Main group mechanochemistry

• Agota A. Gečiauskaitė and
• Felipe García

Beilstein J. Org. Chem. 2017, 13, 2068–2077, doi:10.3762/bjoc.13.204

• halides (AsI3 and SbCl3) have shown that selection of solution or mechanochemical conditions influence product stereoisomer distributions. In this case, the mechanochemical route increases the C1:C3 stereoisomer ratio in complexes 17 and 18 for As and Sb, respectively (see Scheme 7) [100]. The ability to

High-speed vibration-milling-promoted synthesis of symmetrical frameworks containing two or three pyrrole units

• Marco Leonardi,
• Mercedes Villacampa and
• J. Carlos Menéndez

Beilstein J. Org. Chem. 2017, 13, 1957–1962, doi:10.3762/bjoc.13.190

• stereoisomer at the central double bond, which was assumed to be E, while compound 12c, obtained from a 1-homoallyl derivative, was isolated as a 1:1 E/Z mixture (Table 1). Conclusion Symmetrical compounds containing two or three pyrrole or fused pyrrole units joined by a spacer are of interest in the

18-Hydroxydolabella-3,7-diene synthase – a diterpene synthase from Chitinophaga pinensis

• Jeroen S. Dickschat,
• Jan Rinkel,
• Patrick Rabe,
• Arman Beyraghdar Kashkooli and
• Harro J. Bouwmeester

Beilstein J. Org. Chem. 2017, 13, 1770–1780, doi:10.3762/bjoc.13.171

• HdS. (C) Structure of the known stereoisomer 1,11-di-epi-3. NMR data of 3 recorded in C6D6. Supporting Information Supporting Information File 206: Experimental details for gene expression and enzyme incubation experiments, NMR spectra of (1R,3E,7E,11S,12S)-18-hydroxydolabella-3,7-diene, and

The chemistry and biology of mycolactones

• Matthias Gehringer and
• Karl-Heinz Altmann

Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159

A new member of the fusaricidin family – structure elucidation and synthesis of fusaricidin E

• Marcel Reimann,
• Louis P. Sandjo,
• Luis Antelo,
• Eckhard Thines,
• Isabella Siepe and
• Till Opatz

Beilstein J. Org. Chem. 2017, 13, 1430–1438, doi:10.3762/bjoc.13.140

• (Figure 1). Thus, an assumed stereoisomer (containing D-allo-Ile) of the new fusaricidin member was synthesized based on analogy to known members of the series and compared to the natural product [8]. Results and Discussion Isolation and structure elucidation The Paenibacillus strain was cultivated on

• single signal set, so the fate of the assumed minor stereoisomer remains unclear and it was probably lost during HPLC purification. The analysis also revealed that the acylation with the GHPD side chain was selective for the amine and no O-acylated product was formed. Side chain protecting groups were

Total syntheses of the archazolids: an emerging class of novel anticancer drugs

• Stephan Scheeff and
• Dirk Menche

Beilstein J. Org. Chem. 2017, 13, 1085–1098, doi:10.3762/bjoc.13.108

• protection of the free alcohol and deprotection of the primary PMB-protected alcohol with DDQ, the resulting alcohol was oxidized to the corresponding aldehyde. The crude aldehyde was then directly transformed into the (Z)-α,β-unsaturated ester 62 as a single stereoisomer by a Still–Gennari [72] olefination

Total synthesis of TMG-chitotriomycin based on an automated electrochemical assembly of a disaccharide building block

• Yuta Isoda,
• Norihiko Sasaki,
• Kei Kitamura,
• Shuji Takahashi,
• Sujit Manmode,
• Naoko Takeda-Okuda,
• Jun-ichi Tamura,
• Toshiki Nokami and
• Toshiyuki Itoh

Beilstein J. Org. Chem. 2017, 13, 919–924, doi:10.3762/bjoc.13.93

• linkage [26]. Here we report the total synthesis of TMG-chitotriomycin (1) as a single stereoisomer, which was prepared by automated electrochemical assembly started from a disaccharide building block. Results and Discussion To synthesize the potential precursor 7 of TMG-chitotriomycin (1

Synthesis of D-manno-heptulose via a cascade aldol/hemiketalization reaction

• Yan Chen,
• Xiaoman Wang,
• Junchang Wang and
• You Yang

Beilstein J. Org. Chem. 2017, 13, 795–799, doi:10.3762/bjoc.13.79

• -selective coupling intermediate 12 underwent in situ cyclization to provide hemiketal 13 as the major product in about 50–60% yield (35% overall yield from compound 11). Notably, trace amounts of a stereoisomer and a minor highly polar unknown byproduct were also observed in this cascade reaction. The

