Catalysing (organo-)catalysis: Trends in the application of machine learning to enantioselective organocatalysis

• Stefan P. Schmid,
• Leon Schlosser,
• Frank Glorius and
• Kjell Jorner

Beilstein J. Org. Chem. 2024, 20, 2280–2304, doi:10.3762/bjoc.20.196

• physical organic chemistry with data-driven analysis techniques, in particular MLR, to gain a greater understanding of the enantioselectivity-determining steps for a C–N coupling catalysed by CPA derivatives (Figure 15A) [143]. Based on their findings that π–π interactions between the catalyst’s triazole

Introducing a new 7-ring fused diindenone-dithieno[3,2-b:2',3'-d]thiophene unit as a promising component for organic semiconductor materials

• Valentin H. K. Fell,
• Joseph Cameron,
• Alexander L. Kanibolotsky,
• Eman J. Hussien and
• Peter J. Skabara

Beilstein J. Org. Chem. 2022, 18, 944–955, doi:10.3762/bjoc.18.94

• Valentin H. K. Fell Joseph Cameron Alexander L. Kanibolotsky Eman J. Hussien Peter J. Skabara WestCHEM, School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow, G12 8QQ, Scotland Institute of Physical-Organic Chemistry and Coal Chemistry, 02160 Kyiv, Ukraine

Mechanistic studies of the solvolysis of alkanesulfonyl and arenesulfonyl halides

• Malcolm J. D’Souza and
• Dennis N. Kevill

Beilstein J. Org. Chem. 2022, 18, 120–132, doi:10.3762/bjoc.18.13

• acknowledged, in his participation as a co-author of a chapter in “Progress in Physical Organic Chemistry” [31], that this equilibrium needs to be incorporated into treatments based on the magnitudes of the heat capacities of activation (∆Cp#). The need to incorporate the return from an ion pair to a covalent

• structure to the transition state. One can in this regard quote Hammett from the second edition of his classical “Physical Organic Chemistry” text [79] “The hope, which at one time seemed bright, for a simple correlation of the solvent isotope effect with the mechanism of a reaction involving proton

Icilio Guareschi and his amazing “1897 reaction”

• Gian Cesare Tron,
• Alberto Minassi,
• Giovanni Sorba,
• Mara Fausone and
• Giovanni Appendino

Beilstein J. Org. Chem. 2021, 17, 1335–1351, doi:10.3762/bjoc.17.93

• science emphasizes focusing and prizes specialists over generalists. Nowadays, scientists "feed on one plant only", but their ancestors had a more varied diet. Zonation occurred rapidly in chemistry during the first decades of the 20th century, and Hammett, in the introduction of his Physical Organic

• Chemistry textbook, bemoaned already in 1940 that physical chemists and organic chemists proudly boasted their ignorance in one another’s discipline, with physicists considering the study of organic reactions “soapmaking” [1], a technical improvement from the status of “stamp collecting”, where Rutherford

Synthesis and optoelectronic properties of benzoquinone-based donor–acceptor compounds

• Daniel R. Sutherland,
• Nidhi Sharma,
• Georgina M. Rosair,
• Ifor D. W. Samuel,
• Ai-Lan Lee and
• Eli Zysman-Colman

Beilstein J. Org. Chem. 2019, 15, 2914–2921, doi:10.3762/bjoc.15.285

• chemistry; physical organic chemistry; spectroscopy; thermally activated delayed fluorescence; Introduction Substituted benzoquinones and derivatives [1] have generated great interest, in particular due to their redox-active nature and their importance in biological mechanisms [2]. Compounds bearing

Dyes in modern organic chemistry

• Heiko Ihmels

Beilstein J. Org. Chem. 2019, 15, 2798–2800, doi:10.3762/bjoc.15.272

• versatile photocatalysts [17][18][19]. The investigation of dyes is also at the heart of physical organic chemistry. Specifically, the seminal studies to understand the relationship between structure and color are considered highlights in chemistry and contributed significantly to the development of

Synergistic electrodeposition of bilayer films and analysis by Raman spectroscopy

• Saadeldin E. T. Elmasly,
• Luca Guerrini,
• Joseph Cameron,
• Alexander L. Kanibolotsky,
• Neil J. Findlay,
• Karen Faulds and
• Peter J. Skabara

