Vinylphosphonium and 2-aminovinylphosphonium salts – preparation and applications in organic synthesis

• Anna Kuźnik,
• Roman Mazurkiewicz and
• Beata Fryczkowska

Beilstein J. Org. Chem. 2017, 13, 2710–2738, doi:10.3762/bjoc.13.269

• Anna Kuznik Roman Mazurkiewicz Beata Fryczkowska Department of Organic and Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland Biotechnology Center of Silesian University of Technology, B. Krzywoustego 8, 44-100 Gliwice, Poland

An efficient synthesis of 1,6-anhydro-N-acetylmuramic acid from N-acetylglucosamine

• Matthew B. Calvert,
• Christoph Mayer and
• Alexander Titz

Beilstein J. Org. Chem. 2017, 13, 2631–2636, doi:10.3762/bjoc.13.261

• Microbiology and Infection Medicine Tübingen (IMIT), Department of Microbiology and Biotechnology, University of Tübingen, Germany Department of Pharmacy, Saarland University, Saarbrücken, Germany 10.3762/bjoc.13.261 Abstract A novel synthesis of 1,6-anhydro-N-acetylmuramic acid is described, which proceeds

Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

• Tao Fan,
• Wei-Dong Meng and
• Xingang Zhang

Beilstein J. Org. Chem. 2017, 13, 2610–2616, doi:10.3762/bjoc.13.258

• Tao Fan Wei-Dong Meng Xingang Zhang College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai 201620, China, Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road

Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes

• Hui Hong,
• Markiyan Samborskyy,
• Katsiaryna Usachova,
• Katharina Schnatz and
• Peter F. Leadlay

Beilstein J. Org. Chem. 2017, 13, 2408–2415, doi:10.3762/bjoc.13.238

• File 388: Experimental part and additional Figures and Schemes. Acknowledgements We gratefully acknowledge the joint support, for part of this work, of Syngenta and the Biotechnology and Biological Sciences Research Council (U.K., strategic LoLa award BB/K002341/1). K. U. thanks the Darwin Trust of

Mechanically induced oxidation of alcohols to aldehydes and ketones in ambient air: Revisiting TEMPO-assisted oxidations

• Andrea Porcheddu,
• Evelina Colacino,
• Giancarlo Cravotto,
• Francesco Delogu and
• Lidia De Luca

Beilstein J. Org. Chem. 2017, 13, 2049–2055, doi:10.3762/bjoc.13.202

• chemistry, which is crucial for strategic areas of science related to biochemistry and biotechnology [3][4]. In principle, the oxidation of alcohols represents a convenient option for preparing aldehydes and ketones, as alcohols are among the most abundant naturally occurring organic compounds [5][6

2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of ß-barrel hybrid catalyst for phenylacetylene polymerization

• Julia Kinzel,
• Daniel F. Sauer,
• Marco Bocola,
• Marcus Arlt,
• Tayebeh Mirzaei Garakani,
• Andreas Thiel,
• Klaus Beckerle,
• Tino Polen,
• Jun Okuda and
• Ulrich Schwaneberg

Beilstein J. Org. Chem. 2017, 13, 1498–1506, doi:10.3762/bjoc.13.148

• Julia Kinzel Daniel F. Sauer Marco Bocola Marcus Arlt Tayebeh Mirzaei Garakani Andreas Thiel Klaus Beckerle Tino Polen Jun Okuda Ulrich Schwaneberg Institute of Biotechnology, RWTH Aachen University, Worringer Weg 3, 52074 Aachen, Germany Institut für Anorganische Chemie, RWTH Aachen University

• , Landoltweg 1, 52074 Aachen, Germany DWI - Leibniz Institute for Interactive Materials e.V., Forckenbeckstr. 50, 52056, Aachen, Germany Institute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany 10.3762/bjoc.13.148 Abstract Covering hydrophobic regions with

1-Imidoalkylphosphonium salts with modulated C_α–P⁺ bond strength: synthesis and application as new active α-imidoalkylating agents

