Interactions between shape-persistent macromolecules as probed by AFM

• Johanna Blass,
• Jessica Brunke,
• Franziska Emmerich,
• Cédric Przybylski,
• Vasil M. Garamus,
• Artem Feoktystov,
• Roland Bennewitz,
• Gerhard Wenz and
• Marcel Albrecht

Beilstein J. Org. Chem. 2017, 13, 938–951, doi:10.3762/bjoc.13.95

• end groups were prepared starting from diacetylene-modified cyclodextrin monomers by a combined Glaser coupling/click chemistry approach. Structural perfection of the neutral CD polymers and inclusion complex formation with ditopic and monotopic guest molecules were proven by MALDI–TOF and UV–vis

• characteristic bathochromic shift could be observed both in the absorption and emission spectra of polymer 8 (Figure 3) showing the presence of the extended polyconjugated π-system. Quantitative information about the molecular weight distribution of 8 was obtained by MALDI–TOF measurements using an ionic liquid

• matrix (HABA/TMG2) [55]. A representative MALDI spectrum, shown in Figure 4, exhibits a wide range of broad signals starting from the signal of the dimer at m/z 2,621.33 Da detected as [M + Na]+ and ending at the 38mer at m/z 48,196.23 Da for a S/N ratio ≥3, with an average 1297.4 mass units shift

Expression, purification and structural analysis of functional GABA transporter 1 using the baculovirus expression system

• Jing Hu,
• Chris Weise,
• Christoph Böttcher,
• Hua Fan and
• Jian Yin

Beilstein J. Org. Chem. 2017, 13, 874–882, doi:10.3762/bjoc.13.88

• , and tryptic peptides were analyzed either directly by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI–TOF MS) or guanidinated and then analyzed by MALDI. The labeled peptide peaks (Figure 2B) in the mass spectrum were identified as either GAT or GFP by matching the

• -day infection by flow cytometry and fluorescence microscopy to determine the cell surface expression of the GAT1/GFP fusion proteins. MALDI mass fingerprinting Using MALDI–TOF MS, protein fragments with blocked N-termini or that are available in limited concentrations can be easily analyzed. The MALDI

• Blue staining of the GAT1/GFP protein from infected Sf9 cells after immunoprecipitation. Bands a and b (indicated by arrows) were extracted for MALDI–TOF analysis. (B) Mass spectrum of the trypsin digest of band a. The labeled peaks were assigned to either GAT or GFP. Isolation of the GAT1/GFP fusion

Cyclodextrins tethered with oligolactides – green synthesis and structural assessment

• Cristian Peptu,
• Mihaela Balan-Porcarasu,
• Alena Šišková,
• Ľudovít Škultéty and
• Jaroslav Mosnáček

Beilstein J. Org. Chem. 2017, 13, 779–792, doi:10.3762/bjoc.13.77

• ionization like matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI). Liquid chromatography (LC) separation with evaporative light scattering detection (ELSD) and NMR analysis were employed in order to elucidate the structural profiles of the obtained mixtures. The results

• chromatography; L-lactide; MALDI; mass spectrometry; NMR; Introduction Cyclodextrin derivatives are increasingly important and their variety is dictated by the wide range of applications in which these compounds are employed with preponderance in the pharmaceutical field [1][2]. The employed strategies for the

• not asses their products whether these were CD-VL, CD-LA or CD-VL/LA covalent conjugates [19][20]. The results presented by the Harada group generally evaluated the CD-oligoester samples by matrix-assisted laser desorption ionization mass spectrometry (MALDI–MS) and nuclear magnetic resonance (NMR

Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications

• Stephen Hill and
• M. Carmen Galan

Beilstein J. Org. Chem. 2017, 13, 675–693, doi:10.3762/bjoc.13.67

• as the major component in the preparation of this type of CD, as evidenced by 1H, 13C NMR, FTIR and MALDI–MS (Scheme 19). The authors proposed that initial acid catalysed degradation of the sucrose disaccharide to its monosaccharide constituents fructose and glucose, followed by glucose isomerisation

Total synthesis of a Streptococcus pneumoniae serotype 12F CPS repeating unit hexasaccharide

