Search results

Search for "inhibition" in Full Text gives 548 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

  • Jorge de Lima Neto and
  • Paulo Henrique Menezes

Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31

Graphical Abstract
  • characterized as an oxa[1.7]meta-paracyclophane framework. In the literature we can find reports about the isolation/synthesis of combretastatins D and their analogues which showed different biological activities, e.g., antineoplastic, anti-inflammatory, and α-glucosidase inhibition [13][14][15]. The presence
  • ]. However, when tested against the murine P388 lymphocytic leukemia cell line, salts 184–187 did not show enhanced inhibition of the cancer cell line growth compared to combretastatin D-2 (2) or the methylated congener 28. Moreover, for structure–activity relationship studies, combretastatin D-4 (4) proved
  • to be inactive indicating that the olefin was necessary for cancer cell growth inhibition. For salts 184–187, the authors attributed the decrease in the activity to the lack of phosphatases necessary for the cleavage of the prodrug ester bond and needed to regenerate the drug in the isolated cancer
PDF
Album
Review
Published 29 Mar 2023

Recommendations for performing measurements of apparent equilibrium constants of enzyme-catalyzed reactions and for reporting the results of these measurements

  • Robert N. Goldberg,
  • Robert T. Giessmann,
  • Peter J. Halling,
  • Carsten Kettner and
  • Hans V. Westerhoff

Beilstein J. Org. Chem. 2023, 19, 303–316, doi:10.3762/bjoc.19.26

Graphical Abstract
  • is no interference from the enzyme or from the solution in which the enzyme may be situated. 3.9. Definition and establishment of chemical equilibrium Loss of enzyme activity due to product inhibition and thermal instability can lead to a failure to achieve equilibrium and consequently large
  • and kcat,rev are the catalytic rate constants for the forward and reverse reactions, respectively. The use of Equation 10 requires a knowledge of the Michaelis constants KM and KP (also called the product inhibition constant), kcat,for, kcat,rev, and [enzyme]. Since this information is often not
PDF
Album
Perspective
Published 15 Mar 2023

Synthesis, α-mannosidase inhibition studies and molecular modeling of 1,4-imino-ᴅ-lyxitols and their C-5-altered N-arylalkyl derivatives

  • Martin Kalník,
  • Sergej Šesták,
  • Juraj Kóňa,
  • Maroš Bella and
  • Monika Poláková

Beilstein J. Org. Chem. 2023, 19, 282–293, doi:10.3762/bjoc.19.24

Graphical Abstract
  • inhibitor:enzyme complexes were analyzed by molecular modeling. Keywords: glycosidase inhibitor; Golgi mannosidase II; iminosugar; inhibition; molecular modeling; Introduction Iminosugars are analogs of monosaccharides in which the endocyclic oxygen atom is replaced with a nitrogen atom [1][2][3][4][5]. These
  • modifications are possible and many of these compounds inhibit glycoprocessing enzymes [11][12][13][14]. One of the best known iminosugars is the natural alkaloid (−)-swainsonine, which is a nanomolar inhibitor of human Golgi α-mannosidase II (GMII, GH38 family, E.C.3.2.1.114). Although such inhibition has been
  • found to suppress metastasis, the potentially positive effect of swainsonine on cancer patients is strongly reduced by its severe side effects [15][16]. These are associated with the accumulation of oligomannoside structures in tissues, serum, and urine, which is caused by the co-inhibition of lysosomal
PDF
Album
Supp Info
Full Research Paper
Published 06 Mar 2023

Strategies to access the [5-8] bicyclic core encountered in the sesquiterpene, diterpene and sesterterpene series

  • Cécile Alleman,
  • Charlène Gadais,
  • Laurent Legentil and
  • François-Hugues Porée

Beilstein J. Org. Chem. 2023, 19, 245–281, doi:10.3762/bjoc.19.23

Graphical Abstract
  • commercial cyclopentenone 69. Protection of the alcohol function was mandatory prior to the cyclization as the free alcohol substrate failed to cyclize. As proposed by the authors, interaction between the free alcohol 70 and the molybdenum metal center may explain the reaction inhibition. Thus, after
PDF
Album
Review
Published 03 Mar 2023

