Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• (Fe3O4 NPs) are widely used in many biomedical applications (e.g., bioimaging, drug delivery, biosensors, diagnostics, and theranostics). However, the use of NPs does not preclude the possibility of selective toxicity and undesirable effects, including accumulation in tissues and direct interaction with

Green synthesis of carbon dot structures from Rheum Ribes and Schottky diode fabrication

• Muhammed Taha Durmus and
• Ebru Bozkurt

Beilstein J. Nanotechnol. 2024, 15, 1369–1375, doi:10.3762/bjnano.15.110

• range of uses in the fields of electrocatalysis, bioimaging, chemical sensors, biosensors, nanomedicine, biomolecule/drug release, light-emitting diodes, and photocatalysts. They also have promising applications in areas such as lasers and optoelectronic device applications [2][3][4][5]. CDs can be

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• development of nanotechnology, more and more MONPs including zinc, iron, titanium, and copper are being explored in therapeutic applications such as drug delivery, bioimaging, biosensing, bioelectronics, and tissue engineering applications [4][5][6]. Simultaneously, many of these particles also presented

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

Ion beam processing of DNA origami nanostructures

• Leo Sala,
• Agnes Zerolová,
• Violaine Vizcaino,
• Alain Mery,
• Alicja Domaracka,
• Hermann Rothard,
• Philippe Boduch,
• Dominik Pinkas and
• Jaroslav Kocišek

Beilstein J. Nanotechnol. 2024, 15, 207–214, doi:10.3762/bjnano.15.20

• supported by the Czech Science Foundation, Project No. 21-26601X. We also acknowledge the Electron Microscopy Core Facility, IMG ASCR - Prague supported by the MEYS CR (LM2018129 Czech-BioImaging) and ERDF (No. CZ.02.1.01/0.0/0.0/16_013/0001775) for the use of the FIB-SEM. L.S. finally acknowledges support

Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35

• allows a wide variety of nonplanar aromatic hydrocarbons to be built and highly distorted structures to be synthesized. These nonplanar aromatic hydrocarbons are expected to have a wide range of applications, including semiconductors, light-emitting devices, bioimaging, and pharmaceuticals. As a polymer

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• bioimaging of tumors. Finally, the prospects and challenges for the clinical translation of cancer cell membrane-mimetic NPs are discussed. 2 The functions of the cancer cell membrane Different types of proteins present in the cancer cell membrane affect the properties of cancer cells and the way they

Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine

• Zoran M. Marković,
• Milica D. Budimir,
• Martin Danko,
• Dušan D. Milivojević,
• Pavel Kubat,
• Danica Z. Zmejkoski,
• Vladimir B. Pavlović,
• Marija M. Mojsin,
• Milena J. Stevanović and
• Biljana M. Todorović Marković

Beilstein J. Nanotechnol. 2023, 14, 165–174, doi:10.3762/bjnano.14.17

• oxygen species production, and showed low dark cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as probes for bioimaging. Keywords: antibacterial; bioimaging; carbon quantum dots; precursor; reactive oxygen species

• ][20][21]. Because of the low dark cytotoxicity they can be used successfully for bioimaging of different cells [22][23]. In our previous research, we investigated the effect of various parameters on structural, optical, and biomedical properties of CQDs [5]. We reported how heteroatom dopants

• composites has a crucial effect on the properties of CQDs/PU composites. Cellular uptake Photobleaching limits the use of hydrophobic probes (e.g., Nile red) [50]. CQDs can be used as probes for bioimaging because of the tuneable strong photoluminescence and high resistance to photobleaching. In order to

Studies of probe tip materials by atomic force microscopy: a review

• Ke Xu and
• Yuzhe Liu

Beilstein J. Nanotechnol. 2022, 13, 1256–1267, doi:10.3762/bjnano.13.104

• properties, and thus the fluorescence emission can be tuned by controlling different sizes. Due to their unique electronic, physical, and optical properties, metal nanoclusters have attracted great interest in recent years for electronic devices, catalysis, bioimaging, and chemical sensing [18][19][20][21

• ]. In particular, metal nanoclusters exhibit excellent photostability, large Stokes shifts, and low toxicity compared to quantum dots and organic dyes. Researchers increasingly use them in analytical detection fields such as metal ions, small biological molecules, drug delivery, and bioimaging [22][23

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

• sensing, bioimaging, catalysis, medicine, optoelectronics, and drug delivery due to their unique properties, that is, low cytotoxicity, cytocompatibility, water-solubility, multicolor wavelength tuned emission, photo-stability, easy modification, strong chemical inertness, etc. This review article

