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Search for "similarity" in Full Text gives 289 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

  • Mark Kelada,
  • John M. D. Walsh,
  • Robert W. Devine,
  • Patrick McArdle and
  • John C. Stephens

Beilstein J. Org. Chem. 2018, 14, 1222–1228, doi:10.3762/bjoc.14.104

Graphical Abstract
  • compounds, as well as its structural similarity to purine [1][2][3][4]. Pyrazolo[1,5-a]pyrimidinone derivatives have found use in the battle against several illnesses including cancer [5], viral infections [6][7][8], obesity [9], and cystic fibrosis [10] (Figure 1). It is these pharmacological properties
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Published 28 May 2018

Phosphodiester models for cleavage of nucleic acids

  • Satu Mikkola,
  • Tuomas Lönnberg and
  • Harri Lönnberg

Beilstein J. Org. Chem. 2018, 14, 803–837, doi:10.3762/bjoc.14.68

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Published 10 Apr 2018

An uracil-linked hydroxyflavone probe for the recognition of ATP

  • Márton Bojtár,
  • Péter Zoltán Janzsó-Berend,
  • Dávid Mester,
  • Dóra Hessz,
  • Mihály Kállay,
  • Miklós Kubinyi and
  • István Bitter

Beilstein J. Org. Chem. 2018, 14, 747–755, doi:10.3762/bjoc.14.63

Graphical Abstract
  • made to selectively recognize and detect these analytes, especially ATP using small-molecule fluorescent chemosensors. Despite the various solutions, the selective detection of ATP is still challenging due to the structural similarity of various nucleotides. In this paper, we report the conjugation of
  • ], metal-complexes [21][22][23][24][25][26][27] and other direct sensing systems [28][29][30] have significant advantages over the classical, separation-based methods. The primary difficulties in the design of an ATP chemosensor are the structural similarity of ATP to other nucleotides (i.e., to guanosine
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Published 03 Apr 2018

Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications

  • Mattias Bood,
  • Sangamesh Sarangamath,
  • Moa S. Wranne,
  • Morten Grøtli and
  • L. Marcus Wilhelmsson

Beilstein J. Org. Chem. 2018, 14, 114–129, doi:10.3762/bjoc.14.7

Graphical Abstract
  • nucleoside in 65% yield. Subsequent phosphitylation followed by salt-formation finally furnished compound 35 in 52% over two steps. Since the quadracyclic adenine presented an overall structural similarity with adenine and keeping a very rigid heterocyclic system suggesting few options for the molecule to
  • °, respectively, that are in good agreement with the experimentally determined one for the cytosine analogue FRET pair (58°) and the TDDFT-estimated one for the adenine analogue FRET pair (41°) [14][25]. Also the spectral overlap integrals show high similarity to the values resulting from the best fit. Taken
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Published 10 Jan 2018

A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC–HRMS monitoring of the reaction pathway

  • Dmitry Yu. Vandyshev,
  • Khidmet S. Shikhaliev,
  • Andrey Yu. Potapov,
  • Michael Yu. Krysin,
  • Fedor I. Zubkov and
  • Lyudmila V. Sapronova

Beilstein J. Org. Chem. 2017, 13, 2561–2568, doi:10.3762/bjoc.13.252

Graphical Abstract
  • . Allowing for the formal structural similarity of intermediates 5–8d, we assume that one of the chromatographic peaks with the retention time of 3.6 or 3.8 min corresponds to the intermediate diaminoimidazole 5d, and the second one corresponds to one of succinimides 6–8d. The accumulation of the compound
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Published 30 Nov 2017

15N-Labelling and structure determination of adamantylated azolo-azines in solution

  • Sergey L. Deev,
  • Alexander S. Paramonov,
  • Tatyana S. Shestakova,
  • Igor A. Khalymbadzha,
  • Oleg N. Chupakhin,
  • Julia O. Subbotina,
  • Oleg S. Eltsov,
  • Pavel A. Slepukhin,
  • Vladimir L. Rusinov,
  • Alexander S. Arseniev and
  • Zakhar O. Shenkarev

Beilstein J. Org. Chem. 2017, 13, 2535–2548, doi:10.3762/bjoc.13.250

Graphical Abstract
  • vicinal couplings (3JH2-N8 and 3JH6-N8) made this strategy not applicable for compound 24-15N2. In this case, the supposed assignment of the N3 resonance was indirectly confirmed by the similarity of its chemical shifts in compounds 21a-15N2 and 24-15N2. NMR and Х-ray diffraction data revealing several
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Published 29 Nov 2017

Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes

  • Hui Hong,
  • Markiyan Samborskyy,
  • Katsiaryna Usachova,
  • Katharina Schnatz and
  • Peter F. Leadlay

Beilstein J. Org. Chem. 2017, 13, 2408–2415, doi:10.3762/bjoc.13.238

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  • analysis returned two strong matches, Medi4948 (80% identity, 93% similarity) and Medi2865 (82% identity, 92% similarity), both provisionally annotated as agmatinases (the numbers quoted refer to the position of the respective orf in the genome sequence). The next best match was a further agmatinase
  • Medi0234 (41% identity, 57% similarity). Each of these three genes was cloned and expressed in Escherichia coli as an N-terminally histidine-tagged protein as described in the Experimental section, and purified by chromatography on a Ni-NTA column. The putative amidinohydrolases Medi2865 and Medi0234 were
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Published 13 Nov 2017

One-pot syntheses of blue-luminescent 4-aryl-1H-benzo[f]isoindole-1,3(2H)-diones by T3P® activation of 3-arylpropiolic acids

  • Melanie Denißen,
  • Alexander Kraus,
  • Guido J. Reiss and
  • Thomas J. J. Müller

Beilstein J. Org. Chem. 2017, 13, 2340–2351, doi:10.3762/bjoc.13.231

Graphical Abstract
  • sterically more biased carbonyl group (Scheme 7). In addition to NMR spectroscopic and mass spectrometric characterization the crystal structures of the imine condensation products 5 and 6 were determined (Figure 2 and Figure 3) [50]. In similarity to 4b the twist angles of the phenyl substituents (rings A
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Published 03 Nov 2017

Solid-state studies and antioxidant properties of the γ-cyclodextrin·fisetin inclusion compound

  • Joana M. Pais,
  • Maria João Barroca,
  • Maria Paula M. Marques,
  • Filipe A. Almeida Paz and
  • Susana S. Braga

Beilstein J. Org. Chem. 2017, 13, 2138–2145, doi:10.3762/bjoc.13.212

Graphical Abstract
  • traces of crystallites of either γ-CD heptahydrate or pure fisetin (Figure 1). It should be highlighted that the absence of peaks indicating recrystallization of the isolated components is a clear evidence of the formation of a stable and pure inclusion compound [30]. Note also the good similarity
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Published 13 Oct 2017

β-Cyclodextrin- and adamantyl-substituted poly(acrylate) self-assembling aqueous networks designed for controlled complexation and release of small molecules

  • Liang Yan,
  • Duc-Truc Pham,
  • Philip Clements,
  • Stephen F. Lincoln,
  • Jie Wang,
  • Xuhong Guo and
  • Christopher J. Easton

Beilstein J. Org. Chem. 2017, 13, 1879–1892, doi:10.3762/bjoc.13.183

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  • region where those assigned to β-CDen/ADen substituent dipolar interactions arise (Figure 5) indicating that β-CDen substituent proton dipolar interactions with PAAβ-CDen backbone protons are insignificant.) The similarity of the spectra in Figure 5 and Figure S2 (Supporting Information File 1) and the K
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Published 07 Sep 2017

Solvent-free sonochemistry: Sonochemical organic synthesis in the absence of a liquid medium

  • Deborah E. Crawford

Beilstein J. Org. Chem. 2017, 13, 1850–1856, doi:10.3762/bjoc.13.179

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  • recently been recognised for its similarity to mechanochemistry and is now included under the umbrella term of mechanochemistry. Typically, due to the hypothesised cavitation mechanism, a liquid medium is considered as a necessity for a process to take place as a result of ultrasonic irradiation. In view
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Published 04 Sep 2017

The chemistry and biology of mycolactones

  • Matthias Gehringer and
  • Karl-Heinz Altmann

Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159

Graphical Abstract
  • course of mycolactone-mediated apoptosis. Silencing Bim and Fas by RNA interference proved that Bim is the key driver of mycolactone-mediated apoptosis while Fas upregulation may represent a passive bystander effect. Based on these results and considering the remote similarity of mycolactones with
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Published 11 Aug 2017

A new member of the fusaricidin family – structure elucidation and synthesis of fusaricidin E

  • Marcel Reimann,
  • Louis P. Sandjo,
  • Luis Antelo,
  • Eckhard Thines,
  • Isabella Siepe and
  • Till Opatz

