Palladium-catalyzed Sonogashira coupling reactions in γ-valerolactone-based ionic liquids

• László Orha,
• József M. Tukacs,
• László Kollár and
• László T. Mika

Beilstein J. Org. Chem. 2019, 15, 2907–2913, doi:10.3762/bjoc.15.284

• K113177) and the Higher Education Excellence Program of the Ministry of Human Capacities in the frame of Biotechnology research area of Budapest University of Technology and Economics (BME FIKP-BIO). L.T. Mika is grateful for the support of a Scholarship of József Varga Foundation, Budapest University of

Synthetic terpenoids in the world of fragrances: Iso E Super^® is the showcase

• Alexey Stepanyuk and
• Andreas Kirschning

Beilstein J. Org. Chem. 2019, 15, 2590–2602, doi:10.3762/bjoc.15.252

• natural products. Biotechnology is another way to harness fragrance components be it enzymatic or microbial. Nowadays engineered microbes are at hand that, e.g., produce scents, such as patchouli, by fermenting sugar. Patchouli is a complex mixture of sesquiterpenes ((−)-patchoulol, (+)-norpatchoulenol

• linked with a bouquet of methods to broaden the platform of molecules with favourable olfactory properties. These include chemical synthesis, microbiology and molecular biology associated with biotechnology and combinations based on these methods. Hence also the most recent developments in synthetic

Anion-driven encapsulation of cationic guests inside pyridine[4]arene dimers

• Anniina Kiesilä,
• Jani O. Moilanen,
• Anneli Kruve,
• Christoph A. Schalley,
• Perdita Barran and
• Elina Kalenius

Beilstein J. Org. Chem. 2019, 15, 2486–2492, doi:10.3762/bjoc.15.241

• Berlin, Germany Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, UK 10.3762/bjoc.15.241 Abstract Pyridine[4]arenes have previously been considered as anion binding hosts due

Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

• Ronja Driller,
• Daniel Garbe,
• Norbert Mehlmer,
• Monika Fuchs,
• Keren Raz,
• Dan Thomas Major,
• Thomas Brück and
• Bernhard Loll

Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228

• and Genetics, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark present address: Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus C, Denmark Werner Siemens Chair of Synthetic Biotechnology, Dept. of Chemistry

• mutagenesis have exciting applications for the sustainable production of high value bioactive substances. Keywords: biotechnology; CotB2; crystal structure; cyclooctatin; diterpene; reaction mechanism; terpene synthase; Introduction Terpenes represent one of the most diverse groups of natural biomolecules

• . Driller was supported by Elsa-Neumann and Nüsslein-Volhard stipends. D. T. Major acknowledges support from the Israel Science Foundation (Grant #2146/15 and 1683/18). T. Brück gratefully acknowledges funding by the Werner Siemens foundation for establishing the field of Synthetic Biotechnology at the

Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium Microbulbifer sp.

• Amit Raj Sharma,
• Enjuro Harunari,
• Tao Zhou,
• Agus Trianto and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2019, 15, 2327–2332, doi:10.3762/bjoc.15.225

• Amit Raj Sharma Enjuro Harunari Tao Zhou Agus Trianto Yasuhiro Igarashi Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan Faculty of Fisheries and Marine Sciences, Diponegoro University, Tembalang Campus, St

Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids

• Melodi Demiray,
• David J. Miller and
• Rudolf K. Allemann

Beilstein J. Org. Chem. 2019, 15, 2184–2190, doi:10.3762/bjoc.15.215

• Biotechnology and Biological Sciences Research Council (BBSRC) through grants (BB/H01683X/1, BB/M022463/1, BB/N012526/1) and the Engineering and Physical Sciences Research Council (EPSRC) through grant (EP/K502819/1).

Installation of -SO₂F groups onto primary amides

• Jing Liu,
• Shi-Meng Wang,
• Njud S. Alharbi and
• Hua-Li Qin

Beilstein J. Org. Chem. 2019, 15, 1907–1912, doi:10.3762/bjoc.15.186

• Jing Liu Shi-Meng Wang Njud S. Alharbi Hua-Li Qin State Key Laboratory of Silicate Materials for Architectures; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, China Biotechnology Research group, Deportment of Biological

Synthesis and conformational preferences of short analogues of antifreeze glycopeptides (AFGP)

• Małgorzata Urbańczyk,
• Michał Jewgiński,
• Joanna Krzciuk-Gula,
• Jerzy Góra,
• Rafał Latajka and
• Norbert Sewald

Beilstein J. Org. Chem. 2019, 15, 1581–1591, doi:10.3762/bjoc.15.162

• of used backbone dihedral onto cluster size of peptide 4. Supporting Information Supporting Information File 504: Supplemental materials. Acknowledgements The authors acknowledge the support from DAAD (Project 57063993), Wroclaw Centre of Biotechnology, programme The Leading National Research

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

• Maryna V. Murlykina,
• Oleksandr V. Kolomiets,
• Maryna M. Kornet,
• Yana I. Sakhno,
• Sergey M. Desenko,
• Victoriya V. Dyakonenko,
• Svetlana V. Shishkina,
• Oleksandr A. Brazhko,
• Vladimir I. Musatov,
• Alexander V. Tsygankov,
• Erik V. Van der Eycken and
• Valentyn A. Chebanov

