Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• polymer enables drug release by diffusion [21]. Eudragit RS30D is the 30% aqueous dispersion of Eudragit RS100, which is promptly used as coating material [22] or within formulations of drug delivery systems with sustained release characteristics [23]. Although the mucoadhesion of this polymer is known

• negatively charged alginate nanoparticles were then coated with positively charged Eudragit RS100 with the intent of obtaining mucoadhesive nanoparticles with sustained release properties. The characterization of the delivery system was studied in terms of charge, size, encapsulation efficiency, and release

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• efficient sustained release. These nanofibers also exhibit better stability, which are vital properties in drug delivery systems [183][184]. These superior properties have gained recent attention for enhancing the functional performance of chitosan-based nanofibers. Core–shell chitosan nanofibers have been

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• suitable for crossing the BBTB and targeting brain cancer cells. A biphasic drug release profile was observed for all functionalized TMZ-loaded formulations in simulated in vivo conditions, with a sustained release pointing to the potential for controlled release of TMZ in brain tumor cells. The

• the same TMZ-loaded CNs was performed using PEG1500, PEG4000, and PEG6000, sustained release over extended periods of time was also observed, with no significant difference in the drug release profile between the different PEGylated formulations. Therefore, in the current study, PEG6000 was used for

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• effectiveness [34][35]. In addition, conventional delivery systems often cannot provide controlled or sustained release of phytochemicals, leading to fluctuating plasma levels. These fluctuations can result in suboptimal therapeutic effects and increased side effects. Lack of controlled release is particularly

• yields a natural vehicle for drug delivery, and these nanocarriers can easily escape the uptake by macrophages. In this system, the drugs are encapsulated in the lipophilic polymeric core, and the lipids in the outer natural membrane enhance the sustained release of drugs. With the development of these

• . This leads to improved bioavailability and allows for sustained release of the encapsulated therapeutic agents [64][65][66]. The advantages of PEGylated PLHNPs include enhanced biocompatibility and reduced immunogenicity. The PEG layer creates a hydrophilic barrier around the nanoparticles, which

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• sustain the medicine or gene effect in targeted tissues. This sustained release of medication extends the duration of the effect of the drug, ensuring optimal treatment efficacy. Additionally, biopolymeric nanoparticles can carry various functional groups on their surface enabling targeted drug delivery

• NPs, yielding sustained release of the medicine and promising results as a transmucosal DDSs for hydrophobic medicines. Another enhanced cancer drug delivery system was developed by Iranian scientists. They conceived a nanoparticles-in-nanofibers DDS, which they called nano-in-nano delivery technique

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• the surface of the nanofibrous scaffolds increases the therapeutic response to the drugs by a controlled and sustained release in the targeted tissue [35]. (v) Their ability to carry different drugs in their structure reduces the risk of multidrug resistance in cancer treatment with dose-specific or

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• penetrate the highly hydrophobic membrane (Strat-M membrane) with a favorable long-term release time profile. In our study, the DCS nanocrystals in the transdermal patch provided a sustained release for six days. Moreover, the DCS nanocrystal formulation, which showed no color change, suggested the

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• augmenting their dissolution rate, and in vitro–in vivo correlation is normally applied [31]. These drugs are suitable for sustained release and controlled release formulations that provide more stable and predictable plasma levels. Drug solubility can be increased by employing strategies from classical

Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti

• Jonatas L. Duarte,
• Leonardo Delello Di Filippo,
• Anna Eliza Maciel de Faria Mota Oliveira,
• Rafael Miguel Sábio,
• Gabriel Davi Marena,
• Tais Maria Bauab,
• Cristiane Duque,
• Vincent Corbel and
• Marlus Chorilli

Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10

• myrcene or cymene in nanoemulsions led to a sustained release of the compounds, suggesting that they could potentially provide a more efficient method for delivering these compounds compared to free solutions. Furthermore, the study showed that the nanoemulsification process reduced the cytotoxicity of

• had equal or greater insecticidal properties than free terpenes and they might facilitate their dispersion in an aqueous environment. The larvicidal effect of the nanoemulsions, together with their safety and sustained release attributes, holds significant promise for environmentally friendly and

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• , the BBR NPs/PLA nanofiber scaffold had more wettability and higher concentration of BBR NPs dispersed on the surface of PLA nanofibers. This led to a sustained release of 75 wt % of the loaded BBR during the first 24 h, and consequently boosted the antibacterial effectiveness. Moreover, the

• the surface of the fibers. In addition, the reduction in the hydrophobicity of the nanofiber network also caused a faster release of the drug. Meanwhile, the hydrophobic PLA nanofiber carrier showed a sustained release behavior of the Dox-base. This was because hydrophobic Dox-base significantly

• release of BBR, combining a fast-release step of BBR from hydrophilic polypyrrolidone nanofibers (47.9 wt % in the first hour) and a sustained-release step of BBR from the insoluble cellulose acetate microparticles (98.6 wt % for 60 h). In comparison with the aforementioned hybrid nanofibers, the release

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• sustained release and caused extreme changes in parasite tegument. In vivo, nanoparticles could reduce worm load and granuloma diameter and induce new biliary ducts. Nanoformulation was more effective in adult females than in juvenile forms and adult males [92]. Following the aforementioned studies, the

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• important parameter. Tissue distribution and blood circulation Independent of the application route, blood circulation and tissue distribution are important factors regarding the fate of nanoparticles in vivo. The plasma half-life time is not only important for a sustained release but also to enhance the