Beilstein J. Org. Chem. 2017, 13, 1430–1438, doi:10.3762/bjoc.13.140

Graphical Abstract
  • most likely shows similarity to the fatty acid synthesis pathway [2]. All fusaricidins have three amino acids (L-Thr, D-allo-Thr, and D-Ala) in common and are mostly isolated in pairs which differ in a single amino acid (asparagine vs glutamine). There are several known members of the fusaricidin
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Published 20 Jul 2017

Synthesis of alkynyl-substituted camphor derivatives and their use in the preparation of paclitaxel-related compounds

  • M. Fernanda N. N. Carvalho,
  • Rudolf Herrmann and
  • Gabriele Wagner

Beilstein J. Org. Chem. 2017, 13, 1230–1238, doi:10.3762/bjoc.13.122

Graphical Abstract
  • and ring enlargement, with structural similarity to the simple product from the Ti(IV) reaction with 4a. The reducing agent is Pt(II), which is oxidised to Pt(III) during the reaction (Scheme 3d) [34]. Scheme 3 also depicts paclitaxel (taxol, 11), an important anticancer drug, as there are some
  • similarities (shown in red in Scheme 3) but also differences to our compounds obtained by Pt(II) catalysis from, e.g., 4a. The eye-catching dimethylmethylene bridge over the largest carbocyclic ring is of course the most striking similarity, although this ring is in our compounds one-carbon unit smaller (9 vs
  • analogous to the one observed previously with the bis-phenylalkynyl compound [27] as a starting material. Cyclisation of the alkynes and a three-carbon ring enlargement lead in a single step to a rare bicyclic carbon framework that bears some similarity to that of the anticancer drug paclitaxel. Remarkably
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Published 26 Jun 2017
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  • basis for the altered structural diversity of hapalindole-type alkaloids between the two welwitindolinone producers. The extreme sequence similarity (95% identical) between WelO5* and WelO5 allowed us to trace the origin of this observed specificity difference to 11 amino acid residues at a C-terminal
  • two welwitindolinione producers. Furthermore, the close sequence similarity between WelO5* and WelO5 allowed us to reveal a C-terminal sequence motif (residues 215–232) that harbors 11 varied amino acids between the two proteins plays the most critical role on the observed enhanced activity of WelO5
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Published 16 Jun 2017

Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience

  • Serge Pérez and
  • Daniele de Sanctis

Beilstein J. Org. Chem. 2017, 13, 1145–1167, doi:10.3762/bjoc.13.114

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  • is a fucose-binding lectin having similarity with tumour necrosis factor. The structure of the other domain (C-terminal part) which belongs to the superfamily of calcium-dependent lectins displays specificity for mannose and L-glycero-D-manno-heptose monosaccharides. The two domains are linked by a
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Published 14 Jun 2017

Correlation of surface pressure and hue of planarizable push–pull chromophores at the air/water interface

  • Frederik Neuhaus,
  • Fabio Zobi,
  • Gerald Brezesinski,
  • Marta Dal Molin,
  • Stefan Matile and
  • Andreas Zumbuehl

Beilstein J. Org. Chem. 2017, 13, 1099–1105, doi:10.3762/bjoc.13.109

Graphical Abstract
  • is a structural similarity between the flipper probes and cholesterol with both molecules being amphiphilic and flat. This called for a closer look at the influence of both molecules on phospholipid membrane organization (see Figure 4). For DPPC, the first-order phase transition between the
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Published 08 Jun 2017

G-Protein coupled receptors: answers from simulations

  • Timothy Clark

Beilstein J. Org. Chem. 2017, 13, 1071–1078, doi:10.3762/bjoc.13.106

Graphical Abstract
  • it has played a major role in the determination of the mechanisms of action of GPCRs [21][22] and was the only structure available, in general, rhodopsin was not considered the ideal template for GPCR drug targets. This was because of both its relatively low similarity to medicinal targets [23] and
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Published 02 Jun 2017

Cycloheximide congeners produced by Streptomyces sp. SC0581 and photoinduced interconversion between (E)- and (Z)-2,3-dehydroanhydrocycloheximides

  • Li Yang,
  • Ping Wu,
  • Jinghua Xue,
  • Huitong Tan,
  • Zheng Zhang and
  • Xiaoyi Wei

Beilstein J. Org. Chem. 2017, 13, 1039–1049, doi:10.3762/bjoc.13.103

Graphical Abstract
  • correspond to stable 1(n–π*) and 3(π–π*) states of α,β-enones [14], respectively, and the T1 planar maxima, with increased the C1–O1 and C6–Cα bond lengths and a decreased C1–C6 bond length relative to those of T1 minima, show similarity to a T2 π–π* species [14]. Comparison of parameters of geometries in
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Published 30 May 2017