Studies directed toward the exploitation of vicinal diols in the synthesis of (+)-nebivolol intermediates

• Runjun Devi and
• Sajal Kumar Das

Beilstein J. Org. Chem. 2017, 13, 571–578, doi:10.3762/bjoc.13.56

• , respectively, in 93% yield. It is to be mention that the NMR spectra and specific rotations of 2 and 29 matched with those reported in the literature [11][14][15]. For the synthesis of compound 3, stereoisomer 29 was subjected to classical two-step Mitsunobu inversion protocol which was successful but poor

Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia)

• Alexander Bogdanov,
• Cora Hertzer,
• Stefan Kehraus,
• Samuel Nietzer,
• Sven Rohde,
• Peter J. Schupp,
• Heike Wägele and
• Gabriele M. König

Beilstein J. Org. Chem. 2017, 13, 502–519, doi:10.3762/bjoc.13.50

• ) resulted in stronger effects (see Figure 11). Surprisingly, the stereoisomer of 10, 2R-isosarcophytoxide (11) showed no significant deterrence at concentrations up to 2.0% of dry mass. No significant activity could be attributed to the structurally related sarcophytonin B (6) at a concentration up to 1.0

• activity [12]. Remarkable, however, is the inactivity of the (2R)-isosarcophytoxide (11) up to 2% of dry pellet mass, a mere stereoisomer of the active metabolite 10. Such a dependence on stereochemistry may result from a specific interaction with taste receptors in C. solandri lips, oral cavity and

Synthesis of 1-indanones with a broad range of biological activity

• Marika Turek,
• Dorota Szczęsna,
• Marek Koprowski and
• Piotr Bałczewski

Beilstein J. Org. Chem. 2017, 13, 451–494, doi:10.3762/bjoc.13.48

• to obtain alkylidenoindanedione intermediate 171, which was further converted into racemic benzoabicoviromycin 172 (Scheme 49). The racemic benzoabicoviromycin 172 as well as its (Z)-ethylidene stereoisomer have been screened for in vitro biological activity (antiviral, anticancer and antifungal

Polyketide stereocontrol: a study in chemical biology

• Kira J. Weissman

Beilstein J. Org. Chem. 2017, 13, 348–371, doi:10.3762/bjoc.13.39

• so in principle, 1024 (210) different stereoisomers are possible. Yet, nature reliably assembles only one stereoisomer (at least at detectable levels), at once revealing the strict stereocontrol underpinning the pathway and the importance of synthesizing this particular version. Indeed, the crystal

• resulting enantiomeric materials, it was then shown by autoradiography that acylation of all six DEBS proteins is highly specific for the (2S)-isomer (7) [26], implying that the six AT domains present in the multienzymes select exclusively this stereoisomer (Figure 5). Subsequent studies in vitro with a

• . Analysis of results obtained with KRs from the DEBS [68], tylosin (Tyl) [68][72] and amphotericin [58][61] PKSs (Figure 12), showed that when the KRs selected the correct stereoisomer at the C-2 methyl position, reduction occurred almost exclusively in the native direction; the same result was obtained for

Diastereoselective anodic hetero- and homo-coupling of menthol-, 8-methylmenthol- and 8-phenylmenthol-2-alkylmalonates

• Matthias C. Letzel,
• Hans J. Schäfer and
• Roland Fröhlich

Beilstein J. Org. Chem. 2017, 13, 33–42, doi:10.3762/bjoc.13.5

• compound 23b (Figure 2) and converting the sp3 hybridized carbon atoms C2’ and C3’ into sp2 hybrids shows that the minor stereoisomer is formed by the shielding of the re-face through the tert-butyl group. Hence the major diastereomer 23a is formed by an attack via the less shielded si-face. The same

Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B

• Viktor Ilkei,
• András Spaits,
• Anita Prechl,
• Áron Szigetvári,
• Zoltán Béni,
• Miklós Dékány,
• Csaba Szántay Jr,
• Judit Müller,
• Árpád Könczöl,
• Ádám Szappanos,
• Attila Mándi,
• Sándor Antus,
• Ana Martins,
• Attila Hunyadi,
• György Tibor Balogh,
• György Kalaus (†),
• Hedvig Bölcskei,
• László Hazai and
• Tibor Kurtán

