Young investigators in natural products chemistry, biosynthesis, and enzymology

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Editors:
Prof. Jeffrey D. Rudolf, University of Florida
Prof. Lena Barra, Universität Konstanz
Dr. Takayoshi Awakawa, Riken CSRS
 
Natural products are highly functionalized small molecules that possess unrivaled chemical and structural diversities. Accordingly, these molecules possess a wide range of biological activities, serve as useful probes in chemical biology, and inspire discoveries in chemistry, biosynthesis, and enzymology. This thematic issue aims to highlight young investigators in the field of natural products. Research or review topics may include, but are not limited to, i) chemistry: natural product discovery, structural elucidation challenges, total synthesis, chemoenzymatic synthesis, chemical biology probes, mode of action studies, ii) biosynthesis: genome mining, pathway elucidations, heterologous expression, unnatural natural products and combinatorial biosynthesis, and iii) enzymology: functional and mechanistic investigations, structural biology, natural product-inspired biocatalysis.
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Young investigators in natural products chemistry, biosynthesis, and enzymology

  • Jeffrey D. Rudolf,
  • Lena Barra and
  • Takayoshi Awakawa

Beilstein J. Org. Chem. 2024, 20, 2720–2721, doi:10.3762/bjoc.20.229

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Editorial
Published 29 Oct 2024

Unraveling the role of prenyl side-chain interactions in stabilizing the secondary carbocation in the biosynthesis of variexenol B

  • Moe Nakano,
  • Rintaro Gemma and
  • Hajime Sato

Beilstein J. Org. Chem. 2023, 19, 1503–1510, doi:10.3762/bjoc.19.107

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Published 28 Sep 2023

Identification of the p-coumaric acid biosynthetic gene cluster in Kutzneria albida: insights into the diazotization-dependent deamination pathway

  • Seiji Kawai,
  • Akito Yamada,
  • Yohei Katsuyama and
  • Yasuo Ohnishi

Beilstein J. Org. Chem. 2024, 20, 1–11, doi:10.3762/bjoc.20.1

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Published 02 Jan 2024

Discovery of unguisin J, a new cyclic peptide from Aspergillus heteromorphus CBS 117.55, and phylogeny-based bioinformatic analysis of UngA NRPS domains

  • Sharmila Neupane,
  • Marcelo Rodrigues de Amorim and
  • Elizabeth Skellam

Beilstein J. Org. Chem. 2024, 20, 321–330, doi:10.3762/bjoc.20.32

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Published 19 Feb 2024

Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells

  • Fumihiro Ishikawa,
  • Sho Konno,
  • Hideaki Kakeya and
  • Genzoh Tanabe

Beilstein J. Org. Chem. 2024, 20, 445–451, doi:10.3762/bjoc.20.39

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Published 26 Feb 2024

Pseudallenes A and B, new sulfur-containing ovalicin sesquiterpenoid derivatives with antimicrobial activity from the deep-sea cold seep sediment-derived fungus Pseudallescheria boydii CS-793

  • Zhen Ying,
  • Xiao-Ming Li,
  • Sui-Qun Yang,
  • Hong-Lei Li,
  • Xin Li,
  • Bin-Gui Wang and
  • Ling-Hong Meng

Beilstein J. Org. Chem. 2024, 20, 470–478, doi:10.3762/bjoc.20.42

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Published 28 Feb 2024

A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001

  • Rattiya Janthanom,
  • Yuta Kikuchi,
  • Hiroki Kanto,
  • Tomoyasu Hirose,
  • Arisu Tahara,
  • Takahiro Ishii,
  • Arinthip Thamchaipenet and
  • Yuki Inahashi

Beilstein J. Org. Chem. 2024, 20, 497–503, doi:10.3762/bjoc.20.44

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Published 29 Feb 2024

Recent developments in the engineered biosynthesis of fungal meroterpenoids

  • Zhiyang Quan and
  • Takayoshi Awakawa

Beilstein J. Org. Chem. 2024, 20, 578–588, doi:10.3762/bjoc.20.50

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Review
Published 13 Mar 2024

A myo-inositol dehydrogenase involved in aminocyclitol biosynthesis of hygromycin A

