Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups

• H. Bauke Albada,
• Alina-Iulia Chiriac,
• Michaela Wenzel,
• Maya Penkova,
• Julia E. Bandow,
• Hans-Georg Sahl and
• Nils Metzler-Nolte

Beilstein J. Org. Chem. 2012, 8, 1753–1764, doi:10.3762/bjoc.8.200

• Microbiology, Immunology, and Parasitology, Pharmaceutical Microbiology Section, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany Microbial Biology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany 10.3762/bjoc.8.200 Abstract A series

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

• Chao Che,
• Song Li,
• Bo Yang,
• Shengchang Xin,
• Zhixiong Yu,
• Taofeng Shao,
• Chuanye Tao,
• Shuo Lin and
• Zhen Yang

Beilstein J. Org. Chem. 2012, 8, 841–849, doi:10.3762/bjoc.8.94

• Chao Che Song Li Bo Yang Shengchang Xin Zhixiong Yu Taofeng Shao Chuanye Tao Shuo Lin Zhen Yang Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China Shenzhen Shengjie Biotech Co., Ltd., Shenzhen 518055

Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

• Florian Grundmann,
• Veronika Dill,
• Andrea Dowling,
• Aunchalee Thanwisai,
• Edna Bode,
• Narisara Chantratita,
• Richard ffrench-Constant and
• Helge B. Bode

Beilstein J. Org. Chem. 2012, 8, 749–752, doi:10.3762/bjoc.8.85

• Florian Grundmann Veronika Dill Andrea Dowling Aunchalee Thanwisai Edna Bode Narisara Chantratita Richard ffrench-Constant Helge B. Bode Department of Molecular Biotechnology, Goethe-Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany Biosciences, University of Exeter

Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment

• Christiane E. Kupper,
• Ruben R. Rosencrantz,
• Birgit Henßen,
• Helena Pelantová,
• Stephan Thönes,
• Anna Drozdová,
• Vladimir Křen and
• Lothar Elling

Beilstein J. Org. Chem. 2012, 8, 712–725, doi:10.3762/bjoc.8.80

• Christiane E. Kupper Ruben R. Rosencrantz Birgit Henssen Helena Pelantova Stephan Thones Anna Drozdova Vladimir Kren Lothar Elling Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, Aachen, 52074

Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

• Davide Bini,
• Francesca Cardona,
• Matilde Forcella,
• Camilla Parmeggiani,
• Paolo Parenti,
• Francesco Nicotra and
• Laura Cipolla

Beilstein J. Org. Chem. 2012, 8, 514–521, doi:10.3762/bjoc.8.58

• Davide Bini Francesca Cardona Matilde Forcella Camilla Parmeggiani Paolo Parenti Francesco Nicotra Laura Cipolla Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy Department of Chemistry “Ugo Schiff”, University of Florence, Polo

Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure

• Svenja Staudt,
• Christina A. Müller,
• Jan Marienhagen,
• Christian Böing,
• Stefan Buchholz,
• Ulrich Schwaneberg and
• Harald Gröger

Beilstein J. Org. Chem. 2012, 8, 186–191, doi:10.3762/bjoc.8.20

• Svenja Staudt Christina A. Muller Jan Marienhagen Christian Boing Stefan Buchholz Ulrich Schwaneberg Harald Groger Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestr. 42, 91054 Erlangen, Germany Department of Biotechnology, RWTH Aachen University, Worringerweg 1, 52074

• Bundesstiftung Umwelt, DBU) for generous support within the DBU-network “ChemBioTec” of the funding priority “Biotechnology” (Project AZ 13234-32).

Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities

• Hany M. Mohamed,
• Ashraf H. F. Abd EL-Wahab,
• Ahmed M. EL-Agrody,
• Ahmed H. Bedair,
• Fathy A. Eid,
• Mostafa M. Khafagy and
• Kamal A. Abd-EL-Rehem

Beilstein J. Org. Chem. 2011, 7, 1688–1696, doi:10.3762/bjoc.7.199

• microorganisms were obtained from the Regional Center for Mycology & Biotechnology (RCMP), Al-Azhar University. The activities of these compounds were tested by using the disc-diffusion method [23] for bacteria and the paper-disk-diffusion method [24] for fungi. The area of zone inhibition was measured with

Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• indispensable part of industrial biotechnology, and are used in the production of a broad range of bulk and fine chemicals [6]. When a microbial multistep biotransformation is carried out in continuous flow it might formally also be considered as a fourth-generation enzymatic process according to the above

The Eschenmoser coupling reaction under continuous-flow conditions

• Sukhdeep Singh,
• J. Michael Köhler,
• Andreas Schober and
• G. Alexander Groß

Beilstein J. Org. Chem. 2011, 7, 1164–1172, doi:10.3762/bjoc.7.135

• Sukhdeep Singh J. Michael Kohler Andreas Schober G. Alexander Gross Institute for Chemistry and Biotechnology, Technische Universität Ilmenau, Weimarerstr. 32, D-98693-Ilmenau 10.3762/bjoc.7.135 Abstract The Eschenmoser coupling is a useful carbon–carbon bond forming reaction which has been used

