Acid-catalyzed rearrangements in arenes: interconversions in the quaterphenyl series

• Sarah L. Skraba-Joiner,
• Carter J. Holt and
• Richard P. Johnson

Beilstein J. Org. Chem. 2019, 15, 2655–2663, doi:10.3762/bjoc.15.258

• , even at increased reaction times. Minor products with more downfield chemical shifts were also observed via 1H NMR of these crude product mixtures; these were easily separated from quaterphenyl isomers using flash column chromatography. Analysis of the crude product mixtures by MALDI–TOF–MS confirmed

• through time-of-flight matrix assisted laser desorption ionization (MALDI–TOF–MS) mass spectrometry, using sulfur as a matrix. Suzuki–Miyaura coupling to form m,p’-quaterphenyl (13) [35]: 4-Biphenylboronic acid (0.18 g, 0.91 mmol) and 1 M K2CO3 (1.5 mL) were added to a 10 mL Pyrex microwave tube. 3

• the general rearrangement procedure. The crude product was purified via CombiFlash with hexanes to yield an off-white solid (7 mg, 70% yield) consisting of 13 (81%) and 14 (19%). Minor products were eluted with ethyl acetate. MALDI–TOF–MS analysis indicated oligomerization (m/z = 344, 673). o,m

Excited state dynamics for visible-light sensitization of a photochromic benzil-subsituted phenoxyl-imidazolyl radical complex

• Yoichi Kobayashi,
• Yukie Mamiya,
• Katsuya Mutoh,
• Hikaru Sotome,
• Masafumi Koga,
• Hiroshi Miyasaka and
• Jiro Abe

Beilstein J. Org. Chem. 2019, 15, 2369–2379, doi:10.3762/bjoc.15.229

• solvents. Mass spectra (ESI-TOF-MS) were measured by using a Bruker micrOTOFII-AGA1. All reagents were purchased from TCI, Wako Co. Ltd., Aldrich Chemical Company, Inc. and Kanto Chemical Co., Inc., and were used without further purification. The synthetic procedure of Benzil-PIC is shown in Scheme 2. The

• isomers), 7.33–7.30 (m, 4H, two structural isomers), 7.07–7.04 (m, 4H, two structural isomers), 6.73–6.69 (m, 4H, two structural isomers); ESI-TOF MS m/z: [M + H]+ calcd for C35H24N2O3: 521.1859691; found, 521.1836034. Benzil-PIC A solution of potassium ferricyanide (0.968 g, 2.94 mmol) and KOH (0.741 g

• , 1H), 7.31–7.29 (m, 2H), 7.16 (d, J = 7.7 Hz, 1H), 6.64 (d, J = 10.0 Hz, 2H), 6.36 (d, J = 10.0 Hz, 2H); ESI-TOF MS m/z: [M + H]+ calcd for C35H22N2O3, 519.1703190; found, 519.1696883. Experimental setups Steady-state measurements Steady-state absorption spectra were measured with an UV-3600 Plus

Aggregation-induced emission effect on turn-off fluorescent switching of a photochromic diarylethene

• Luna Kono,
• Yuma Nakagawa,
• Ayako Fujimoto,
• Ryo Nishimura,
• Yohei Hattori,
• Toshiki Mutai,
• Nobuhiro Yasuda,
• Kenichi Koizumi,
• Satoshi Yokojima,
• Shinichiro Nakamura and
• Kingo Uchida

Beilstein J. Org. Chem. 2019, 15, 2204–2212, doi:10.3762/bjoc.15.217

• follows: s (singlet); d (doublet); dd (double doublet); t (triplet); q (quartet); m (multiplet) and br (broad). Chemical shifts are denoted in δ (ppm) referenced to the residual protic solvent peaks. Coupling constants J are denoted in Hz. Mass spectra were recorded on a MALDI-Spiral-TOF-MS mass

Isolation of fungi using the diffusion chamber device FIND technology

• Benjamin Libor,
• Henrik Harms,
• Stefan Kehraus,
• Ekaterina Egereva,
• Max Crüsemann and
• Gabriele M. König

