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Search for "perspective" in Full Text gives 223 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.
Modern flow chemistry – prospect and advantage
Beilstein J. Org. Chem. 2023, 19, 33–35, doi:10.3762/bjoc.19.3
- solutions from an engineering perspective, the advent of computer-aided design (CAD) in combination with widely available 3D printing has become a preferred choice. Prototyping aided by these technologies has significantly accelerated the development of novel flow reactor designs [14]. The challenging
Inline purification in continuous flow synthesis – opportunities and challenges
Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182
- exploited to achieve effective and reliable flow processes. This perspective article summarizes recent applications of different inline purification techniques such as chromatography, extractions, and crystallization from academic and industrial laboratories. A discussion of the advantages and drawbacks of
- these tools is provided as a guide to aid researchers in selecting the most appropriate approach for future applications. It is hoped that this perspective contributes to new developments in this field in the context of process and cost efficiency, sustainability and industrial uptake of new flow
- approaches for integrating inline purification into flow processes have been reported over the years by scientists from academic and industrial laboratories and this perspective article aims to share these whilst highlighting further opportunities and remaining challenges. Perspective As outlined above
Total synthesis of grayanane natural products
Beilstein J. Org. Chem. 2022, 18, 1707–1719, doi:10.3762/bjoc.18.181
- survey the literature for synthetic approaches to access grayanane natural products. We will focus mainly on completed total syntheses, but will also mention unfinished synthetic efforts. This work aims at providing a critical perspective on grayanane synthesis, highlighting the advantages and downsides
Redox-active molecules as organocatalysts for selective oxidative transformations – an unperceived organocatalysis field
Beilstein J. Org. Chem. 2022, 18, 1672–1695, doi:10.3762/bjoc.18.179
- perspective is shown in Scheme 1. The organocatalyzed processes in which the oxidation states of atoms at reacting centers of substrates are not changed can be called “redox-neutral” (Scheme 1, type I). This is a very large group of reactions which may be the first coming to mind when talking about
- are generally similar to those used in redox-neutral organocatalysis. These reactions are shortly discussed in the beginning of the main part of this perspective. In the second type of redox-organocatalysis redox-active molecules are used, which undergo reduction and oxidation during the catalytic
- demonstration of diversity and synthetic potential of redox-active molecules in the ground state as organocatalysts for selective oxidative transformations (Scheme 1, type III organocatalysis), as well as highlighting latest achievements in this field and perspective research trends. The discussed processes are
Navigating and expanding the roadmap of natural product genome mining tools
Beilstein J. Org. Chem. 2022, 18, 1656–1671, doi:10.3762/bjoc.18.178
- lack genes with conserved signature sequences. In this perspective, we take a closer look at state-of-the-art genome mining tools that are based on either hard-coded rules or machine learning algorithms, with an emphasis on the confidence of their predictions and potential to identify non-canonical
- metabolites is significantly larger than that of experimentally verified BGCs [20]. The accuracy of the predicted core structures on the other hand might restrict the approach. In this perspective, we will take a closer look at the most commonly used state-of-the-art genome mining tools, ranging from
- potential strategies for the targeted identification of non-canonical pathways to chart the full biosynthetic potential encoded in bacterial genomes. Perspective Natural product biosynthetic principles NPs are structurally highly diverse and can be divided into several classes depending on their
Dissecting Mechanochemistry III
Beilstein J. Org. Chem. 2022, 18, 1454–1456, doi:10.3762/bjoc.18.150
- these past initiatives encouraged us to organize Mechanochemistry III, a new Thematic Issue in which the readership of the journal will find a collection of full research papers, letters and, for the first time, a Perspective article. In more detail, the readers will find new mechanochemical protocols