• Jakub Adamek,
• Roman Mazurkiewicz,
• Anna Węgrzyk and
• Karol Erfurt

Beilstein J. Org. Chem. 2017, 13, 1446–1455, doi:10.3762/bjoc.13.142

• Jakub Adamek Roman Mazurkiewicz Anna Wegrzyk Karol Erfurt Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland Biotechnology Centre of Silesian University of Technology, B. Krzywoustego 8, 44-100

Mechanochemical synthesis of graphene oxide-supported transition metal catalysts for the oxidation of isoeugenol to vanillin

• Ana Franco,
• Sudipta De,
• Alina M. Balu,
• Araceli Garcia and
• Rafael Luque

Beilstein J. Org. Chem. 2017, 13, 1439–1445, doi:10.3762/bjoc.13.141

• % of total vanilla production is from extraction of natural material. This extraction is a very long and expensive process [6]. The remaining 99% is being produced via chemical and biochemical routes. Biotechnology-based approaches, particularly enzymatic processes, have been well known for many years

A new member of the fusaricidin family – structure elucidation and synthesis of fusaricidin E

• Marcel Reimann,
• Louis P. Sandjo,
• Luis Antelo,
• Eckhard Thines,
• Isabella Siepe and
• Till Opatz

Beilstein J. Org. Chem. 2017, 13, 1430–1438, doi:10.3762/bjoc.13.140

• Catarina, Florianópolis 88040-900, SC, Brazil Institute of Biotechnology and Drug Research, Erwin Schrödinger-Str. 56, 66776 Kaiserslautern, Germany Institute of Molecular Physiology, Microbiology and Wine Research, Johannes Gutenberg University Mainz, Johann-Joachim-Becher-Weg 15, 55128 Mainz, Germany

New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized

• Maryna V. Murlykina,
• Maryna N. Kornet,
• Sergey M. Desenko,
• Svetlana V. Shishkina,
• Oleg V. Shishkin,
• Aleksander A. Brazhko,
• Vladimir I. Musatov,
• Erik V. Van der Eycken and
• Valentin A. Chebanov

Beilstein J. Org. Chem. 2017, 13, 1050–1063, doi:10.3762/bjoc.13.104

• National Academy of Sciences of Ukraine, Nauky Ave., 60, 61001, Kharkiv, Ukraine Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium Laboratory of Biotechnology of Physiologically Active Substances, Zaporizhzhya National University

Glyco-gold nanoparticles: synthesis and applications

• Federica Compostella,
• Olimpia Pitirollo,
• Alessandro Silvestri and
• Laura Polito

Beilstein J. Org. Chem. 2017, 13, 1008–1021, doi:10.3762/bjoc.13.100

• Federica Compostella Olimpia Pitirollo Alessandro Silvestri Laura Polito Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Saldini 50, 20133 Milan, Italy Department of Chemistry, University of Milan, Via C. Golgi 19, 20133 Milan, Italy, CNR – ISTM

Aggregation behaviour of a single-chain, phenylene-modified bolalipid and its miscibility with classical phospholipids

• Simon Drescher,
• Vasil M. Garamus,
• Christopher J. Garvey,
• Annette Meister and
• Alfred Blume

Beilstein J. Org. Chem. 2017, 13, 995–1007, doi:10.3762/bjoc.13.99

• -Planck-Str. 1, 21502 Geesthacht, Germany Australian Nuclear Science and Technology Organisation (ANSTO), Kirrawee DC, NSW, Australia Institute of Chemistry, MLU Halle-Wittenberg, von-Danckelmann-Platz 4, 06120 Halle (Saale), Germany Institute of Biochemistry and Biotechnology, MLU Halle-Wittenberg, Kurt

• lipids consist of two transmembrane alkyl chains (caldarchaeol-type). Especially this type of bolalipids is of great interest for applications in material sciences, biotechnology, and pharmaceuticals [10][11][12][13][14][15]. Since these bolalipids are able to span the membrane of classical phospholipid

Total synthesis of TMG-chitotriomycin based on an automated electrochemical assembly of a disaccharide building block