• Peter H. Seeberger,
• Claney L. Pereira and
• Subramanian Govindan

Beilstein J. Org. Chem. 2017, 13, 164–173, doi:10.3762/bjoc.13.19

• -dimethylformamide; EtOAc: ethyl acetate; GlcA: glucouronic acid; HPLC: high-performance liquid chromatography; Lev: levulinoyl; MALDI–TOF MS: matrix-assisted laser desorption/ionization–time of flight mass spectrometry; NAP: 2-naphthylmethyl; TBS: tert-butyldimethylsilyl; THF: tetrahydrofuran; TMSOTf

A postsynthetically 2’-“clickable” uridine with arabino configuration and its application for fluorescent labeling and imaging of DNA

• Heidi-Kristin Walter,
• Bettina Olshausen,
• Ute Schepers and
• Hans-Achim Wagenknecht

Beilstein J. Org. Chem. 2017, 13, 127–137, doi:10.3762/bjoc.13.16

• modified oligonucleotides were purified by ethanol precipitation in the presence of EDTA to remove copper ions and subsequently by semi-preparative HPLC. Finally, the modified oligonucleotides were identified by MALDI–TOF mass spectrometry (see Supporting Information File 1) and annealed with the

• -10AT, controller SCL-10A, diode array detector SPD-M10A). Purification was confirmed by MS (MALDI–TOF) on a Biflex-IV spectrometer from Bruker Daltonics in the linear negative mode (matrix: 1:9 mixture of diammonium hydrogencitrate (100 g/L) and a saturated 3-hydroxypicolinic acid solution (10 g/L in

Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

• Keiichi Motoyama,
• Rena Nishiyama,
• Yuki Maeda,
• Taishi Higashi,
• Yoichi Ishitsuka,
• Yuki Kondo,
• Tetsumi Irie,
• Takumi Era and
• Hidetoshi Arima

Beilstein J. Org. Chem. 2017, 13, 10–18, doi:10.3762/bjoc.13.2

• cyanotrihydroborate in dimethyl sulfoxide (DMSO) at 90 °C for 24 h. The product yield of multi-Lac-β-CD was 25%, and no unreacted compounds were confirmed by thin-layer chromatography (TLC). The MALDI–TOF MS spectrum of multi-Lac-β-CD revealed several peaks at m/z 2804, m/z 3006, m/z 3139, m/z 3296, and m/z 3454

• significant. Schematic representation for synthesis of multi-Lac-β-CD (5), β-CD (1), per-chloro-β-CD (2), per-azido-β-CD (3), per-amino-β-CD, (4), multi-Lac-β-CD (DSL5.6), DSL, degree of substitution of lactose, DMAc, dimethylacetamide. MALDI–TOFMS (A) and 1H NMR spectra (B) of multi-Lac-β-CD (DSL5.6

Supramolecular frameworks based on [60]fullerene hexakisadducts

• Andreas Kraft,
• Johannes Stangl,
• Ana-Maria Krause,
• Klaus Müller-Buschbaum and
• Florian Beuerle

Beilstein J. Org. Chem. 2017, 13, 1–9, doi:10.3762/bjoc.13.1

• , C(CH3)3), 141.15 (24C, C60 sp2), 145.99 (24C, C60 sp2), 163.75 (12C, O2CCH2CO2), 171.89 ppm (12C, CO2 t-Bu); UV–vis (CH2Cl2) λ: 281, 315 (sh), 334 (sh) nm; MS (MALDI, DCTB, pos) m/z: 3038 [M]+; anal, calcd for C174H180O48: C, 68.76; H, 5.97; found: C, 68.87; H, 6.09. Hexakisadduct C4: TFA (1.7 mL

• , rt) δ 23.47 (12C, CH2CO2H), 29.71 (12C, CH2CH2CH2), 45.44 (6C, O2CCH2CO2), 66.35 (12C, COOCH2), 68.67 (12C, C60 sp3), 140.71 (24C, C60 sp2), 145.02 (24C, C60 sp2), 162.75 (12C, O2CCH2CO2), 173.64 ppm (12C, CO2H); UV–vis (CH2Cl2) λ: 281, 315 (sh), 334 (sh) nm; MS (MALDI, DCTB, pos) m/z: 2365 [M

Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934

• Veronika Ulrich,
• Clara Brieke and
• Max J. Cryle

Beilstein J. Org. Chem. 2016, 12, 2849–2864, doi:10.3762/bjoc.12.284

• Scientific, Waltham, USA) and the calculated extinction coefficient of the protein at λ = 280 nm. Furthermore, the protein identity was confirmed by MALDI–TOF MS peptide map fingerprinting of a tryptic digest of excised protein bands from SDS-PAGE analysis. StaF was finally stored in SEC buffer in aliquots

A self-assembled cyclodextrin nanocarrier for photoreactive squaraine

• Ulrike Kauscher and
• Bart Jan Ravoo

Beilstein J. Org. Chem. 2016, 12, 2535–2542, doi:10.3762/bjoc.12.248

• , 17-C), 29.47, 29.38 (2CH2, 14-C), 28.38 (2CH, 22-C), 26.09, 26.02 (2CH2, 15-C), 25.99, 25.76 (2CH2, 16-C), 18.69 ppm; MALDI–MS (m/z): calcd for [C54H68N2O4S2]+: 872,46; found: 872,47. Schematic representation of adamantane-substituted squaraine (AdSq) binding as a divalent guest to the surface of

High performance p-type molecular electron donors for OPV applications via alkylthiophene catenation chromophore extension

• Paul B. Geraghty,
• Calvin Lee,
• Jegadesan Subbiah,
• Wallace W. H. Wong,
• James L. Banal,
• Mohammed A. Jameel,
• Trevor A. Smith and
• David J. Jones

Beilstein J. Org. Chem. 2016, 12, 2298–2314, doi:10.3762/bjoc.12.223

• solar cells. Supporting Information Supporting Information File 390: Synthetic procedures, NMR spectra, MALDI, TGA, DSC, CVs, POM methods and images, UV–vis, fluorescence, and DFT cartesian coordinates. Acknowledgements This work was made possible by support from the Australian Renewable Energy Agency

Determination of the absolute stereostructure of a cyclic azobenzene from the crystal structure of the precursor containing a heavy element

• Reji Thomas and
• Nobuyuki Tamaoki

Beilstein J. Org. Chem. 2016, 12, 2211–2215, doi:10.3762/bjoc.12.212

• ionization time-of-flight mass spectrometry (MALDI–TOFMS) was performed with an Applied Biosystems Voyager-DE pro instrument. Absorption spectra were recorded with an Agilent 8453 spectrophotometer and the CD spectra were recorded with a JASCO J-S720 CD spectrophotometer. High-performance liquid

Superelectrophilic activation of 5-hydroxymethylfurfural and 2,5-diformylfuran: organic synthesis based on biomass-derived products

• Dmitry S. Ryabukhin,
• Dmitry N. Zakusilo,
• Mikhail O. Kompanets,
• Anton A.Tarakanov,
• Irina A. Boyarskaya,
• Tatiana O. Artamonova,
• Mikhail A. Khohodorkovskiy,
• Iosyp O. Opeida and
• Aleksander V. Vasilyev

Beilstein J. Org. Chem. 2016, 12, 2125–2135, doi:10.3762/bjoc.12.202

• superacid TfOH o- and m-xylenes gave rise to complex oligomeric mixtures (Table 5, entries 10 and 12) having masses up to 1400–1500 Da according to MALDI–MS (see Supporting Information File 1). These oligomers may have formed due to the participation of both aldehyde groups of species D (see Scheme 1 and

Thiophene-forming one-pot synthesis of three thienyl-bridged oligophenothiazines and their electronic properties

• Dominik Urselmann,
• Konstantin Deilhof,
• Bernhard Mayer and
• Thomas J. J. Müller

Beilstein J. Org. Chem. 2016, 12, 2055–2064, doi:10.3762/bjoc.12.194

• mass spectrometry (MALDI–TOF). The proton and carbon NMR spectra unambiguously support the formation of the oligomers 3, and expectedly, in agreement with the molecular symmetry, the appearance of one (3a), two (3b), and three (3c) distinct resonances for the nitrogen-bound methylene carbon nuclei in

• ), 128.4 (2CH), 129.6 (2Cquat), 142.5 (2Cquat), 145.5 (2Cquat), 145.8 (2Cquat); MS (MALDI) m/z: 646.3 ([M]+); UV–vis (CH2Cl2), λmax [nm] (ε): 246 (39600), 261 (39100), 318 (27000), 395 (33100); IR (KBr) [cm−1]: 3057 (w), 2951 (w), 2926 (w), 2851 (w), 1917 (w), 1597 (w), 1576 (w), 1539 (w), 1489 (w), 1458