On drug discovery against infectious diseases and academic medicinal chemistry contributions
Beilstein J. Org. Chem. 2022, 18, 1355–1378, doi:10.3762/bjoc.18.141
- Yves L. Janin Structure et Instabilité des Génomes (StrInG), Muséum National d'Histoire Naturelle, INSERM, CNRS, Alliance Sorbonne Université, 75005 Paris, France 10.3762/bjoc.18.141 Abstract This perspective is an attempt to document the problems that medicinal chemists are facing in drug
- pharmaceutical industry which certainly owe some of its origin to the academic world [34][35][36][37]. This perspective will not describe the true chemical challenges as well as the many environmental issues surrounding this last problem. All these are actually well described in books [38][39][40][41][42][43
- ]. This text only focuses on what happens chemistry-wise during the first two phases: hit discovery and hit to lead, since these are so far remaining within the realm of academia. Perspective Hit discovery, frequent hitters and virtual screening contributions The first problem is that the discovery of a
Make or break: the thermodynamic equilibrium of polyphosphate kinase-catalysed reactions
Beilstein J. Org. Chem. 2022, 18, 1278–1288, doi:10.3762/bjoc.18.134
- model enzymes for PPK1 and PPK2 [9][10]. From a structure perspective, PPK1 enzymes form tetramers in solution with a mass of approximately 80 kDa for the monomer (Figure 2b). Although not being an integral membrane protein, the enzyme is described to be membrane-associated [11][12][13]. The phosphate
Polymer and small molecule mechanochemistry: closer than ever
Beilstein J. Org. Chem. 2022, 18, 1225–1235, doi:10.3762/bjoc.18.128
- between these practical strategies seem to have created two seemingly distinct lines of thought within the field of mechanochemistry. However, in this Perspective article, the reader will encounter a series of studies in which some aspects believed to be inherently related to either polymer or small
- to promote the thermodynamically disfavored SN2 cleavage of an individual protein disulfide bond by poorly nucleophilic organic thiols [21]. On the other hand, as for the connection or correlation between polymer and small molecule mechanochemistry, this Perspective article discusses recent studies
Mechanochemical bottom-up synthesis of phosphorus-linked, heptazine-based carbon nitrides using sodium phosphide
Beilstein J. Org. Chem. 2022, 18, 1203–1209, doi:10.3762/bjoc.18.125
- such techniques are beneficial not only from a green chemistry perspective [11], but they also afford conditions conducive to new reactivities and the development of novel materials [9]. Previously, we have explored the synthesis of phosphorus-bridged g-CN-type materials produced from a triazine unit
Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544
Beilstein J. Org. Chem. 2022, 18, 1009–1016, doi:10.3762/bjoc.18.101
- rare class of a tricyclic 6/5/6 system, could also belong to p-terphenyl derivatives from a biosynthetic perspective. To date, more than 230 natural products containing p-terphenyl have been unearthed in nature, among them many p-terphenyls were isolated from fungi, only a few were discovered from
Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities
Beilstein J. Org. Chem. 2022, 18, 524–532, doi:10.3762/bjoc.18.54
- test systems, show EC50 values in the lower nM range [36][37][38][39]. Thus, the newly reported compounds are a valuable enrichment from the chemical perspective and have promising potential for further optimization or combination with other compounds. The structures of chloroquine, hydroxychloroquine
Anomeric 1,2,3-triazole-linked sialic acid derivatives show selective inhibition towards a bacterial neuraminidase over a trypanosome trans-sialidase
Beilstein J. Org. Chem. 2022, 18, 208–216, doi:10.3762/bjoc.18.24
- sterically hindered active site (comparison shown with black arrows – Figure 5C and Figure 5D), which in turn conferred selectivity towards the neuraminidase. From the analogues perspective, the absence of TcTS inhibition could be also attributed to the lack of flexibility of the substituents rather than
The enzyme mechanism of patchoulol synthase
Beilstein J. Org. Chem. 2022, 18, 13–24, doi:10.3762/bjoc.18.2
- of such studies are. Today 13C and 2H-labellings in conjunction with NMR and MS-based analysis can be used, with strong advantages over radioactive labellings, not only from a safety perspective, but also with respect to the ease of data interpretation. Overall, our study gives another example of
