Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids

• Paweł Borowiecki,
• Małgorzata Milner-Krawczyk and
• Jan Plenkiewicz

Beilstein J. Org. Chem. 2013, 9, 516–525, doi:10.3762/bjoc.9.56

• liquids to exhibit excellent antimicrobial activity, raising the possibility that ionic liquids could find application as biocidal agents in the control of microorganism growth [42][43][44][45]. Herein, we report the results of our investigation on the chemoenzymatic synthesis of new chiral ionic liquids

Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica

• Lu Zou,
• Ruixiang Blake Zheng and
• Todd L. Lowary

Beilstein J. Org. Chem. 2012, 8, 1219–1226, doi:10.3762/bjoc.8.136

• enzyme. When taken into consideration with other previously published work, it appears that this enzyme has potential utility for the chemoenzymatic synthesis of GDP-Manp analogues, which are useful probes for studying enzymes that employ this sugar nucleotide as a substrate. Keywords: chemoenzymatic

• enzyme for the chemoenzymatic synthesis of modified GDP-Manp derivatives, we describe here the preparation of all four singly methylated Manp-1P analogues 9–12, as well as the 6-deoxy-Manp-1P derivative 13, and an initial evaluation of their ability to serve as a substrate for S. enterica GDP-ManPP

• synthesis; kinetics; methylation; pyrophosphorylase; sugar nucleotide; Introduction Modified sugar nucleotide analogues are valuable probes to study glycosyltransferases and other enzymes that use these activated glycosylating agents as substrates [1][2][3][4][5]. The synthesis of natural and non-natural

Synthetic glycopeptides and glycoproteins with applications in biological research

• Ulrika Westerlind

Beilstein J. Org. Chem. 2012, 8, 804–818, doi:10.3762/bjoc.8.90

• water-soluble radical initiator VA-044 [73]. The radical-induced desulfurization method has also been applied in the total synthesis of an EPO glycoprotein analogue [69]. Another promising path to prepare homogenous glycoproteins is represented by chemoenzymatic synthesis. Both glycosyltransferases and

Chemical synthesis using enzymatically generated building units for construction of the human milk pentasaccharides sialyllacto-N-tetraose and sialyllacto-N-neotetraose epimer

• Dirk Schmidt and
• Joachim Thiem

Beilstein J. Org. Chem. 2010, 6, No. 18, doi:10.3762/bjoc.6.18

• human milk oligosaccharides are considered as soluble receptor analogues of epithelial cell surfaces [6]. Results and Discussion Previously, we reported the chemoenzymatic synthesis of the 3-sialylated lactosamine derivative 3 obtained by the enzymatic β-galactosylation of the 2-azidothioglucoside with