Assembly strategy for thieno[3,2-b]thiophenes via a disulfide intermediate derived from 3-nitrothiophene-2,5-dicarboxylate

• Roman A. Irgashev

Beilstein J. Org. Chem. 2025, 21, 2489–2497, doi:10.3762/bjoc.21.191

• bromoacetonitrile significantly improved the result, allowing product 5a to be obtained in 91% yield. Furthermore, we extended our approach to phenacyl-type alkylators to access 3-(phenacyl)thio compounds 6a and 6b, as well as their 3-[(thiophen-2-yl)carbonylmethyl]thio analog 6c. The corresponding phenacyl

Synthesis of electrophile-tethered preQ₁ analogs for covalent attachment to preQ₁ RNA

• Laurin Flemmich and
• Ronald Micura

Beilstein J. Org. Chem. 2025, 21, 483–489, doi:10.3762/bjoc.21.35

• highly electrophilic warheads otherwise typically employed in RNA-small molecule crosslinking [18][19][20][21]. Instead, primary alkyl halides (or mesylates, Scheme 1, in particular compounds 3a, 3b and 4c) were found to be potent yet mild alkylators that minimize off-target reactivity, while providing

An overview of recent advances in duplex DNA recognition by small molecules

• Sayantan Bhaduri,
• Nihar Ranjan and
• Dev P. Arya

Beilstein J. Org. Chem. 2018, 14, 1051–1086, doi:10.3762/bjoc.14.93

• the past few years. Keywords: alkylators; antibiotic; anticancer; antineoplastic; antiproliferative; DNA recognition; groove binders; hairpin polyamides; Hoechst 33258; intercalators; Review 1. Introduction DNA is one of the central components of cellular machinery and storage unit of genetic