New terpenoids from the fermentation broth of the edible mushroom Cyclocybe aegerita

• Frank Surup,
• Florian Hennicke,
• Nadine Sella,
• Maria Stroot,
• Steffen Bernecker,
• Sebastian Pfütze,
• Marc Stadler and
• Martin Rühl

Beilstein J. Org. Chem. 2019, 15, 1000–1007, doi:10.3762/bjoc.15.98

• Site Hannover-Braunschweig, Inhoffenstraße 7, 38124 Braunschweig, Germany Junior Research Group Genetics and Genomics of Fungi, Senckenberg Gesellschaft für Naturforschung, Georg-Voigt-Str. 14–16, 60325 Frankfurt am Main, Germany Institute of Food Chemistry and Food Biotechnology, Justus Liebig

Synthesis of the aglycon of scorzodihydrostilbenes B and D

• Katja Weimann and
• Manfred Braun

Beilstein J. Org. Chem. 2019, 15, 610–616, doi:10.3762/bjoc.15.56

• %; 13: 17%. Supporting Information Supporting Information File 114: 1H NMR and 13C NMR spectra of all new compounds. Acknowledgements We would like to thank Prof. Dr. Peter Proksch and Dr. Andreas Marmann (Institute of Pharmaceutical Biology and Biotechnology, University of Düsseldorf) for fruitful

Selectivity in multiple multicomponent reactions: types and synthetic applications

• Ouldouz Ghashghaei,
• Francesca Seghetti and
• Rodolfo Lavilla

Beilstein J. Org. Chem. 2019, 15, 521–534, doi:10.3762/bjoc.15.46

• Ouldouz Ghashghaei Francesca Seghetti Rodolfo Lavilla Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain Department of Pharmacy and Biotechnology (FaBiT), University

Synthesis and biological activity of methylated derivatives of the Pseudomonas metabolites HHQ, HQNO and PQS

• Sven Thierbach,
• Max Wienhold,
• Susanne Fetzner and
• Ulrich Hennecke

Beilstein J. Org. Chem. 2019, 15, 187–193, doi:10.3762/bjoc.15.18

• Sven Thierbach Max Wienhold Susanne Fetzner Ulrich Hennecke Institute for Molecular Microbiology and Biotechnology, University of Münster, Corrensstr. 3, 48149 Münster, Germany Organic Chemistry Institute, University of Münster, Corrensstr. 40, 48149 Münster, Germany Organic Chemistry Research

Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis

• Daniel F. Sauer,
• Johannes Schiffels,
• Takashi Hayashi,
• Ulrich Schwaneberg and
• Jun Okuda

Beilstein J. Org. Chem. 2018, 14, 2861–2871, doi:10.3762/bjoc.14.265

• Daniel F. Sauer Johannes Schiffels Takashi Hayashi Ulrich Schwaneberg Jun Okuda Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany Department of Applied Chemistry

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids

• Eszter Lajkó,
• Sarah Spring,
• Rózsa Hegedüs,
• Beáta Biri-Kovács,
• Sven Ingebrandt,
• Gábor Mező and
• László Kőhidai

Beilstein J. Org. Chem. 2018, 14, 2495–2509, doi:10.3762/bjoc.14.226

• conjugates could induce apoptosis and/or cell cycle arrest in melanoma cells. The pro-apoptotic effects of conjugates and Dau at 10−5 M concentration was studied after 24 h incubation by flow cytometry using FITC-annexin V (Sony Biotechnology, Weybridge, UK) and a novel image cytometer (NucleoCounter® NC

Correction: Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291

• Peng Zhang,
• Xiao-Ming Li,
• Xin-Xin Mao,
• Attila Mándi,
• Tibor Kurtán and
• Bin-Gui Wang

Beilstein J. Org. Chem. 2018, 14, 2394–2395, doi:10.3762/bjoc.14.215

• Peng Zhang Xiao-Ming Li Xin-Xin Mao Attila Mandi Tibor Kurtan Bin-Gui Wang Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road

β-Hydroxy sulfides and their syntheses

• Mokgethwa B. Marakalala,
• Edwin M. Mmutlane and
• Henok H. Kinfe

Beilstein J. Org. Chem. 2018, 14, 1668–1692, doi:10.3762/bjoc.14.143

• Fujisawa and co-workers in 1984 as depicted in Scheme 22 [57]. Coincidentally, the presence of the sulfenyl group at the α-position of the carbonyl center was found to be crucial for the stereoselectivity. Despite the sharp advancement in the field of biotechnology in the last decade, the application of

Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)

• Lucky S. Mulwa,
• Rolf Jansen,
• Dimas F. Praditya,
• Kathrin I. Mohr,
• Patrick W. Okanya,
• Joachim Wink,
• Eike Steinmann and
• Marc Stadler

Beilstein J. Org. Chem. 2018, 14, 1554–1562, doi:10.3762/bjoc.14.132

• Hannover, Germany. Tel: +49(0)511-220027-133 Department of Biochemistry and Biotechnology, The Technical University of Kenya, P.O. Box 52428 – 00200, Located along Haile Selassie Avenue, Nairobi, Kenya. Tel: +254(020) 2219929 Department of Molecular and Medical Virology, Ruhr-University Bochum, 44801

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp.

