Diastereoselective synthesis of highly substituted cyclohexanones and tetrahydrochromene-4-ones via conjugate addition of curcumins to arylidenemalonates

• Deepa Nair,
• Abhishek Tiwari,
• Banamali Laha and
• Irishi N. N. Namboothiri

Beilstein J. Org. Chem. 2024, 20, 2016–2023, doi:10.3762/bjoc.20.177

• . Reaction optimisation using phase-transfer catalysts.a Scope of alkylidenemalonates and curcumins.a Supporting Information Supporting Information File 38: Experimental procedures and characterization data. Supporting Information File 39: Copies of NMR spectra of all new compounds. Supporting Information

Fluorohydration of alkynes via I(I)/I(III) catalysis

• Jessica Neufeld,
• Constantin G. Daniliuc and
• Ryan Gilmour

Beilstein J. Org. Chem. 2020, 16, 1627–1635, doi:10.3762/bjoc.16.135

• parentheses (determined by 19F NMR analysis of the crude reaction mixture using ethyl fluoroacetate as internal standard). See Supporting Information File 1 for the exact calculation of the amine/HF mixtures. Reaction optimisation for the synthesis of α-fluoroketone 2 from alkyne 1.a Investigating the role of

One-pot multistep mechanochemical synthesis of fluorinated pyrazolones

• Joseph L. Howard,
• William Nicholson,
• Yerbol Sagatov and
• Duncan L. Browne

Beilstein J. Org. Chem. 2017, 13, 1950–1956, doi:10.3762/bjoc.13.189

• optimum reaction time for the isolated step rather than two-step, i.e., the pyrazolone material was isolated from step one and purified before subjecting to this second reaction optimisation. With no additives, the fluorination was complete after 2 hours (Table 2, entry 4), notably an extra hour returned

3D printed fluidics with embedded analytic functionality for automated reaction optimisation

• Andrew J. Capel,
• Andrew Wright,
• Matthew J. Harding,
• George W. Weaver,
• Yuqi Li,
• Russell A. Harris,
• Steve Edmondson,
• Ruth D. Goodridge and
• Steven D. R. Christie

Beilstein J. Org. Chem. 2017, 13, 111–119, doi:10.3762/bjoc.13.14

• reaction analysis; reaction optimisation; selective laser melting; stereolithography; Introduction Additive manufacturing (AM), or as it is widely known ‘3D printing’, is the internationally recognised term used to describe a wide range of manufacturing processes that can generate complex three

Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

• Kirsty L. Wilson,
• Alan R. Kennedy,
• Jane Murray,
• Ben Greatrex,
• Craig Jamieson and
• Allan J. B. Watson

Beilstein J. Org. Chem. 2016, 12, 2005–2011, doi:10.3762/bjoc.12.187

• Sonogashira cross-coupling: Substrate scope. Isolated yields. aYield using DMF as solvent. b2 equiv of Et3N used. c24 h reaction time. Cacchi-type annulation of o-amino/hydroxy iodoarenes. Isolated yields. aYield using DMF as solvent. Reaction optimisation and comparison with existing solvents.a Evaluation of

4-Hydroxy-6-alkyl-2-pyrones as nucleophilic coupling partners in Mitsunobu reactions and oxa-Michael additions

• Michael J. Burns,
• Thomas O. Ronson,
• Richard J. K. Taylor and
• Ian J. S. Fairlamb

Beilstein J. Org. Chem. 2014, 10, 1159–1165, doi:10.3762/bjoc.10.116

• . Following reaction optimisation, we applied these conditions to a number of different propiolate esters and alkylated 4-hydroxy-2-pyrones (Table 3). Surprisingly, the tolerance of the reaction to different ester groups proved rather limited. The switch from methyl propiolate to tert-butyl propiolate (6b

• desired product. The phacelocarpus 2-pyrones 1 and 2. Generalised O-functionalisation of 6-alkyl-4-hydroxy-2-pyrones 3. Synthesis of alkylated 2-pyrones 3b–e. Michael addition of 3a to allene 8 and internal alkyne 10. Synthesis of 2-pyronyl ethers 4a–l. Michael addition reaction optimisation. Synthesis of

Camera-enabled techniques for organic synthesis

• Steven V. Ley,
• Richard J. Ingham,
• Matthew O’Brien and
• Duncan L. Browne

Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118

• product within the microdroplets to be visualised accurately (Figure 6). Another beneficial way to use a camera to assist in a reaction optimisation is simply to see what is happening in an otherwise inaccessible reaction vessel or closed cavity. During studies on the Friedel–Crafts alkylation of anisole

Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated S_NAr reaction

• Charlotte Wiles and
• Paul Watts

Beilstein J. Org. Chem. 2011, 7, 1360–1371, doi:10.3762/bjoc.7.160

• alternative to DMA. Screening of organic bases: With one of the salient features of microreaction technology being the speed of reaction optimisation, due to the low system hold-up volume, we subsequently investigated the effect of base type and stoichiometry on the reaction in MeCN. Whilst this would

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

• Alessandro Palmieri,
• Steven V. Ley,
• Anastasios Polyzos,
• Mark Ladlow and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2009, 5, No. 23, doi:10.3762/bjoc.5.23

• –20 mL/min, and can be configured for multistep or parallel operation. Exiting products can be collected as aliquots using an automated fraction collector for reaction optimisation or as a bulk sample for scale-up. In addition, product purification can be achieved as part of the overall flow process