Beilstein J. Org. Chem. 2018, 14, 2186–2189, doi:10.3762/bjoc.14.191

• Glasgow, University Place, Glasgow, G12 8QQ, UK Institute of Physical-Organic Chemistry and Coal Chemistry, 02160 Kyiv, Ukraine 10.3762/bjoc.14.191 Abstract A novel methodology towards fabrication of multilayer organic devices, employing electrochemical polymer growth to form PEDOT and PEDTT layers, is

Enhanced quantum yields by sterically demanding aryl-substituted β-diketonate ancillary ligands

• Rebecca Pittkowski and
• Thomas Strassner

Beilstein J. Org. Chem. 2018, 14, 664–671, doi:10.3762/bjoc.14.54

• Rebecca Pittkowski Thomas Strassner Physical Organic Chemistry, Technische Universität Dresden, Bergstraße, 01069 Dresden, Germany 10.3762/bjoc.14.54 Abstract Luminescent organometallic platinum(II) compounds are of interest as phosphors for organic light emitting devices. Their emissive

Preparation and isolation of isobenzofuran

• Morten K. Peters and
• Rainer Herges

Beilstein J. Org. Chem. 2017, 13, 2659–2662, doi:10.3762/bjoc.13.263

• general interest in synthetic and physical organic chemistry because it is one of the most reactive dienes known. A number of synthetic pathways have been published which all suffer from disadvantages such as low yields and difficult purification. We present a synthetic pathway to prepare isobenzofuran in

Mechanochemical N-alkylation of imides

• Anamarija Briš,
• Mateja Đud and
• Davor Margetić

Beilstein J. Org. Chem. 2017, 13, 1745–1752, doi:10.3762/bjoc.13.169

• Anamarija Bris Mateja Dud Davor Margetic Laboratory for Physical-organic Chemistry, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia 10.3762/bjoc.13.169 Abstract The mechanochemical N-alkylation of imide derivatives was studied

Thiophene-forming one-pot synthesis of three thienyl-bridged oligophenothiazines and their electronic properties

• Dominik Urselmann,
• Konstantin Deilhof,
• Bernhard Mayer and
• Thomas J. J. Müller

Beilstein J. Org. Chem. 2016, 12, 2055–2064, doi:10.3762/bjoc.12.194

• ]. Over the past one and a half decades the synthetic and physical organic chemistry of oligophenothiazines have been intensively studied in linear [45] and cyclic [46] topologies, as diphenothiazinyl dumbbells brigded by heterocycles [47][48][49], and as acceptor [50][51], ferrocenyl [52], and alkynyl

From supramolecular chemistry to the nucleosome: studies in biomolecular recognition

• Marcey L. Waters

Beilstein J. Org. Chem. 2016, 12, 1863–1869, doi:10.3762/bjoc.12.175

• first place. I had a penchant for physical organic chemistry (I wanted to know how things worked), so this was a good fit for me. I also participated in a summer NSF-REU program at Columbia University in Professor Ged Parkin’s group and got a taste of inorganic chemistry and all the fun of Schlenk line

• education! With my research experiences in physical organic chemistry and inorganic chemistry, and with the boom in organometallic research at that time, I chose to pursue mechanistic organometallic chemistry for my Ph.D. at the University of Chicago in the group of Bill Wulff. Research in the group spanned

• when I was an undergraduate. I took a graduate physical organic chemistry class from Jay Siegel, who was an assistant professor at the time. In his class, in addition to presenting the usual material, he covered recent published literature on molecular recognition that caught my attention, such as

Organic chemistry meets polymers, nanoscience, therapeutics and diagnostics

• Vincent M. Rotello

Beilstein J. Org. Chem. 2016, 12, 1638–1646, doi:10.3762/bjoc.12.161

• before heading off to Scripps. While in the Rebek group I used my synthetic abilities while gaining the insight into physical organic chemistry that has informed the rest of my career. I started out working on self-replicating systems [3], developing new systems that had novel capabilities, including

From steroids to aqueous supramolecular chemistry: an autobiographical career review