• Dandan Li,
• Naoya Oku,
• Atsumi Hasada,
• Masafumi Shimizu and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2018, 14, 1446–1451, doi:10.3762/bjoc.14.122

• Dandan Li Naoya Oku Atsumi Hasada Masafumi Shimizu Yasuhiro Igarashi Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan Laboratory of Plant Pathology, Faculty of Applied Biological Sciences, Gifu University, 1

A selective removal of the secondary hydroxy group from ortho-dithioacetal-substituted diarylmethanols

• Anna Czarnecka,
• Emilia Kowalska,
• Agnieszka Bodzioch,
• Joanna Skalik,
• Marek Koprowski,
• Krzysztof Owsianik and
• Piotr Bałczewski

Beilstein J. Org. Chem. 2018, 14, 1229–1237, doi:10.3762/bjoc.14.105

• Structural and Material Research, Institute of Chemistry, Environmental Protection and Biotechnology, Faculty of Mathematics and Natural Sciences, Jan Długosz University in Częstochowa, Armii Krajowej 13/15, 42-200 Częstochowa, Poland 10.3762/bjoc.14.105 Abstract We present a successful deoxygenation

Crystal structure of the inclusion complex of cholesterol in β-cyclodextrin and molecular dynamics studies

• Elias Christoforides,
• Andreas Papaioannou and
• Kostas Bethanis

Beilstein J. Org. Chem. 2018, 14, 838–848, doi:10.3762/bjoc.14.69

• Elias Christoforides Andreas Papaioannou Kostas Bethanis Department of Biotechnology, Agricultural University of Athens, 75 Iera Odos, Athens 11855, Greece 10.3762/bjoc.14.69 Abstract The role of beta-cyclodextrin (β-CD) in cholesterol removal primarily from mammalian cells and secondly from

Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactor

• Morten M. C. H. van Schie,
• Tiago Pedroso de Almeida,
• Gabriele Laudadio,
• Florian Tieves,
• Elena Fernández-Fueyo,
• Timothy Noël,
• Isabel W. C. E. Arends and
• Frank Hollmann

Beilstein J. Org. Chem. 2018, 14, 697–703, doi:10.3762/bjoc.14.58

• Morten M. C. H. van Schie Tiago Pedroso de Almeida Gabriele Laudadio Florian Tieves Elena Fernandez-Fueyo Timothy Noel Isabel W. C. E. Arends Frank Hollmann Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands Department of Chemical

Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review

• Fabio Tonin and
• Isabel W. C. E. Arends

Beilstein J. Org. Chem. 2018, 14, 470–483, doi:10.3762/bjoc.14.33

• Fabio Tonin Isabel W. C. E. Arends Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands 10.3762/bjoc.14.33 Abstract Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile acid it solubilizes cholesterol

Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries

• Ruth Suchsland,
• Bettina Appel and
• Sabine Müller

Beilstein J. Org. Chem. 2018, 14, 397–406, doi:10.3762/bjoc.14.28

• Ruth Suchsland Bettina Appel Sabine Muller Institut für Biochemie, Ernst-Moritz-Arndt-Universität Greifswald, Felix-Hausdorff-Str. 4, D-17489 Greifswald, Germany 10.3762/bjoc.14.28 Abstract The preparation of protein libraries is a key issue in protein engineering and biotechnology. Such

• selection and identification of mutants with improved properties is a favoured method in the field of white biotechnology and biocatalysis, to improve the fitness of enzymes for industrial application [5]. In general, directed evolution may be summarized as an iterative two-step process which involves the

• is that small molecular reagents can be easily removed after coupling and 5'-O-deprotection, by quantitative precipitation of the soluble support in a polar solvent, such as methanol. With the developments in the field of biotechnology and protein engineering, the preparation of gene libraries has

Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays

• Marco Russo,
• Daniele La Corte,
• Annalisa Pisciotta,
• Serena Riela,
• Rosa Alduina and
• Paolo Lo Meo

Beilstein J. Org. Chem. 2017, 13, 2751–2763, doi:10.3762/bjoc.13.271

• bottleneck in bacterial genetic manipulation and microbial biotechnology, since the procedures to get recombinant bacterial strains are cost and time-consuming. Thus, an increased transformation efficiency for difficult-to-manipulate strains can be very useful. Taking into account the results obtained by

Vinylphosphonium and 2-aminovinylphosphonium salts – preparation and applications in organic synthesis

• Anna Kuźnik,
• Roman Mazurkiewicz and
• Beata Fryczkowska

Beilstein J. Org. Chem. 2017, 13, 2710–2738, doi:10.3762/bjoc.13.269

• Anna Kuznik Roman Mazurkiewicz Beata Fryczkowska Department of Organic and Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland Biotechnology Center of Silesian University of Technology, B. Krzywoustego 8, 44-100 Gliwice, Poland

An efficient synthesis of 1,6-anhydro-N-acetylmuramic acid from N-acetylglucosamine