Beilstein J. Org. Chem. 2019, 15, 2191–2203, doi:10.3762/bjoc.15.216

• , MeOH); UV (MeOH) λmax (log ε): 203 (4.0), 261 (3.5) nm; CD (c 4.0 × 10−3 M, MeOH) λmax (Δ ε) 203 (1.33), 207 (1.21), 213 (−0.57), 321 (−0.75); IR νmax: 3648, 2930, 1706, 1683, 1558, 1540, 1507, 1435, 1376, 1237, 634 cm−1; HRESI-TOF-MS m/z: [M + H]+ calcd for C15H21O3 249.1481; found, 249.1485. For 1H

• , 1376, 1237, 1037, 634 cm−1; HRESI-TOF-MS m/z: [M + H]+ calcd for C15H23O3 251.1641; found, 251.1642. For 1H and 13C NMR data see Supporting Information File 1, Table S5. Agar diffusion assay Culture plates (5% sheep blood Columbia agar, BD) were overlaid with 3 mL tryptic soy soft agar, inoculated with

Analysis of sesquiterpene hydrocarbons in grape berry exocarp (Vitis vinifera L.) using in vivo-labeling and comprehensive two-dimensional gas chromatography–mass spectrometry (GC×GC–MS)

• Philipp P. Könen and
• Matthias Wüst

Beilstein J. Org. Chem. 2019, 15, 1945–1961, doi:10.3762/bjoc.15.190

• ) coupled to a time-of-flight mass spectrometer (TOF–MS) after headspace-solid phase microextraction (HS-SPME). The identification of structurally complex natural compounds, such as sesquiterpenes from fruits and vegetables, is often reported as “tentative”, as authentic standards are not commercially

• the unlabeled and deuterated compounds, mechanisms for sesquiterpene formation in V. vinifera could be proposed and already known pathways could be confirmed or disproved. For example, the HS-SPME–GC×GC–TOF–MS measurements of fed sample material showed that the tricyclic sesquiterpene hydrocarbons α

• -copaene, β-copaene, α-cubebene, β-cubebene and the bicyclic δ-cadinene were biosynthesized via (S)-(−)-germacrene D rather than via (R)-(+)-germacrene D as intermediate. Keywords: biosynthesis; deuterium labeling; germacrene; HS-SPME; terpenes; TOF–MS; Introduction The aroma profile of grape berries at

Bambusuril analogs based on alternating glycoluril and xylylene units

• Tomáš Lízal and
• Vladimír Šindelář

Beilstein J. Org. Chem. 2019, 15, 1268–1274, doi:10.3762/bjoc.15.124

• ESI/APCI as an ion source and a manual pump for sampling. Matrix-assisted laser desorption ionization–time-of-flight mass spectra (MALDI–TOF MS) were measured on a MALDI–TOF MS UltrafleXtreme (Bruker Daltonics) and samples were ionized with the aid of a Nd:YAG laser (355 nm) from α-cyano-4

Electrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection

• Shahien Shahsavari,
• Dhananjani N. A. M. Eriyagama,
• Bhaskar Halami,
• Vagarshak Begoyan,
• Marina Tanasova,
• Jinsen Chen and
• Shiyue Fang

Beilstein J. Org. Chem. 2019, 15, 1116–1128, doi:10.3762/bjoc.15.108

• (profile d). The purified de-tritylated ODN was further analyzed with polyacrylamide gel electrophoresis (PAGE), a single band was observed (Lane 1, Figure 5). The HPLC purified ODN was also analyzed with MALDI–TOF MS, molecular mass corresponding to correct ODN structure was found (Figure 6). The

• . The HPLC profiles of crude and pure 30c are given in Figure 4. Its PAGE and MALDI–TOF MS images are in Figure 5 and Figure 6, respectively. All analytical data for 30d,e are given in Supporting Information File 2. It is noted that aminolysis and hydrolysis of the sensitive groups in the ODNs, which

• ODN. The pure ODN was analyzed with PAGE and MALDI–TOF MS. Information about OD260 of the ODNs (30a–e) and a comparison of the synthesis yields of 30a using the dM-Dmoc (OD260 of 0.52 µmol synthesis, 2.94) and standard (OD260 of 0.52 µmol synthesis, 8.30) ODN synthesis technologies are provided in the

A simple and effective preparation of quercetin pentamethyl ether from quercetin

• Jin Tatsuzaki,
• Tomohiko Ohwada,
• Yuko Otani,
• Reiko Inagi and
• Tsutomu Ishikawa

