A practical synthesis of the ¹³C/¹⁵N- labelled tripeptide N-formyl- Met-Leu-Phe, useful as a reference in solid- state NMR spectroscopy

• Sven T. Breitung,
• Jakob J. Lopez,
• Gerd Dürner,
• Clemens Glaubitz,
• Michael W. Göbel and
• Marcel Suhartono

Beilstein J. Org. Chem. 2008, 4, No. 35, doi:10.3762/bjoc.4.35

• Wolfgang Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany 10.3762/bjoc.4.35 Abstract A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully

Ru-catalyzed dehydrogenative coupling of carboxylic acids and silanes - a new method for the preparation of silyl ester

• Guo-Bin Liu and
• Hong-Yun Zhao

Beilstein J. Org. Chem. 2008, 4, No. 27, doi:10.3762/bjoc.4.27

• esters are formed in the case of coupling nitro-, bromo-, and chlorobenzoic acid with silanes. We believe that the Ru3(CO)12/EtI-catalyzed dehydrosilylation of carboxylic acids with silanes provides another important protocol for a one-step, highly selective, atom-economical and efficient synthetic

• method. We are currently broadening the scope of this dehydrosilylation of carboxylic acids and silanes in our laboratory and the results will be published elsewhere. Experimental To a mixture of propionic acid (40 mmol, 2.96 g), and triethylsilane (40 mmol, 4.64 g) in toluene (20 ml) was added Ru3(CO)12

One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines

• Dipak Prajapati,
• Partha P. Baruah,
• Baikuntha J. Gogoi and
• Jagir S. Sandhu

Beilstein J. Org. Chem. 2006, 2, No. 5, doi:10.1186/1860-5397-2-5

• ring products 3 (Scheme 1). This mechanism explains the formation of both the products 3 &4 i.e. the presence of an aliphatic CH and loss of PhCN from M+, although they differ in their tautomeric forms. Further study of this effective synthetic method is in progress. To investigate further the