An accelerated Rauhut–Currier dimerization enabled the synthesis of (±)-incarvilleatone and anticancer studies

  • Tharun K. Kotammagari,
  • Sweta Misra,
  • Sayantan Paul,
  • Sunita Kunte,
  • Rajesh G. Gonnade,
  • Manas K. Santra and
  • Asish K. Bhattacharya

Beilstein J. Org. Chem. 2023, 19, 204–211, doi:10.3762/bjoc.19.19

Graphical Abstract
  • on the growth of the breast cancer cell line MCF7. For instance, we did not observe the 50% growth inhibition event at 100 µM. In contrast, 5-fluorouracil potently inhibited the growth of MCF7 cells with 50% growth inhibition at 7.1 ± 0.62 µM (Figure 2). Conclusion In summary, we have successfully
PDF
Album
Supp Info
Full Research Paper
Published 21 Feb 2023

Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors

  • Sedat Ünal,
  • Gamze Varan,
  • Juan M. Benito,
  • Yeşim Aktaş and
  • Erem Bilensoy

Beilstein J. Org. Chem. 2023, 19, 139–157, doi:10.3762/bjoc.19.14

Graphical Abstract
  • -C6 nanoparticle formulation decreased upon incubation. Based on previous studies with breast cancer cell lines, it is comprehensible that anionic nanoparticles induce cell proliferation inhibition earlier than polycationic nanoparticles. The impact of anionic nanoparticles on free cholesterol level
PDF
Album
Full Research Paper
Published 13 Feb 2023

Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds

  • Kah Yean Lum,
  • Jonathan M. White,
  • Daniel J. G. Johnson,
  • Vicky M. Avery and
  • Rohan A. Davis

Beilstein J. Org. Chem. 2023, 19, 107–114, doi:10.3762/bjoc.19.11

Graphical Abstract
  • ][8][9]. Interfering with this process means the parasite is unable to regulate Na+ [10], resulting in a significant increase in the acid load of the cell, which can lead to parasite growth inhibition and ultimately parasite death [8][9]. One of the current Series 4 aims includes lead optimisation to
PDF
Album
Supp Info
Full Research Paper
Published 31 Jan 2023

Combining the best of both worlds: radical-based divergent total synthesis

  • Kyriaki Gennaiou,
  • Antonios Kelesidis,
  • Maria Kourgiantaki and
  • Alexandros L. Zografos

Beilstein J. Org. Chem. 2023, 19, 1–26, doi:10.3762/bjoc.19.1

Graphical Abstract
  • properties, such as potent inhibition of 11-β-hydroxysteroid dehydrogenase type I and inhibition of Candida albicans [48]. Although earlier syntheses have been reported recently for magninoids [50][51], Lou’s group envisioned a divergent plan based on a late-stage bioinspired semipinacol rearrangement
PDF
Album
Review
Published 02 Jan 2023

A new route for the synthesis of 1-deazaguanine and 1-deazahypoxanthine

  • Raphael Bereiter,
  • Marco Oberlechner and
  • Ronald Micura

Beilstein J. Org. Chem. 2022, 18, 1617–1624, doi:10.3762/bjoc.18.172

Graphical Abstract
  • ]-pyrimidines) [7][8][9] have been in the center of attention and were found to be effective compounds for the inhibition of various molecular targets associated with dysfunction of the central nervous system (e.g., as GABA and serotonin receptor modulators, or as inhibitors of phosphodiesterase PDE10A
  • nucleosides thereof [10][11][12], mostly associated with the inhibition of adenosine deaminase (ADA) [11] and as adenosine receptor antagonists [10]. Another important field of applications for deaza-modified nucleobases is their use in atom-specific mutagenesis experiments. For example, site specific 1-, 3
PDF
Album
Supp Info
Full Research Paper
Published 29 Nov 2022

Using UHPLC–MS profiling for the discovery of new sponge-derived metabolites and anthelmintic screening of the NatureBank bromotyrosine library

  • Sasha Hayes,
  • Aya C. Taki,
  • Kah Yean Lum,
  • Joseph J. Byrne,
  • Merrick G. Ekins,
  • Robin B. Gasser and
  • Rohan A. Davis

