Synthesis of sulfonimidamides from sulfinamides by oxidation with N-chlorosuccinimide

• Olga García Mancheño and
• Carsten Bolm

Beilstein J. Org. Chem. 2007, 3, No. 25, doi:10.1186/1860-5397-3-25

• ] were tested as well (Table 1, Entries 8–10), but they exhibited a significantly lower efficiency than the previous chlorinating agents. Since N-chlorosuccinimide (NCS) had been applied for the oxidation of 4-(methylthio)morpholine towards the synthesis of diazasulfonium salts[22] and the preparation of

Stereoselective α-fluoroamide and α-fluoro- γ-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement

• Kenny Tenza,
• Julian S. Northen,
• David O'Hagan and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2005, 1, No. 13, doi:10.1186/1860-5397-1-13

• phenylglycine as previously described.[20] In the first instance a Yb(OTf)3 mediated aza-Claisen rearrangement using allyl morpholine 10 and acid chloride 9 was explored following MacMillan's protocol.[21] This proceeded smoothly to give the α-fluoroamide 11 in good yield although reduction of the equivalence