Novel multi-responsive P2VP-block-PNIPAAm block copolymers via nitroxide-mediated radical polymerization

• Cathrin Corten,
• Katja Kretschmer and
• Dirk Kuckling

Beilstein J. Org. Chem. 2010, 6, 756–765, doi:10.3762/bjoc.6.89

• with large property changes to small external chemical or physical stimuli, are so called “smart”, “responsive” or “intelligent” polymers [1][2], constitute a very interesting group of functional polymers. Such polymers have found applications as reactive surfaces [3], in drug delivery and separation

• , we describe the synthesis of new multi-responsible diblock copolymers poly(2-vinylpyridine-block-N-isopropylacrylamide), which form schizophrenic micelles. Such micellation behavior is interesting for drug delivery systems in the gastro-intestinal tract [36][37]. Results and Discussion Polymerization

• aqueous solution, the block copolymers form so called schizophrenic micelles. The hydrodynamic radius Rh of these micelles associated with pH values and temperature was analyzed by dynamic light scattering (DLS). Such kind of block copolymers has potential for many applications, such as controlled drug

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

• Otman Otman,
• Paul Boullanger,
• Eric Drockenmuller and
• Thierry Hamaide

Beilstein J. Org. Chem. 2010, 6, No. 58, doi:10.3762/bjoc.6.58

• towards new formulations that can enhance the activity of drugs, as well as the elaboration of new drug delivery systems. The main objectives are the transport of active hydrophilic or lipophilic substances, while minimizing drug degradation, increasing drug availability and localization in the required

• . These parameters are closely connected. For instance, the chemical composition of the polymer matrix may affect the particle morphology because of thermodynamic interactions between the hydrophobic drug and the polymer. Whatever the drug delivery system, surfactants, and in particular polymer non-ionic

Ru-catalyzed dehydrogenative coupling of carboxylic acids and silanes - a new method for the preparation of silyl ester

• Guo-Bin Liu and
• Hong-Yun Zhao

Beilstein J. Org. Chem. 2008, 4, No. 27, doi:10.3762/bjoc.4.27

• greatly due to biomedical field and environmental concerns [2][3][4]. Obviously, silyl esters are very important intermediates for the preparation of easily degradable functional poly(silyl ester)s, widely utilized as gene delivery carriers, matrices for drug delivery, biodegradable surgical devices, and