Nanomedicine is the research field dedicated to the application of nanotechnology in the medical field by combining nano- and biomaterials to improve drug delivery and address the diagnosis and treatment of complex pathologies. One of the main goals of this research field is to enhance drug efficacy while minimizing side effects. Some strategies, such as modification of interface properties and functionalization of drug delivery systems improve the properties of drug delivery systems for precision medicine. Research efforts are also focused on the identification of factors affecting drug targeting and efficacy. New strategies, such as stimuli-responsive materials and endogenous targeting, are emerging to overcome current barriers in drug delivery. With respect to targeting, passive targeting, takes advantage of the permeability of tumor blood vessels to accumulate in tumor tissue, thus it is a common approach in nanomedicine for cancer therapy. Active targeting involves functionalizing nanomedicines with ligands to specifically recognize targeted areas.

The main goals of this thematic issue are to collect contributions emerging from the Beilstein Nanomedicine Symposium (taking place in September 3–5, 2024, Rüdesheim, Germany) and also to allow for submissions of worldwide pre-clinical research in several topics of nanomedicine.

Contributions to this thematic issue are invited, including (but not limited to):

• Advances of nanomedicines and their potential in precise targeting therapies.
• Personalized medicine and reliable pre-clinical assessments.
• Synthesis and functionalization of nanobiomaterials.
• Nanotechnology applied to therapy and medical diagnostics.
• Pharmaceutical nanotechnology.

Submission deadline: February 28, 2025