Natural resorcylic lactones derived from alternariol

• Joachim Podlech

Beilstein J. Org. Chem. 2024, 20, 2171–2207, doi:10.3762/bjoc.20.187

• from an unidentified endophytic fungus [124] and later from colletotrichum sp. [125], Lachnum abnorme [126], Diaporthe phragmitis [127] and a further D. sp. [128], and deviantly from the flower buds of the banana species Musa nana [129]. Its structure was determined by NMR spectroscopy [126] and

• lysilactone A in LC–MS/MS analyses of invested cereals based on comparison with synthesized samples [141], but seems to have never been isolated or further investigated. 3-O-Acetyl-9-O-methylalternariol (11) was isolated from an unidentified endophytic fungus [124] and 3,9-O,O-diacetylalternariol (12) was

Secondary metabolites of Diaporthe cameroonensis, isolated from the Cameroonian medicinal plant Trema guineensis

• Bel Youssouf G. Mountessou,
• Élodie Gisèle M. Anoumedem,
• Blondelle M. Kemkuignou,
• Yasmina Marin-Felix,
• Frank Surup,
• Marc Stadler and
• Simeon F. Kouam

Beilstein J. Org. Chem. 2023, 19, 1555–1561, doi:10.3762/bjoc.19.112

• elucidation of a new polyketide 1 and a new acetylated alternariol derivative 2 as well as fifteen known compounds including three alternariol derivatives 3–5, one chromone 6, one biphenyl 7, seven cytochalasins 8–14, two cytosporones 15 and 16, and one macrolide 17 from the endophytic fungus, Diaporthe

• measured in methanol by using an Anton Paar MCP-150 polarimeter (Seelze, Germany) at 20 °C. Isolation and identification of the endophytic fungus The fresh root of Trema guineesis was collected in January 2019 in Kala Mountain (near Yaoundé), in the Centre region of Cameroon. It was identified at the

Volatile emission and biosynthesis in endophytic fungi colonizing black poplar leaves

• Christin Walther,
• Pamela Baumann,
• Katrin Luck,
• Beate Rothe,
• Peter H. W. Biedermann,
• Jonathan Gershenzon,
• Tobias G. Köllner and
• Sybille B. Unsicker

Beilstein J. Org. Chem. 2021, 17, 1698–1711, doi:10.3762/bjoc.17.118

• exhibit antimicrobial activity; however, they are also known to induce the growth and vigor of the host plant and to shape plant community structure [27][28][29][30][31]. Furthermore, volatiles released from endophytic fungi can also affect insect behavior. Daisy et al. isolated the endophytic fungus

• the volatile profiles of endophytic fungi has increased in recent years, only little is known about endophyte terpene synthases that may catalyze volatile terpene formation [44][45]. For the endophytic fungus Cladosporium sp., we identified and characterized two TPS, CxTPS1 and CxTPS2 (Figure 2

• that an endophytic fungus (Acremonium strictum) alters the volatile composition of the tomato plant Solanum lycopersicum and attracts Helicoverpa armigera moth for oviposition [80]. The endophytic fungus Beauveria bassiana also increased the emission of some terpenes from tomato plants resulting in a

Total synthesis of decarboxyaltenusin

• Lucas Warmuth,
• Aaron Weiß,
• Marco Reinhardt,
• Anna Meschkov,
• Ute Schepers and
• Joachim Podlech

Beilstein J. Org. Chem. 2021, 17, 224–228, doi:10.3762/bjoc.17.22

• . [3][5][6], and from the endophytic fungus Botryosphaeria dothidea in Melia azedarach [7] it turned out to be a widely occurring natural product. It shows marked DPPH radical scavenging activities with determined IC50 values of 18.7 ± 0.2 μM [7] and 148 ± 3 μM [2], respectively, and displays

Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale

• Ken-ichi Nakashima,
• Junko Tomida,
• Tomoe Tsuboi,
• Yoshiaki Kawamura and
• Makoto Inoue

Beilstein J. Org. Chem. 2020, 16, 2100–2107, doi:10.3762/bjoc.16.177

• -cho, Chikusa-ku, Nagoya, Aichi, Japan 10.3762/bjoc.16.177 Abstract Two new azaphilones, namely muyocopronones A (1) and B (2), were isolated from the cultures of an endophytic fungus Muyocopron laterale ECN279. Their structures were elucidated by extensive spectroscopic analysis. Their absolute

• fungal metabolites produced by Muyocopron spp. Thus, as part of our research into the natural products produced by plant-associated fungi [13][14][15], we isolated two new azaphilones from the cultures of an endophytic fungus, namely Muyocopron laterale ECN279. Herein, the isolation, structural

• few such compounds have been previously reported. Conclusion In summary, we successfully performed the isolation and structural determination of muyocopronones A (1) and B (2) from the cultures of an endophytic fungus Muyocopron laterale ECN279. Muyocopronones A (1) and B (2) are both azaphilones

Absolute configurations of talaromycones A and B, α-diversonolic ester, and aspergillusone B from endophytic Talaromyces sp. ECN211

• Ken-ichi Nakashima,
• Junko Tomida,
• Takao Hirai,
• Yoshiaki Kawamura and
• Makoto Inoue