Beilstein J. Org. Chem. 2022, 18, 1544–1552, doi:10.3762/bjoc.18.164

Graphical Abstract
  • (6), hexadellin A (9) and bastadin 4 (5) showed inhibition towards larval motility after 72 h of exposure with IC50 values of 1.6 µM, 10.0 µM and 33.3 µM, respectively. Keywords: alkaloid; anthelmintic; biodiscovery; bromotyrosine; 5-debromopurealidin H; Ianthella; NatureBank; sponge; Introduction
  • ), 8 (6) and 13 (7), aerothionin (8) and hexadellin A (9). The extraction and isolation of these known compounds has been previously reported elsewhere [11][28][29][30] Compounds 1−9 were assessed for their activities and potencies in a dose-response assay by measuring the inhibition level on larval
  • motility after 72 h of exposure (Figure 5). Compound 6 was the most potent compound at inhibiting exsheathed third-stage larvae (xL3) motility after 72 h, with an IC50 value of 1.6 ± 0.4 µM (65.2 ± 4.7% inhibition at 100 µM). Two other compounds showed relatively high potency: compounds 9 (IC50 = 10.0
PDF
Album
Supp Info
Full Research Paper
Published 15 Nov 2022

New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling

  • Elenilson F. da Silva,
  • Krist Helen Antunes Fernandes,
  • Denise Diedrich,
  • Jessica Gotardi,
  • Marcia Silvana Freire Franco,
  • Carlos Henrique Tomich de Paula da Silva,
  • Ana Paula Duarte de Souza and
  • Simone Cristina Baggio Gnoatto

Beilstein J. Org. Chem. 2022, 18, 1524–1531, doi:10.3762/bjoc.18.161

Graphical Abstract
  • , Figure 1), is one of the few licensed drugs for treating RSV infections [8][9]. Although there are many suggested mechanisms of action, the main mechanisms for RBV involve the inhibition of the enzymes RNA-dependent RNA polymerase and inosine monophosphate dehydrogenase (IMPDH). IMPDH is required for the
  • ) acids (Figure 1) have demonstrated various antiviral activities, such as by HIV protease inhibition (IC50 = 8 and 9 μM) [22]. In addition, compound 1 has demonstrated some anti-SARS-CoV activity (EC50 = 10 μM; SI = >10) by having an inhibitory effect on the 3CL protease function [21][23]. Moreover
  • ). One of the main known mechanisms of action of RBV is the depletion of intracellular GTP pools via the inhibition of cellular IMPDH induced by the 5-monophosphate metabolite of RBV [44]. Thus, our finding based on these results is that compound 8 may act similarly to IMPDH inhibitors and the active
PDF
Album
Supp Info
Full Research Paper
Published 09 Nov 2022

One-pot synthesis of 2-arylated and 2-alkylated benzoxazoles and benzimidazoles based on triphenylbismuth dichloride-promoted desulfurization of thioamides

  • Arisu Koyanagi,
  • Yuki Murata,
  • Shiori Hayakawa,
  • Mio Matsumura and
  • Shuji Yasuike

Beilstein J. Org. Chem. 2022, 18, 1479–1487, doi:10.3762/bjoc.18.155

Graphical Abstract
  • corresponding 2-phenylbenzothiazole (9) was isolated in 93% yield. Tafamidis (13), a compound with a 2-arylbenzoxazole skeleton is a clinically used drug for transthyretin amyloid inhibition [38][39], and was first synthesized by Kelly et al. [40]. We synthesized compound 13 by the developed
  • , and achieved the syntheses of 2-aryl- and 2-alkylbenzazoles, such as oxazoles, imidazoles, and thiazole, in satisfactory yields. The protocol was successfully applied to the synthesis of tafamidis, a clinically used drug for transthyretin amyloid inhibition. The reaction is simple, can be performed in
PDF
Album
Supp Info
Full Research Paper
Published 18 Oct 2022

Synthesis of the biologically important dideuterium-labelled adenosine triphosphate analogue ApppI(d2)

