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Search for "perspective" in Full Text gives 219 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Application of olefin metathesis in the synthesis of functionalized polyhedral oligomeric silsesquioxanes (POSS) and POSS-containing polymeric materials

  • Patrycja Żak and
  • Cezary Pietraszuk

Beilstein J. Org. Chem. 2019, 15, 310–332, doi:10.3762/bjoc.15.28

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  • cross metathesis much more readily and are clearly better than internal alkenes from the cost perspective. However, internal alkenes are less volatile and cannot produce any ethene, which makes them interesting starting materials. A slight vacuum had to be applied to reactions with terminal alkenes in
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Published 04 Feb 2019

Asymmetric synthesis of a high added value chiral amine using immobilized ω-transaminases

  • Antonella Petri,
  • Valeria Colonna and
  • Oreste Piccolo

Beilstein J. Org. Chem. 2019, 15, 60–66, doi:10.3762/bjoc.15.6

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  • consequence is limited to 50% maximum yield of the desired product. The second process employs non-commercial enzymes which might be a limitation in the perspective of a potential large-scale industrial application. More recently, the synthesis of the (S)-enantiomer of minor application interest has been
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Published 07 Jan 2019

Lectins of Mycobacterium tuberculosis – rarely studied proteins

  • Katharina Kolbe,
  • Sri Kumar Veleti,
  • Norbert Reiling and
  • Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2019, 15, 1–15, doi:10.3762/bjoc.15.1

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  • ][133] including many of the putative Mtb lectins and indeed, Mtb lectins have been poorly studied in mycobacteria. This account has thus focused on reviewing the available knowledge on Mtb lectins, which are a promising field of research with a diagnostic and therapeutic perspective in the field of
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Published 02 Jan 2019

Protein–protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics

  • Laura Carro

Beilstein J. Org. Chem. 2018, 14, 2881–2896, doi:10.3762/bjoc.14.267

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  • drug discovery perspective, its structure differs significantly from the eukaryotic equivalent clamp (PCNA, proliferating cell nuclear activity) [51][57]. O’Donnell et al. first identified the structure of an inhibitor of the E. coli sliding clamp (ECSC) [58]. In the search for a molecule that binds to
  • ]. Similarly to the aforementioned sliding clamp, the structural arrangement of most bacterial SSBs differs significantly to its homolog in eukaryotic cells (replication protein A, RPA) [74]. This dissimilarity could be beneficial from a drug discovery perspective because it would enable selective targeting of
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Published 21 Nov 2018

Synthesis of α-D-GalpN3-(1-3)-D-GalpN3: α- and 3-O-selectivity using 3,4-diol acceptors

  • Emil Glibstrup and
  • Christian Marcus Pedersen

Beilstein J. Org. Chem. 2018, 14, 2805–2811, doi:10.3762/bjoc.14.258

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  • perspective, a few closely related glycosylations are shown in Scheme 4. Firstly, our own glycosylations using the 4-O-Bz variants, gave a lower yield, when using the TBDPS–TBDPS variant, of 36% [44]. The less sterically hindered Bn–TBDPS variant gave yields of 47%, which are comparable to the 3,4-diol
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Published 08 Nov 2018

Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

  • Christian Schütz and
  • Martin Empting

Beilstein J. Org. Chem. 2018, 14, 2627–2645, doi:10.3762/bjoc.14.241

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  • of about 6 years or less [90] are quite unrealistic in this field. This actually underpins the urgency for current anti-infective discovery efforts to enable refilling the pipeline in due time before available treatment options run out. However, we believe the translational perspective for such
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Published 15 Oct 2018

Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains

  • Jiang Liu,
  • Peter Leonard,
  • Sebastian L. Müller,
  • Constantin Daniliuc and
  • Frank Seela

Beilstein J. Org. Chem. 2018, 14, 2404–2410, doi:10.3762/bjoc.14.217

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  • functional elucidation. Energy-minimized models of the two macrocycles derived from dC (left) and dU (right) acquired by MM+ simulation using Hyperchem 8.0.10; both showing the accessibility of the Watson–Crick recognition sites. A perspective view of 8 showing the atomic numbering scheme. Displacement
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Letter
Published 13 Sep 2018

Determining the predominant tautomeric structure of iodine-based group-transfer reagents by 17O NMR spectroscopy

  • Nico Santschi,
  • Cody Ross Pitts,
  • Benson J. Jelier and
  • René Verel

Beilstein J. Org. Chem. 2018, 14, 2289–2294, doi:10.3762/bjoc.14.203

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  • over 50 kcal/mol, a high kinetic barrier suppresses the [a → b] isomerization (Figure 1) [5][6]. With SCF3 reagent 5a/5b, structure determination was notably challenging and solely provides a solid-state structural perspective. Thus, we wondered whether a correct structural assignment of reagent 5a/b
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Published 30 Aug 2018

Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry

  • Michael K. Bogdos,
  • Emmanuel Pinard and
  • John A. Murphy

Beilstein J. Org. Chem. 2018, 14, 2035–2064, doi:10.3762/bjoc.14.179

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Published 03 Aug 2018

Recent advances in materials for organic light emitting diodes

  • Eli Zysman-Colman

Beilstein J. Org. Chem. 2018, 14, 1944–1945, doi:10.3762/bjoc.14.168

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  • Organic Chemistry covers novel phosphorescent and TADF materials design and their inclusion as emitters in OLEDs. Some highlights in this issue include the work of Thanh-Tuân Bui et al., who provide a welcome perspective on blue TADF materials for OLEDs in the form of a review article [2]. Cristina
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Editorial
Published 27 Jul 2018

A pyridinium/anilinium [2]catenane that operates as an acid–base driven optical switch

  • Sarah J. Vella and
  • Stephen J. Loeb

Beilstein J. Org. Chem. 2018, 14, 1908–1916, doi:10.3762/bjoc.14.165

Graphical Abstract
  • derivatize, [2]rotaxanes are deemed easier to fine-tune from a structural perspective than [2]catenanes. Although we were able to create an optically sensitive [2]catenane molecular shuttle with the bis(pyridinium)ethane and benzylanilinium recognition motifs, we could not achieve the true ON/OFF, bistable
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Published 25 Jul 2018

Recent applications of chiral calixarenes in asymmetric catalysis

  • Mustafa Durmaz,
  • Erkan Halay and
  • Selahattin Bozkurt

Beilstein J. Org. Chem. 2018, 14, 1389–1412, doi:10.3762/bjoc.14.117

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  • performed using 118a–e as catalysts and isopropanol as a secondary alcohol hydride donor (Scheme 38). Although 99% ee was achieved with catalyst 118a in initial conversion stage, from the perspective of yield and enantioselectivity VANOL-derived phosphite catalyst 118d which has an extended π-delocalization
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Published 08 Jun 2018

Oligonucleotide analogues with cationic backbone linkages

  • Melissa Meng and
  • Christian Ducho

Beilstein J. Org. Chem. 2018, 14, 1293–1308, doi:10.3762/bjoc.14.111

Graphical Abstract
  • systems, vide supra) as the stereoselective synthesis of stereogenic phosphate derivatives is challenging. Therefore, achiral artificial linkages such as guanidinium groups may be considered advantageous from a stereochemical perspective. For the first synthesis of a pentameric thymidinyl DNG in 1996
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Published 04 Jun 2018

Stereoselective nucleophilic addition reactions to cyclic N-acyliminium ions using the indirect cation pool method: Elucidation of stereoselectivity by spectroscopic conformational analysis and DFT calculations

  • Koichi Mitsudo,
  • Junya Yamamoto,
  • Tomoya Akagi,
  • Atsuhiro Yamashita,
  • Masahiro Haisa,
  • Kazuki Yoshioka,
  • Hiroki Mandai,
  • Koji Ueoka,
  • Christian Hempel,
  • Jun-ichi Yoshida and
  • Seiji Suga

Beilstein J. Org. Chem. 2018, 14, 1192–1202, doi:10.3762/bjoc.14.100

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  • physiological and pharmacological activities [1][2][3]. As many of these compounds feature asymmetric carbon atoms at the α-position of the cyclic amine, the stereoselective carbon–carbon bond formation at this position is of great importance from the perspective of drug discovery [4][5]. Meanwhile the “cation
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Letter
Published 24 May 2018

Are dispersion corrections accurate outside equilibrium? A case study on benzene

  • Tim Gould,
  • Erin R. Johnson and
  • Sherif Abdulkader Tawfik

Beilstein J. Org. Chem. 2018, 14, 1181–1191, doi:10.3762/bjoc.14.99

Graphical Abstract
  • forces Dispersion forces are a semi-classical effect coming from quantum fluctuations. Most simply, they can be viewed from the perspective of pairs of interacting fluctuating dipoles, in which a temporary dipole in one (sub)system induces a dipole in the other, and consequently lowers the total energy
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Published 23 May 2018

Mechanochemistry of nucleosides, nucleotides and related materials

  • Olga Eguaogie,
  • Joseph S. Vyle,
  • Patrick F. Conlon,
  • Manuela A. Gîlea and
  • Yipei Liang

Beilstein J. Org. Chem. 2018, 14, 955–970, doi:10.3762/bjoc.14.81

Graphical Abstract
  • Strecker-type reaction could be effected in a ball mill using catalytic anhydrous ferricyanide in the presence of silica [114]. From a theoretical perspective, Hansma proposed that such mechanical energy could be supplied within moving mica sheets under high molecular crowding conditions [115]. In contrast
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Published 27 Apr 2018