Beilstein J. Org. Chem. 2016, 12, 2523–2534, doi:10.3762/bjoc.12.247

• racemates (2a, 2c/2b, 2d; 3a, 3c/3b, 3d) by HPLC–ECD analysis (Figure 1). The planar structure and absolute configuration of the first-eluted stereoisomer of dracocephins A (±)-2a–d was determined by single-crystal X-ray diffraction analysis as (2R,5”S)-2a [2]. The biosynthesis of these flavonoid

• /TZVP and CAM-B3LYP/TZVP ECD spectra of (2R,5’’R)-2d showed a better agreement with the ECD of 2a (second-eluted stereoisomer) on the basis of the agreement with the 202 nm positive CE but the negative 330 nm n–π* transition was missing from the computed ECDs. The negative 330 nm n–π* transition could

• /TZVP ECD spectra of (2R,5’’S)-2a gave a perfect agreement with the HPLC–ECD of (2R,5’’R)-2d (fourth eluted stereoisomer). All these calculation results would favor the configurational assignment (2R,5’’S)-2d (fourth eluted stereoisomer) and (2R,5’’R)-2a (second eluted stereoisomer), which, however

β-Amino functionalization of cinnamic Weinreb amides in ionic liquid

• Yi-Ning Wang,
• Guo-Xiang Sun and
• Gang Qi

Beilstein J. Org. Chem. 2016, 12, 2372–2377, doi:10.3762/bjoc.12.231

• aziridines derived from compounds 6a-A and 6a-B, the vicinal proton coupling constants were 7.5 Hz and 4.5 Hz, respectively. Therefore, compound 6a-A was assigned as syn-stereoisomer, and compound 6a-B was assigned as anti-stereoisomer. In the 1H NMR spectra of the isolated diastereomers, an obvious and

A new and expeditious synthesis of all enantiomerically pure stereoisomers of rosaprostol, an antiulcer drug

• Wiesława Perlikowska,
• Remigiusz Żurawiński and
• Marian Mikołajczyk

Beilstein J. Org. Chem. 2016, 12, 2234–2239, doi:10.3762/bjoc.12.215

• rosaprostol (1), an antiulcer drug, were efficiently synthesized from the enantiomers of 2-(dimethoxyphosphoryl)-3-hexylcyclopentanone (3) as chiral substrates. The latter were obtained by resolution of racemic 3 with (+)-(R)-1-(1-naphthyl)ethylamine. The conversion of (+)-3 into rosaprostol stereoisomer

• (−)-1a was accomplished in four steps in 56% overall yield. According to the same protocol, the second stereoisomer (+)-1c was obtained from (−)-3 in 55% overall yield. A slightly improved procedure of the last two steps of the transformation of (+)-3 into (−)-1a allowed an increase in the overall yield

• atom and step economy. Since a detailed evaluation of the biological activity and preclinical studies requires gram quantities of each stereoisomer of 1, we sought a shorter and more efficient approach to our targets. Herein we disclose a new total synthesis of all enantiomerically pure rosaprostol

The direct oxidative diene cyclization and related reactions in natural product synthesis

• Juliane Adrian,
• Leona J. Gross and
• Christian B. W. Stark

Beilstein J. Org. Chem. 2016, 12, 2104–2123, doi:10.3762/bjoc.12.200

• already exist or followed [32][33][34][35][36][37][38][39]. Starting from the readily available C2-symmetric 1,5-diene 4 the 2,3,4,5-tetra-substituted THF diol 5 was obtained as a single stereoisomer with a yield of 84%, following the type A cyclization. Deprotection led to natural (+)-anhydro-D-glucitol

• prepared from commercially available neryl acetate (15). The auxiliary-controlled, permanganate-promoted oxidation of diene 16 proceeded selectively at low temperatures, affording the corresponding diastereomeric THF diols as an inseparable mixture (dr 7:1, major stereoisomer shown in Scheme 6). Compound

• of dienyne 57 proceeded rapidly and selectively at low temperatures, affording the corresponding diastereomeric THF diols as a separable mixture (dr 6:1, major stereoisomer shown in Scheme 13). Semi hydrogenation of the triple bond using the Lindlar catalyst gave the bis-homoallylic alcohol 58a

Chiral ammonium betaine-catalyzed asymmetric Mannich-type reaction of oxindoles

• Masahiro Torii,
• Kohsuke Kato,
• Daisuke Uraguchi and
• Takashi Ooi

Beilstein J. Org. Chem. 2016, 12, 2099–2103, doi:10.3762/bjoc.12.199

• reduced diastereoselectivity (Table 2, entries 1–4). Sterically demanding 2-tolualdehyde-derived imine 3f served as a good electrophile and the corresponding Mannich adduct 4af was isolated as virtually a single stereoisomer (Table 2, entry 5). 3-Thiophenyl aldimine 3g was also well tolerated, but a