  • Petri A. Turhanen

Beilstein J. Org. Chem. 2022, 18, 1466–1470, doi:10.3762/bjoc.18.153

Graphical Abstract
  • the formation of ApppI, i.e., the isopentenyl ester of ATP (Figure 2), which may also isomerize to ApppD (Figure 2). The authors have also concluded that these compounds can act in two different ways: inhibition of the mevalonate pathway and blockade of mitochondrial ADP/ATP translocase, which is
PDF
Album
Supp Info
Letter
Published 14 Oct 2022

Sinensiols H–J, three new lignan derivatives from Selaginella sinensis (Desv.) Spring

  • Qinfeng Zhu,
  • Beibei Gao,
  • Qian Chen,
  • Tiantian Luo,
  • Guobo Xu and
  • Shanggao Liao

Beilstein J. Org. Chem. 2022, 18, 1410–1415, doi:10.3762/bjoc.18.146

Graphical Abstract
  • on LPS-induced nitric oxide production in RAW 264.7 macrophages. Keywords: lignan derivatives; nitric oxide production inhibition; norlignans; Selaginella sinensis; Introduction Selaginella is the only genus of Selaginellaceae. As a representative of the earliest and still-surviving vascular plant
  • control. As a result, compounds 1, 2, 4, and 5 showed mild inhibitory activities with inhibition rates in the range of 9.47–18.75%, compound 3 showed moderate activity with an inhibition rate of 42.06 ± 2.02% at a concentration of 50 μM (ʟ-NMMA, 59.31 ± 2.19%, Table 2). Conclusion In summary, three new
PDF
Album
Supp Info
Full Research Paper
Published 07 Oct 2022

On drug discovery against infectious diseases and academic medicinal chemistry contributions

  • Yves L. Janin

Beilstein J. Org. Chem. 2022, 18, 1355–1378, doi:10.3762/bjoc.18.141

Graphical Abstract
  • of antivirals which solely target the dengue virus via the inhibition of an essential interaction between the viral proteins NS3 and NS4B [200]. Still in the domain of infectious diseases, there are two very advanced public-based endeavors aiming at providing drugs against malaria which are
PDF
Album
Perspective
Published 29 Sep 2022

Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites

  • Houchao Xu,
  • Anne Wochele,
  • Minghe Luo,
  • Gregor Schnakenburg,
  • Yuhui Sun,
  • Heike Brötz-Oesterhelt and
  • Jeroen S. Dickschat

Beilstein J. Org. Chem. 2022, 18, 1159–1165, doi:10.3762/bjoc.18.120

Graphical Abstract
  • growth retardation of the Gram-positive species Bacillus subtilis 168 and Acinetobacter baumannii 09987 (Figure 3A and B). However, growth inhibition was not strong enough to yield a clear MIC value, as the determination of a MIC requires complete inhibition of visible bacterial growth and residual
  • /mL), a MIC of 128 mg/mL was achieved (Figure 3C). We also investigated whether the reported inhibition of glutathione S-transferase [11] is a result of a Michael addition of glutathione to TDD. However, no reaction occurred between glutathione and TDD in DMF/H2O (1:1) under prolonged stirring at room
  • inactivity of 4 against bacteria was confirmed in this study, and also 2 is an inactive metabolite of S. spectabilis, while for 1 moderate growth retardation against A. baumannii and B. subtilis, and growth inhibition against PMBN-treated E. coli was observed. However, the low activity of 1 in these assays
PDF
Album
Supp Info
Letter
Published 07 Sep 2022

A Streptomyces P450 enzyme dimerizes isoflavones from plants

  • Run-Zhou Liu,
  • Shanchong Chen and
  • Lihan Zhang

Beilstein J. Org. Chem. 2022, 18, 1107–1115, doi:10.3762/bjoc.18.113

Graphical Abstract
  • mL MeOH was added and the mixture was treated with ultrasound for 15 min. After centrifugation, the supernatant was directly analyzed by HPLC following analytical method A. Chemical genetics experiments All samples involved in inhibition experiments were set up using 100 mL flasks containing 20 mL
PDF
Album
Supp Info
Full Research Paper
Published 26 Aug 2022

Scope of tetrazolo[1,5-a]quinoxalines in CuAAC reactions for the synthesis of triazoloquinoxalines, imidazoloquinoxalines, and rhenium complexes thereof