Beilstein J. Org. Chem. 2020, 16, 290–296, doi:10.3762/bjoc.16.28

• -cho, Chikusa-ku, Nagoya, Aichi, Japan 10.3762/bjoc.16.28 Abstract Talaromycones A (1) and B (2), new xanthenediones, were isolated from the cultures of Talaromyces sp. ECN211, an endophytic fungus, along with α-diversonolic ester (3), aspergillusone B (4), glauconic acid (5), and rosellisin (6). The

• first time in over 50 years. Keywords: absolute configuration; endophytic fungus; glauconic acid; Talaromyces; tetrahydroxanthone; xanthenedione; Introduction The xanthones, which are a class of phenolic compounds produced by many different organisms, including plants, lichens, fungi, and bacteria

Correction: Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291

• Peng Zhang,
• Xiao-Ming Li,
• Xin-Xin Mao,
• Attila Mándi,
• Tibor Kurtán and
• Bin-Gui Wang

Beilstein J. Org. Chem. 2018, 14, 2394–2395, doi:10.3762/bjoc.14.215

New furoisocoumarins and isocoumarins from the mangrove endophytic fungus Aspergillus sp. 085242

• Ze’en Xiao,
• Senhua Chen,
• Runlin Cai,
• Shao’e Lin,
• Kui Hong and
• Zhigang She

Beilstein J. Org. Chem. 2016, 12, 2077–2085, doi:10.3762/bjoc.12.196

• District, Shenzhen, 518102, China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education of China, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China 10.3762/bjoc.12.196 Abstract The chemical investigation of the mangrove endophytic fungus Aspergillus

• known compounds (3, 4, 7–9) (Figure 1). Details of the isolation, structure elucidation, and biological activity of these compounds are reported herein. Results and Discussion The mangrove endophytic fungus Aspergillus sp. 085242 was cultured on solid rice medium with saline water for four weeks. The

Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291

• Peng Zhang,
• Xiao-Ming Li,
• Xin-Xin Mao,
• Attila Mándi,
• Tibor Kurtán and
• Bin-Gui Wang

Beilstein J. Org. Chem. 2016, 12, 2012–2018, doi:10.3762/bjoc.12.188

• indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative, varioloid A (1), was isolated from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291. Its structure was elucidated on the basis of extensive analysis of 1D and 2D NMR data and the absolute configuration was determined by

• variotii EN-291, an endophytic fungus isolated from the red alga Grateloupia turuturu. The investigation of the chemical constituents of this fungal strain had been performed and as a result, three new oxepine-containing alkaloids with antimicrobial activities [9][10], two new butenolide derivatives with

• continues to be a prolific source of bioactive secondary metabolites with diverse structures. In this paper, two indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivatives, varioloids A (1) and B (2), were isolated from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291. The

New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y₂) isolated from the South China Sea

• Senhua Chen,
• Zhaoming Liu,
• Yayue Liu,
• Yongjun Lu,
• Lei He and
• Zhigang She

Beilstein J. Org. Chem. 2015, 11, 1187–1193, doi:10.3762/bjoc.11.133

• A and B (7 and 9), along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii, derived from the mangrove plant Kandelia obovata. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry (HREIMS). Compounds 1–6

• exhibited strong α-glucosidase inhibitory activity with IC50 values ranging from 2.1 to 13.3 μM. Moreover, kinetic studies of compounds 2 and 6 showed that both of them were noncompetitive inhibitors of α-glucosidase. Keywords: endophytic fungus; depsidone; α-glucosidase inhibitory activity; isoindolinone

Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp. YXf3

• Zhi Kai Guo,
• Rong Wang,
• Wei Huang,
• Xiao Nian Li,
• Rong Jiang,
• Ren Xiang Tan and
• Hui Ming Ge

Beilstein J. Org. Chem. 2014, 10, 2677–2682, doi:10.3762/bjoc.10.282

• Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China 10.3762/bjoc.10.282 Abstract An unusual C18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus

• , antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated. Keywords: Aspergillus; endophytic fungus; Ginkgo biloba; natural product; norditerpenoid; Trichocomaceae; Introduction Plant-derived fungi, which have drawn considerable attention from natural product chemists, have been proved

• -unsaturated spirolactone moiety in ring B. The skeleton, tentatively named aspergilane, represents a new subclass of norditerpenoids. The endophytic fungus Aspergillus sp. YXf3 can produce different types of diterpenoids, including pimarane-type diterpenoids (sphaeropsidin A and B, aspergiloid D and E

The chemistry of isoindole natural products

• Klaus Speck and
• Thomas Magauer

Beilstein J. Org. Chem. 2013, 9, 2048–2078, doi:10.3762/bjoc.9.243

• completed the synthesis of stachybotrylactam I (157). Chlorinated isoindolinone alkaloids: Pestalachloride A (193) was isolated from the plant endophytic fungus Pestalotiopsis adusta as a racemate and displays potent antifungal activities against Fusarium culmorum (IC50 = 0.89 µM) [147]. Pestalone (192), a

The volatiles of pathogenic and nonpathogenic mycobacteria and related bacteria

• Thorben Nawrath,
• Georgies F. Mgode,
• Bart Weetjens,
• Stefan H. E. Kaufmann and
• Stefan Schulz

Beilstein J. Org. Chem. 2012, 8, 290–299, doi:10.3762/bjoc.8.31

• is a known volatile from several plants [29], and the endophytic fungus Muscodor albus [30]. The structure of 19 has recently been revised [29]. This compound may act as marker for norcardiae, as it was produced as a single compound by Nocardia spp. grown on a 7H11 medium and has so far not been