Chemistry in flow systems II

• Andreas Kirschning

Beilstein J. Org. Chem. 2011, 7, 1046–1047, doi:10.3762/bjoc.7.119

• the scope of this enabling technology with far reaching implications even for industrial biotechnology. I am thankful to all my colleagues who have helped to create this diverse and state of the art flow series. Finally, special thanks are dedicated to the staff of the Beilstein-Institut for their

Synthesis of glycoconjugate fragments of mycobacterial phosphatidylinositol mannosides and lipomannan

• Benjamin Cao,
• Jonathan M. White and
• Spencer J. Williams

Beilstein J. Org. Chem. 2011, 7, 369–377, doi:10.3762/bjoc.7.47

• Benjamin Cao Jonathan M. White Spencer J. Williams School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia, Fax: +61 3 9347 8124; Tel: +61 3 8344 2422 10.3762/bjoc.7.47 Abstract Mycobacterium tuberculosis, the causitive

Michael-type addition of azoles of broad-scale acidity to methyl acrylate

• Sławomir Boncel,
• Kinga Saletra,
• Barbara Hefczyc and
• Krzysztof Z. Walczak

Beilstein J. Org. Chem. 2011, 7, 173–178, doi:10.3762/bjoc.7.24

• Slawomir Boncel Kinga Saletra Barbara Hefczyc Krzysztof Z. Walczak Silesian University of Technology, Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Krzywoustego 4, 44-100 Gliwice, Poland, Tel.: +48 32 237 1792, Fax: +48 32 237 2094 Silesian University of Technology

SbCl₃-catalyzed one-pot synthesis of 4,4′-diaminotriarylmethanes under solvent-free conditions: Synthesis, characterization, and DFT studies

• Ghasem Rezanejade Bardajee

Beilstein J. Org. Chem. 2011, 7, 135–144, doi:10.3762/bjoc.7.19

• [11][12][13], antitubercular [14], anti-infective, and antimicrobial activity [15]. Additionally, they have been used for sterilization of trypanosome cruizi-infected blood [16], in biotechnology process control [17][18], in dye-assisted laser inactivation of enzymes [19], in wastewater treatment

The C–F bond as a conformational tool in organic and biological chemistry

• Luke Hunter

Beilstein J. Org. Chem. 2010, 6, No. 38, doi:10.3762/bjoc.6.38

• ]. The concept of controlling peptide conformation using fluorine atoms is exciting because the conformation of a peptide critically affects its biological activity and consequently, there are many potential applications in medicinal chemistry and biotechnology. Collagen Collagen is the most abundant

• properties of functional molecules to be optimised through selective fluorination chemistry. This concept has been demonstrated in diverse areas including medicine, catalysis, materials science and biotechnology. It is hoped that the examples highlighted in this review have persuaded the reader of the great

Synthesis of gem-difluoromethylenated analogues of boronolide

• Jing Lin,
• Xiao-Long Qiu and
• Feng-Ling Qing

Beilstein J. Org. Chem. 2010, 6, No. 37, doi:10.3762/bjoc.6.37

• Jing Lin Xiao-Long Qiu Feng-Ling Qing College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu

Symmetrical and unsymmetrical α,ω-nucleobase amide-conjugated systems

• Sławomir Boncel,
• Maciej Mączka,
• Krzysztof K. K. Koziol,
• Radosław Motyka and
• Krzysztof Z. Walczak

Beilstein J. Org. Chem. 2010, 6, No. 34, doi:10.3762/bjoc.6.34

• Slawomir Boncel Maciej Maczka Krzysztof K. K. Koziol Radoslaw Motyka Krzysztof Z. Walczak Silesian University of Technology, Department of Organic Chemistry, Biochemistry and Biotechnology, Krzywoustego 4, 44-100 Gliwice, Poland, Tel.: +48 32 237 1792, Fax: +48 32 237 2094 University of Cambridge

Understanding the mechanism of Pd-catalyzed allylic substitution of the cyclic difluorinated carbonates

• Jun Xu,
• Xiao-Long Qiu and
• Feng-Ling Qing

Beilstein J. Org. Chem. 2008, 4, No. 18, doi:10.3762/bjoc.4.18

• Jun Xu Xiao-Long Qiu Feng-Ling Qing Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu

Synthesis of the Benzo- fused Indolizidine Alkaloid Mimics

• Daniel L. Comins and
• Kazuhiro Higuchi

Beilstein J. Org. Chem. 2007, 3, No. 42, doi:10.1186/1860-5397-3-42

• by grants from the North Carolina Biotechnology Center and the National Science Foundation (Grant CHE-0078253).

N-1 regioselective Michael- type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate

• Sławomir Boncel,
• Dominika Osyda and
• Krzysztof Z. Walczak

Beilstein J. Org. Chem. 2007, 3, No. 40, doi:10.1186/1860-5397-3-40

• Slawomir Boncel Dominika Osyda Krzysztof Z. Walczak Department of Organic Chemistry, Biochemistry and Biotechnology Silesian University of Technology, Krzywoustego 4, PL-44100 Gliwice, Poland 10.1186/1860-5397-3-40 Abstract N-1 regioselective Michael-type addition of 5-substituted uracils to (2