• especially focuses on the recent advancement (2015–2022) in the green synthesis of CDs, their application in metal ions sensing and microbial bioimaging, detection, and viability studies as well as their applications in pathogenic control and plant growth promotion. Keywords: bioimaging; carbon dots; carbon

• nanomaterials has proved to be useful for applications in a variety of disciplines, including chemical or biological sensing, bioimaging, drug delivery, photodynamic therapy, electrocatalysis, and photocatalysis, with advantages over commonly used semiconductor dots or conventional fluorescent probes such as

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• tissue engineering, drug delivery, diagnostic, and bioimaging applications due to its biocompatibility, tuneable size, and ability to cover different kinds of therapeutic agents. Gold nanoparticles control osteoclastic differentiation [113][114][115]. Osteogenic properties of AuNPs were proven by in

• demonstrated the best biocompatible behaviour which is suitable for bone tissue engineering applications [80]. Chitosan–graphene oxide nanocomposites Graphene oxide is gaining much attention in biomedical applications including drug delivery, tissue engineering, and bioimaging applications due to its large

• , graphene oxide, and biosilica nanocomposites has bioconductive and osteoinductive behaviour with suitable mechanical strength. The chitosan–graphene oxide composite is gaining much attention in biomedical applications including drug delivery, tissue engineering, and bioimaging, due to its large surface

Detection and imaging of Hg(II) in vivo using glutathione-functionalized gold nanoparticles

• Gufeng Li,
• Shaoqing Li,
• Rui Wang,
• Min Yang,
• Lizhu Zhang,
• Yanli Zhang,
• Wenrong Yang and
• Hongbin Wang

Beilstein J. Nanotechnol. 2022, 13, 549–559, doi:10.3762/bjnano.13.46

• to other non-GNP methods. It must be acknowledged that the detection window of GNPs-GSH-Rh6G2 is very wide (0.025–0.3 mM) but at the cost of a high LOD. GNPs-GSH-Rh6G2 bioimaging in living cells To study bioimaging of GSH-Rh6G2 and GNPs-GSH-Rh6G2 in living cells, confocal laser scanning microscopy

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• diagnostics (biosensing, bioimaging) [2][3]. Such prevalence has raised concerns among the regulatory authorities about the safety of AgNPs for humans due to significant lack of relevant regulatory data. Thus, the Scientific Committee on Consumer Safety (SCCS) highlighted in its final Opinion on Colloidal

Imaging of SARS-CoV-2 infected Vero E6 cells by helium ion microscopy

• Natalie Frese,
• Patrick Schmerer,
• Martin Wortmann,
• Matthias Schürmann,
• Matthias König,
• Michael Westphal,
• Friedemann Weber,
• Holger Sudhoff and
• Armin Gölzhäuser

Beilstein J. Nanotechnol. 2021, 12, 172–179, doi:10.3762/bjnano.12.13

• bioimaging, especially for the imaging of interactions between viruses and their host organisms. Keywords: bioimaging; cell membrane; charge compensation; helium ion microscopy; SARS-CoV-2; Vero E6 cells; Introduction The last decade of helium ion microscopy (HIM) was characterized by a rapid exploration

• ], various phases of the life cycle of the bacterial predator Bdellovibrio bacteriovorus [9] and the vesicular structure of ethane-oxidizing archaea [10]. A comprehensive review on the subject of bioimaging with HIM has recently been published by Schmidt and co-workers [11]. In this work, we use HIM to

• deposition renders the sample surface sufficiently conductive to be imaged without charge compensation. The presented images demonstrate the potential of the HIM in bioimaging, especially for the imaging of interactions between viruses and their host organisms. HIM thus represents a versatile complement to

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

• Cynthia Kembuan,
• Helena Oliveira and
• Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3

• chemical inertness and relatively low toxicity are also claimed advantages [7][10][11]. Due to these unique features, UCNPs have already been used in medical and biological applications, such as multimodal bioimaging, drug delivery, photodynamic therapy, and biosensing [9][12][13][14][15][16][17]. However

• as in the present work [76]. These results suggest that silica is a suitable coating material to reduce cytotoxicity. The effect of UCNPs on RAW 246.7 cells has not been studied so far. Conclusion In bioimaging applications using UCNPs, it is crucial to keep the particles intact (i.e., without

A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans

• Selene Acosta,
• Carlos Moreno-Aguilar,
• Dania Hernández-Sánchez,
• Beatriz Morales-Cruzado,
• Erick Sarmiento-Gomez,
• Carla Bittencourt,
• Luis Octavio Sánchez-Vargas and
• Mildred Quintana

