Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

• Zong-Bo Xie,
• Na Wang,
• Ming-Yu Wu,
• Ting He,
• Zhang-Gao Le and
• Xiao-Qi Yu

Beilstein J. Org. Chem. 2012, 8, 534–538, doi:10.3762/bjoc.8.61

• environmentally hazardous residues and undesirable byproducts [25][26][27][28][29][30]. As one part of our continuing efforts toward the development of green synthesis methods for Michael additions of nitroalkenes, we have previously reported an enzymatic tandem reaction to form 5-hydroxyimino-4,5-dihydrofurans