Biocatalysis for the application of CO₂ as a chemical feedstock

• Apostolos Alissandratos and
• Christopher J. Easton

Beilstein J. Org. Chem. 2015, 11, 2370–2387, doi:10.3762/bjoc.11.259

• future biotechnology that aims to use CO2 as a feedstock for the generation of other materials. Here we provide an overview of the biocatalysts that have already been applied to relevant technologies and are set to play an important role in future bioprocesses for the transformation of CO2 into fuels and

• received much attention for application in biotechnology for CO2-fixation, particularly using engineered photosynthetic hosts, such as plants and algae. The inefficiency of RuBisCO and promiscuity towards oxygen have directed efforts in protein engineering towards the generation of optimised mutants that

Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction

• Yitao Duan,
• Peiyuan Yao,
• Yuncheng Du,
• Jinhui Feng,
• Qiaqing Wu and
• Dunming Zhu

Beilstein J. Org. Chem. 2015, 11, 2245–2251, doi:10.3762/bjoc.11.243

• Yitao Duan Peiyuan Yao Yuncheng Du Jinhui Feng Qiaqing Wu Dunming Zhu National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China 10.3762

Engineering Pichia pastoris for improved NADH regeneration: A novel chassis strain for whole-cell catalysis

• Martina Geier,
• Christoph Brandner,
• Gernot A. Strohmeier,
• Mélanie Hall,
• Franz S. Hartner and
• Anton Glieder

Beilstein J. Org. Chem. 2015, 11, 1741–1748, doi:10.3762/bjoc.11.190

• Martina Geier Christoph Brandner Gernot A. Strohmeier Melanie Hall Franz S. Hartner Anton Glieder Austrian Centre of Industrial Biotechnology (ACIB GmbH), Petersgasse 14, Graz, 8010, Austria Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria

• Department of Chemistry, University of Graz, Heinrichstrasse 28, Graz, 8010, Austria Sandoz GmbH, Biochemiestrasse 10, 6250, Kundl, Austria Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, Graz, 8010, Austria 10.3762/bjoc.11.190 Abstract Many synthetically useful

Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

• Paul P. Kelly,
• Anja Eichler,
• Susanne Herter,
• David C. Kranz,
• Nicholas J. Turner and
• Sabine L. Flitsch

Beilstein J. Org. Chem. 2015, 11, 1713–1720, doi:10.3762/bjoc.11.186

• Paul P. Kelly Anja Eichler Susanne Herter David C. Kranz Nicholas J. Turner Sabine L. Flitsch School of Chemistry & Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, M1 7DN, Manchester, United Kingdom 10.3762/bjoc.11.186 Abstract Cytochrome P450

Dicarboxylic esters: Useful tools for the biocatalyzed synthesis of hybrid compounds and polymers

• Ivan Bassanini,
• Karl Hult and
• Sergio Riva

Beilstein J. Org. Chem. 2015, 11, 1583–1595, doi:10.3762/bjoc.11.174

• Ivan Bassanini Karl Hult Sergio Riva Istituto di Chimica del Riconoscimento Molecolare, CNR, via Mario Bianco 9, Milano, Italy School of Biotechnology, Department of Industrial Biotechnology, Albanova KTH, Royal Institute of Technology, Stockholm, Sweden 10.3762/bjoc.11.174 Abstract Dicarboxylic

A new method for the synthesis of α-aminoalkylidenebisphosphonates and their asymmetric phosphonyl-phosphinyl and phosphonyl-phosphinoyl analogues

• Anna Kuźnik,
• Roman Mazurkiewicz,
• Mirosława Grymel,
• Katarzyna Zielińska,
• Jakub Adamek,
• Ewa Chmielewska,
• Marta Bochno and
• Sonia Kubica

Beilstein J. Org. Chem. 2015, 11, 1418–1424, doi:10.3762/bjoc.11.153

• Anna Kuznik Roman Mazurkiewicz Miroslawa Grymel Katarzyna Zielinska Jakub Adamek Ewa Chmielewska Marta Bochno Sonia Kubica Department of Organic Chemistry, Biochemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland Department of Bioorganic

Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds

• Michaela Mühlberg,
• Michael G. Hoesl,
• Christian Kuehne,
• Jens Dernedde,
• Nediljko Budisa and
• Christian P. R. Hackenberger

Beilstein J. Org. Chem. 2015, 11, 784–791, doi:10.3762/bjoc.11.88

• modification; lectin; multivalency; Introduction The chemical modification of proteins has been developed to a core discipline in chemical biology with diverse applications in all areas of the life sciences, including pharmacology, biophysics, biotechnology and cell biology [1][2][3][4]. In addition to the

Synthesis and surface grafting of a β-cyclodextrin dimer facilitating cooperative inclusion of 2,6-ANS

• Lars W. Städe,
• Thorbjørn T. Nielsen,
• Laurent Duroux,
• Reinhard Wimmer,
• Kyoko Shimizu and
• Kim L. Larsen

