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Search for "perspective" in Full Text gives 219 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Navigating and expanding the roadmap of natural product genome mining tools

  • Friederike Biermann,
  • Sebastian L. Wenski and
  • Eric J. N. Helfrich

Beilstein J. Org. Chem. 2022, 18, 1656–1671, doi:10.3762/bjoc.18.178

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  • lack genes with conserved signature sequences. In this perspective, we take a closer look at state-of-the-art genome mining tools that are based on either hard-coded rules or machine learning algorithms, with an emphasis on the confidence of their predictions and potential to identify non-canonical
  • metabolites is significantly larger than that of experimentally verified BGCs [20]. The accuracy of the predicted core structures on the other hand might restrict the approach. In this perspective, we will take a closer look at the most commonly used state-of-the-art genome mining tools, ranging from
  • potential strategies for the targeted identification of non-canonical pathways to chart the full biosynthetic potential encoded in bacterial genomes. Perspective Natural product biosynthetic principles NPs are structurally highly diverse and can be divided into several classes depending on their
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Perspective
Published 06 Dec 2022

Dissecting Mechanochemistry III

  • Lars Borchardt and
  • José G. Hernández

Beilstein J. Org. Chem. 2022, 18, 1454–1456, doi:10.3762/bjoc.18.150

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  • these past initiatives encouraged us to organize Mechanochemistry III, a new Thematic Issue in which the readership of the journal will find a collection of full research papers, letters and, for the first time, a Perspective article. In more detail, the readers will find new mechanochemical protocols
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Editorial
Published 12 Oct 2022

On drug discovery against infectious diseases and academic medicinal chemistry contributions

  • Yves L. Janin

Beilstein J. Org. Chem. 2022, 18, 1355–1378, doi:10.3762/bjoc.18.141

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  • Yves L. Janin Structure et Instabilité des Génomes (StrInG), Muséum National d'Histoire Naturelle, INSERM, CNRS, Alliance Sorbonne Université, 75005 Paris, France 10.3762/bjoc.18.141 Abstract This perspective is an attempt to document the problems that medicinal chemists are facing in drug
  • pharmaceutical industry which certainly owe some of its origin to the academic world [34][35][36][37]. This perspective will not describe the true chemical challenges as well as the many environmental issues surrounding this last problem. All these are actually well described in books [38][39][40][41][42][43
  • ]. This text only focuses on what happens chemistry-wise during the first two phases: hit discovery and hit to lead, since these are so far remaining within the realm of academia. Perspective Hit discovery, frequent hitters and virtual screening contributions The first problem is that the discovery of a
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Perspective
Published 29 Sep 2022

Make or break: the thermodynamic equilibrium of polyphosphate kinase-catalysed reactions

  • Michael Keppler,
  • Sandra Moser,
  • Henning J. Jessen,
  • Christoph Held and
  • Jennifer N. Andexer

Beilstein J. Org. Chem. 2022, 18, 1278–1288, doi:10.3762/bjoc.18.134

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  • model enzymes for PPK1 and PPK2 [9][10]. From a structure perspective, PPK1 enzymes form tetramers in solution with a mass of approximately 80 kDa for the monomer (Figure 2b). Although not being an integral membrane protein, the enzyme is described to be membrane-associated [11][12][13]. The phosphate
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Full Research Paper
Published 20 Sep 2022

Polymer and small molecule mechanochemistry: closer than ever

  • José G. Hernández

Beilstein J. Org. Chem. 2022, 18, 1225–1235, doi:10.3762/bjoc.18.128

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  • between these practical strategies seem to have created two seemingly distinct lines of thought within the field of mechanochemistry. However, in this Perspective article, the reader will encounter a series of studies in which some aspects believed to be inherently related to either polymer or small
  • to promote the thermodynamically disfavored SN2 cleavage of an individual protein disulfide bond by poorly nucleophilic organic thiols [21]. On the other hand, as for the connection or correlation between polymer and small molecule mechanochemistry, this Perspective article discusses recent studies
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Perspective
Published 14 Sep 2022

Mechanochemical bottom-up synthesis of phosphorus-linked, heptazine-based carbon nitrides using sodium phosphide

  • Blaine G. Fiss,
  • Georgia Douglas,
  • Michael Ferguson,
  • Jorge Becerra,
  • Jesus Valdez,
  • Trong-On Do,
  • Tomislav Friščić and
  • Audrey Moores

Beilstein J. Org. Chem. 2022, 18, 1203–1209, doi:10.3762/bjoc.18.125

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  • such techniques are beneficial not only from a green chemistry perspective [11], but they also afford conditions conducive to new reactivities and the development of novel materials [9]. Previously, we have explored the synthesis of phosphorus-bridged g-CN-type materials produced from a triazine unit
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Letter
Published 12 Sep 2022

Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544

  • Yin Chen,
  • Jinqiu Ren,
  • Ruimin Yang,
  • Jie Li,
  • Sheng-Xiong Huang and
  • Yijun Yan