• Yuta Isoda,
• Norihiko Sasaki,
• Kei Kitamura,
• Shuji Takahashi,
• Sujit Manmode,
• Naoko Takeda-Okuda,
• Jun-ichi Tamura,
• Toshiki Nokami and
• Toshiyuki Itoh

Beilstein J. Org. Chem. 2017, 13, 919–924, doi:10.3762/bjoc.13.93

• Yuta Isoda Norihiko Sasaki Kei Kitamura Shuji Takahashi Sujit Manmode Naoko Takeda-Okuda Jun-ichi Tamura Toshiki Nokami Toshiyuki Itoh Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan Department of Regional

Expression, purification and structural analysis of functional GABA transporter 1 using the baculovirus expression system

• Jing Hu,
• Chris Weise,
• Christoph Böttcher,
• Hua Fan and
• Jian Yin

Beilstein J. Org. Chem. 2017, 13, 874–882, doi:10.3762/bjoc.13.88

• Jing Hu Chris Weise Christoph Bottcher Hua Fan Jian Yin Wuxi School of Medicine, Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Lihu Avenue 1800, 214122, Wuxi, China Institut für Biochemie und Molekularbiologie, Campus Benjamin Franklin

• 63, Berlin D-14195, Germany Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie, Charité Universitätsmedizin Berlin, Berlin D-13353, Germany Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Lihu

A practical and efficient approach to imidazo[1,2-a]pyridine-fused isoquinolines through the post-GBB transformation strategy

• Taofeng Shao,
• Zhiming Gong,
• Tianyi Su,
• Wei Hao and
• Chao Che

Beilstein J. Org. Chem. 2017, 13, 817–824, doi:10.3762/bjoc.13.82

• Taofeng Shao Zhiming Gong Tianyi Su Wei Hao Chao Che Laboratory of Chemical Genomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China 10.3762/bjoc.13.82 Abstract Diversity-oriented

Ultrasound-promoted organocatalytic enamine–azide [3 + 2] cycloaddition reactions for the synthesis of ((arylselanyl)phenyl-1H-1,2,3-triazol-4-yl)ketones

• Gabriel P. Costa,
• Natália Seus,
• Juliano A. Roehrs,
• Raquel G. Jacob,
• Ricardo F. Schumacher,
• Thiago Barcellos,
• Rafael Luque and
• Diego Alves

Beilstein J. Org. Chem. 2017, 13, 694–702, doi:10.3762/bjoc.13.68

• Biotechnology of Natural and Synthetic Products, Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil Departamento de Quimica Organica, Universidad de Cordoba, Campus de Rabanales, Cordoba, Spain 10.3762/bjoc.13.68 Abstract The use of sonochemistry is described in the organocatalytic enamine–azide [3 + 2

Synthesis of 1-indanones with a broad range of biological activity

• Marika Turek,
• Dorota Szczęsna,
• Marek Koprowski and
• Piotr Bałczewski

Beilstein J. Org. Chem. 2017, 13, 451–494, doi:10.3762/bjoc.13.48

• Marika Turek Dorota Szczesna Marek Koprowski Piotr Balczewski Institute of Chemistry, Environmental Protection and Biotechnology, The Faculty of Mathematics and Natural Sciences, Jan Długosz University in Częstochowa, Armii Krajowej 13/15, Częstochowa, 42-201, Poland Department of Structural

Biosynthetic origin of butyrolactol A, an antifungal polyketide produced by a marine-derived Streptomyces

• Enjuro Harunari,
• Hisayuki Komaki and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2017, 13, 441–450, doi:10.3762/bjoc.13.47

• Enjuro Harunari Hisayuki Komaki Yasuhiro Igarashi Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan Biological Resource Center, National Institute of Technology and Evaluation (NBRC), 2-5-8 Kazusakamatari

Decarboxylative and dehydrative coupling of dienoic acids and pentadienyl alcohols to form 1,3,6,8-tetraenes

• Ghina’a I. Abu Deiab,
• Mohammed H. Al-Huniti,
• I. F. Dempsey Hyatt,
• Emma E. Nagy,
• Kristen E. Gettys,
• Sommayah S. Sayed,
• Christine M. Joliat,
• Paige E. Daniel,
• Rupa M. Vummalaneni,
• Andrew T. Morehead Jr,
• Andrew L. Sargent and
• Mitchell P. Croatt

