log-periodic antenna. Conclusion In this work, we have presented a comprehensive electromagnetic study on the design and optimization of a metamaterial receiver based on split-ring resonators integrated with cold-electron bolometers. The

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• in countries like India. These institutions often function as vehicles for CSR spending and tax optimization, rather than as centers of cutting-edge nanoscience. Indeed, they contribute to the perception of large-scale investment in the sector, the actual return in terms of disruptive technologies

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• for the Pt atoms and a double-zeta polarized basis set was used for all other atoms. Geometry optimization was performed with the LBFGS algorithm until all forces are converged below 0.05 eV·Å−1. The k-point density was selected to be four k-points per angstrom. In case of NEGF, the k-point density in

• h-BN with Stone–Wales defect. For graphite and bulk h-BN, we adopt a graphite unit cell with A–B stacking consisting of two layers and two atoms per layer. We perform geometry optimization, density of states (DOS) calculations, and band structure calculations. For graphite and h-BN with Stone–Wales

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• cytotoxicity and skin irritation [8]. Furthermore, the optimization of microemulsion formulations may be time-consuming and costly, and their stability is often sensitive to environmental factors (e.g., pH, salinity, and temperature). These challenges highlight the importance of a comprehensive understanding

• variability and supporting the systematic optimization of the formulation [10][12]. Therefore, the present study aimed to develop and optimize a low-surfactant microemulsion containing PEG-30 castor oil and Span® 80, based on the approach described by Dourado et al. (2022) [13], as a topical delivery system

• formulation to ensure quality consistency. Experimental design for the development and optimization of Passiflora setacea microemulsion An initial exploratory 23 full factorial applied was employed to evaluate the effects and interactions among key formulation variables (see Supporting Information File 1

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• infections dominated by this pathogen. However, their relatively weaker activity against E. coli and B. subtilis suggests that optimization may be necessary to broaden their spectrum through surface modification, particle size reduction, or combination with other antibacterial agents. Cytotoxicity of AgSbS2

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• measurements are required. Future research should prioritize a systematic parameter optimization study to establish guidelines for balancing contrast enhancement with measurement fidelity across a wide range of material systems. A particular focus should be on understanding the influence of eigenmode selection

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• due to deformation control from the FE-coupling spring but also due to interplay between molecular and continuum forces. The number of required iterations depends on the FE-coupling spring constant and should be considered during their optimization. A smaller FE-coupling spring constant leads to

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• the chromatographic separation of enantiomers. Despite these materials being highly engineered and commercially available, optimization was often done empirically. A rational design of future and improved solid phases for chiral chromatography requires that one understands how the chemical structure

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• structural integrity and effectively encapsulating a core comprising a nanoemulsion containing β-caryophyllene (NE-βCp) alongside HA. A rigorous optimization of the electrospinning process was critical, involving the systematic evaluation of key parameters. This optimization successfully identified the

• materials) [15]. However, achieving high-quality structures for biomedical use with tailored properties requires careful management of various processes, materials, and environmental parameters [16], necessitating thorough optimization of the electrospinning conditions. This includes precise control over

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• incorporated [17][18][19][20]. These findings indicate that trends in LNP characterization change by varying PEG lipids cannot be universally applied across all PEGylated LNP formulations. Rational LNP design should consider the distinct structural attributes of PEG lipid, recognizing that optimization of LNP

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• it as a quantitative, mechanistic probe that directly informs materials design and process optimization. By continuing to refine its resolution, sensitivity, and integration with complementary modalities, APXPS is positioned to contribute to pressing societal challenges, including clean energy

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• synthesis, hybrid system integration, and machine learning optimization. Together, these approaches aim to establish a comprehensive, scalable, and environmentally safe solution for the remediation of MPs in wastewater systems. Keywords: artificial intelligence; membrane technology; microplastic

• generating highly reactive radicals through techniques such as Fenton and photo-Fenton reactions, UV/H2O2 systems, ozonation, TiO2, photocatalysis, and electrochemical oxidation [53]. These methods hold potential for breaking down MPs into smaller, less harmful by products, although optimization and

• nanoparticles, enhanced through machine learning (ML) optimization, enable dual removal of MPs and organic pollutants with efficient magnetic recovery. Despite their potential, concerns remain regarding synthesis complexity, environmental safety of nanomaterials, and real-water applicability. These emerging

Few-photon microwave fields for superconducting transmon-based qudit control

• Irina A. Solovykh,
• Andrey V. Pashchenko,
• Natalya A. Maleeva,
• Nikolay V. Klenov,
• Olga V. Tikhonova and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1580–1591, doi:10.3762/bjnano.16.112

• qubits; Introduction Currently, quantum computing is under active development, opening new horizons for solving a number of problems that are difficult for classical processors, including modeling the behavior of quantum systems, optimization problems, breaking cryptographic systems, solving large

Modeling magnetic properties of cobalt nanofilms used as a component of spin hybrid superconductor–ferromagnetic structures

• Aleksey Fedotov,
• Olesya Severyukhina,
• Anastasia Salomatina and
• Anatolie Sidorenko

Beilstein J. Nanotechnol. 2025, 16, 1557–1566, doi:10.3762/bjnano.16.110

• . Due to active experimental and theoretical research on thin films, significant progress has been made in recent years. Since the information in the field of thin film technologies is updated quite rapidly, there is a need for a thorough study and optimization of the main technological processes that

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• beam shaping can be considered as an important parameter in the optimization of Si NPs synthesis in terms of morphology control of the produced NPs and as a viable approach to expand laser ablation capabilities in the field of material processing. Nanocrystalline particles of silicon were synthesized

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• ]. Unlike methods that focus on bulk transformations, this technique enables the targeted introduction and fine-tuning of specific defects, unlocking unprecedented opportunities for advanced material design and performance optimization [86]. By carefully adjusting the laser parameters, the spatial

The role of biochar in combating microplastic pollution: a bibliometric analysis in environmental contexts

• Tuan Minh Truong Dang,
• Thao Thu Thi Huynh,
• Guo-Ping Chang-Chien and
• Ha Manh Bui

Beilstein J. Nanotechnol. 2025, 16, 1401–1416, doi:10.3762/bjnano.16.102

• removal efficiency in wastewater treatment applications. Biochar synthesis techniques and functional optimization Biochar synthesis The synthesis methods for biochar, as illustrated in Figure 4, encompass traditional hydrolysis techniques and modified approaches utilizing materials such as magnetic

• magnetic biochar, further demonstrating its adaptability as a remediation tool. Despite significant progress, several critical challenges must be addressed before biochar can be widely applied for MP remediation. Optimization of surface properties remains essential to enhance removal efficiency

Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• , parylene-C encapsulation, and laser-assisted nanowire tip exposure. The nanowire electrode structure and the corresponding functionality are described. Electrochemical testing results of dopamine and glucose detection are also presented. Results and Discussion After optimization of the growth parameters