Polymerization of novel methacrylated anthraquinone dyes

• Christian Dollendorf,
• Susanne Katharina Kreth,
• Soo Whan Choi and
• Helmut Ritter

Beilstein J. Org. Chem. 2013, 9, 453–459, doi:10.3762/bjoc.9.48

• /cm2 2500 h) for 100 days. As an example, Figure 4 shows the transmission spectrum for the polymer containing cross-linker 6. After 100 days, no changes in the transmission spectra could be observed, which proves the monomer dye stability and is also a hint toward its biocompatibility. Mixture of

Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

• Lena Möller,
• Christian Hess,
• Jiří Paleček,
• Yi Su,
• Axel Haverich,
• Andreas Kirschning and
• Gerald Dräger

Beilstein J. Org. Chem. 2013, 9, 270–277, doi:10.3762/bjoc.9.33

• ]. Finally, TPX surfaces 8a and 8b functionalized with cRGD behaved differently regarding their cell-adhesion properties (Figure 5e and 5g). These tests strongly indicate that copper-catalyzed attachment of cRGD pentapeptides only provides a minor increase of biocompatibility, despite the fact that the

• copper-free “click” protocols on TPX surfaces. Finally, cRGD-functionalized TPX membrane surfaces showed excellent biocompatibility regarding the adhesion of endothelial cells. These studies pave the way for the development of improved, extracorporeal oxygenators. We believe that the combination of

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• cyclodextrin nanosponges in drug delivery By virtue of their biocompatibility and versatility, nanosponges have many potential applications in the pharmaceutical field. One recent EU commission report focused on the use of cyclodextrin nanosponges as a promising innovative system for drug delivery. They can be

• are a new type of biocompatible cross-linked polymer, whose production is flexible and cost-effective. Cyclodextrin nanosponges possess particular properties in terms of their encapsulation ability, biocompatibility and solubilisation capacity with regard to different types of molecules. Nanosponges

Control over molecular motion using the cis–trans photoisomerization of the azo group

• Estíbaliz Merino and
• María Ribagorda

Beilstein J. Org. Chem. 2012, 8, 1071–1090, doi:10.3762/bjoc.8.119

• does not affect cell survival, and similarly irradiation of incubated cells with LAMs not containing CPT, did not lead to cell death, thus confirming the biocompatibility of the LAMs with the cells. Molecular lift The individual molecular motion of azobenzene in the cis–trans isomerization process can

Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles

• Kathrin Fiege,
• Heinrich Lünsdorf,
• Sevil Atarijabarzadeh and
• Petra Mischnick

Beilstein J. Org. Chem. 2012, 8, 551–566, doi:10.3762/bjoc.8.63

• biocompatibility, dextrans are applied as blood-plasma expander. Dextran derivatives are used in many biomedical and bioanalytical applications [34] and are the subject of further developments in this field [35]. Therefore, we selected pullulan and dextran as candidates for a linear and a branched polysaccharide

Hyperbranched polyethylenimine bearing cyclodextrin moieties showing temperature and pH controlled dye release

• Indra Böhm,
• Susanne Katharina Kreth and
• Helmut Ritter

Beilstein J. Org. Chem. 2011, 7, 1130–1134, doi:10.3762/bjoc.7.130

• ability to release molecules in response to temperature or pH change is an important feature of new biopharmaceutical compounds [6][7][8][9][10][11]. Hyperbranched polyethylenimine (PEI) is a promising material for medical applications due to its high biocompatibility [12][13]. Active drugs bearing

ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering

• Franziska Weichelt,
• Solvig Lenz,
• Stefanie Tiede,
• Ingrid Reinhardt,
• Bernhard Frerich and
• Michael R. Buchmeiser

Beilstein J. Org. Chem. 2010, 6, 1199–1205, doi:10.3762/bjoc.6.137

• pore size and pore structure, biocompatibility, biodegradability or mechanical strength. Due to their unitary porous structure and the ease of synthesis via polymerization or consolidation processes, monolithic materials were introduced into the field of TE some years ago [6][7]. Several studies have

• scaffold materials in TE with specific properties, e.g., high mechanical strength and biocompatibility, we report here ROMP-derived cyclooctene-based monoliths reinforced with two of the most frequently used inorganic materials in nature, i.e., calcite and calcium hydroxyapatite [19], respectively. Results

• biocompatibility of the monolithic hybrid support as well as sufficient cell adhesion on the monolithic material. Conclusion COE-based monolithic scaffolds have been prepared via ROMP in the presence of two different types of inorganic nanoparticles. It was shown that variation of both the nanoparticle type and

Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels

• Andreea Pasc,
• Firmin Obounou Akong,
• Sedat Cosgun and
• Christine Gérardin

Beilstein J. Org. Chem. 2010, 6, 973–977, doi:10.3762/bjoc.6.109

• acid-based amphiphiles have been received much attention in the recent past on account of their biocompatibility and eco-friendly nature. Biologically inspired His-based surfactants are of particular interest not only for their antioxidant properties and their potential therapeutic effects, but also as

Hybrid biofunctional nanostructures as stimuli-responsive catalytic systems

• Gernot U. Marten,
• Thorsten Gelbrich and
• Annette M. Schmidt

Beilstein J. Org. Chem. 2010, 6, 922–931, doi:10.3762/bjoc.6.98

• , biocompatibility, and a tunable lower critical solution temperature (LCST) in water. The phase separation can alternatively be initiated by magnetic heating caused by magnetic losses in ac magnetic fields. The immobilization of porcine pancreas trypsin to the core–shell nanoparticles results in highly active

• heat generation, owing to its behavior in static and dynamic magnetic fields. The polymer shell is the anchor for covalent attachment of the enzyme, and allows the introduction of thermoresponsive behavior. At the same time, it improves biocompatibility and stabilization against agglomeration. Finally

• water. By proper choice of the copolymer composition, the thermoflocculation temperature of the core–shell particles can be adjusted [34][35]. The biocompatibility of poly(ethylene glycol) derivates is helpful to obtain nanoparticles acceptable for use in in vitro biological systems. The direct

Poly(glycolide) multi-arm star polymers: Improved solubility via limited arm length

• Florian K. Wolf,
• Anna M. Fischer and
• Holger Frey

Beilstein J. Org. Chem. 2010, 6, No. 67, doi:10.3762/bjoc.6.67

• polyesters such as polylactic acid (PLA) and poly(ε-caprolactone) [1] are of great interest due to their biodegradability, biocompatibility and permeability for many drugs. In contrast, poly(glycolic acid) (PGA) is scarcely used because of its high degree of crystallinity and its insolubility in all common