Beilstein J. Org. Chem. 2018, 14, 3112–3121, doi:10.3762/bjoc.14.291

• the solvent peak for the 1H and 13C NMR spectra. The following abbreviations are used: s = singlet, d = doublet, t = triplet, q = quartet, dd = double doublet. Electron spray ionization time-of-flight mass spectra (ESI–TOF MS) were recorded on a Bruker micrOTOF-05 to give high-resolution mass spectra

Cross metathesis-mediated synthesis of hydroxamic acid derivatives

• Shital Kumar Chattopadhyay,
• Subhankar Ghosh and
• Suman Sil

Beilstein J. Org. Chem. 2018, 14, 3070–3075, doi:10.3762/bjoc.14.285

• (100 MHz, DMSO-d6) δ 163.4 (CO), 144.3 (C3), 136.4 (ArC), 129.2 (ArCH), 128.7 (ArCH), 121.1 (C2), 77.4 (OCH2), 31.8 (C4), 31.7 (C5), 29.3 (CH2), 29.1 (CH2), 29.0 (CH2), 28.2 (CH2), 22.6 (CH2), 14.3 (C11); HRMS (TOF MS ES+) m/z: [M + Na]+ calcd for C18H27NNaO2, 312.1939; found, 312.1956. General

• ), 29.3 (CH2), 29.1 (CH2), 28.9 (CH2), 25.5 (CH2), 22.5 (CH2), 14.3 (C11); HRMS (TOF MS ES+) m/z: [M + Na]+ calcd for C11H23NNaO2, 224.1626; found, 224.1638. Some bioactive molecules containing hydroxamate functionality. Cross metathesis between a class-I alkene and N-benzyloxyacryl amide. Hydroxamates

Reactions of 3-(p-substituted-phenyl)-5-chloromethyl-1,2,4-oxadiazoles with KCN leading to acetonitriles and alkanes via a non-reductive decyanation pathway

• Akın Sağırlı and
• Yaşar Dürüst

Beilstein J. Org. Chem. 2018, 14, 3011–3017, doi:10.3762/bjoc.14.280

• compounds were identified by means of IR, 1H NMR, 13C NMR, 2D NMR spectra, TOF–MS and X-ray measurements. Keywords: decyanation; KCN; 1,2,4-oxadiazole; Introduction Heterocyclic scaffolds bearing 1,2,4-oxadiazole rings have been the subject of an increasing and remarkable attention due to their various

Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis

• Daniel F. Sauer,
• Johannes Schiffels,
• Takashi Hayashi,
• Ulrich Schwaneberg and
• Jun Okuda

Beilstein J. Org. Chem. 2018, 14, 2861–2871, doi:10.3762/bjoc.14.265

• nm indicated the presence of the GH-type catalyst. Finally, the peak for the biohybrid conjugate was observed in ESI–TOF–MS suggesting successful covalent anchoring. Beside ring-closing metathesis (RCM) of 2,2-diallylpropane-1,3-diol to yield the corresponding cyclopentane derivative, the synthesized

• C545. Furthermore, E501 was substituted by phenylalanine to prevent coordination of the Glu side chain to the metal site and deactivation of the catalyst. Two specific TEV (Tobacco Etch Virus protease) cleavage sites were further introduced into loops 7 and 8 to facilitate MALDI–TOF–MS analysis. The

Copolymerization of epoxides with cyclic anhydrides catalyzed by dinuclear cobalt complexes

• Yo Hiranoi and
• Koji Nakano

Beilstein J. Org. Chem. 2018, 14, 2779–2788, doi:10.3762/bjoc.14.255

• spectrometry (MALDI–TOF MS, Figure 2). Several series of signals with a regular interval of 206.1 (repeating unit) were observed in the lower mass range. The m/z value of each signal of the major distribution corresponds with [166.0 (C6F5COO, initiating group) + 206.1n (repeating unit) + 59.1 (CH2CHMeOH

Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH

• Femke Beiroth,
• Tomas Koudelka,
• Thorsten Overath,
• Stefan D. Knight,
• Andreas Tholey and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2018, 14, 1890–1900, doi:10.3762/bjoc.14.163

