Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• played a crucial role in the successful coating of these nanoparticles, significantly increasing their zeta potential and improving cellular uptake. Moreover, εPLL-coated GNPs were found to provide robust protection for the ASOs against nuclease degradation, maintaining over 78% of the oligonucleotides

• CpG. This prolonged retention translated into potent antitumor efficacy, as PG-CpG triggered robust activation of antigen-specific CD8+ T-cell responses and significantly inhibited tumour growth. Polyamines Polyamines are among the most extensively studied polymeric materials for assisted ASO delivery

Quantification of lead through rod-shaped silver-doped zinc oxide nanoparticles using an electrochemical approach

• Ravinder Lamba,
• Gaurav Bhanjana,
• Neeraj Dilbaghi,
• Vivek Gupta and
• Sandeep Kumar

Beilstein J. Nanotechnol. 2025, 16, 422–434, doi:10.3762/bjnano.16.33

• uncomplicated method for producing Ag@ZnO NRs. These fabricated Ag@ZnO NRs play an effective role as an electron mediator in the development of lead chemical sensors which are both highly sensitive and robust in nature. Based on our current understanding, the lead sensor we developed exhibits the most notable

Engineered PEG–PCL nanoparticles enable sensitive and selective detection of sodium dodecyl sulfate: a qualitative and quantitative analysis

• Soni Prajapati and
• Ranjana Singh

Beilstein J. Nanotechnol. 2025, 16, 385–396, doi:10.3762/bjnano.16.29

• SDS detection. This rapid colorimetric response, coupled with the specificity and selectivity of the system, highlights the potential of the PEG–PCL nanoparticle-based method as a robust tool for environmental monitoring and analysis of SDS contamination. The simplicity of visual detection, alongside

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• mimicking the nanomechanical and nanostructural features of the ECM with their ability to withstand load-bearing applications, given their high porosity. Additionally, conventional electrospun fibers cannot withstand 150 MPa, which is a requirement for load-bearing applications. Thus, a more robust method

Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts

• Yunus Ahmed,
• Keya Rani Dutta,
• Parul Akhtar,
• Md. Arif Hossen,
• Md. Jahangir Alam,
• Obaid A. Alharbi,
• Hamad AlMohamadi and
• Abdul Wahab Mohammad

Beilstein J. Nanotechnol. 2025, 16, 264–285, doi:10.3762/bjnano.16.21

• materials as photocatalysts. GO has attracted interest as another metal-free carbon material, owing to its two-dimensional ultrathin layered structure, robust stability, and remarkable capacity to transport charge carriers [110]. When coupled with suitable semiconductor materials or modified to other forms

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• ablate the injected collagen opacities [122]. Cationic carbon quantum dots, known for their robust light absorption across a broad spectrum of wavelengths, have also been proven effective in breaking down collagen fibers and vitreous opacities through the VNBs generated by low-flux pulsed lasers [69][123

Probing the potential of rare earth elements in the development of new anticancer drugs: single molecule studies

• Josiane A. D. Batista,
• Rayane M. de Oliveira,
• Carlos H. M. Lima,
• Milton L. Lana Júnior,
• Virgílio C. dos Anjos,
• Maria J. V. Bell and
• Márcio S. Rocha

Beilstein J. Nanotechnol. 2025, 16, 187–194, doi:10.3762/bjnano.16.15

• extracted as well, providing robust information about the effects of the rare earths on the DNA double helix [19][16]. In addition, atomic force microscopy (AFM) imaging assays were also performed to confirm DNA compaction/condensation by erbium and neodymium, allowing for a direct visualization of these

• procedure has been proved to be very robust in determining changes in the mechanical properties of DNA–ligand complexes as a function of the ligand concentration in the sample. The complete details can be found in [21]. A model to determine the binding parameters from the persistence length data A quenched

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• excellent separation properties and robust MMM stability. One of the first MMMs developed with inorganic fillers in the context of the separation of gaseous compounds dates back to 1912 by Steinitzer [81]. Although not denoted as a MMM at the time, the material prepared by Steinitzer is a rubber comprising

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• target key signaling pathways [62]. M1 polarization in cancer therapy: Inducing or sustaining M1 polarization has proven effective in enhancing antitumor immunity. For example, chimeric antigen receptor macrophages (CAR-Ms), engineered by Klichinsky et al., sustained a robust M1 phenotype for over 40

• detached, exposing GLC and enhancing miRNA uptake by TAMs. This nanovector, sPEG/GLC/155, increased miR-155 expression in TAMs 100–400-fold, leading to a robust M1-like polarization characterized by upregulated IL-12, iNOS, and MHC II, along with reduced M2 markers such as Arg1 and Msr2. The therapy also

Modeling and simulation of carbon-nanocomposite-based gas sensors

• Roopa Hegde,
• Punya Prabha V,
• Shipra Upadhyay and
• Krishna S B

Beilstein J. Nanotechnol. 2025, 16, 90–96, doi:10.3762/bjnano.16.9

• the Langmuir isotherm model indicated good alignment, suggesting potential for accurate predictive modeling. The simulation provides an economical approach to predict the behavior of the sensor, reducing the costs associated with sensor development. Overall, these findings lay a robust groundwork for

Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258

• Prashantkumar Siddappa Chakra,
• Aishwarya Banakar,
• Shriram Narayan Puranik,
• Vishwas Kaveeshwar,
• C. R. Ravikumar and
• Devaraja Gayathri

Beilstein J. Nanotechnol. 2025, 16, 78–89, doi:10.3762/bjnano.16.8

• with data from the JCPDS card no.89-7102. Remarkably, there were no indications of any other phases, indicating a high purity of the ZnO NPs. The XRD reflections were remarkably well-defined and narrow. This signifies the distinctive crystalline arrangement, indicating a robust crystalline structure

• frequency (ω), Y, and n. The obtained results suggest robust electron transfer and enhanced electrocatalytic efficiency in dextrose oxidation [19][20][21] (Figure 5). Antibacterial activity of ZnO NPs The biogenic ZnO NPs presented a good dispersion and exhibited antibacterial activity against both Gram

• , indicating robust colloidal stability, contrasting with the moderately negative zeta potential (−15.3 mV) reported by Selvarajan and Mohanasrinivasan [24], which shows possible variations in ZnO NP characteristics, size distribution, surface modification, and experimental conditions. Nonetheless, both

Advanced atomic force microscopy techniques V

• Philipp Rahe,
• Ilko Bald,
• Nadine Hauptmann,
• Regina Hoffmann-Vogel,
• Harry Mönig and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 54–56, doi:10.3762/bjnano.16.6

• precision of scanning probe microscopy experiments by introducing a software for lateral drift correction [1]. Post-data acquisition drift correction for longer series of consecutively recorded image sets can be cumbersome and extremely time consuming. Here, the authors develop an easy-to-use and robust

• software tool (”unDrift”), which allows reliable and fast drift correction. Dickbreder et al. demonstrate the robust performance of the software tool by AFM data recorded under varying conditions (vacuum or liquid environment) on calcite surfaces with recording times up to several hours. The work by Nony

Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• simulations bridge the gap between experimental observations and mechanistic understanding. They also provide a robust framework for designing and optimizing innovative strategies for endosomal escape. Understanding these molecular interactions is akin to solving a complex puzzle, where each detail

• approaches in unraveling the complex mechanisms of intracellular trafficking. Further in vivo validation is necessary to confirm the efficacy of SO in various therapeutic nanotherapies, potentially broadening its application in nanomedicine. This work provides a robust framework for the rational design of

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• , sulfated polysaccharides and other biomolecules. The latter include flavonoids, alkaloids, steroids, phenols, and saponins with hydroxy, carboxyl, and amino functional groups, which are effective agents in metal reduction and also provide a robust coating on the metallic nanoparticles in a single step [42

The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential

• Dimitra-Danai Varsou,
• Arkaprava Banerjee,
• Joyita Roy,
• Kunal Roy,
• Giannis Savvas,
• Haralambos Sarimveis,
• Ewelina Wyrzykowska,
• Mateusz Balicki,
• Tomasz Puzyn,
• Georgia Melagraki,
• Iseult Lynch and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121

• individual models through average and weighted average, to acquire more robust and stable results. While the dataset’s extent and, consequently, the generated models’ applicability domain are rather limited, this initiative underscores the potential of synergistic approaches in the nanoinformatics field. By

• robust and accurate prediction, which individual trees cannot always provide. This algorithm constructs a forest of independent trees. Each tree is being trained on a random subset of data and features. The regressor’s output is calculated based on the average predictions from all individual trees. Some

• ensure that the model is robust and no single data point is actually responsible for the enhanced quality of fit. The performance in LOO cross-validation was assessed by calculating (leave-one-out Q2), a form of cross-validated R2 of the predictions (Equation 6) [56]. where N is the number of training

Electrochemical nanostructured CuBTC/FeBTC MOF composite sensor for enrofloxacin detection

• Thi Kim Ngan Nguyen,
• Tien Dat Doan,
• Huy Hieu Luu,
• Hoang Anh Nguyen,
• Thi Thu Ha Vu,
• Quang Hai Tran,
• Ha Tran Nguyen,
• Thanh Binh Dang,
• Thi Hai Yen Pham and
• Mai Ha Hoang

Beilstein J. Nanotechnol. 2024, 15, 1522–1535, doi:10.3762/bjnano.15.120

• from 1 to 13 µM at an accumulation time of 0 s. The linear relationship obtained is represented by the regression equation Ip (µA) = 1.225 × CENR (µM) + 0.557 (R2 = 0.9992). The consistently high correlation coefficients indicate the robust performance of the developed sensor. From the calibration

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

• and data formats with computational frameworks is crucial for effective integration and accurate prediction of materials properties. Data security and privacy are also important considerations, requiring robust security measures and adherence to data privacy regulations. Establishing secure data