Beilstein J. Nanotechnol. 2020, 11, 1054–1061, doi:10.3762/bjnano.11.90

• biological applications, such as biosensors, protein detection, bioimaging and drug delivery [17][18]. In recent years, graphene nanoparticles have been used in many different applications ranging from enhanced spectroscopy techniques, coatings, polymeric composites, sensors, drug delivery systems and others

Hexagonal boron nitride: a review of the emerging material platform for single-photon sources and the spin–photon interface

• Stefania Castelletto,
• Faraz A. Inam,
• Shin-ichiro Sato and
• Alberto Boretti

Beilstein J. Nanotechnol. 2020, 11, 740–769, doi:10.3762/bjnano.11.61

Soybean-derived blue photoluminescent carbon dots

• Shanshan Wang,
• Wei Sun,
• Dong-sheng Yang and
• Fuqian Yang

Beilstein J. Nanotechnol. 2020, 11, 606–619, doi:10.3762/bjnano.11.48

• Engineering and Environmental Engineering, Liaoning Shihua University, Fushun, Liaoning, 113001, China 10.3762/bjnano.11.48 Abstract Biomass-derived carbon dots (CDs) are biocompatible and have potential for a variety of applications, including bioimaging and biosensing. In this work, we use ground soybean

• wavelength [7], and low cost [8]. CDs have been considered as a group of important nanomaterials with potential applications in nanotechnology [9], electrocatalysis [10], metal-ion detection [2], thermal sensing [11], drug delivery [12], and biosensing and bioimaging [1]. Several methods are available for

• CDs in bioimaging and biosensing, we synthesize biocompatible CDs from soybean residuals using two strategies. The first strategy uses a one-step HTC process to produce CDs directly from the soybean residuals, and the second one uses multiple steps to produce CDs from the same soybean precursors

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• emerged as attractive candidates for sensing, catalysis and bioimaging applications in recent years. For practical use in bioimaging, nanomaterials with high photoluminescence, quantum yield, photostability and large Stokes shifts are needed. While offering high photoluminescence and quantum yield

• optoelectronic properties make them suitable for bioimaging and biosensing applications. In this review, an overview of the sensing of pathogens, and of in vitro and in vivo bioimaging using luminescent gold nanoclusters along with the limitations with selected examples are discussed. Keywords: bioimaging

• bioimaging in preclinical, clinical evaluation and patient treatment has encouraged extensive investigation to develop new imaging methods [3][4]. Among several imaging techniques, fluorescence microscopy has evolved as a widely used non-invasive method to visualize real-time biological processes with high

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• /biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency

• Arianna Gennari,
• Julio M. Rios de la Rosa,
• Erwin Hohn,
• Maria Pelliccia,
• Enrique Lallana,
• Roberto Donno,
• Annalisa Tirella and
• Nicola Tirelli

Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250

• the BioAFM Facility of the University of Manchester. Funding This study was supported by EPSRC (PhD studentship for Mr. Rios de la Rosa as part of the North-West Nanoscience (NoWNano) Doctoral Training Centre, EPSRC grant EP/G03737X/1). The Bioimaging Facility of the Faculty of Life Sciences

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

• Cynthia Kembuan,
• Maysoon Saleh,
• Bastian Rühle,
• Ute Resch-Genger and
• Christina Graf

Beilstein J. Nanotechnol. 2019, 10, 2410–2421, doi:10.3762/bjnano.10.231

• such as peptides, antibodies or nucleic acids for bioimaging applications or fluorescence assays. The growth of a mesoporous silica shell on a microporous silica shell can also be applied for the subsequent use of these nanomaterials for drug loading and delivery [69]. Experimental All syntheses were

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• expected health crisis [1]. However, the single modal drug delivery system is hampered by low bioavailability (about 5–10%), burst release, and lower target efficiency. Multifunctional theranostic nanoparticles that can respond to an external magnetic field for drug release and assist in bioimaging

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• applications, is given in [21], which includes details on biosensing, bioimaging and drug delivery as well as biocompatibility. The toxicity of diamond nanostructures is also discussed. Electron spin resonance (ESR) of the NVs themselves is exploited in [22] to achieve single-spin subwavelength resolution in

• modulated with a magnetic field giving increased sensitivity. As bioimaging probes, they are versatile, cost-effective and easily functionalized, in addition to being easy to coat with silica for biomedical applications. Background-free imaging, both in vivo and in vitro, is achieved by applying an