Beilstein J. Org. Chem. 2019, 15, 1281–1288, doi:10.3762/bjoc.15.126

• (LOMAC), KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium Laboratory of Biotechnology of Physiologically Active Substances, Zaporizhzhia National University, Zhukovsky str., 66, Zaporizhzhya, Ukraine, 69600 National Technical University “Kharkiv Polytechnic Institute”, Kyrpychova str., 2, 61002

New terpenoids from the fermentation broth of the edible mushroom Cyclocybe aegerita

• Frank Surup,
• Florian Hennicke,
• Nadine Sella,
• Maria Stroot,
• Steffen Bernecker,
• Sebastian Pfütze,
• Marc Stadler and
• Martin Rühl

Beilstein J. Org. Chem. 2019, 15, 1000–1007, doi:10.3762/bjoc.15.98

• Site Hannover-Braunschweig, Inhoffenstraße 7, 38124 Braunschweig, Germany Junior Research Group Genetics and Genomics of Fungi, Senckenberg Gesellschaft für Naturforschung, Georg-Voigt-Str. 14–16, 60325 Frankfurt am Main, Germany Institute of Food Chemistry and Food Biotechnology, Justus Liebig

Synthesis of the aglycon of scorzodihydrostilbenes B and D

• Katja Weimann and
• Manfred Braun

Beilstein J. Org. Chem. 2019, 15, 610–616, doi:10.3762/bjoc.15.56

• %; 13: 17%. Supporting Information Supporting Information File 114: 1H NMR and 13C NMR spectra of all new compounds. Acknowledgements We would like to thank Prof. Dr. Peter Proksch and Dr. Andreas Marmann (Institute of Pharmaceutical Biology and Biotechnology, University of Düsseldorf) for fruitful

Selectivity in multiple multicomponent reactions: types and synthetic applications

• Ouldouz Ghashghaei,
• Francesca Seghetti and
• Rodolfo Lavilla

Beilstein J. Org. Chem. 2019, 15, 521–534, doi:10.3762/bjoc.15.46

• Ouldouz Ghashghaei Francesca Seghetti Rodolfo Lavilla Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain Department of Pharmacy and Biotechnology (FaBiT), University

Synthesis and biological activity of methylated derivatives of the Pseudomonas metabolites HHQ, HQNO and PQS

• Sven Thierbach,
• Max Wienhold,
• Susanne Fetzner and
• Ulrich Hennecke

Beilstein J. Org. Chem. 2019, 15, 187–193, doi:10.3762/bjoc.15.18

• Sven Thierbach Max Wienhold Susanne Fetzner Ulrich Hennecke Institute for Molecular Microbiology and Biotechnology, University of Münster, Corrensstr. 3, 48149 Münster, Germany Organic Chemistry Institute, University of Münster, Corrensstr. 40, 48149 Münster, Germany Organic Chemistry Research

Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis

• Daniel F. Sauer,
• Johannes Schiffels,
• Takashi Hayashi,
• Ulrich Schwaneberg and
• Jun Okuda

Beilstein J. Org. Chem. 2018, 14, 2861–2871, doi:10.3762/bjoc.14.265

• Daniel F. Sauer Johannes Schiffels Takashi Hayashi Ulrich Schwaneberg Jun Okuda Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany Department of Applied Chemistry

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids

• Eszter Lajkó,
• Sarah Spring,
• Rózsa Hegedüs,
• Beáta Biri-Kovács,
• Sven Ingebrandt,
• Gábor Mező and
• László Kőhidai

Beilstein J. Org. Chem. 2018, 14, 2495–2509, doi:10.3762/bjoc.14.226

• conjugates could induce apoptosis and/or cell cycle arrest in melanoma cells. The pro-apoptotic effects of conjugates and Dau at 10−5 M concentration was studied after 24 h incubation by flow cytometry using FITC-annexin V (Sony Biotechnology, Weybridge, UK) and a novel image cytometer (NucleoCounter® NC

Correction: Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291

• Peng Zhang,
• Xiao-Ming Li,
• Xin-Xin Mao,
• Attila Mándi,
• Tibor Kurtán and
• Bin-Gui Wang

Beilstein J. Org. Chem. 2018, 14, 2394–2395, doi:10.3762/bjoc.14.215

• Peng Zhang Xiao-Ming Li Xin-Xin Mao Attila Mandi Tibor Kurtan Bin-Gui Wang Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road

β-Hydroxy sulfides and their syntheses

• Mokgethwa B. Marakalala,
• Edwin M. Mmutlane and
• Henok H. Kinfe

Beilstein J. Org. Chem. 2018, 14, 1668–1692, doi:10.3762/bjoc.14.143

• Fujisawa and co-workers in 1984 as depicted in Scheme 22 [57]. Coincidentally, the presence of the sulfenyl group at the α-position of the carbonyl center was found to be crucial for the stereoselectivity. Despite the sharp advancement in the field of biotechnology in the last decade, the application of

Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)

• Lucky S. Mulwa,
• Rolf Jansen,
• Dimas F. Praditya,
• Kathrin I. Mohr,
• Patrick W. Okanya,
• Joachim Wink,
• Eike Steinmann and
• Marc Stadler

Beilstein J. Org. Chem. 2018, 14, 1554–1562, doi:10.3762/bjoc.14.132

• Hannover, Germany. Tel: +49(0)511-220027-133 Department of Biochemistry and Biotechnology, The Technical University of Kenya, P.O. Box 52428 – 00200, Located along Haile Selassie Avenue, Nairobi, Kenya. Tel: +254(020) 2219929 Department of Molecular and Medical Virology, Ruhr-University Bochum, 44801

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp.

• Dandan Li,
• Naoya Oku,
• Atsumi Hasada,
• Masafumi Shimizu and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2018, 14, 1446–1451, doi:10.3762/bjoc.14.122

• Dandan Li Naoya Oku Atsumi Hasada Masafumi Shimizu Yasuhiro Igarashi Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan Laboratory of Plant Pathology, Faculty of Applied Biological Sciences, Gifu University, 1

A selective removal of the secondary hydroxy group from ortho-dithioacetal-substituted diarylmethanols

• Anna Czarnecka,
• Emilia Kowalska,
• Agnieszka Bodzioch,
• Joanna Skalik,
• Marek Koprowski,
• Krzysztof Owsianik and
• Piotr Bałczewski

Beilstein J. Org. Chem. 2018, 14, 1229–1237, doi:10.3762/bjoc.14.105

• Structural and Material Research, Institute of Chemistry, Environmental Protection and Biotechnology, Faculty of Mathematics and Natural Sciences, Jan Długosz University in Częstochowa, Armii Krajowej 13/15, 42-200 Częstochowa, Poland 10.3762/bjoc.14.105 Abstract We present a successful deoxygenation

Crystal structure of the inclusion complex of cholesterol in β-cyclodextrin and molecular dynamics studies

• Elias Christoforides,
• Andreas Papaioannou and
• Kostas Bethanis

Beilstein J. Org. Chem. 2018, 14, 838–848, doi:10.3762/bjoc.14.69

• Elias Christoforides Andreas Papaioannou Kostas Bethanis Department of Biotechnology, Agricultural University of Athens, 75 Iera Odos, Athens 11855, Greece 10.3762/bjoc.14.69 Abstract The role of beta-cyclodextrin (β-CD) in cholesterol removal primarily from mammalian cells and secondly from

Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactor

• Morten M. C. H. van Schie,
• Tiago Pedroso de Almeida,
• Gabriele Laudadio,
• Florian Tieves,
• Elena Fernández-Fueyo,
• Timothy Noël,
• Isabel W. C. E. Arends and
• Frank Hollmann

Beilstein J. Org. Chem. 2018, 14, 697–703, doi:10.3762/bjoc.14.58

• Morten M. C. H. van Schie Tiago Pedroso de Almeida Gabriele Laudadio Florian Tieves Elena Fernandez-Fueyo Timothy Noel Isabel W. C. E. Arends Frank Hollmann Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands Department of Chemical

Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review

• Fabio Tonin and
• Isabel W. C. E. Arends

Beilstein J. Org. Chem. 2018, 14, 470–483, doi:10.3762/bjoc.14.33

• Fabio Tonin Isabel W. C. E. Arends Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands 10.3762/bjoc.14.33 Abstract Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile acid it solubilizes cholesterol

Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries

• Ruth Suchsland,
• Bettina Appel and
• Sabine Müller

Beilstein J. Org. Chem. 2018, 14, 397–406, doi:10.3762/bjoc.14.28

• Ruth Suchsland Bettina Appel Sabine Muller Institut für Biochemie, Ernst-Moritz-Arndt-Universität Greifswald, Felix-Hausdorff-Str. 4, D-17489 Greifswald, Germany 10.3762/bjoc.14.28 Abstract The preparation of protein libraries is a key issue in protein engineering and biotechnology. Such

• selection and identification of mutants with improved properties is a favoured method in the field of white biotechnology and biocatalysis, to improve the fitness of enzymes for industrial application [5]. In general, directed evolution may be summarized as an iterative two-step process which involves the

• is that small molecular reagents can be easily removed after coupling and 5'-O-deprotection, by quantitative precipitation of the soluble support in a polar solvent, such as methanol. With the developments in the field of biotechnology and protein engineering, the preparation of gene libraries has

Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays

• Marco Russo,
• Daniele La Corte,
• Annalisa Pisciotta,
• Serena Riela,
• Rosa Alduina and
• Paolo Lo Meo

Beilstein J. Org. Chem. 2017, 13, 2751–2763, doi:10.3762/bjoc.13.271

• bottleneck in bacterial genetic manipulation and microbial biotechnology, since the procedures to get recombinant bacterial strains are cost and time-consuming. Thus, an increased transformation efficiency for difficult-to-manipulate strains can be very useful. Taking into account the results obtained by