• Bruce C. Gibb

Beilstein J. Org. Chem. 2016, 12, 684–701, doi:10.3762/bjoc.12.69

• theme of the different androstane targets was the presence of a cyclopropane moiety in the A-ring. Figure 1 shows two of my favorite molecules synthesized in my work. What fascinated me about these molecules – and I now realize that this was a sign of my physical-organic chemistry leanings – was the

Art, auto-mechanics, and supramolecular chemistry. A merging of hobbies and career

• Eric V. Anslyn

Beilstein J. Org. Chem. 2016, 12, 362–376, doi:10.3762/bjoc.12.40

• , involving molecular orbital theory and the rendering of orbitals. Both Professors taught me various aspects of the art of physical organic chemistry. In addition, Dr. Dennis Dougherty welcomed me to his group meetings, where various topics of supramolecular chemistry were common. Little did either of us

• suspect we’d co-author a physical organic textbook together about 15 years later [24]. Using the combined experience from Grubbs, Goddard, and Dougherty, physical organic chemistry as applied to biological problems was a main interest, which became the topic of my post-doctoral work with Dr. Ronald

• the graduate-level textbook “Modern Physical Organic Chemistry”, co-authored with Dennis Dougherty, was the result [24]. Similarly, due to a long friendship with Brent Iverson, dating back to graduate school, the undergraduate book “Organic Chemistry” was produced [53]. Writing the graduate level

My maize and blue brick road to physical organic chemistry in materials

• Anne J. McNeil

Beilstein J. Org. Chem. 2016, 12, 229–238, doi:10.3762/bjoc.12.24

• opportunity to gain even more breadth and depth in organic chemistry. Entering graduate school at Cornell, I wanted to continue using physical organic chemistry principles to solve chemical mysteries. Although Cornell had a great selection of professors doing both fundamental and applied physical organic

• organic materials, I began to see the field of physical organic chemistry more broadly. For my postdoctoral studies, I wanted to learn more about how (macro)molecular structure influences a material’s solution and solid-state properties. I was drawn to Professor Tim Swager’s research based on his

• chemistry, I was most interested in working with Professor Dave Collum. He was known for unraveling complex mechanisms using a seemingly simple combination of kinetic, spectroscopic, and computational studies. I was fortunate, and will be forever grateful, that Dave accepted me into his group. We embarked

Life lessons

• Jonathan R. Nitschke

Beilstein J. Org. Chem. 2015, 11, 2350–2354, doi:10.3762/bjoc.11.256

• gotten in by the skin of my teeth – that I would have to work twice as hard as anyone else just to scrape through. The first year of the program was a trial by fire, involving coursework – an excellent Physical Organic Chemistry course taught by Bob Bergman stood out – teaching a laboratory section

Photoinduced 1,2,3,4-tetrahydropyridine ring conversions

• Baiba Turovska,
• Henning Lund,
• Viesturs Lūsis,
• Anna Lielpētere,
• Edvards Liepiņš,
• Sergejs Beljakovs,
• Inguna Goba and
• Jānis Stradiņš

Beilstein J. Org. Chem. 2015, 11, 2166–2170, doi:10.3762/bjoc.11.234

• Baiba Turovska Henning Lund Viesturs Lusis Anna Lielpetere Edvards Liepins Sergejs Beljakovs Inguna Goba Janis Stradins Physical-organic Chemistry Laboratory, Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., Riga LV-1006, Latvia Department of Organic Chemistry, Aarhus University

Supramolecular chemistry: from aromatic foldamers to solution-phase supramolecular organic frameworks

• Zhan-Ting Li

Beilstein J. Org. Chem. 2015, 11, 2057–2071, doi:10.3762/bjoc.11.222

• realized that this was an important research project in physical organic chemistry in China in the 1980s. After graduation from Zhengzhou University, I was assigned to work at Henan Medical University as a teaching assistant. Two years later, I was enrolled as a graduate student at SIOC, the top research

• institution for organic chemistry in China. Studying at SIOC: N···I interaction I joined SIOC in late August of 1987. For many years, graduate students in the first year studied physical organic chemistry, organic synthesis, and organic analytical chemistry. Impressively, all students performed 6–8 multistep

• where he was born. Early research at SIOC In January 1996, I returned to SIOC. Although I had hoped to continue research in fluorine chemistry, I was assigned to work for a big contract project in the laboratory of physical-organic chemistry. After finishing the contract research, I also did a small