Synthesis of a novel aminobenzene-containing hemicucurbituril and its fluorescence spectral properties with ions
Beilstein J. Org. Chem. 2021, 17, 2840–2847, doi:10.3762/bjoc.17.195
- −1. In another perspective, the presence of the coordination of selected anions to the macrocyclic sensor enhanced the fluorescence emission in various degree, extremely contrary to the classic heavy-atom effect caused by a heavy atom. In general, this macrocyclic sensor showed high fluorescence
A tribute to Carsten Schmuck
Beilstein J. Org. Chem. 2021, 17, 2795–2798, doi:10.3762/bjoc.17.190
- cooked for all professors on our faculty excursions, even in the confined space of the kitchen on a traditional sailing ship! Carsten always had a view for the larger perspective. Soon he initiated talks with several institutions, which led to the establishment of three Junior Professor positions in
Synthetic strategies toward 1,3-oxathiolane nucleoside analogues
Beilstein J. Org. Chem. 2021, 17, 2680–2715, doi:10.3762/bjoc.17.182
Adjusting the length of supramolecular polymer bottlebrushes by top-down approaches
Beilstein J. Org. Chem. 2021, 17, 2621–2628, doi:10.3762/bjoc.17.175
- methods represent an easily implementable technique toward 1D polymer nanostructures with an adjustable length in the range of interest for perspective biomedical applications. Keywords: distribution; dual centrifugation; filomicelles; self-assembly; ultrasonication; Introduction Cylindrical polymer
Base-free enantioselective SN2 alkylation of 2-oxindoles via bifunctional phase-transfer catalysis
Beilstein J. Org. Chem. 2021, 17, 2287–2294, doi:10.3762/bjoc.17.146
- of HBr in these processes. The influence of steric and electronic factors from both the perspective of the nucleophile and electrophile were investigated and levels of enantiocontrol up to 90% ee obtained. The synthetic utility of the methodology was demonstrated via the concise enantioselective
Asymmetric organocatalyzed synthesis of coumarin derivatives
Beilstein J. Org. Chem. 2021, 17, 1952–1980, doi:10.3762/bjoc.17.128
- synthetic perspective, coumarin derivatives have received much attention due to their pivotal role in organic synthesis [16][17][18]. The development of efficient synthetic processes with eco-friendliness and sustainability that avoid the extensive use of toxic and hazardous reagents and solvents, as well
Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution
Beilstein J. Org. Chem. 2021, 17, 1939–1951, doi:10.3762/bjoc.17.127
- regioselectivity is absent (ratio 75:76 and 77:78 ≈ 1:1, Table 6, entries 7–9) under conditions B, most likely due to solvent-separated ion pair formation. Conclusion Both 1H- and 2H-indazoles represent a core heterocyclic motif in many therapeutic small molecule drugs. Thus, from a synthetic perspective, the
Development of N-F fluorinating agents and their fluorinations: Historical perspective
Beilstein J. Org. Chem. 2021, 17, 1752–1813, doi:10.3762/bjoc.17.123
- and reactions of these reagents are described chronologically and the review also discusses the relative fluorination power of each reagent and their mechanisms chronicling developments from a historical perspective. Keywords: N-F fluorinating agent; fluorination; fluorodiazoniabicyclo[2.2.2]octane
A systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis
Beilstein J. Org. Chem. 2021, 17, 1712–1724, doi:10.3762/bjoc.17.119
- exact test, to associate the TFs with signaling pathways [12]. Signaling pathway enrichments with adjusted p(FDR) < 0.1 were kept. A high p-value cutoff was chosen to allow users to gain a high-level perspective as to what potential pathways may be regulating enriched TFs. The connection between cell
Design, synthesis and photophysical properties of novel star-shaped truxene-based heterocycles utilizing ring-closing metathesis, Clauson–Kaas, Van Leusen and Ullmann-type reactions as key tools
Beilstein J. Org. Chem. 2021, 17, 1374–1384, doi:10.3762/bjoc.17.96
- Inspired from the available potential applications, and also bearing in mind the applicability of truxene-based materials from future perspective in addition to as a part of our major program on the synthesis of PAHs in general and functionalized truxenes in particular, our voyage for the synthesis of
Icilio Guareschi and his amazing “1897 reaction”
Beilstein J. Org. Chem. 2021, 17, 1335–1351, doi:10.3762/bjoc.17.93
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