Beilstein J. Org. Chem. 2022, 18, 1009–1016, doi:10.3762/bjoc.18.101

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  • rare class of a tricyclic 6/5/6 system, could also belong to p-terphenyl derivatives from a biosynthetic perspective. To date, more than 230 natural products containing p-terphenyl have been unearthed in nature, among them many p-terphenyls were isolated from fungi, only a few were discovered from
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Published 09 Aug 2022

Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities

  • Viktor A. Zapol’skii,
  • Isabell Berneburg,
  • Ursula Bilitewski,
  • Melissa Dillenberger,
  • Katja Becker,
  • Stefan Jungwirth,
  • Aditya Shekhar,
  • Bastian Krueger and
  • Dieter E. Kaufmann

Beilstein J. Org. Chem. 2022, 18, 524–532, doi:10.3762/bjoc.18.54

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  • test systems, show EC50 values in the lower nM range [36][37][38][39]. Thus, the newly reported compounds are a valuable enrichment from the chemical perspective and have promising potential for further optimization or combination with other compounds. The structures of chloroquine, hydroxychloroquine
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Published 09 May 2022

Anomeric 1,2,3-triazole-linked sialic acid derivatives show selective inhibition towards a bacterial neuraminidase over a trypanosome trans-sialidase

  • Peterson de Andrade,
  • Sanaz Ahmadipour and
  • Robert A. Field

Beilstein J. Org. Chem. 2022, 18, 208–216, doi:10.3762/bjoc.18.24

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  • sterically hindered active site (comparison shown with black arrows – Figure 5C and Figure 5D), which in turn conferred selectivity towards the neuraminidase. From the analogues perspective, the absence of TcTS inhibition could be also attributed to the lack of flexibility of the substituents rather than
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Published 17 Feb 2022

The enzyme mechanism of patchoulol synthase

  • Houchao Xu,
  • Bernd Goldfuss,
  • Gregor Schnakenburg and
  • Jeroen S. Dickschat

Beilstein J. Org. Chem. 2022, 18, 13–24, doi:10.3762/bjoc.18.2

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  • of such studies are. Today 13C and 2H-labellings in conjunction with NMR and MS-based analysis can be used, with strong advantages over radioactive labellings, not only from a safety perspective, but also with respect to the ease of data interpretation. Overall, our study gives another example of
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Published 03 Jan 2022

Synthesis of a novel aminobenzene-containing hemicucurbituril and its fluorescence spectral properties with ions

  • Qingkai Zeng,
  • Qiumeng Long,
  • Jihong Lu,
  • Li Wang,
  • Yuting You,
  • Xiaoting Yuan,
  • Qianjun Zhang,
  • Qingmei Ge,
  • Hang Cong and
  • Mao Liu

Beilstein J. Org. Chem. 2021, 17, 2840–2847, doi:10.3762/bjoc.17.195

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  • −1. In another perspective, the presence of the coordination of selected anions to the macrocyclic sensor enhanced the fluorescence emission in various degree, extremely contrary to the classic heavy-atom effect caused by a heavy atom. In general, this macrocyclic sensor showed high fluorescence
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Letter
Published 06 Dec 2021

A tribute to Carsten Schmuck

  • Jochen Niemeyer,
  • Ivo Piantanida and
  • Thomas Schrader

Beilstein J. Org. Chem. 2021, 17, 2795–2798, doi:10.3762/bjoc.17.190

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  • cooked for all professors on our faculty excursions, even in the confined space of the kitchen on a traditional sailing ship! Carsten always had a view for the larger perspective. Soon he initiated talks with several institutions, which led to the establishment of three Junior Professor positions in
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Editorial
Published 29 Nov 2021

Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

  • Umesh P. Aher,
  • Dhananjai Srivastava,
  • Girij P. Singh and
  • Jayashree B. S

Beilstein J. Org. Chem. 2021, 17, 2680–2715, doi:10.3762/bjoc.17.182

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Review
Published 04 Nov 2021

Adjusting the length of supramolecular polymer bottlebrushes by top-down approaches

  • Tobias Klein,
  • Franka V. Gruschwitz,
  • Maren T. Kuchenbrod,
  • Ivo Nischang,
  • Stephanie Hoeppener and
  • Johannes C. Brendel

Beilstein J. Org. Chem. 2021, 17, 2621–2628, doi:10.3762/bjoc.17.175

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  • methods represent an easily implementable technique toward 1D polymer nanostructures with an adjustable length in the range of interest for perspective biomedical applications. Keywords: distribution; dual centrifugation; filomicelles; self-assembly; ultrasonication; Introduction Cylindrical polymer
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Letter
Published 21 Oct 2021

Base-free enantioselective SN2 alkylation of 2-oxindoles via bifunctional phase-transfer catalysis

  • Mili Litvajova,
  • Emiliano Sorrentino,
  • Brendan Twamley and
  • Stephen J. Connon

Beilstein J. Org. Chem. 2021, 17, 2287–2294, doi:10.3762/bjoc.17.146

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  • of HBr in these processes. The influence of steric and electronic factors from both the perspective of the nucleophile and electrophile were investigated and levels of enantiocontrol up to 90% ee obtained. The synthetic utility of the methodology was demonstrated via the concise enantioselective
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Letter
Published 02 Sep 2021

