Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

• Anton V. Gulevich,
• Lyudmila S. Koroleva,
• Olga V. Morozova,
• Valentina N. Bakhvalova,
• Vladimir N. Silnikov and
• Valentine G. Nenajdenko

Beilstein J. Org. Chem. 2011, 7, 1135–1140, doi:10.3762/bjoc.7.131

• especially important because multicomponent reactions (MCR) could be adapted to a high throughput synthesis of libraries of compounds. It is known that isocyanide-based MCR are very efficient for synthesis of peptides and peptide molecules [19][20][21][22][23][24]. We proposed that the desired compounds 5

Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts

• Esther Vicente-García,
• Rosario Ramón,
• Sara Preciado and
• Rodolfo Lavilla

Beilstein J. Org. Chem. 2011, 7, 980–987, doi:10.3762/bjoc.7.110

• through the Povarov MCR (the interaction of anilines, aldehydes and activated olefin inputs under acid catalysis) [4][5][6][7][8]. Interestingly, this process allows cyclic enol ethers and enamines to be used as electron-rich alkenes, leading to heterocycle-fused tetrahydroquinolines, usually as a mixture

• reaction for library preparation, as one reaction affords several products, when ideally it should give only one. However, these adducts can be subjected to oxidation, which will lead to the corresponding quinolines, preserving the substituents and functionalization already introduced in the preceding MCR

• the Povarov MCR without oxidative interference [18]. The same trend (oxidation–fragmentation) can be observed using nitrobenzene [21] as the oxidant. Analogously, elemental sulfur and palladium, although requiring drastic conditions, also lead to the fragmented quinolines when the substrates bear O

Multicomponent reactions

• Thomas J. J. Müller

Beilstein J. Org. Chem. 2011, 7, 960–961, doi:10.3762/bjoc.7.107

• highly diverse. Additionally, the criterion of selectivity has to be matched with increasing significance economical and ecological aspects. In particular multicomponent reactions (MCR) [3] are masterpieces of synthetic efficiency and reaction design. These one-pot processes consist of concatenations of

• Passerini reaction and the conclusions he drew from this. Now the major conceptual challenge comprises the engineering of novel types of MCR. Most advantageously and practically, MCR can often be extended into combinatorial, solid phase or flow syntheses promising manifold opportunities for developing novel

• lead structures of active agents, catalysts and even novel molecule-based materials. This Thematic Series on multicomponent reactions represents a snapshot of a highly dynamic field and spans a broad range, from recent advances in isonitrile-based MCR to transition metal catalysis in MCR; from peptidic

Zeolite catalyzed solvent- free one-pot synthesis of dihydropyrimidin- 2(1H)-ones – A practical synthesis of monastrol

• Mukund G. Kulkarni,
• Sanjay W. Chavhan,
• Mahadev P. Shinde,
• Dnyaneshwar D. Gaikwad,
• Ajit S. Borhade,
• Attrimuni P. Dhondge,
• Yunnus B. Shaikh,
• Vijay B. Ningdale,
• Mayur P. Desai and
• Deekshaputra R. Birhade

Beilstein J. Org. Chem. 2009, 5, No. 4, doi:10.3762/bjoc.5.4

• monastrol, a potent inhibitor of kinesin Eg5. Keywords: Biginelli reaction; DHPMs; neat; MCR; zeolite; Introduction The Biginelli reaction is a well-known multicomponent reaction involving a one-pot cyclocondensation of an aldehyde, β-ketoester and urea/thiourea [1][2][3]. Multicomponent reactions (MCRs

Synthesis of dihydrophenanthridines by a sequence of Ugi-4CR and palladium- catalyzed intramolecular C-H functionalization

• Florence Bonnaterre,
• Michèle Bois-Choussy and
• Jieping Zhu

Beilstein J. Org. Chem. 2008, 4, No. 10, doi:10.3762/bjoc.4.10

• the past twenty years [3]. In order to further increase its versatility and the complexity-generating power, a variety of reaction types have been associated with Ugi-4CRs for the synthesis of medicinally relevant heterocycles [4][5][6]. Using this MCR/post functionalization strategy, we have