Beilstein J. Org. Chem. 2015, 11, 514–523, doi:10.3762/bjoc.11.58

• Lars W. Stade Thorbjorn T. Nielsen Laurent Duroux Reinhard Wimmer Kyoko Shimizu Kim L. Larsen Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Frederik Bajers Vej 7H, DK-9220 Aalborg East, Denmark Department of Chemistry, Aarhus University, Langelandsgade

Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo

• Alireza Shakoori,
• John B. Bremner,
• Mohammed K. Abdel-Hamid,
• Anthony C. Willis,
• Rachada Haritakun and
• Paul A. Keller

Beilstein J. Org. Chem. 2015, 11, 481–492, doi:10.3762/bjoc.11.54

• Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Phaholyothin Road, Klong1, Klong Luang, Pathumanthani 12120, Thailand 10.3762/bjoc.11.54 Abstract Diversity-directed synthesis based on the cascade allylation chemistry of indigo, with its

Matsuda–Heck reaction with arenediazonium tosylates in water

• Ksenia V. Kutonova,
• Marina E. Trusova,
• Andrey V. Stankevich,
• Pavel S. Postnikov and
• Victor D. Filimonov

Beilstein J. Org. Chem. 2015, 11, 358–362, doi:10.3762/bjoc.11.41

• Ksenia V. Kutonova Marina E. Trusova Andrey V. Stankevich Pavel S. Postnikov Victor D. Filimonov Department of Biotechnology and Organic Chemistry, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia Laboratory of Materials and Technologies of Liquid Crystal Devices, Institute of

Formation of nanoparticles by cooperative inclusion between (S)-camptothecin-modified dextrans and β-cyclodextrin polymers

• Thorbjørn Terndrup Nielsen,
• Catherine Amiel,
• Laurent Duroux,
• Kim Lambertsen Larsen,
• Lars Wagner Städe,
• Reinhard Wimmer and
• Véronique Wintgens

Beilstein J. Org. Chem. 2015, 11, 147–154, doi:10.3762/bjoc.11.14

• Thorbjorn Terndrup Nielsen Catherine Amiel Laurent Duroux Kim Lambertsen Larsen Lars Wagner Stade Reinhard Wimmer Veronique Wintgens Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, 9000 Aalborg, Denmark Systèmes Polymères Complexes

First chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine

• Paweł Borowiecki,
• Daniel Paprocki and
• Maciej Dranka

Beilstein J. Org. Chem. 2014, 10, 3038–3055, doi:10.3762/bjoc.10.322

• - and air-stability make tandem chemoenzymatic processes attractive for both: laboratory and industrial applications. Since enzyme-catalyzed processes provide an access to enantiomerically enriched compounds, they became an extremely practical tool for chemistry and biotechnology [14][15][16][17][18][19

Trogopterins A–C: Three new neolignans from feces of Trogopterus xanthipes

• Soyoon Baek,
• Xuikui Xia,
• Byung Sun Min,
• Chanil Park and
• Sang Hee Shim

Beilstein J. Org. Chem. 2014, 10, 2955–2962, doi:10.3762/bjoc.10.313

• Soyoon Baek Xuikui Xia Byung Sun Min Chanil Park Sang Hee Shim School of Biotechnology, Yeungnam University, Daedong, Gyeongsan, Gyeongbuk 712-749, South Korea Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, P. R

• deposited in the Natural Products Chemistry Laboratory of the School of Biotechnology, Yeungnam University (Gyeongsan, South Korea). Extraction and isolation The air-dried Trogopterus feces (1 kg) were subjected to extraction three times (3 h per cycle) with refluxing methanol. The solvent was evaporated

Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application

• Juliana P. L. Gonçalves,
• Afnan Q. Shaikh,
• Manuela Reitzig,
• Daria A. Kovalenko,
• Jan Michael,
• René Beutner,
• Gianaurelio Cuniberti,
• Dieter Scharnweber and
• Jörg Opitz

Beilstein J. Org. Chem. 2014, 10, 2765–2773, doi:10.3762/bjoc.10.293

• nanodiamonds are a promising nanoscale material in various applications such as microelectronics, polishing, optical monitoring, medicine and biotechnology. Beyond the typical diamond characteristics like extreme hardness or high thermal conductivity, they have additional benefits as intrinsic fluorescence due

Removal of volatile organic compounds using amphiphilic cyclodextrin-coated polypropylene

• Ludmilla Lumholdt,
• Sophie Fourmentin,
• Thorbjørn T. Nielsen and
• Kim L. Larsen

Beilstein J. Org. Chem. 2014, 10, 2743–2750, doi:10.3762/bjoc.10.290

• Ludmilla Lumholdt Sophie Fourmentin Thorbjorn T. Nielsen Kim L. Larsen Section of Chemistry, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 57, DK-9000 Aalborg, Denmark University Lille Nord de France, F-59000 Lille, France ULCO, UCEIV

Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp. YXf3

• Zhi Kai Guo,
• Rong Wang,
• Wei Huang,
• Xiao Nian Li,
• Rong Jiang,
• Ren Xiang Tan and
• Hui Ming Ge

Beilstein J. Org. Chem. 2014, 10, 2677–2682, doi:10.3762/bjoc.10.282

• Zhi Kai Guo Rong Wang Wei Huang Xiao Nian Li Rong Jiang Ren Xiang Tan Hui Ming Ge Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, People’s