  • Laura Holzhauer,
  • Chloé Liagre,
  • Olaf Fuhr,
  • Nicole Jung and
  • Stefan Bräse

Beilstein J. Org. Chem. 2022, 18, 1088–1099, doi:10.3762/bjoc.18.111

Graphical Abstract
  • formation from tetrazolo[1,5-a]quinoxalines 1 is still limited. Triazole-linked N-heterocycles like pyridotriazoles and quinolinotriazoles exert a variety of favorable biological properties like anticancer and antimicrobial activities as well as protein kinase inhibition [10][13][14][15]. Moreover, a vast
PDF
Album
Supp Info
Full Research Paper
Published 24 Aug 2022

Anti-inflammatory aromadendrane- and cadinane-type sesquiterpenoids from the South China Sea sponge Acanthella cavernosa

  • Shou-Mao Shen,
  • Qing Yang,
  • Yi Zang,
  • Jia Li,
  • Xueting Liu and
  • Yue-Wei Guo

Beilstein J. Org. Chem. 2022, 18, 916–925, doi:10.3762/bjoc.18.91

Graphical Abstract
  • anti-inflammatory activity by the inhibition of LPS-induced TNF-α and CCL2 release in RAW 264.7 macrophages. Keywords: Acanthella cavernosa; anti-inflammatory; biosynthetic pathway; chiral separation; marine sponge; sesquiterpenoid; Introduction Marine sponges of the genus Acanthella (class
  • tumor necrosis factor-α (TNF-α) and C–C motif chemokine ligand 2 (CCL2) were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, using NF-κB inhibitor BAY-11-7082 as the positive control. Compound 3 displayed promising dose-dependent anti-inflammatory activity with the inhibition
PDF
Album
Supp Info
Full Research Paper
Published 25 Jul 2022

Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids

  • Virginija Jakubkiene,
  • Gabrielius Ernis Valiulis,
  • Markus Schweipert,
  • Asta Zubriene,
  • Daumantas Matulis,
  • Franz-Josef Meyer-Almes and
  • Sigitas Tumkevicius

Beilstein J. Org. Chem. 2022, 18, 837–844, doi:10.3762/bjoc.18.84

Graphical Abstract
  • the IC50 values for compounds 12–18, which differ only in the substituent at the second position of the pyrimidine ring, reveals that the presence of a methylthio group at this position gives compound 12 a slight advantage in the inhibition of the HDAC4 isoform, while the presence of a more bulky
  • substituent at the second position of the pyrimidine ring favors the inhibition of HDAC8 isoforms (Table 2, compounds 13–15 and 17). However, most of the compounds tested, with the exception of 29, were inactive or showed weak inhibitory effect on the HDAC4 isoform. Comparison of the potency of the HDAC8
PDF
Album
Supp Info
Full Research Paper
Published 13 Jul 2022

The stereochemical course of 2-methylisoborneol biosynthesis

  • Binbin Gu,
  • Anwei Hou and
  • Jeroen S. Dickschat

Beilstein J. Org. Chem. 2022, 18, 818–824, doi:10.3762/bjoc.18.82

Graphical Abstract
  • in other foodstuff such as fish and coffee contaminations with 1 are perceived as unpleasant flavor constituents [15][16][17][18]. Despite its occurrence in fungi, 1 also has moderate antifungal activity as observed for its inhibition of mycelial growth and sporulation in Fusarium moniliforme [19
PDF
Album
Supp Info
Letter
Published 08 Jul 2022

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment

  • Anas J. Rasras,
  • Mohamed El-Naggar,
  • Nesreen A. Safwat and
  • Raed A. Al-Qawasmeh