Asymmetric organocatalyzed synthesis of coumarin derivatives

  • Natália M. Moreira,
  • Lorena S. R. Martelli and
  • Arlene G. Corrêa

Beilstein J. Org. Chem. 2021, 17, 1952–1980, doi:10.3762/bjoc.17.128

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  • synthetic perspective, coumarin derivatives have received much attention due to their pivotal role in organic synthesis [16][17][18]. The development of efficient synthetic processes with eco-friendliness and sustainability that avoid the extensive use of toxic and hazardous reagents and solvents, as well
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Review
Published 03 Aug 2021

Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution

  • Ryan M. Alam and
  • John J. Keating

Beilstein J. Org. Chem. 2021, 17, 1939–1951, doi:10.3762/bjoc.17.127

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  • regioselectivity is absent (ratio 75:76 and 77:78 ≈ 1:1, Table 6, entries 7–9) under conditions B, most likely due to solvent-separated ion pair formation. Conclusion Both 1H- and 2H-indazoles represent a core heterocyclic motif in many therapeutic small molecule drugs. Thus, from a synthetic perspective, the
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Published 02 Aug 2021

Development of N-F fluorinating agents and their fluorinations: Historical perspective

  • Teruo Umemoto,
  • Yuhao Yang and
  • Gerald B. Hammond

Beilstein J. Org. Chem. 2021, 17, 1752–1813, doi:10.3762/bjoc.17.123

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  • and reactions of these reagents are described chronologically and the review also discusses the relative fluorination power of each reagent and their mechanisms chronicling developments from a historical perspective. Keywords: N-F fluorinating agent; fluorination; fluorodiazoniabicyclo[2.2.2]octane
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Review
Published 27 Jul 2021

A systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis

  • Theodore Groth,
  • Rudiyanto Gunawan and
  • Sriram Neelamegham

Beilstein J. Org. Chem. 2021, 17, 1712–1724, doi:10.3762/bjoc.17.119

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  • exact test, to associate the TFs with signaling pathways [12]. Signaling pathway enrichments with adjusted p(FDR) < 0.1 were kept. A high p-value cutoff was chosen to allow users to gain a high-level perspective as to what potential pathways may be regulating enriched TFs. The connection between cell
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Published 22 Jul 2021
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  • Inspired from the available potential applications, and also bearing in mind the applicability of truxene-based materials from future perspective in addition to as a part of our major program on the synthesis of PAHs in general and functionalized truxenes in particular, our voyage for the synthesis of
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Published 02 Jun 2021

Icilio Guareschi and his amazing “1897 reaction”

  • Gian Cesare Tron,
  • Alberto Minassi,
  • Giovanni Sorba,
  • Mara Fausone and
  • Giovanni Appendino

Beilstein J. Org. Chem. 2021, 17, 1335–1351, doi:10.3762/bjoc.17.93

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Review
Published 25 May 2021

Photoinduced post-modification of graphitic carbon nitride-embedded hydrogels: synthesis of 'hydrophobic hydrogels' and pore substructuring

  • Cansu Esen and
  • Baris Kumru

Beilstein J. Org. Chem. 2021, 17, 1323–1334, doi:10.3762/bjoc.17.92

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  • for hydrogel post-modification are presented, and final products could be of great interest from the materials science perspective. Visible-light-induced post modification technology by semiconductors on porous networks could be extended to other porous systems as well, such as carbonecous networks
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Published 21 May 2021

A new glance at the chemosphere of macroalgal–bacterial interactions: In situ profiling of metabolites in symbiosis by mass spectrometry

  • Marine Vallet,
  • Filip Kaftan,
  • Veit Grabe,
  • Fatemeh Ghaderiardakani,
  • Simona Fenizia,
  • Aleš Svatoš,
  • Georg Pohnert and
  • Thomas Wichard

Beilstein J. Org. Chem. 2021, 17, 1313–1322, doi:10.3762/bjoc.17.91

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  • used mass spectrometry profiling and imaging techniques with high spatial resolution and sensitivity to gain a new perspective on the mutualistic interactions between bacteria and macroalgae. Using atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionisation high-resolution mass
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Published 19 May 2021

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

  • Guido Gambacorta,
  • James S. Sharley and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

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  • rates, defined and reproducible reaction timing and exacting control over all processing parameters). Flow chemistry therefore offers a powerful tool for chemists both from a research perspective and later in terms of manufacturing capacity. This has already been widely demonstrated by the
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Review
Published 18 May 2021

Synthetic accesses to biguanide compounds

  • Oleksandr Grytsai,
  • Cyril Ronco and
  • Rachid Benhida

Beilstein J. Org. Chem. 2021, 17, 1001–1040, doi:10.3762/bjoc.17.82

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  • catalysts in various organic reactions [1] such as the Ullmann coupling, Suzuki coupling, Suzuki–Miyaura coupling, and the Heck reaction. Aside from being useful synthetic agents, biguanides gained particular interest from the perspective of medicinal chemistry. For the first time, the biological activity
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Published 05 May 2021
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