• together with 5 mg/mL α-cyano-4-hydroxycinnamic acid (HCCA) matrix (70% ACN in 0.1% TFA solution in double distilled water). MALDI–TOF MS was performed on a AB 5800 MS (AB Sciex, Darmstadt, Germany) in positive ion mode. FimHtr FimHtr (3.36 nmol) was dissolved in PBS buffer (pH 7.8). Ligand 3 was dissolved

• –TOF mass spectrometer Bruker Biflex III with 19 kV acceleration voltage (matrix: 2,5-dihydroxybenzoic acid) and with a ESI–TOF MS spectrometer Applied Biosystems Mariner ESI–TOF 5280. UV data were obtained with the Perkin-Elmer UV–vis spectrometer Lambda 14 at 25 °C. All reactions and purification

• ), 75.4 (1C, C-5), 72.4 (1C, C-3), 72.0 (1C, C-2), 60.3 (1C, C-4), 62.6 (1C, C-6), 43.8 (1C, CH2-ethyl), 42.1 (1C, CH2-ethyl) ppm; not visible owing to slow relaxation: 2 squaric acid C=O), CF3; 19F NMR (471 MHz, MeOH-d4) δ −66.84 (s) ppm; MALDI–TOF MS m/z: 620.72 [M]+. Nα-Boc-glycin-[p-(α-D

Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniae

• Bimal Koirala,
• Robert A. Hillman,
• Erin K. Tiwold,
• Michael A. Bertucci and
• Yftah Tal-Gan

Beilstein J. Org. Chem. 2018, 14, 1769–1777, doi:10.3762/bjoc.14.151

• desorption ionization time-of-flight mass spectrometry (MALDI–TOF MS) data were obtained on either a Bruker Autoflex or Bruker Microflex spectrometer equipped with a 60 Hz nitrogen laser and a reflectron. In positive ion mode, the acceleration voltage on Ion Source 1 was 19.01 kV. Exact mass (EM) data were

• peaks with UV detection at 220 nm. Only peptide fractions that were purified to homogeneity (>95%) were used for the biological assays. TOF-MS was used to validate the presence of synthesized peptides. The observed mass-to-charge (m/z) ratio of the peptide was compared to the expected m/z ratio for each

Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion

• Susanne Huhmann,
• Anne-Katrin Stegemann,
• Kristin Folmert,
• Damian Klemczak,
• Johann Moschner,
• Michelle Kube and
• Beate Koksch

Beilstein J. Org. Chem. 2017, 13, 2869–2882, doi:10.3762/bjoc.13.279

• , reduced in vacuo and lyophilized to give the peptides as a white powder. The purity of the peptides was controlled by analytical HPLC (LUNATM C8 (2) column, 5 μm, 250 × 4.6 mm, Phenomenex®, Torrance, CA, USA), and the products were identified by high-resolution ESI–ToF–MS (see Supporting Information File

• the reaction (see Supporting Information File 1). The FA peptide was used as a reference. Each fragment cleaved from the full-length peptide was identified by ESI–ToF mass analysis on an Agilent 6220 ESI–ToF–MS spectrometer (Agilent Technologies, Santa Clara, CA, USA, see Supporting Information File 1

Synthesis of 2-aminosuberic acid derivatives as components of some histone deacetylase inhibiting cyclic tetrapeptides

• Shital Kumar Chattopadhyay,
• Suman Sil and
• Jyoti Prasad Mukherjee

Beilstein J. Org. Chem. 2017, 13, 2153–2156, doi:10.3762/bjoc.13.214

• , 32.2, 31.4, 28.3, 28.1, 23.8 ppm; HRMS (TOF–MS ES+) m/z: [M + Na]+ calcd for C18H31NNaO6, 380.2049; found, 380.2056. Biologically active naturally occurring cyclic tetrapeptide HDAC inhibitors. Reagents and conditions: (i) Triethyl phosphonoacetate, n-Bu4N+I−, aq K2CO3, rt, 18 h, 86%; (ii) H2, Pd/C

Enzymatic separation of epimeric 4-C-hydroxymethylated furanosugars: Synthesis of bicyclic nucleosides

• Neha Rana,
• Manish Kumar,
• Vinod Khatri,
• Jyotirmoy Maity and
• Ashok K. Prasad