• (Cquat); MS (MALDI) m/z: 1208.5 ([M]+); UV–vis (CH2Cl2), λmax [nm] (ε): 266 (52100), 284 (45900), 319 (32500), 404 (27700); IR (KBr) [cm−1]: 2951 (w), 2922 (w), 2853 (w), 1456 (s), 1416 (w), 1375 (w), 1364 (w), 1331 (m), 1292 (w), 1238 (m), 1192 (w), 1138 (w), 1105 (w), 1063 (w), 1040 (w), 872 (m), 797

Synthesis and characterization of fluorinated azadipyrromethene complexes as acceptors for organic photovoltaics

• Forrest S. Etheridge,
• Roshan J. Fernando,
• Sandra Pejić,
• Matthias Zeller and
• Geneviève Sauvé

Beilstein J. Org. Chem. 2016, 12, 1925–1938, doi:10.3762/bjoc.12.182

• analogs for the synthesis of L3 and L4 were synthesized according to literature procedures and used without purification [35][36]. The Stille cross coupling reactions for the synthesis of L3 and L4 were monitored by MALDI–TOF–MS and were found to not be complete after increasing the reaction time to 48 h

• spectroscopy, MALDI–TOF–MS and elemental analysis. In the case of L2, the pure BF2+ chelate could not be isolated by column chromatography, and will therefore be omitted from further analysis. The thermal stability of the zinc(II) complexes was examined by thermal gravity analysis and the results are shown in

• spectra were recorded using a 500 MHz Bruker Ascend Avance III HDTM equipped with ProdigyTM ultra-high sensitivity Multinuclear Broadband CryoProbe or a Varian 400 MHz spectrometer in parts-per-million with respect to tetramethylsilane. MALDI–TOF–MS samples were prepared from chloroform solutions in a

Effect of the π-conjugation length on the properties and photovoltaic performance of A–π–D–π–A type oligothiophenes with a 4,8-bis(thienyl)benzo[1,2-b:4,5-b′]dithiophene core

• Ni Yin,
• Lilei Wang,
• Yi Lin,
• Jinduo Yi,
• Lingpeng Yan,
• Junyan Dou,
• Hai-Bo Yang,
• Xin Zhao and
• Chang-Qi Ma

Beilstein J. Org. Chem. 2016, 12, 1788–1797, doi:10.3762/bjoc.12.169

• solar cells based on COOP-nHT-TBDT at different blend ratios, a J–V comparison of devices based on 4:PC61BM and 4:PC71BM, UV–vis absorption spectra of COOP-nHT-TBDT:PC61BM blended films, as well as the NMR and MALDI–TOF MS spectra of COOP-nHT-TBDT. Supporting Information File 274: Additional

Organic chemistry meets polymers, nanoscience, therapeutics and diagnostics

• Vincent M. Rotello

Beilstein J. Org. Chem. 2016, 12, 1638–1646, doi:10.3762/bjoc.12.161

• notion of taking some cells, putting in nanoparticles, and then throwing them in the matrix-assisted laser desorption ionization (MALDI) mass spectrometer without matrix. Quite surprisingly, all the student could see was the ligand on the particle – with essentially no signal from all of the rest of the

Star-shaped and linear π-conjugated oligomers consisting of a tetrathienoanthracene core and multiple diketopyrrolopyrrole arms for organic solar cells

• Hideaki Komiyama,
• Chihaya Adachi and
• Takuma Yasuda

Beilstein J. Org. Chem. 2016, 12, 1459–1466, doi:10.3762/bjoc.12.142

• photoabsorption properties. Experimental General methods Matrix-assisted laser desorption ionization time-of-flight (MALDI–TOF) mass spectra were collected on a Bruker Daltonics Autoflex III spectrometer using dithranol as the matrix. Elemental analysis was carried out using a YANACO CHN coder MT-6

• provide TTA-DPP4 as a dark purple solid. This compound was further purified by recycling preparative gel permeation chromatography (GPC; eluent: chloroform) prior to use (yield = 0.36 g, 44%). MS (MALDI–TOF) m/z: [M]+ calcd for 3133.42; found 3133.51; anal. calcd (%) for C190H226N8O8S12: C, 72.80; H, 7.27