Beilstein J. Org. Chem. 2017, 13, 384–392, doi:10.3762/bjoc.13.41

• North Carolina Biotechnology Center (BRG-1205) and University of North Carolina at Greensboro is gratefully acknowledged. The authors thank Dr. Franklin J. Moy for assisting with analysis of NMR data and Dr. Daniel A. Todd for acquisition of the high resolution mass spectrometry data at the Triad Mass

(Z)-Selective Takai olefination of salicylaldehydes

• Stephen M. Geddis,
• Caroline E. Hagerman,
• Warren R. J. D. Galloway,
• Hannah F. Sore,
• Jonathan M. Goodman and
• David R. Spring

Beilstein J. Org. Chem. 2017, 13, 323–328, doi:10.3762/bjoc.13.35

• funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no [279337/DOS]. In addition, the group research was supported by grants from the Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences

A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues

• Arno Verlee,
• Thomas Heugebaert,
• Tom van der Meer,
• Pavel I. Kerchev,
• Frank Van Breusegem and
• Christian V. Stevens

Beilstein J. Org. Chem. 2017, 13, 303–312, doi:10.3762/bjoc.13.33

• Systems Biology, VIB, Ghent University, Technologiepark 927, B-9000 Ghent, Belgium Department of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium 10.3762/bjoc.13.33 Abstract For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are

Self-optimisation and model-based design of experiments for developing a C–H activation flow process

• Alexander Echtermeyer,
• Yehia Amar,
• Jacek Zakrzewski and
• Alexei Lapkin

Beilstein J. Org. Chem. 2017, 13, 150–163, doi:10.3762/bjoc.13.18

• Alexander Echtermeyer Yehia Amar Jacek Zakrzewski Alexei Lapkin Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom 10.3762/bjoc.13.18 Abstract A

• Yehia Amar is grateful to UCB Pharma for his Ph.D. scholarship. Jacek Zakrzewski is grateful to the Department of Chemical Engineering and Biotechnology for funding his Ph.D. scholarship within Catalysis@Cambridge programme.

Stabilization of nanosized titanium dioxide by cyclodextrin polymers and its photocatalytic effect on the degradation of wastewater pollutants

• Tamás Zoltán Agócs,
• István Puskás,
• Erzsébet Varga,
• Mónika Molnár and
• Éva Fenyvesi

Beilstein J. Org. Chem. 2016, 12, 2873–2882, doi:10.3762/bjoc.12.286

• Tamas Zoltan Agocs Istvan Puskas Erzsebet Varga Monika Molnar Eva Fenyvesi CycloLab Cyclodextrin R&D Laboratory Ltd, Illatos út 7, Budapest, 1097, Hungary Department of Applied Biotechnology and Food Science, Budapest University of Technology and Economics, Szent Gellért tér 4, Budapest, 1111

Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases

• Vladimir A. Stepchenko,
• Anatoly I. Miroshnikov,
• Frank Seela and
• Igor A. Mikhailopulo

Beilstein J. Org. Chem. 2016, 12, 2588–2601, doi:10.3762/bjoc.12.254

• tight place of the catalytic site of the enzymes. Conclusion The substrate properties of 4(2)-thioxo- and 6-azapyrimidines as well as their nucleosides for E. coli UP and TP have been investigated leading to a number of observations that are of importance for the biotechnology of pyrimidine nucleosides

A direct method for the N-tetraalkylation of azamacrocycles

• Andrew J. Counsell,
• Angus T. Jones,
• Matthew H. Todd and
• Peter J. Rutledge

Beilstein J. Org. Chem. 2016, 12, 2457–2461, doi:10.3762/bjoc.12.239

• primary alcohols to aldehydes [45], although little explanation of these observations has been put forward. Shaking reaction media is also well established as a preferred method of sample agitation in biotechnology, where it allows additional parameters (e.g., oxygen supply and hydromechanical stress) to