Beilstein J. Org. Chem. 2017, 13, 2078–2086, doi:10.3762/bjoc.13.205

• , 62.25, 26.45, 26.22, 20.85; HR-ESI-TOF-MS m/z: [M + Na]+ calcd. for [C11H18O7Na]+ 285.0945, found: 285.0947, 5-O-Acetyl-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-xylofuranose (4b). It was obtained as colourless oil (1.10 g, 46% yield). Rf = 0.3 (5.0% methanol in chloroform); [α]D22 −13.85 (c 0.1, MeOH

• , 100.6 MHz) δ 170.76, 113.56, 104.64, 86.87, 79.44, 72.84, 65.70, 62.23, 26.43, 26.20, 20.84; HR-ESI-TOF-MS m/z: [M + H]+ calcd. for [C11H19O7]+ 263.1125, found 263.1130. General procedure for the tosylation of monoacetylated sugar derivatives 4a and 4b: synthesis of compounds 5 and 10. Similar as

• , 1H), 4.64 (dd, J = 5.7 and 4.2 Hz, 1H), 4.38–4.02 (m, 5H), 2.71 (d, J = 6.9 Hz, 1H), 2.41 (s, 3H), 1.99 (s, 3H), 1.42 (s, 3H), 1.31 (s, 3H); 13C NMR (CDCl3, 100.6 MHz) δ 170.34, 144.92, 132.43, 129.79, 128.10, 113.81, 104.54, 84.37, 79.31, 73.06, 68.19, 64.75, 26.20, 21.60, 20.69; HR-ESI-TOF-MS m/z

An efficient Pd–NHC catalyst system in situ generated from Na₂PdCl₄ and PEG-functionalized imidazolium salts for Mizoroki–Heck reactions in water

• Nan Sun,
• Meng Chen,
• Liqun Jin,
• Wei Zhao,
• Baoxiang Hu,
• Zhenlu Shen and
• Xinquan Hu

Beilstein J. Org. Chem. 2017, 13, 1735–1744, doi:10.3762/bjoc.13.168

• characterized by 1H NMR, 13C NMR and MALDI–TOF–MS analyses (see Supporting Information File 1). The catalytic performance of the synthesized imidazolium salts as NHC precursors for Pd-catalyzed Mizoroki–Heck reactions in water was investigated. A model reaction was carried out by using 4-bromoacetophenone (1a

• , NCH2), 3.66–3.42 (m, 196H, CH2 of PEG chain), 3.24 (s, 3H, PEG-OCH3); 13C NMR (CDCl3) δ 153.7, 149.6, 137.6, 137.3, 123.7, 123.0, 122.9, 122.7, 71.2–68.3 (CPEG), 58.1, 53.0, 49.0; MALDI–TOF–MS m/z: [Mn=49 − Br]+ calcd for C110H212N3O50, 2375.4; found, 2375.8. Imidazolium salt L2. Yield: 3.9 g (92

• , 128.7, 128.4, 123.1, 122.2, 71.34–68.2 (CPEG), 58.0, 51.7, 49.0; MALDI–TOF–MS m/z: [Mn=49 − Br]+ calcd for C111H213N2O50, 2374.4; found, 2374.8. Imidazolium salt L3. Yield: 3.8 g (88%), pale white solid; 1H NMR (DMSO-d6) δ 9.28 (s, 1H, CHimid), 8.15 (d, J = 8.0 Hz, 1H, CHAr), 8.04–8.03 (m, 2H, CHAr

2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of ß-barrel hybrid catalyst for phenylacetylene polymerization

• Julia Kinzel,
• Daniel F. Sauer,
• Marco Bocola,
• Marcus Arlt,
• Tayebeh Mirzaei Garakani,
• Andreas Thiel,
• Klaus Beckerle,
• Tino Polen,
• Jun Okuda and
• Ulrich Schwaneberg

Beilstein J. Org. Chem. 2017, 13, 1498–1506, doi:10.3762/bjoc.13.148

• -d1 was dried over calcium hydride, distilled, degassed and stored in a glove box. NMR spectra were recorded on a Bruker DRX 400 spectrometer (1H, 400.1 MHz). Chemical shifts were referenced internally by using the residual solvent resonances [50]. MALDI–TOF MS spectra were recorded on an Ultraflex

