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Beilstein J. Org. Chem. 2024, 20, 3191–3197, doi:10.3762/bjoc.20.264
Graphical Abstract
Scheme 1: Approaches to 2H-azirine-2,2-dicarboxylic acid derivatives.
Scheme 2: Synthesis of 2H-azirine-2,2-dicarboxylic acids 6.
Scheme 3: Transformations of 3-(tert-butyl)-5-chloroisoxazole-4-carbonyl chloride (1j).
Scheme 4: Synthesis of amides 10. aFiltration through celite after reaction with amine (without aqueous worku...
Scheme 5: Synthesis of esters 11.
Scheme 6: Synthesis of dicarbonyl azide 12.