A practical synthesis of the ¹³C/¹⁵N- labelled tripeptide N-formyl- Met-Leu-Phe, useful as a reference in solid- state NMR spectroscopy

• Sven T. Breitung,
• Jakob J. Lopez,
• Gerd Dürner,
• Clemens Glaubitz,
• Michael W. Göbel and
• Marcel Suhartono

Beilstein J. Org. Chem. 2008, 4, No. 35, doi:10.3762/bjoc.4.35

• .) Coupling of further building blocks: In case of quantitative conversion, the resin was washed with N,N-dimethylformamide (DMF, 5 ×) and treated three times (15 min, 10 min, 5 min) with a piperidine solution (25% in DMF). Then the resin was washed with N-methylpyrrolidone (NMP, 5 ×) and a solution of 13C

Ru-catalyzed dehydrogenative coupling of carboxylic acids and silanes - a new method for the preparation of silyl ester

• Guo-Bin Liu and
• Hong-Yun Zhao

Beilstein J. Org. Chem. 2008, 4, No. 27, doi:10.3762/bjoc.4.27

• detected (12–22%) (Table 2, Runs 2–8). In N,N-dimethylformamide (DMF) and N,N-dimethylacetamide (DMAc), the dehydrocoupling failed to reach completion being heated at 100 °C for 48 h, and significant amounts of Et3SiH were detected (Table 2, Runs 9 and 10). Other Ru complexes were also tested as catalysts

Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• , DMAP, Et3N; b) MeONa at 0°C; c) TFA; d) glutaric anhydride, dimethylformamide (DMF) Reagents and conditions for protection of paclitaxel and coupling to N-glutaryl-deacetylcolchicine (6). The reagents used at each step are: a) TBDMSCl, DMAP; b) DCC, DMAP; c) TBAF. Comparison of the logP values