• mmol), and Pd(PPh3)4 (0.015 g, 0.013 mmol). The product was purified by silica gel column chromatography (eluent: chloroform/hexane 1:1, v/v) and GPC to give TTA-DPP2 as a dark purple solid (yield = 0.32 g, 49%). MS (MALDI–TOF) m/z: [M]+ calcd for 1991.95; found 1991.67; anal. calcd (%) for

Automated glycan assembly of a S. pneumoniae serotype 3 CPS antigen

• Markus W. Weishaupt,
• Stefan Matthies,
• Mattan Hurevich,
• Claney L. Pereira,
• Heung Sik Hahm and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2016, 12, 1440–1446, doi:10.3762/bjoc.12.139

• of the glycosylation solutions exiting the reaction chamber was tested and found to be strongly acidic. After cleavage from the solid support, HPLC analysis of the crude product showed one major product (Figure 4). However, MALDI–TOF MS analysis indicated that this fraction corresponded to a

• . Acknowledgements We thank the Max Planck Society and the BMBF (Das Taschentuchlabor: Impulszentrum für integrierte Bioanalyse (IZIB), Förderkennzeichen 03IS2201G) for financial support. We also thank Mrs. Eva Settels and Ms. Janine Stuwe for MALDI–TOF measurements. Furthermore, we would like to thank Dr. Sebastian

3,6-Carbazole vs 2,7-carbazole: A comparative study of hole-transporting polymeric materials for inorganic–organic hybrid perovskite solar cells

• Wei Li,
• Munechika Otsuka,
• Takehito Kato,
• Yang Wang,
• Takehiko Mori and
• Tsuyoshi Michinobu

Beilstein J. Org. Chem. 2016, 12, 1401–1409, doi:10.3762/bjoc.12.134

• , 28.74, 27.71, 27.32, 26.96, 26.73, 24.27, 22.96, 17.37, 13.94, 13.58, 13.48, 10.75, 9.59 ppm; FTIR (neat) ν: 2955, 2923, 2852, 2361, 1798, 1652, 1614, 1581, 1462, 1419, 1376, 1342, 1276, 1258, 1218, 1143, 1063, 1014, 961, 867, 794, 749, 698, 679, 654, 624, 607 cm−1; MALDI–TOF MS (Mw = 859.4): m/z

• , 14.00, 11.21, 10.08, 7.84 ppm; FTIR (neat) v: 2955, 2923, 2870, 2852, 1485, 1458, 1441, 1415, 1376, 1339, 1319, 1250, 1200, 1146, 1071, 996, 962, 911, 860, 826, 814, 794, 741, 723, 710, 695, 653, 633, 616 cm−1; MALDI–TOF MS (Mw = 859.4): m/z = 860.5 ([M + H]+). Synthesis of 3,6-Cbz-EDOT Analogously to

• on a JASCO FT/IR-4100 spectrometer in the range from 4000 to 600 cm−1. MALDI–TOF mass spectra were measured on a Shimadzu/Kratos AXIMA-CFR mass spectrometer equipped with nitrogen laser (λ = 337 nm) and pulsed ion extraction, which was operated in a linear-positive ion mode at an accelerating

Artificial Diels–Alderase based on the transmembrane protein FhuA

• Hassan Osseili,
• Daniel F. Sauer,
• Klaus Beckerle,
• Marcus Arlt,
• Tomoki Himiyama,
• Tino Polen,
• Akira Onoda,
• Ulrich Schwaneberg,
• Takashi Hayashi and
• Jun Okuda

Beilstein J. Org. Chem. 2016, 12, 1314–1321, doi:10.3762/bjoc.12.124

• oxidized to Cu(II) by contamination with air. Cu(II) led to protein aggregation and precipitation. This was shown in an independent experiment. When one equiv of Cu(NO3)2·3H2O was added to a solution of FhuA ΔCVFtev, the protein precipitated rapidly and quantitatively. MALDI–TOF–MS analysis for the whole

• catalyst 17 was successful. Comparison of the MALDI–TOF– MS spectrum with FhuA ΔCVFtev (calcd (M + Na+): m/z = 5925 Da; found: m/z = 5925 Da) indicates successful coupling. The signal of m/z = 6301 Da indicates the FhuA fragment with the attached ligand framework (calcd (M): m/z = 6302 Da; found: m/z