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• release of CUR for 6 h. The cumulative release of CUR was 35% when dispersed in 50% ethanol in PBS at pH 7, and 7% when dispersed in RPMI 1640 medium. However, the release in PBS (pH 7.4) was less than 1% after 96 h, as shown in Figure 5. Sustained release is a desirable property in the treatment of

• % (Huh-7, Figure 6B) and 58% to 32% (MCF-7, Figure 6D). The CUR-HSA-MPs showed lower cytotoxicity than free CUR at the same drug concentrations. This could be explained by its drug delivery process, which is a common feature of polymer anticancer drugs. Enhanced and sustained release of CUR is attributed

• constant. When the CUR concentration reached the maximum of 2 mg/mL, CUR started to precipitate and form aggregates after centrifugation. This led to a miscalculation of the EE% and the absolute amount of entrapped CUR (Figure 4B). Release study of CUR from CUR-HSA-MPs CUR-HSA-MPs yielded a sustained

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• profiles (Figure 8) showed that 78% of the free drug was dissolved in the first 15 min of the experiment. In contrast, during the first 15 min only about 12% of the drug was released from the NLC formulation. An initial burst release was observed, followed by a sustained release. This phenomenon could be

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

• Santiago Grijalvo and
• Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

• %) decreased as the O/S ratio increased, and DXM-loaded PLGA nanoparticles showed dose-dependent cytotoxicity (A549 cell line) and hemolytic response. Encapsulation of DXM in PLGA nanoparticles resulted in slower and sustained release as compared to non-encapsulated DXM. Nanoemulsions formed in a 0.16 M PBS (W

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• solution, the authors proposed administering the drug in the form of a single microneedle with detachable tip, which remains in the cornea for a certain period of time, ensuring sustained release (Figure 9). Two model drugs were used, namely FITC-dextran for the determination of release profiles and

• about 90%. Moreover, due to the double compartment structure of the MNs, the rapid release of the anti-inflammatory compound (diclofenac) from the fast dissolving HA-based core provided a synergistic effect with the sustained release of DC101 from the outer layer. The authors also emphasized that it is

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

Detection and imaging of Hg(II) in vivo using glutathione-functionalized gold nanoparticles

• Gufeng Li,
• Shaoqing Li,
• Rui Wang,
• Min Yang,
• Lizhu Zhang,
• Yanli Zhang,
• Wenrong Yang and
• Hongbin Wang

Beilstein J. Nanotechnol. 2022, 13, 549–559, doi:10.3762/bjnano.13.46

• within 20 h, which indicates a sustained release of RGCOOH from the Rh6G2-loaded GNPs-GSH. Based on the experimental results, the release mechanism of GNPs-GSH-Rh6G2 by Hg2+ is illustrated in Figure 8a. Rh6G2, when conjugated with GNPs-GSH, does not exhibit fluorescence due to the closed spirolactam ring

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• the solution form of EGCG was found to be significantly lower with nanoformulations. It is thought that this low inhibition failed to maintain the efficacy of the solution form throughout the experiment, whereas sustained release formulations provided higher inhibition. Previous studies have proven

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• chondrogenesis of MSCs and cartilage regeneration, which should be performed over a period of several days or weeks. However, a few of the proposed methods achieved the prolonged sustained release of bioactive molecules. For example, low molecular weight polyethyleneimine precoated poly(lactide-co-glycolide

• , microsphere structures can be independently used as carriers for the delivery of drugs and bioactive molecules to repair cartilage defects. The sustained release of PTH (1-34) from PLGA microspheres improved papain-induced defects in a rat model of OA and retained the bioactivity of the released peptide up to

• cells. The incorporation of NPs loaded with bioactive agents in hydrogels has a tremendous impact on the properties and functionality of tissue-engineered scaffolds. In addition to providing sustained release properties, which is a major challenge in TE programs, the incorporation of NPs can improve the

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• , were also used to improve the titania implant properties, and the material showed significant antibacterial activity against Staphylococcus aureus with sustained release of vancomycin [64]. Furthermore, the biological activity of TiO2 nanowires, nanofibres, and nanoneedles, was investigated and

• hindrance inside the tubular structure. This stage of drug release is known as sustained release. The controlled release of drugs is triggered by various external or internal stimuli. Changes in pH value, redox reactions, and enzyme activity are internal stimuli, while light, magnetic fields, and ultrasound

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• of nanosystems, precise drug delivery, and sustained release support their recommendation to be used as a drug delivery mechanism to induce apoptosis due to hyperthermia (41.85 °C) [136] and higher drug concentration at the target site [138]. Photodynamic nanosystems. Photodynamic therapy is based on

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation

• Shuoye Yang,
• Zhenwei Wang,
• Yahong Ping,
• Yuying Miao,
• Yongmei Xiao,
• Lingbo Qu,
• Lu Zhang,
• Yuansen Hu and
• Jinshui Wang

Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155

• leakage of drug molecules is prevented, leading to a sustained release. Here, the release of DOX from CNT carriers was investigated in PBS at different pH values. Figure 6 shows the release curves of DOX from different drug-loaded CNTs. CNTs-COOH and CNTs-PEG exhibit a gradual release of DOX in PBS at pH

• [30] exhibited sustained release at pH 7.4, and responsive release under relatively acidic condition, which was similar to our results. In this study, a series of experimental observations with MCF-7 cells were conducted and the results verify the delivery capacity and in vitro antitumor activity