• Republic of China Hainan Academy of Ocean and Fisheries Sciences, Haikou, Hainan 570203, People’s Republic of China Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People’s Republic of China State Key Laboratory of

Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens

• Véronique Nardello-Rataj and
• Loïc Leclercq

Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273

• ), and v) they are biodegradable and do not pollute the environment. Their main fields of application are: agriculture, food industry, biotechnology, pharmaceutical industry, chemical and biological analysis, chemical synthesis, catalysis, materials, cosmetic industry, environmental protection

Autonomous assembly of synthetic oligonucleotides built from an expanded DNA alphabet. Total synthesis of a gene encoding kanamycin resistance

• Kristen K. Merritt,
• Kevin M. Bradley,
• Daniel Hutter,
• Mariko F. Matsuura,
• Diane J. Rowold and
• Steven A. Benner

Beilstein J. Org. Chem. 2014, 10, 2348–2360, doi:10.3762/bjoc.10.245

• ) ultralong DNA (UL-DNA) constructs, including whole chromosomes. Experimental Materials and methods Design The sequence for an aminoglycoside 3’-phosphotransferase that encodes resistance to kanamycin is commonly used in cloning vectors and was obtained from the National Center for Biotechnology Information

Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum

• Naoya Oku,
• Miyako Matsumoto,
• Kohsuke Yonejima,
• Keijiroh Tansei and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2014, 10, 1808–1816, doi:10.3762/bjoc.10.190

• Naoya Oku Miyako Matsumoto Kohsuke Yonejima Keijiroh Tansei Yasuhiro Igarashi Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan Suizenjinori-Hompo Tanseidoh, 5-13-3 Tsuboi, Chuo-ku, Kumamoto, Kumamoto 860-0863

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach

• Barbara Palka,
• Angela Di Capua,
• Maurizio Anzini,
• Gyté Vilkauskaité,
• Algirdas Šačkus and
• Wolfgang Holzer

Beilstein J. Org. Chem. 2014, 10, 1759–1764, doi:10.3762/bjoc.10.183

• Barbara Palka Angela Di Capua Maurizio Anzini Gyte Vilkauskaite Algirdas Sackus Wolfgang Holzer Division of Drug Synthesis, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria Department of Biotechnology, Chemistry and

Multicomponent reactions in nucleoside chemistry

• Mariola Koszytkowska-Stawińska and
• Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

• ][9], anti-infective agents [10][11][12], or molecular probes [13][14]. Taking into account the importance of nucleoside analogs in medicine and biotechnology, there is a considerable interest in the development of simple and efficient synthesis of these compounds. Multicomponent reactions (MCRs

Bifunctional dendrons for multiple carbohydrate presentation via carbonyl chemistry

• Davide Bini,
• Francesco Nicotra and
• Laura Cipolla

Beilstein J. Org. Chem. 2014, 10, 1686–1691, doi:10.3762/bjoc.10.177

• Davide Bini Francesco Nicotra Laura Cipolla Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy 10.3762/bjoc.10.177 Abstract The synthesis of new dendrons of the generations 0, 1 and 2 with a double bond at the focal point and a

Pd/C-catalyzed aerobic oxidative esterification of alcohols and aldehydes: a highly efficient microwave-assisted green protocol

• Marina Caporaso,
• Giancarlo Cravotto,
• Spyros Georgakopoulos,
• George Heropoulos,
• Katia Martina and
• Silvia Tagliapietra

Beilstein J. Org. Chem. 2014, 10, 1454–1461, doi:10.3762/bjoc.10.149

• interfaces and surfaces NIS, University of Turin, Via P. Giuria 7–9, 10125 Torino, Italy Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48. Vas. Constantinou Ave., 11635 Athens, Greece 10.3762/bjoc.10.149 Abstract We herein describe an environmentally

Synthesis, characterization and DNA interaction studies of new triptycene derivatives

• Sourav Chakraborty,
• Snehasish Mondal,
• Rina Kumari,
• Sourav Bhowmick,
• Prolay Das and
• Neeladri Das

Beilstein J. Org. Chem. 2014, 10, 1290–1298, doi:10.3762/bjoc.10.130

• curve with 5 and 6. Supporting Information File 286: Synthesis and characterization of compounds 1–8. Acknowledgements N.D. and P.D. thank the Department of Science and Technology, Govt. of India (DST No.: SR/FT/CS-028/2009 and SR/FT/LS-036/2010), Department of Biotechnology, Govt. of India (BT/PR3444

Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally “frozen” analogues of L-glutamic acid

• Beatrice Bechi,
• David Amantini,
• Cristina Tintori,
• Maurizio Botta and
• Romano di Fabio

Beilstein J. Org. Chem. 2014, 10, 1114–1120, doi:10.3762/bjoc.10.110

• Beatrice Bechi David Amantini Cristina Tintori Maurizio Botta Romano di Fabio Università degli Studi di Siena, Dipartimento Farmaco Chimico Tecnologico, Via A. Moro 2, 53100, Siena, Italy Present address: Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Oxford