Beilstein J. Org. Chem.2012,8, 534–538, doi:10.3762/bjoc.8.61
environmentally hazardous residues and undesirable byproducts [25][26][27][28][29][30].
As one part of our continuing efforts toward the development of greensynthesis methods for Michael additions of nitroalkenes, we have previously reported an enzymatic tandem reaction to form 5-hydroxyimino-4,5-dihydrofurans
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Graphical Abstract
Scheme 1:
Michael addition under catalyst- and solvent-free conditions.