• Matthew B. Calvert,
• Christoph Mayer and
• Alexander Titz

Beilstein J. Org. Chem. 2017, 13, 2631–2636, doi:10.3762/bjoc.13.261

• Microbiology and Infection Medicine Tübingen (IMIT), Department of Microbiology and Biotechnology, University of Tübingen, Germany Department of Pharmacy, Saarland University, Saarbrücken, Germany 10.3762/bjoc.13.261 Abstract A novel synthesis of 1,6-anhydro-N-acetylmuramic acid is described, which proceeds

Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

• Tao Fan,
• Wei-Dong Meng and
• Xingang Zhang

Beilstein J. Org. Chem. 2017, 13, 2610–2616, doi:10.3762/bjoc.13.258

• Tao Fan Wei-Dong Meng Xingang Zhang College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China, Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road

Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes

• Hui Hong,
• Markiyan Samborskyy,
• Katsiaryna Usachova,
• Katharina Schnatz and
• Peter F. Leadlay

Beilstein J. Org. Chem. 2017, 13, 2408–2415, doi:10.3762/bjoc.13.238

• File 388: Experimental part and additional Figures and Schemes. Acknowledgements We gratefully acknowledge the joint support, for part of this work, of Syngenta and the Biotechnology and Biological Sciences Research Council (U.K., strategic LoLa award BB/K002341/1). K. U. thanks the Darwin Trust of

Mechanically induced oxidation of alcohols to aldehydes and ketones in ambient air: Revisiting TEMPO-assisted oxidations

• Andrea Porcheddu,
• Evelina Colacino,
• Giancarlo Cravotto,
• Francesco Delogu and
• Lidia De Luca

Beilstein J. Org. Chem. 2017, 13, 2049–2055, doi:10.3762/bjoc.13.202

• chemistry, which is crucial for strategic areas of science related to biochemistry and biotechnology [3][4]. In principle, the oxidation of alcohols represents a convenient option for preparing aldehydes and ketones, as alcohols are among the most abundant naturally occurring organic compounds [5][6

2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of ß-barrel hybrid catalyst for phenylacetylene polymerization

• Julia Kinzel,
• Daniel F. Sauer,
• Marco Bocola,
• Marcus Arlt,
• Tayebeh Mirzaei Garakani,
• Andreas Thiel,
• Klaus Beckerle,
• Tino Polen,
• Jun Okuda and
• Ulrich Schwaneberg

Beilstein J. Org. Chem. 2017, 13, 1498–1506, doi:10.3762/bjoc.13.148

• Julia Kinzel Daniel F. Sauer Marco Bocola Marcus Arlt Tayebeh Mirzaei Garakani Andreas Thiel Klaus Beckerle Tino Polen Jun Okuda Ulrich Schwaneberg Institute of Biotechnology, RWTH Aachen University, Worringer Weg 3, 52074 Aachen, Germany Institut für Anorganische Chemie, RWTH Aachen University

• , Landoltweg 1, 52074 Aachen, Germany DWI - Leibniz Institute for Interactive Materials e.V., Forckenbeckstr. 50, 52056, Aachen, Germany Institute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany 10.3762/bjoc.13.148 Abstract Covering hydrophobic regions with

1-Imidoalkylphosphonium salts with modulated C_α–P⁺ bond strength: synthesis and application as new active α-imidoalkylating agents

• Jakub Adamek,
• Roman Mazurkiewicz,
• Anna Węgrzyk and
• Karol Erfurt

Beilstein J. Org. Chem. 2017, 13, 1446–1455, doi:10.3762/bjoc.13.142

• Jakub Adamek Roman Mazurkiewicz Anna Wegrzyk Karol Erfurt Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland Biotechnology Centre of Silesian University of Technology, B. Krzywoustego 8, 44-100

Mechanochemical synthesis of graphene oxide-supported transition metal catalysts for the oxidation of isoeugenol to vanillin

• Ana Franco,
• Sudipta De,
• Alina M. Balu,
• Araceli Garcia and
• Rafael Luque

Beilstein J. Org. Chem. 2017, 13, 1439–1445, doi:10.3762/bjoc.13.141

• % of total vanilla production is from extraction of natural material. This extraction is a very long and expensive process [6]. The remaining 99% is being produced via chemical and biochemical routes. Biotechnology-based approaches, particularly enzymatic processes, have been well known for many years

A new member of the fusaricidin family – structure elucidation and synthesis of fusaricidin E

• Marcel Reimann,
• Louis P. Sandjo,
• Luis Antelo,
• Eckhard Thines,
• Isabella Siepe and
• Till Opatz

Beilstein J. Org. Chem. 2017, 13, 1430–1438, doi:10.3762/bjoc.13.140

• Catarina, Florianópolis 88040-900, SC, Brazil Institute of Biotechnology and Drug Research, Erwin Schrödinger-Str. 56, 66776 Kaiserslautern, Germany Institute of Molecular Physiology, Microbiology and Wine Research, Johannes Gutenberg University Mainz, Johann-Joachim-Becher-Weg 15, 55128 Mainz, Germany