Beilstein J. Org. Chem.2024,20, 2799–2805, doi:10.3762/bjoc.20.235
efficiently converted to the target products under solvent-free conditions. The reactions proceed at room temperature and are complete within 90 minutes, demonstrating both efficiency and experimental simplicity.
Keywords: ball milling; difluorocarbene; difluoromethylations; difluoromethyl enol ether
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Graphical Abstract
Scheme 1:
Overview over difluoromethyl enol ether syntheses from acyclic and cyclic 1,3-diones (A), acyclic k...