Stereo- and regioselectivity of the hetero-Diels–Alder reaction of nitroso derivatives with conjugated dienes

• Lucie Brulíková,
• Aidan Harrison,
• Marvin J. Miller and
• Jan Hlaváč

Beilstein J. Org. Chem. 2016, 12, 1949–1980, doi:10.3762/bjoc.12.184

Conjugate addition–enantioselective protonation reactions

• James P. Phelan and
• Jonathan A. Ellman

Beilstein J. Org. Chem. 2016, 12, 1203–1228, doi:10.3762/bjoc.12.116

• , Frost reported that using the same catalyst system, phenyltrimethoxysilane (49a) could be added to dimethyl itaconate (50) with modest enantioselectivity and without defining the absolute configuration of the major stereoisomer (Scheme 11b) [32]. Darses and Genet reported the highly enantioselective Rh

One-pot synthesis of enantiomerically pure N-protected allylic amines from N-protected α-amino esters

• Gastón Silveira-Dorta,
• Sergio J. Álvarez-Méndez,
• Víctor S. Martín and
• José M. Padrón

Beilstein J. Org. Chem. 2016, 12, 957–962, doi:10.3762/bjoc.12.94

• [6] but this is the first time it is described the synthesis of its (dia)stereoisomer (Z)-2b. The olefination with the non-stabilized ylide of pentadecyltriphenylphosphonium bromide led exclusively to (Z)-2c. Likewise, the results obtained for (E)-2a, the use of stabilized ylides (Table 2, entries 3

Enantioselective carbenoid insertion into C(sp³)–H bonds

• J. V. Santiago and
• A. H. L. Machado

Beilstein J. Org. Chem. 2016, 12, 882–902, doi:10.3762/bjoc.12.87

• of 5 mol % of copper chloride salt, 6 mol % of ligand 1c and 6 mol % of sodium tetrakis[(3,5-tri-fluoromethyl)phenyl]borate (NaBARF). The cyclic sulfones 52 were obtained in good yields and excellent enantiomeric excesses (85–98%) favoring the cis-1,2-di-substituted stereoisomer (Table 5). The

• authors also performed the copper carbenoid insertion reaction to yield five-membered cyclic sulfones 54, under similar experimental conditions, in moderate yields and enantiomeric excesses of the trans stereoisomer (Table 6). Independent to the size of the product, the authors emphasize the low

Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents

• Daniel Wiegmann,
• Stefan Koppermann,
• Marius Wirth,
• Giuliana Niro,
• Kristin Leyerer and
• Christian Ducho

Beilstein J. Org. Chem. 2016, 12, 769–795, doi:10.3762/bjoc.12.77

• be proven that (5'S,6'S)-GlyU 101 is the stereoisomer furnished in this reaction, so that no epimerisation at a later stage of the biosynthetic route is required for the formation of the A-90289 nucleoside antibiotics. Based on the elucidation of the LipK-mediated reaction, Van Lanen et al. then

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

• Sophie Letort,
• Sébastien Balieu,
• William Erb,
• Géraldine Gouhier and
• François Estour

Beilstein J. Org. Chem. 2016, 12, 204–228, doi:10.3762/bjoc.12.23

• phosphonate group for the three methylfluorophosphonates do not result in fundamental changes of the dissociation constants. However, the rather slow hydrolysis rate of P(R)-sarin can be explained by the space arrangement of this stereoisomer into the β-CD cavity. Sarin is the smallest of the three

• β-CD cavity could therefore be at the origin of the rather low reaction rate observed for this stereoisomer. Thus, in all the studies of Cabal, the P(R)-stereoisomers of soman, sarin and cyclosarin are faster hydrolyzed than the P(S)-stereoisomers in presence of CDs. Nevertheless, due to the

Organocatalytic and enantioselective Michael reaction between α-nitroesters and nitroalkenes. Syn/anti-selectivity control using catalysts with the same absolute backbone chirality

• Jose I. Martínez,
• Uxue Uria,
• Maria Muñiz,
• Efraím Reyes,
• Luisa Carrillo and
• Jose L. Vicario

Beilstein J. Org. Chem. 2015, 11, 2577–2583, doi:10.3762/bjoc.11.277

• therefore access to any stereoisomer at will from the same set of starting materials with full absolute and relative stereocontrol is not trivial. Previous reports show that the diastereoselection can be directed by different approaches that include the modification of reaction conditions [7][8][9], the