• workflows, where data and information link the components at different abstraction levels [60]. The practical implementation of this kind of integration strategy requires a strong low-level integration technology involving a broad range of components [11]. Robust and efficient software infrastructures are

• . With these criteria in mind, we recently worked at the development of MAMBO, the “Materials and Molecules Basic Ontology”. MAMBO - the Materials and Molecules Basic Ontology In the context of the applications of semantic technologies, a solid ontology is the ground of a robust infrastructure. In real

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model

• Aram Shirinyan and
• Yuriy Bilogorodskyy

Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117

• deficiency in theoretical descriptions, particularly regarding thermodynamic calculations, which could elucidate the phase stability and radiation stability of nanodispersed particles under irradiation. In essence, there is a lack of robust theory to inform studies of HDCMs under irradiation. The authors

Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control

• Midhun Murali,
• Amit Banerjee and
• Tanmoy Basu

Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114

• photonic devices. Moreover, the enhancement of typically feeble light–matter interaction is enabled by robust light confinement. These characteristics can be exploited to mitigate the intrinsic limitations of photonics technologies compared to electronic and optoelectronic technologies [5]. Distributed

• ), enables a high bandwidth [33]. In short, LN emerges as an optimal candidate material for one-dimensional photonic crystal design due to its superior optical properties, robust electro-optic effect, and compatibility with integrated optical systems. Leveraging these attributes holds promise for advancing

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• observed in big-headed ants (Pheidole) offer insights into creating robust and efficient cutting tools that can perform specialized tasks with precision [71]. Other species awaiting study may possess even greater potential for fine object manipulation. For example, Probolomyrmex and Thaumatomyrmex (Figure

• the total wing area, these hooks play a crucial role in continuously transferring forces between the wings, withstanding forces up to 180 times the insect’s body weight and 40 times the aerodynamic forces encountered during flight [123]. This robust design of the coupling mechanism is essential for

• more below the surface [145]. This activity is possible through the use of legs and mouthparts with morphologies highly adapted to this task, including, for example, robust spurs (legs) and large mandibles [146][147][148]. Hence, these structures and their movements while digging may be used as bionic

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• that is rapid and affordable for the detection of heavy metal ions as well as for the degradation of organic pollutants such as 4-nitrophenol. Developing a robust sensing platform based on metal nanoparticles requires a modulation of the surface chemistry, which is governed by the choice of capping

• synthesized using wet chemical reduction, as shown in Figure 1a. A unique feature of CTAB is its robust and selective binding to certain crystal facets of metal surfaces that define the growth and nucleation of nanoparticles. CTAB on metal surfaces plays a key role in nanoparticle stabilization but hinders

• and AuNR11.0) without NaOH showed no metal detection (Supporting Information File 1, Figure S15 and Figure S16). The robust nature of CTAB on nanoparticle surfaces is well known, thus resisting the interaction with target molecules without surface modification. In our case, NaOH was used to weaken

Functional morphology of cleaning devices in the damselfly Ischnura elegans (Odonata, Coenagrionidae)

• Silvana Piersanti,
• Gianandrea Salerno,
• Wencke Krings,
• Stanislav Gorb and
• Manuela Rebora

Beilstein J. Nanotechnol. 2024, 15, 1260–1272, doi:10.3762/bjnano.15.102

• along its medially oriented side (Figure 1c–e). In the cross section, the asymmetrical and concave shape of the grooming structures was clearly visible, with a thin lamina originating from a robust seta (Figure 1f). Dirt particles tended to accumulate inside the flag-shaped structures in correspondence

A low-kiloelectronvolt focused ion beam strategy for processing low-thermal-conductance materials with nanoampere currents

• Annalena Wolff,
• Nico Klingner,
• William Thompson,
• Yinghong Zhou,
• Jinying Lin and
• Yin Xiao

Beilstein J. Nanotechnol. 2024, 15, 1197–1207, doi:10.3762/bjnano.15.97

• various ion species in bulk as well as thin samples (where ions might transmit through the sample) should be systematically investigated and evaluated with 1D and 3D models. The proposed further studies will help develop faster and more robust approaches, especially with the increase in biological and

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• quantitative descriptors. As an alternative to the most robust but computationally more expensive density functional theory (DFT) method, DFTB was used. A reference electron density ρ0 represents the sum of the neutral atomic densities [40]. Within the third-order approach DFTB3, the ground state density ρ(r

Quantum-to-classical modeling of monolayer Ge₂Se₂ and its application in photovoltaic devices

• Anup Shrivastava,
• Shivani Saini,
• Dolly Kumari,
• Sanjai Singh and
• Jost Adam

Beilstein J. Nanotechnol. 2024, 15, 1153–1169, doi:10.3762/bjnano.15.94

• promising and expedient because it has the potential to address the current energy demand without making a hazardous impact on the environment [1][2]. Henceforth, researchers have made continuous efforts to design efficient and robust PV devices and solar cells. The systematic study of various solar cells