Crystalline and amorphous structure selectivity of ignoble high-entropy alloy nanoparticles during laser ablation in organic liquids is set by pulse duration

• Robert Stuckert,
• Felix Pohl,
• Oleg Prymak,
• Ulrich Schürmann,
• Christoph Rehbock,
• Lorenz Kienle and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 1141–1159, doi:10.3762/bjnano.16.84

• constituting elements to carbon or carbon solubility [40][95][96]. Note that the degradation of solvent molecules is even higher for ps-LAL than for ns-LAL [54], meaning that the resulting structural differences in HEA NPs do not occur due to a higher availability of carbon. Diffusing carbon into a metallic

A calix[4]arene-based supramolecular nanoassembly targeting cancer cells and triggering the release of nitric oxide with green light

• Cristina Parisi,
• Loredana Ferreri,
• Tassia J. Martins,
• Francesca Laneri,
• Samantha Sollima,
• Antonina Azzolina,
• Antonella Cusimano,
• Nicola D’Antona,
• Grazia M. L. Consoli and
• Salvatore Sortino

Beilstein J. Nanotechnol. 2025, 16, 1003–1013, doi:10.3762/bjnano.16.75

• . Compound 2 and its non-nitrosated precursor 2b were characterized by 1D NMR (Figures S8,S9, Supporting Information File 1). Self-assembling and spectroscopic properties of 1 Due to the polycationic structure, compound 1 showed good water solubility as evidenced by its absorption spectrum dominated by the

Changes of structural, magnetic and spectroscopic properties of microencapsulated iron sucrose nanoparticles in saline

• Sabina Lewińska,
• Pavlo Aleshkevych,
• Roman Minikayev,
• Anna Bajorek,
• Mateusz Dulski,
• Krystian Prusik,
• Tomasz Wojciechowski and
• Anna Ślawska-Waniewska

Beilstein J. Nanotechnol. 2025, 16, 762–784, doi:10.3762/bjnano.16.59

• °, 34.03°, 35.65°, and 37.63° (marked with asterisks in Figure 4). According to [27][28], they reflect ascorbic acid present in this sample. The lack of these peaks in the pattern of the FST sample is related to the solubility of ascorbic acid in saline. The diffraction peaks (dot marks) in Figure 4

• about the solubility of calcium alginate in the solution of water and NaCl. The N 1s and C 1s lines presented in Figure 12e,f also deserve a comment. Among the substances in the sample composition, nitrogen atoms are contained in vitamins B2, B6, B12, and B9; thus, the N 1s spectrum is most probably

Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles

• Demian van Straten,
• Luuk van de Schepop,
• Rowan Frunt,
• Pieter Vader and
• Raymond M. Schiffelers

Beilstein J. Nanotechnol. 2025, 16, 740–748, doi:10.3762/bjnano.16.57

• inherent limitations of different classes of therapeutics, ranging from small molecule drugs, to biologicals such as proteins and nucleic acids. Nanoparticles can enhance the solubility and stability of their payload, prolong its circulation time, and improve its biodistribution to increase their safety

Synthesis of a multicomponent cellulose-based adsorbent for tetracycline removal from aquaculture water

• Uyen Bao Tran,
• Ngoc Thanh Vo-Tran,
• Khai The Truong,
• Dat Anh Nguyen,
• Quang Nhat Tran,
• Huu-Quang Nguyen,
• Jaebeom Lee and
• Hai Son Truong-Lam

Beilstein J. Nanotechnol. 2025, 16, 728–739, doi:10.3762/bjnano.16.56

• (–CH2COOH) groups. The introduction of carboxymethyl groups greatly enhances the water solubility of CMC relative to that of cellulose. CMC, recognized as one of the most promising cellulose derivatives, was first synthesized in 1918 [18]. Owing to its unique surface properties, high mechanical strength

• approximately 0.1. A substantial decrease in X4 leads to a corresponding decline in the dependent variable Y, particularly in the X1‒X4 and X3‒X4 interactions. This effect arises because a reduction in X4 decreases water solubility and hinders the formation of a homogeneous cellulose mixture. Additionally

• hydroxy groups interact with the functional groups of the cross-linking agent, reducing the polymer’s water solubility while increasing its stiffness and chemical stability [35][36]. Glutaraldehyde (GA), a linear five-carbon dialdehyde, is regarded as a more effective cross-linking agent compared to