  • Michael O. Akintubosun and
  • Melanie A. Higgins

Beilstein J. Org. Chem. 2024, 20, 589–596, doi:10.3762/bjoc.20.51

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Published 14 Mar 2024

Chemical and biosynthetic potential of Penicillium shentong XL-F41

  • Ran Zou,
  • Xin Li,
  • Xiaochen Chen,
  • Yue-Wei Guo and
  • Baofu Xu

Beilstein J. Org. Chem. 2024, 20, 597–606, doi:10.3762/bjoc.20.52

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Published 15 Mar 2024

Production of non-natural 5-methylorsellinate-derived meroterpenoids in Aspergillus oryzae

  • Jia Tang,
  • Yixiang Zhang and
  • Yudai Matsuda

Beilstein J. Org. Chem. 2024, 20, 638–644, doi:10.3762/bjoc.20.56

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Published 20 Mar 2024

Isolation and structure determination of a new analog of polycavernosides from marine Okeania sp. cyanobacterium

  • Kairi Umeda,
  • Naoaki Kurisawa,
  • Ghulam Jeelani,
  • Tomoyoshi Nozaki,
  • Kiyotake Suenaga and
  • Arihiro Iwasaki

Beilstein J. Org. Chem. 2024, 20, 645–652, doi:10.3762/bjoc.20.57

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Published 21 Mar 2024

New variochelins from soil-isolated Variovorax sp. H002

  • Jabal Rahmat Haedar,
  • Aya Yoshimura and
  • Toshiyuki Wakimoto

Beilstein J. Org. Chem. 2024, 20, 692–700, doi:10.3762/bjoc.20.63

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Published 02 Apr 2024

Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (−)-sandaracopimaradiene in the fungus Arthrinium sacchari

  • Fumito Sato,
  • Terutaka Sonohara,
  • Shunta Fujiki,
  • Akihiro Sugawara,
  • Yohei Morishita,
  • Taro Ozaki and
  • Teigo Asai

Beilstein J. Org. Chem. 2024, 20, 714–720, doi:10.3762/bjoc.20.65

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Published 03 Apr 2024

Chemoenzymatic synthesis of macrocyclic peptides and polyketides via thioesterase-catalyzed macrocyclization

  • Senze Qiao,
  • Zhongyu Cheng and
  • Fuzhuo Li

Beilstein J. Org. Chem. 2024, 20, 721–733, doi:10.3762/bjoc.20.66

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Published 04 Apr 2024

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

  • Zhongwei Hua,
  • Nan Liu and
  • Xiaohui Yan

Beilstein J. Org. Chem. 2024, 20, 741–752, doi:10.3762/bjoc.20.68

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Published 09 Apr 2024

Methodology for awakening the potential secondary metabolic capacity in actinomycetes

  • Shun Saito and
  • Midori A. Arai

Beilstein J. Org. Chem. 2024, 20, 753–766, doi:10.3762/bjoc.20.69

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Published 10 Apr 2024

Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus

  • Dongxu Zhang,
  • Wenyu Du,
  • Xingming Pan,
  • Xiaoxu Lin,
  • Fang-Ru Li,
  • Qingling Wang,
  • Qian Yang,
  • Hui-Min Xu and
  • Liao-Bin Dong

Beilstein J. Org. Chem. 2024, 20, 815–822, doi:10.3762/bjoc.20.73

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Published 16 Apr 2024

Activity assays of NnlA homologs suggest the natural product N-nitroglycine is degraded by diverse bacteria

  • Kara A. Strickland,
  • Brenda Martinez Rodriguez,
  • Ashley A. Holland,
  • Shelby Wagner,
  • Michelle Luna-Alva,
  • David E. Graham and
  • Jonathan D. Caranto

Beilstein J. Org. Chem. 2024, 20, 830–840, doi:10.3762/bjoc.20.75

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Published 17 Apr 2024

Confirmation of the stereochemistry of spiroviolene

  • Yao Kong,
  • Yuanning Liu,
  • Kaibiao Wang,
  • Tao Wang,
  • Chen Wang,
  • Ben Ai,
  • Hongli Jia,
  • Guohui Pan,
  • Min Yin and
  • Zhengren Xu

Beilstein J. Org. Chem. 2024, 20, 852–858, doi:10.3762/bjoc.20.77

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Published 18 Apr 2024

Enhancing structural diversity of terpenoids by multisubstrate terpene synthases

  • Min Li and
  • Hui Tao

Beilstein J. Org. Chem. 2024, 20, 959–972, doi:10.3762/bjoc.20.86

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Published 30 Apr 2024

A Diels–Alder probe for discovery of natural products containing furan moieties

  • Alyssa S. Eggly,
  • Namuunzul Otgontseren,
  • Carson B. Roberts,
  • Amir Y. Alwali,
  • Haylie E. Hennigan and
  • Elizabeth I. Parkinson