On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site

  • Eirinaios I. Vrettos,
  • Gábor Mező and
  • Andreas G. Tzakos

Beilstein J. Org. Chem. 2018, 14, 930–954, doi:10.3762/bjoc.14.80

Graphical Abstract
  • . The general architecture of PDCs consists of three building blocks: the tumor-homing peptide, the cytotoxic agent and the biodegradable connecting linker. The aim of the current review is to provide a spherical perspective on the basic principles governing PDCs, as also the methodology to construct
  • Table 2. Representative examples of PDCs targeting cancer cells Integrating the basic design principles in PDCs pinpointed above, a list of representative developed examples is analyzed below, so as to provide a spherical perspective regarding peptide–drug conjugation chemistry. Currently, there are two
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Published 26 Apr 2018

Phosphodiester models for cleavage of nucleic acids

  • Satu Mikkola,
  • Tuomas Lönnberg and
  • Harri Lönnberg

Beilstein J. Org. Chem. 2018, 14, 803–837, doi:10.3762/bjoc.14.68

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Published 10 Apr 2018

An air-stable bisboron complex: a practical bidentate Lewis acid catalyst

  • Longcheng Hong,
  • Sebastian Ahles,
  • Andreas H. Heindl,
  • Gastelle Tiétcha,
  • Andrey Petrov,
  • Zhenpin Lu,
  • Christian Logemann and
  • Hermann A. Wegner

Beilstein J. Org. Chem. 2018, 14, 618–625, doi:10.3762/bjoc.14.48

Graphical Abstract
  • attributed to the free vacant p-orbital of the boron atom leading to further transformations, such as decomposition via radicals (O2), reactions with nucleophiles (H2O) as well as the formations of adducts. From this perspective, a suitable Lewis base may form a Lewis complex and subsequently occupy the p
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Published 13 Mar 2018

Mechanochemistry

  • José G. Hernández

Beilstein J. Org. Chem. 2017, 13, 2372–2373, doi:10.3762/bjoc.13.234

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  • otherwise impossible chemical reactivity in many cases. From a green chemistry perspective, mechanochemical activation conducted by milling, shearing, pulling or ultrasonic irradiation allows for the possibility to drastically reduce the amount of solvent needed during chemical reactions, even to the point
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Published 07 Nov 2017

Conjugated nitrosoalkenes as Michael acceptors in carbon–carbon bond forming reactions: a review and perspective

  • Yaroslav D. Boyko,
  • Valentin S. Dorokhov,
  • Alexey Yu. Sukhorukov and
  • Sema L. Ioffe

Beilstein J. Org. Chem. 2017, 13, 2214–2234, doi:10.3762/bjoc.13.220

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  • nucleophile as well as asymmetric catalysis still remains to be studied in these reactions. The high efficiency and stereoselectivity of the enolate addition to nitrosoalkenes make this strategy perspective for application in total synthesis that has been recognized since 1970s. Thus, Oppolzer and co-workers
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Published 23 Oct 2017

Intramolecular glycosylation

  • Xiao G. Jia and
  • Alexei V. Demchenko

Beilstein J. Org. Chem. 2017, 13, 2028–2048, doi:10.3762/bjoc.13.201

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  • seems to have wide applicability…” and disclosed their attempts to link the reaction counterparts with dicarboxylic acids. This served as an ultimate perspective on future developments in the field, but about a decade had passed before Ziegler resurrected this concept. Flexible succinoyl and related
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Published 29 Sep 2017

A recursive microfluidic platform to explore the emergence of chemical evolution

  • David Doran,
  • Marc Rodriguez-Garcia,
  • Rebecca Turk-MacLeod,
  • Geoffrey J. T. Cooper and
  • Leroy Cronin

Beilstein J. Org. Chem. 2017, 13, 1702–1709, doi:10.3762/bjoc.13.164

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  • way towards answering the latter question. This approach engenders a “chemically agnostic” perspective, in which strict adherence to the chemical repertoire found in currently extant biochemistry is not required [9]. Indeed, the simplest biological units can be considered as nothing more than complex
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Published 17 Aug 2017

Chemical systems, chemical contiguity and the emergence of life

  • Terrence P. Kee and
  • Pierre-Alain Monnard

Beilstein J. Org. Chem. 2017, 13, 1551–1563, doi:10.3762/bjoc.13.155

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  • membrane components. Furthermore, experimental conditions are sometimes implausible from the geochemical perspective. Finally, the evolutionary continuity of the systems, which should be paramount to explain the emergence of protocellular systems and evolution towards true cells, is often neglected in
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Published 07 Aug 2017

Direct catalytic arylation of heteroarenes with meso-bromophenyl-substituted porphyrins

  • Alexei N. Kiselev,
  • Olga K. Grigorova,
  • Alexei D. Averin,
  • Sergei A. Syrbu,
  • Oskar I. Koifman and
  • Irina P. Beletskaya

Beilstein J. Org. Chem. 2017, 13, 1524–1532, doi:10.3762/bjoc.13.152

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  • application of such medicaments are antitumor remedies and non-invasive diagnostic imaging agents for PET, SPECT and MRI methods [5]. The combination of porphyrin and heterocyclic moieties in one molecule is perspective for the design of new compounds with potential powerful pharmaceutical properties. Up to
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Published 03 Aug 2017
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