• = 6301 Da). The signal of m/z = 6111 Da results from saponification of the ester and the maleimide moiety (calcd (M + H2O + Na+): m/z = 6111 Da, found: m/z = 6111 Da). We were unable to detect the copper ion in the MALDI–TOF–MS. The isolated biohybrid catalysts were tested in the Diels–Alder reaction of

Aluminacyclopentanes in the synthesis of 3-substituted phospholanes and α,ω-bisphospholanes

• Vladimir A. D’yakonov,
• Alevtina L. Makhamatkhanova,
• Rina A. Agliullina,
• Leisan K. Dilmukhametova,
• Tat’yana V. Tyumkina and
• Usein M. Dzhemilev

Beilstein J. Org. Chem. 2016, 12, 406–412, doi:10.3762/bjoc.12.43

• , C(3)), 43.02 (JPC = 1.0 Hz, C(3)), 126.87 (C(9)), 127.90, 127.91 (JPC = 5.0 Hz, C(8), C(10)), 130.07 (JPC = 16.1 Hz, C(7), C(11)), 130.13 (JPC = 15.1 Hz, C(7), C(11)), 142.47, 142.84 (JPC = 23.1 Hz, C(6)) (P-Ph); 31P NMR (161.97 MHz, CDCl3) δ −13.5, −13.9; MALDI–TOF: m/z сalcd for C18H30P ([M + H

• ), C(10)), 129.55 (JPC = 10.1 Hz, C(7), C(11)), 131.40 (JPC = 3.0 Hz, C(9)), 133.90 (JPC = 89.5 Hz, C(6)), 134.00 (JPC = 90.5 Hz, C(6)) (P-Ph); 31P NMR (161.97 MHz, CDCl3) δ 59.7, 59.4; MALDI TOF: m/z calculated for C18H30OP ([M+ H]+): 293.4040; found: 293.5. General procedure for the preparation of 3

• )), 41.94 (JPC = 54.3 Hz, С(2)), 42.38 (JPC = 53.3 Hz, C(2)), 128.30 (JPC = 12.1 Hz, C(8), C(10)), 130.00 (JPC = 11.1 Hz, C(7), C(11)), 131.07 (JPC = 2.0 Hz, C(9)), 133.76, 133.84 (JPC = 70.4 Hz, C(6)) (P-Ph); 31P NMR (161.97 MHz, CDCl3) δ 57.72; MALDI TOF: m/z сalculated for C16H26PS ([M + H]+): 281.4174

Size-controlled and redox-responsive supramolecular nanoparticles

• Raquel Mejia-Ariza,
• Gavin A. Kronig and
• Jurriaan Huskens

Beilstein J. Org. Chem. 2015, 11, 2388–2399, doi:10.3762/bjoc.11.260

• chemical shift value, 400 MHz is reported as δ using the residual solvent signal as internal standard at ≈22 °C. Mass spectrometry Mass analysis was done using matrix-assisted laser desorption ionization (MALDI) on a Waters Synapt G1 using 2,5-dihydroxybenzoic acid as the matrix. Microcalorimetric

Convenient preparation of high molecular weight poly(dimethylsiloxane) using thermally latent NHC-catalysis: a structure-activity correlation

• Stefan Naumann,
• Johannes Klein,
• Dongren Wang and
• Michael R. Buchmeiser

Beilstein J. Org. Chem. 2015, 11, 2261–2266, doi:10.3762/bjoc.11.246

• up, ranging from 200 000 g/mol to over 400 000 g/mol (Mn). Importantly, in all these cases very high conversion is observed. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI–ToF MS) and NMR experiments clearly show that BnOH is incorporated in the resulting PDMS (S1

Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition

• Nicolas Desbois,
• Sandrine Pacquelet,
• Adrien Dubois,
• Clément Michelin and
• Claude P. Gros

Beilstein J. Org. Chem. 2015, 11, 2202–2208, doi:10.3762/bjoc.11.239

• dissolved in benzonitrile and then refluxed to yield 9d. The target metalated porphyrins 9a–d were isolated in moderate to good yields ranging from 51 to 82% and were fully characterized by 1H NMR, MS (MALDI–TOF) and HRMS (ESI) spectrometry. Alkynyl DOTA/NOTA In a second step, the successful preparation of