Integrated multistep flow synthesis
The University of Adelaide, Australia
This Thematic Series is inspired by the research on integrated multistep flow synthesis as proposed by the just started FET-OPEN ONE-FLOW project of EU.
The ONE-FLOW idea is to translate 'vertical hierarchy' of common multistep flow synthesis with its complex machinery (many serially connected reactors and separators; all being process controlled) into a self-organising 'horizontal hierarchy' of a compartmentalized flow reactor system - a biomimetic digital flow cascade machinery with just one reactor passage. Along those lines, this project aims to develop a digital flow cascade machinery which performs all the multiple reactions in one step, which includes inventing innovative catalytic cascades, and uplift that by enabling the best bio- and chemocatalysts working door by door.
A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic
- Marcus Baumann,
- Ian R. Baxendale and
- Fabien Deplante
Beilstein J. Org. Chem. 2017, 13, 2549–2560, doi:10.3762/bjoc.13.251
Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review
- Fabio Tonin and
- Isabel W. C. E. Arends
Beilstein J. Org. Chem. 2018, 14, 470–483, doi:10.3762/bjoc.14.33
Continuous multistep synthesis of 2-(azidomethyl)oxazoles
- Thaís A. Rossa,
- Nícolas S. Suveges,
- Marcus M. Sá,
- David Cantillo and
- C. Oliver Kappe
Beilstein J. Org. Chem. 2018, 14, 506–514, doi:10.3762/bjoc.14.36
High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine
- Eric Yu,
- Hari P. R. Mangunuru,
- Nakul S. Telang,
- Caleb J. Kong,
- Jenson Verghese,
- Stanley E. Gilliland III,
- Saeed Ahmad,
- Raymond N. Dominey and
- B. Frank Gupton
Beilstein J. Org. Chem. 2018, 14, 583–592, doi:10.3762/bjoc.14.45
Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry
- Katharina Hiebler,
- Georg J. Lichtenegger,
- Manuel C. Maier,
- Eun Sung Park,
- Renie Gonzales-Groom,
- Bernard P. Binks and
- Heidrun Gruber-Woelfler
Beilstein J. Org. Chem. 2018, 14, 648–658, doi:10.3762/bjoc.14.52
Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactor
- Morten M. C. H. van Schie,
- Tiago Pedroso de Almeida,
- Gabriele Laudadio,
- Florian Tieves,
- Elena Fernández-Fueyo,
- Timothy Noël,
- Isabel W. C. E. Arends and
- Frank Hollmann
Beilstein J. Org. Chem. 2018, 14, 697–703, doi:10.3762/bjoc.14.58
Nanoreactors for green catalysis
- M. Teresa De Martino,
- Loai K. E. A. Abdelmohsen,
- Floris P. J. T. Rutjes and
- Jan C. M. van Hest
Beilstein J. Org. Chem. 2018, 14, 716–733, doi:10.3762/bjoc.14.61
Assessing the possibilities of designing a unified multistep continuous flow synthesis platform
- Mrityunjay K. Sharma,
- Roopashri B. Acharya,
- Chinmay A. Shukla and
- Amol A. Kulkarni
Beilstein J. Org. Chem. 2018, 14, 1917–1936, doi:10.3762/bjoc.14.166
A general and atom-efficient continuous-flow approach to prepare amines, amides and imines via reactive N-chloramines
- Katherine E. Jolley,
- Michael R. Chapman and
- A. John Blacker
Beilstein J. Org. Chem. 2018, 14, 2220–2228, doi:10.3762/bjoc.14.196