Efficiency of single-pulse laser fragmentation of organic nutraceutical dispersions in a circular jet flow-through reactor

• Tina Friedenauer,
• Maximilian Spellauge,
• Alexander Sommereyns,
• Verena Labenski,
• Tuba Esatbeyoglu,
• Christoph Rehbock,
• Heinz P. Huber and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 711–727, doi:10.3762/bjnano.16.55

• nutraceuticals aiming at solubility enhancements. However, current discontinuously operated fragmentation setups suffer from chemical degradation by multipulse laser excitation at high fluence and do not allow for systematic studies of the fragmentation mechanisms. In this work, continuous-flow microparticle

• goes along with an elevated specific surface area that improves solubility and bioavailability of these nutraceuticals. Consequently, the amount of degradation products per generated surface area within one laser passage is a particularly interesting assessment criterion for process efficiency

• . Moreover, the created surface area is also a descriptor highly relevant for application (as the solubility of hydrophobic particle dispersions in water is proportional to the surface [67][68]). For simplified calculations of the total surface created by LFL, we assumed all particles to be ideal spheres

The impact of tris(pentafluorophenyl)borane hole transport layer doping on interfacial charge extraction and recombination

• Konstantinos Bidinakis and
• Stefan A. L. Weber

Beilstein J. Nanotechnol. 2025, 16, 678–689, doi:10.3762/bjnano.16.52

• )amine] (PTAA) [24]. These compounds exhibit favorable solubility, reasonable energetic alignment with most perovskites, and an amorphous nature. The main issues that arise from their usage involve poor conductivity and mechanical stability [25], the existence of pinholes, and a poor adhesion with the

• solubility in solvents orthogonal to the underlying perovskite active layer. Such an alternative compound is tris(pentafluorophenyl)borane (BCF), which is an electrophilic Lewis acid that interacts with the organic semiconductor and increases its conductivity. Here, we performed a dedicated study for the HTL

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

• Mazhar Hussain,
• Muhammad Farooq,
• Muhammad Asad Saeed,
• Muhammad Ijaz,
• Sherjeel Adnan,
• Zeeshan Masood,
• Muhammad Waqas,
• Wafa Ishaq and
• Nabeela Ameer

Beilstein J. Nanotechnol. 2025, 16, 652–663, doi:10.3762/bjnano.16.50

• , Robert Stevenson Road, Edinburgh, EH9 3FB, United Kingdom 10.3762/bjnano.16.50 Abstract Objectives of the present study are the development of aprepitant (APT)-loaded solid lipid nanoparticles (SLNs) using the polymers poloxamer 407 and β-cyclodextrin for enhanced solubility and their pharmacokinetic

• analysis. APT-loaded SLNs were prepared by the precipitation method and characterized by physicochemical studies including particle size and zeta potential measurements, drug content, encapsulation efficiency and solubility studies, Fourier-transform infrared spectroscopy (FTIR), scanning electron

• concentration of β-CD showed the highest drug solubility (93.50% ± 3.73%) in PBS (pH 7.4) and drug content (96.75% ± 0.24%); particle size, zeta potential, and polydispersity index of APT-CD-NP4 were 121.1 ± 0.72 nm, −18.8 ± 0.94 mV, and 0.15 ± 0.35, respectively. SEM analysis showed that APT was converted from

A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

• Ailton Santos Sena-Júnior,
• Cleverton Nascimento Santana Andrade,
• Pedro Henrique Macedo Moura,
• Jocsã Hémany Cândido dos Santos,
• Cauãn Torres Trancoso,
• Eloia Emanuelly Dias Silva,
• Deise Maria Rego Rodrigues Silva,
• Ênio Pereira Telles,
• Luiz André Santos Silva,
• Isabella Lima Dantas Teles,
• Sara Fernanda Mota de Almeida,
• Daniel Alves de Souza,
• Jileno Ferreira Santos,
• Felipe José Aidar Martins,
• Ana Mara de Oliveira e Silva,
• Sandra Lauton-Santos,
• Guilherme Rodolfo Souza de Araujo,
• Cristiane Bani Correa,
• Rogéria De Souza Nunes,
• Lysandro Pinto Borges and
• Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

• after in vivo administration [8]. Among these systems, microemulsions (MEs) stand out for their ability to increase the solubility, absorption, and bioavailability of lipophilic compounds such as EOs. MEs are transparent, thermodynamically stable, low-viscosity systems containing oil and water