Sugar-based micro/mesoporous hypercross-linked polymers with in situ embedded silver nanoparticles for catalytic reduction

• Qing Yin,
• Qi Chen,
• Li-Can Lu and
• Bao-Hang Han

Beilstein J. Org. Chem. 2017, 13, 1212–1221, doi:10.3762/bjoc.13.120

• structures of Sug-2 and Sug-3 have been characterized by 1H NMR, 13C NMR, and MALDI–TOF MS. The chemical structure of the obtained polymers was confirmed by 13C CP/MAS NMR and Fourier transform infrared spectroscopy (FTIR) (Figure S1, Supporting Information File 1). For example, the backbone and structure

Expression, purification and structural analysis of functional GABA transporter 1 using the baculovirus expression system

• Jing Hu,
• Chris Weise,
• Christoph Böttcher,
• Hua Fan and
• Jian Yin

Beilstein J. Org. Chem. 2017, 13, 874–882, doi:10.3762/bjoc.13.88

• , and tryptic peptides were analyzed either directly by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI–TOF MS) or guanidinated and then analyzed by MALDI. The labeled peptide peaks (Figure 2B) in the mass spectrum were identified as either GAT or GFP by matching the

• -day infection by flow cytometry and fluorescence microscopy to determine the cell surface expression of the GAT1/GFP fusion proteins. MALDI mass fingerprinting Using MALDI–TOF MS, protein fragments with blocked N-termini or that are available in limited concentrations can be easily analyzed. The MALDI

Total synthesis of a Streptococcus pneumoniae serotype 12F CPS repeating unit hexasaccharide

• Peter H. Seeberger,
• Claney L. Pereira and
• Subramanian Govindan

Beilstein J. Org. Chem. 2017, 13, 164–173, doi:10.3762/bjoc.13.19

• -dimethylformamide; EtOAc: ethyl acetate; GlcA: glucouronic acid; HPLC: high-performance liquid chromatography; Lev: levulinoyl; MALDI–TOF MS: matrix-assisted laser desorption/ionization–time of flight mass spectrometry; NAP: 2-naphthylmethyl; TBS: tert-butyldimethylsilyl; THF: tetrahydrofuran; TMSOTf

Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

• Keiichi Motoyama,
• Rena Nishiyama,
• Yuki Maeda,
• Taishi Higashi,
• Yoichi Ishitsuka,
• Yuki Kondo,
• Tetsumi Irie,
• Takumi Era and
• Hidetoshi Arima

Beilstein J. Org. Chem. 2017, 13, 10–18, doi:10.3762/bjoc.13.2

• cyanotrihydroborate in dimethyl sulfoxide (DMSO) at 90 °C for 24 h. The product yield of multi-Lac-β-CD was 25%, and no unreacted compounds were confirmed by thin-layer chromatography (TLC). The MALDI–TOF MS spectrum of multi-Lac-β-CD revealed several peaks at m/z 2804, m/z 3006, m/z 3139, m/z 3296, and m/z 3454

Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934

• Veronika Ulrich,
• Clara Brieke and
• Max J. Cryle

Beilstein J. Org. Chem. 2016, 12, 2849–2864, doi:10.3762/bjoc.12.284

• Scientific, Waltham, USA) and the calculated extinction coefficient of the protein at λ = 280 nm. Furthermore, the protein identity was confirmed by MALDI–TOF MS peptide map fingerprinting of a tryptic digest of excised protein bands from SDS-PAGE analysis. StaF was finally stored in SEC buffer in aliquots

Electron-transfer-initiated benzoin- and Stetter-like reactions in packed-bed reactors for process intensification

• Anna Zaghi,
• Daniele Ragno,
• Graziano Di Carmine,
• Carmela De Risi,
• Olga Bortolini,
• Pier Paolo Giovannini,
• Giancarlo Fantin and
• Alessandro Massi

Beilstein J. Org. Chem. 2016, 12, 2719–2730, doi:10.3762/bjoc.12.268

• mode by Agilent 6520 HPLC-Chip Q/TOF-MS (nanospray) using a quadrupole, a hexapole, and a time-of-flight unit to produce spectra. The capillary source voltage was set at 1700 V; the gas temperature and drying gas were kept at 350 °C and 5 L/min, respectively. The MS analyzer was externally calibrated