Beilstein J. Org. Chem. 2024, 20, 1001–1010, doi:10.3762/bjoc.20.88

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Published 02 May 2024

Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis

  • Jinmin Gao,
  • Liyuan Li,
  • Shijie Shen,
  • Guomin Ai,
  • Bin Wang,
  • Fang Guo,
  • Tongjian Yang,
  • Hui Han,
  • Zhengren Xu,
  • Guohui Pan and
  • Keqiang Fan

Beilstein J. Org. Chem. 2024, 20, 1198–1206, doi:10.3762/bjoc.20.102

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Published 23 May 2024

Computation-guided scaffold exploration of 2E,6E-1,10-trans/cis-eunicellanes

  • Zining Li,
  • Sana Jindani,
  • Volga Kojasoy,
  • Teresa Ortega,
  • Erin M. Marshall,
  • Khalil A. Abboud,
  • Sandra Loesgen,
  • Dean J. Tantillo and
  • Jeffrey D. Rudolf

Beilstein J. Org. Chem. 2024, 20, 1320–1326, doi:10.3762/bjoc.20.115

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Published 07 Jun 2024

Bioinformatic prediction of the stereoselectivity of modular polyketide synthase: an update of the sequence motifs in ketoreductase domain

  • Changjun Xiang,
  • Shunyu Yao,
  • Ruoyu Wang and
  • Lihan Zhang

Beilstein J. Org. Chem. 2024, 20, 1476–1485, doi:10.3762/bjoc.20.131

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Published 02 Jul 2024

Mining raw plant transcriptomic data for new cyclopeptide alkaloids

  • Draco Kriger,
  • Michael A. Pasquale,
  • Brigitte G. Ampolini and
  • Jonathan R. Chekan

Beilstein J. Org. Chem. 2024, 20, 1548–1559, doi:10.3762/bjoc.20.138

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Published 11 Jul 2024

Polymer degrading marine Microbulbifer bacteria: an un(der)utilized source of chemical and biocatalytic novelty

  • Weimao Zhong and
  • Vinayak Agarwal

Beilstein J. Org. Chem. 2024, 20, 1635–1651, doi:10.3762/bjoc.20.146

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Published 17 Jul 2024

Methyltransferases from RiPP pathways: shaping the landscape of natural product chemistry

  • Maria-Paula Schröder,
  • Isabel P.-M. Pfeiffer and
  • Silja Mordhorst

Beilstein J. Org. Chem. 2024, 20, 1652–1670, doi:10.3762/bjoc.20.147

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Published 18 Jul 2024

Chemo-enzymatic total synthesis: current approaches toward the integration of chemical and enzymatic transformations

  • Ryo Tanifuji and
  • Hiroki Oguri

Beilstein J. Org. Chem. 2024, 20, 1693–1712, doi:10.3762/bjoc.20.151

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Published 23 Jul 2024

Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity

  • Moisés Alejandro Alejo Hernandez,
  • Katia Pamela Villavicencio Sánchez,
  • Rosendo Sánchez Morales,
  • Karla Georgina Hernández-Magro Gil,
  • David Silverio Moreno-Gutiérrez,
  • Eddie Guillermo Sanchez-Rueda,
  • Yanet Teresa-Cruz,
  • Brian Choi,
  • Armando Hernández Garcia,
  • Alba Romero-Rodríguez,
  • Oscar Juárez,
  • Siseth Martínez-Caballero,
  • Mario Figueroa and
  • Corina-Diana Ceapă

Beilstein J. Org. Chem. 2024, 20, 1800–1816, doi:10.3762/bjoc.20.159

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Published 30 Jul 2024

Cell-free protein synthesis with technical additives – expanding the parameter space of in vitro gene expression

  • Tabea Bartsch,
  • Stephan Lütz and
  • Katrin Rosenthal

Beilstein J. Org. Chem. 2024, 20, 2242–2253, doi:10.3762/bjoc.20.192

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Published 04 Sep 2024

Improved deconvolution of natural products’ protein targets using diagnostic ions from chemical proteomics linkers

  • Andreas Wiest and
  • Pavel Kielkowski

Beilstein J. Org. Chem. 2024, 20, 2323–2341, doi:10.3762/bjoc.20.199

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Published 12 Sep 2024
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