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• , produced by silkworms, beetles, mites, and spiders [14]. Silk is an FDA-approved biomaterial for medical applications [15]. SF has distinctive physical, chemical, and mechanical properties [16]. Its characteristics, including biocompatibility, biodegradability, elasticity, solubility in water, and ease of

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• further be reduced through PEGylation, which offers significant advantages by addressing common limitations of dendrimer-based systems such as drug leakage, immunogenicity, and poor ASO solubility [144]. Patil et al. demonstrated that PAMAM-b-PEG3000-b-PLL–siRNA triblock copolymers exhibited reduced

Quantification of lead through rod-shaped silver-doped zinc oxide nanoparticles using an electrochemical approach

• Ravinder Lamba,
• Gaurav Bhanjana,
• Neeraj Dilbaghi,
• Vivek Gupta and
• Sandeep Kumar

Beilstein J. Nanotechnol. 2025, 16, 422–434, doi:10.3762/bjnano.16.33

• particularly well-suited for ZnO doping because of its notable characteristics, including strong conductivity, solubility, favorable ionic size, and low orbital energy. These features contribute to the improvement of optical and electrical characteristics of ZnO. The incorporation of silver boosts the mobility

Engineered PEG–PCL nanoparticles enable sensitive and selective detection of sodium dodecyl sulfate: a qualitative and quantitative analysis

• Soni Prajapati and
• Ranjana Singh

Beilstein J. Nanotechnol. 2025, 16, 385–396, doi:10.3762/bjnano.16.29

• and PCL to produce amphiphilic nanoparticles which possess both hydrophilic and hydrophobic segments. PEG, known for its water solubility and biocompatibility, provides the hydrophilic component, while PCL, a biodegradable polyester, contributes with hydrophobicity, enabling the formation of

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• water treatment. Table 1 shows the properties applications of chitosan that have been studied. Among the crucial factors in the electrospinning process is the solubility of the polymer [51]. Chitosan is soluble in organic acids such as diluted aqueous acetic, formic, and lactic acids, but it is

• high solubility [53]. This phenomenon makes it difficult to electrospin chitosan because of its high viscosity [54]. Moreover, the formation of strong hydrogen bonds in a 3D network contributes to difficulties in the mobility of polymeric chains when an electric field is applied [55]. Because of these

• entanglement and promoting fiber formation [58]. A summary of the applications of chitosan/PVA nanofibers is provided in Table 2. PVA is a synthetic polymer widely utilized in various industries because of its versatile properties. Its water solubility allows for a wide range of applications, while its carbon

Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts

• Yunus Ahmed,
• Keya Rani Dutta,
• Parul Akhtar,
• Md. Arif Hossen,
• Md. Jahangir Alam,
• Obaid A. Alharbi,
• Hamad AlMohamadi and
• Abdul Wahab Mohammad

Beilstein J. Nanotechnol. 2025, 16, 264–285, doi:10.3762/bjnano.16.21

• inclusion of bismuth in photocatalytic research is justified because of its limited solubility in water, which contributes to the compounds’ ecological safety. Nevertheless, Bi-based photocatalysts have certain limitations, including reduced surface area, diminished absorption efficiency, poor

Preferential enrichment and extraction of laser-synthesized nanoparticles in organic phases

• Theo Fromme,
• Maximilian L. Spiekermann,
• Florian Lehmann,
• Stephan Barcikowski,
• Thomas Seidensticker and
• Sven Reichenberger

Beilstein J. Nanotechnol. 2025, 16, 254–263, doi:10.3762/bjnano.16.20

• synthesize heterogeneous catalysts by deposition of nanoparticles, the specific nanoparticle solubility, and eventually also the colloidal stability of the individual nanoparticles, in different solvents is required [47][48]. If the colloid does not possess required properties such as colloidal stability

• (with 1-nonanol being an exception) pose a sweet spot for the “solubility” of LAL-synthesized copper nanoparticles. In this regard, the solubility of the solvents in each other cannot be neglected. The solubility of alcohol in PC and vice versa is highest for 1-hexanol and decreases with increasing

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• the structure [65]. There is also a great possibility that the changes in size and structure of CNs impact their physicochemical and biopharmaceutical properties (including solubility and permeability) [47]. The changes in the structure of the CNs after exposure to radiation were analyzed using XRPD