Polythiophene and oligothiophene systems modified by TTF electroactive units for organic electronics

• Alexander L. Kanibolotsky,
• Neil J. Findlay and
• Peter J. Skabara

Beilstein J. Org. Chem. 2015, 11, 1749–1766, doi:10.3762/bjoc.11.191

• Alexander L. Kanibolotsky Neil J. Findlay Peter J. Skabara WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, United Kingdom Institute of Physical-Organic Chemistry and Coal Chemistry, 02160 Kyiv, Ukraine 10.3762/bjoc.11.191

Thiazole-induced rigidification in substituted dithieno-tetrathiafulvalene: the effect of planarisation on charge transport properties

• Rupert G. D. Taylor,
• Joseph Cameron,
• Iain A. Wright,
• Neil Thomson,
• Olena Avramchenko,
• Alexander L. Kanibolotsky,
• Anto R. Inigo,
• Tell Tuttle and
• Peter J. Skabara

Beilstein J. Org. Chem. 2015, 11, 1148–1154, doi:10.3762/bjoc.11.129

• Physical-Organic Chemistry and Coal Chemistry, 02160 Kyiv, Ukraine 10.3762/bjoc.11.129 Abstract Two novel tetrathiafulvalene (TTF) containing compounds 1 and 2 have been synthesised via a four-fold Stille coupling between a tetrabromo-dithienoTTF 5 and stannylated thiophene 6 or thiazole 4. The optical

Synthesis and properties of novel star-shaped oligofluorene conjugated systems with BODIPY cores

• Clara Orofino-Pena,
• Diego Cortizo-Lacalle,
• Joseph Cameron,
• Muhammad T. Sajjad,
• Pavlos P. Manousiadis,
• Neil J. Findlay,
• Alexander L. Kanibolotsky,
• Dimali Amarasinghe,
• Peter J. Skabara,
• Tell Tuttle,
• Graham A. Turnbull and
• Ifor D. W. Samuel

Beilstein J. Org. Chem. 2014, 10, 2704–2714, doi:10.3762/bjoc.10.285

• Strathclyde, Glasgow, G1 1XL, UK Organic Semiconductor Centre, SUPA, School of Physics & Astronomy, University of St. Andrews, St. Andrews, KY16 9SS, UK Institute of Physical-Organic Chemistry and Coal Chemistry, 83114 Donetsk, Ukraine 10.3762/bjoc.10.285 Abstract Star-shaped conjugated systems with varying

One-pot three-component synthesis and photophysical characteristics of novel triene merocyanines

• Christian Muschelknautz,
• Robin Visse,
• Jan Nordmann and
• Thomas J. J. Müller

Beilstein J. Org. Chem. 2014, 10, 599–612, doi:10.3762/bjoc.10.51

• been accessed by Knoevenagel condensations [12][13][14] or substitution reactions [15][16][17][18]. Still the quest for new synthetic strategies, novel substitution patterns, and eventually unusual properties and effects has become an ongoing challenge for organic synthesis, physical organic chemistry

The renaissance of organic radical chemistry – deja vu all over again

• Corey R. J. Stephenson,
• Armido Studer and
• Dennis P. Curran

Beilstein J. Org. Chem. 2013, 9, 2778–2780, doi:10.3762/bjoc.9.312

• in polymer and physical (especially physical organic) chemistry of radicals. In turn, the knowledge gained during Renaissance I was diverted to spark new waves of developments in neighboring disciplines such as biology and materials science. A comprehensive overview of the various aspects of modern

Thermochemistry and photochemistry of spiroketals derived from indan-2-one: Stepwise processes versus coarctate fragmentations

• Götz Bucher,
• Gernot Heitmann and
• Rainer Herges

Beilstein J. Org. Chem. 2013, 9, 1668–1676, doi:10.3762/bjoc.9.191

• study. Possible fragmentation pathways in the FVP of 1. Possible fragmentation pathways in the FVP of 2. Possible fragmentation pathways in the FVP of 3. Acknowledgements Financial support by the Deutsche Forschungsgemeinschaft and EPSRC (Glasgow Centre for Physical Organic Chemistry as part of