Beilstein J. Org. Chem. 2022, 18, 631–638, doi:10.3762/bjoc.18.63

Graphical Abstract
  • against the pathogenic fungal strains Aspergillus fumigatus and Candida albicans. The sensitivity of the organisms was assayed against the activity of tested compounds solutions (at 10 mg/mL concentration) using a modified agar well diffusion method with determination of the inhibition zone diameter in mm
  • was confirmed by the MIC values measured by the broth microdilution method by recording the lowest concentration that showed inhibition of microbial growth (Table 2). The results of the determined MIC values showed the same trend of the antimicrobial activities explored by determination of the
  • inhibition zone diameter using the agar well diffusion method. The structure–activity relationship (SAR) elaborated that piperazines with aliphatic groups on the nitrogen atom are more active than those with aromatic substituents against the fungus C. albicans. On the other hand, compounds comprising
PDF
Album
Supp Info
Full Research Paper
Published 31 May 2022

Heteroleptic metallosupramolecular aggregates/complexation for supramolecular catalysis

  • Prodip Howlader and
  • Michael Schmittel

Beilstein J. Org. Chem. 2022, 18, 597–630, doi:10.3762/bjoc.18.62

Graphical Abstract
  • replicating their structures). The structural dissimilarity between the reactants and the subsequent product often contributes to the successful release of the product from the reaction vessel, thus, reducing product inhibition. Hence, it can be envisioned that the introduction of functionality within the
  • product inhibition, and b) higher nanomechanical speed enlarges catalyst liberation. While the development of multicomponent rotors has started almost 20 years ago with seminal works by Shionoya [78][79][80] and Kume [81][82], the fascinating prospects of discrete nanomechanical motion was impressively
  • geometrical or constitutional situation at the binding sites [92]. In a detailed recent study, the finding of a Hammett correlation in such nanorotors corroborated that a rate-determining dissociation at the rotator–metal binding interaction dictated the rotational speed [93]. Reducing Product Inhibition (RPI
PDF
Album
Review
Published 27 May 2022

Shift of the reaction equilibrium at high pressure in the continuous synthesis of neuraminic acid

  • Jannis A. Reich,
  • Miriam Aßmann,
  • Kristin Hölting,
  • Paul Bubenheim,
  • Jürgen Kuballa and
  • Andreas Liese

Beilstein J. Org. Chem. 2022, 18, 567–579, doi:10.3762/bjoc.18.59

Graphical Abstract
  • pressure on the inhibition by pyruvate was measured and is shown in Figure 9. The value for the inhibition constant is in the same order of magnitude as results of other groups, measured at ambient pressure (0.146 ± 0.019 mol/L [5]). Since the KI value changes with pressure (Table 4), the concentrations
  • were kept constant and only the pressure was varied, resulting in the reactions rates shown in Figure 10 (left). By rearranging the rate expression and inserting the previously calculated kinetic parameters, the inhibition constant was calculated (Figure 10 (right)). The change in molar volume
  • suggests a reduction in molar volume. The circular reactor setup allowed for easy sampling and enabled the analysis of the resulting progress curve. The findings for the epimerase indicate that some inconspicuous reactions, such as the inhibition by pyruvate, can be influenced by pressure. In both
PDF
Album
Full Research Paper
Published 20 May 2022

Synthesis of sulfur karrikin bioisosteres as potential neuroprotectives

  • Martin Pošta,
  • Václav Zima,
  • Lenka Poštová Slavětínská,
  • Marika Matoušová and
  • Petr Beier

Beilstein J. Org. Chem. 2022, 18, 549–554, doi:10.3762/bjoc.18.57

Graphical Abstract
  • oxygen with sulfur. In particular, we present synthetic procedures toward bioisosteres of karrikins with one or two sulfur heteroatoms incorporated into the core backbone together with evaluation of their biological activity in inhibition of acetylcholinesterase. Keywords: acetylcholinesterase
  • brain of patients suffering with the Parkinson’s and the Alzheimer’s disease, respectively. Therefore, research is focused on the discovery of new drugs protecting acetylcholine and dopamine levels via inhibition of acetylcholinesterase (AChE) and monoamine oxidase (MAO). A promising source of such
  • derivatives 27–30 were prepared from 8, 20, 21, and 26 using microwave heating with Lawesson’s reagent and HMDO (Scheme 6). Thionation provided the title compounds in good to high yields. Biochemical study – AchE inhibition The compounds were further tested for their ability to inhibit AChE in vitro [24
PDF
Album
Supp Info
Full Research Paper
Published 16 May 2022
Other Beilstein-Institut Open Science Activities