• indicate that chemically modified CNs are highly water soluble and that their toxicity depends on the degree of functionalization. Considering the specific targeting ligands used for dual functionalization of the CNs in the present study, aside from their effects on the solubility of CNs, one cannot

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• photothermal agents [61]. Organic small molecule dyes are easy to remove from the eye, however, they suffer from low photothermal conversion efficiency, easy photobleaching, low water solubility, and low stability [39]. Common organic small molecule dyes include cyanine dyes (e.g., indocyanine green (ICG

• molecule dyes can be modulated by intramolecular rotation or intermolecular interactions [63]. By using nanocarrier encapsulation and self-assembly strategies, the water solubility and stability of organic small molecule dyes can be improved, and photobleaching can be reduced [64]. Materials that undergo

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• size tuning, the gas solubility and diffusivity within the polymer matrix must be optimized for the specific CO2 mixed gas separation application for optimal CO2 capture [112]. Particularly, the free volume within the polymer matrix and the polymer composition determine the gas diffusivity and

• solubility through the polymer matrix of the MMM [27]. Moreover, the MOF and polymer must be sufficiently compatible to avoid the formation of defects due to poor MOF–polymer matrix interfaces [90]. Notably, in addition to the benefit of providing LBSs for CO2 adsorption described in section 2, amino

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• .16.10 Abstract In the coming decades, the development of nanocarriers (NCs) for targeted drug delivery will mark a significant advance in the field of pharmacology. NCs can improve drug solubility, ensure precise distribution, and enable passage across biological barriers. Despite these potential

• nanomedicine landscape, the design and development of nanocarriers (NCs) for precise drug delivery are a pivotal innovation. NCs address significant pharmacological challenges, such as enhancing drug solubility, ensuring specific distribution, and facilitating the crossing of biological barriers [1]. Tailoring

• such as iron and gold [4][5]. Each material is chosen for its unique properties, such as size, hydrophilicity, and charge, that make it suitable for acting as a drug carrier. NCs can be functionalized on their surface to improve the stability and solubility of high-payload encapsulated cargos, promote

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• adverse reactions. The toxicity of MNPs depends on various factors such as size, shape, structure, surface modification, concentration, dosage, biodistribution, bioavailability, solubility, immunogenicity, and pharmacokinetics [23][24]. Their use in some clinical applications is limited by low solubility

• , it can be concluded that the effects of all investigated samples on liver tissue exhibit a multifaceted character and diverse mechanisms of activity. These mechanisms depend on the size of Fe3O4 NPs, the hydrophilic shell diameter, solubility, aggregation, stability, and various other physicochemical

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• characteristics such as greater absorption capacity, greater bioavailability, controlled release of active ingredients, improved solubility of hydrophobic substances in water, and good kinetic stability [12][13][14]. Metallic nanoparticles have been investigated as a promising approach for vector control. The

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• wide range of therapeutic properties, including antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, their clinical application is often hindered by poor water solubility, low bioavailability, rapid metabolism, and instability under physiological conditions. Polymer lipid

• diseases. Keywords: bioavailability; phytochemical; polymer lipid hybrid nanoparticles; solubility; stability; surface modification; Introduction Phytochemicals are naturally occurring compounds found in plants (from the Greek word “phyton” meaning plant) [1]. These bioactive compounds are responsible

• compounds, and antimicrobials, offering a natural and multifaceted arsenal for combating a wide array of diseases [6][7][8]. Despite their promising bioactivities, the clinical application of phytochemicals is often limited by several inherent drawbacks such as poor water solubility, low bioavailability

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• approximately 30% compared to non-coated counterparts, where this derivative was chosen because of its solubility at physiological nasal pH [97]. Additionally, the powder form of the formulation showed stronger mucin adhesion and better enzymatic degradation protection [98]. Moreover, researchers developed in

Green synthesis of carbon dot structures from Rheum Ribes and Schottky diode fabrication

• Muhammed Taha Durmus and
• Ebru Bozkurt

Beilstein J. Nanotechnol. 2024, 15, 1369–1375, doi:10.3762/bjnano.15.110

• nanostructures are carbon dot structures (CDs). These structures have recently become a common field of study because of their properties including chemical stability, water solubility, and easy synthesis and functionalization. Carbon dots, were first discovered by Xu and his working group [1] while purifying