Synthesis and enzymatic ketonization of the 5-(halo)-2-hydroxymuconates and 5-(halo)-2-hydroxy-2,4-pentadienoates

  • Tyler M. M. Stack,
  • William H. Johnson Jr. and
  • Christian P. Whitman

Beilstein J. Org. Chem. 2017, 13, 1022–1031, doi:10.3762/bjoc.13.101

Graphical Abstract
  • similarity (78% identity and 87% similarity) with the one found in Comamonas sp. strain CNB-1, which is not available [11]. The Lc 4-OT is more distantly related to the Pp 4-OT (45% identity and 71% similarity). The kinetic parameters are shown in Table 1 and Table 2. The kinetic parameters are comparable
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Published 26 May 2017

Inclusion complexes of β-cyclodextrin with tricyclic drugs: an X-ray diffraction, NMR and molecular dynamics study

  • Franca Castiglione,
  • Fabio Ganazzoli,
  • Luciana Malpezzi,
  • Andrea Mele,
  • Walter Panzeri and
  • Giuseppina Raffaini

Beilstein J. Org. Chem. 2017, 13, 714–719, doi:10.3762/bjoc.13.70

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  • and the other aromatic ring protruding above the secondary rim, quite similar to the arrangement experimentally determined in the solid state by X-ray diffraction with a very similar depth of inclusion. In view of the geometrical similarity achieved in the two different simulation environments, in the
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Published 13 Apr 2017

Secondary metabolome and its defensive role in the aeolidoidean Phyllodesmium longicirrum, (Gastropoda, Heterobranchia, Nudibranchia)

  • Alexander Bogdanov,
  • Cora Hertzer,
  • Stefan Kehraus,
  • Samuel Nietzer,
  • Sven Rohde,
  • Peter J. Schupp,
  • Heike Wägele and
  • Gabriele M. König

Beilstein J. Org. Chem. 2017, 13, 502–519, doi:10.3762/bjoc.13.50

Graphical Abstract
  • and does not allow indicating any configuration for C-1 in compound 5. Due to the instability of the substance and its rapid degradation, it was not possible to determine the absolute configuration unambiguously. Structural similarity of the compound 5 with pavidolide A and close relationship between
  • ., compounds 8 and 9. The planar structure of 8 and 9 was established as that of isosarcophine by 1D and 2D NMR data (1H, 13C, COSY, HSQC and HMBC). Specific optical rotation measurements in chloroform (c 0.1 each substance) yielded [α]D20 values of +92.0 for 8 and −38.0 for 9. Due to the close similarity of
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Published 13 Mar 2017

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues

  • Sarah Wallrodt,
  • Edward L. Simpson and
  • Andreas Marx

Beilstein J. Org. Chem. 2017, 13, 495–501, doi:10.3762/bjoc.13.49

Graphical Abstract
  • [25] and can be detected by some minor staining of the involved proteins, which is also visible in some of the investigated reactions. As expected from the close structural similarity between ARTD1 and ARTD2 (panel a and b), both enzymes behave similarly in histone ADP-ribosylation (Supporting
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Published 10 Mar 2017

Polyketide stereocontrol: a study in chemical biology

  • Kira J. Weissman

Beilstein J. Org. Chem. 2017, 13, 348–371, doi:10.3762/bjoc.13.39

Graphical Abstract
  • )- and (4S)-[4-2H]NADPH) with modules 1, 2, 5 and 6 from the DEBS PKS and analysis of the resulting products by GC-MS, showed that all of the KRs are specific for the 4′-pro-S hydride of the nicotinamide cofactor [52][53], as found for fatty acid biosynthesis [54][55]. Given the high sequence similarity
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Published 24 Feb 2017

Posttranslational isoprenylation of tryptophan in bacteria

  • Masahiro Okada,
  • Tomotoshi Sugita and
  • Ikuro Abe

Beilstein J. Org. Chem. 2017, 13, 338–346, doi:10.3762/bjoc.13.37

Graphical Abstract
  • ABBA fold and exhibits some similarity to other dimethylallyltransferases for cyanobactins and prenyltransferases for indole alkaloids, but lacks similarity to cysteine isoprenyltransferases and ComQs [2][37][38][39][40][41][42][43][44]. Considering the in vitro prenylation analysis of KgpF together
  • the core peptide sequence for directing KgpF is unlikely to be required. In addition, the prenylation reaction by KgpF does not seem to need a specific amino acid motif within the core cyclic peptide, because there is no similarity between the sequences surrounding the two tryptophan residues (PWL and
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Published 22 Feb 2017
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