Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model

• Aram Shirinyan and
• Yuriy Bilogorodskyy

Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117

• data, under operating conditions, HDCMs are susceptible to risks such as radiation-induced vacancy saturation (the accumulation of vacancy-type defects), swelling (an increase in linear dimensions and volume upon irradiation), damage, amorphization (crystal-to-glass transition), and other phase

• thermodynamic stimulus for phase change, (ii) the contribution of surface energy due to a high percentage of surface atoms, (iii) interfaces acting as sinks for radiation-induced point defects, (iv) the accumulation of defects (saturation of vacancies) in the material as a driving force of phase changes, and (v

• about 2 [18]. Wei et al. investigated typical bcc metals and found that (i) vacancy accumulation is lower in metals with small vacancy migration energies, such as V, Cr, Fe, and Nb, and (ii) the relationship between vacancy concentration and grain size (ranging from 10−9 to 10−6 m) under an irradiation

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• the BBB through a direct connection [18][19]. When combined with nanotechnology, N2B delivery becomes even more attractive since nanotechnology-driven DDSs have enabled improved drug accumulation at the target site [20]. DDSs, such as polymeric or lipid-based nanoparticles (NPs), can provide an

• authors presented that PLGA NPs with larger particle sizes (520 nm) were accumulated in neural bundles. They showed that this accumulation could enable intracellular uptake in neuronal axons and further provide transcellular transport with the olfactory or trigeminal nerve pathways [81]. It should be

• visualization and to deliver anti-eGFP siRNA and double-stranded DNA. The formulation offered advantages over others as an effective tracker. It confirmed the accumulation of NPs in the olfactory bulbs and other regions of the brain via intranasal administration [159]. Additionally, Jeong et al. focused on

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• during flight, as many hymenopterans (e.g., chrysidids, scelionids, and mutillids) have dimples on the cuticle that might have the same aerodynamic effect as those on golf balls [13]. Setose cuticle in hymenopterans also exhibits an interesting function, namely, reducing the accumulation and deposition

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• , 5 μM particle size, New Objective). The source temperature was set to 275 °C and the nanoelectrospray voltage to 2.2 kV. The mass spectrometer operated in data-dependent acquisition mode, where full scan MS1 spectra (m/z 300–1,600) were acquired at resolution r = 60,000 after accumulation of 1 × 106

• proves to be a successful model that can be extended to other types of NPs, such as degradable mesoporous silica nanoparticles, which are highly porous and can degrade under specific biological conditions, thus preventing inconvenient accumulation in the body. a) Representation of the synthesis steps of

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• actively targeted usNPs, revealing increased tumor accumulation and retention compared to non-targeted counterparts. In this review, we explore actively targeted inorganic usNPs, highlighting their biological properties and behavior, along with applications in both preclinical and clinical settings

• driving passive NP delivery to tumors [4][5]. In this model, leaky blood vessels and a compromised lymphatic drainage system contribute to the preferential NP extravasation and accumulation within solid tumors. However, recent evidence challenges this paradigm, suggesting that NP extravasation into tumors

• primarily occurs via transendothelial transport pathways [6][7]. Regardless of the mode of NP extravasation, active targeting strategies have been widely explored to further enhance NP accumulation in tumors and NP internalization by cancer cells [8][9]. Active targeting involves the modification of NPs

A low-kiloelectronvolt focused ion beam strategy for processing low-thermal-conductance materials with nanoampere currents

• Annalena Wolff,
• Nico Klingner,
• William Thompson,
• Yinghong Zhou,
• Jinying Lin and
• Yin Xiao

Beilstein J. Nanotechnol. 2024, 15, 1197–1207, doi:10.3762/bjnano.15.97

• and fast processing times. Suitable ion beam parameters for lower-energy ions (5 keV) are assessed, and the results are compared to the conventionally used 30 keV ions. The interactions of 5 keV gallium ions and the effect on heat accumulation due to ion impacts with the sample (skin) were

• accumulation within a single scan point when using nanoampere beam currents and nanometer spot sizes. For 5 keV ions, the cooling time constant was determined from the COMSOL simulations to be around 170 ps, which is similar to the time between ion impacts for nanoampere ion beam currents and significantly

• modelling approach. To simulate the heat accumulation of multiple ion impacts occurring within a time frame of several nanoseconds, Python was used to implement a forward time–centered space method as a finite-difference method for three dimensions, similar to [29][30]. According to a von Neumann stability

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• phase of a two-phase octanol–water mixture [39]. Similarly, LogS, related to the water solubility of a substance, was considered. Besides, PSA, as molecular surface associated with charge accumulation due to heteroatoms and polar groups, as well as polarizability (α) associated with the tendency of a

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• treatment. The enhanced permeability and retention (EPR) effect, first described by Maeda and co-workers in 1986, allows for high accumulation of the drug nanocarriers via the leaky vasculature and the deficient lymphatic system around solid tumors, as illustrated in the right panel of Figure 1 [3][4][5

• accumulation selectively through specific binding to receptors overexpressed by cancer cells (left panel of Figure 1), resulting in enhanced therapeutic activity and reduced systemic toxicity. Globally, there are around 15 approved cancer drug nanoformulations for clinical use, and 80 candidates for novel

• their derivatives, and inorganic NPs. We also discuss the underlying mechanisms of some nanocarriers to yield selective liver accumulation and enhance therapeutic action. In the final section, we mention the future perspective of the development of nanomedicine-based drug delivery for liver fibrosis

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• decades. These techniques aim to improve disease treatment by increasing targeted accumulation of drugs into diseased tissues while minimizing side effects and toxicity. Nanoparticle-based drug delivery strategies have evolved since the 1970s, when researchers first investigated the use of nanoparticles

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• accumulation of collagen leading to the foreign-body reaction. This phenomenon involves the formation of a fibrous capsule around the implant, which compromises its functionality (such as the flexibility of cardiovascular stents) and, thus, limits the integration of soft tissue implants. The effect of

Entry of nanoparticles into cells and tissues: status and challenges

• Kirsten Sandvig,
• Tore Geir Iversen and
• Tore Skotland

Beilstein J. Nanotechnol. 2024, 15, 1017–1029, doi:10.3762/bjnano.15.83

• of dynamin, such as dynasore and Dyngo, is inhibited by the presence of serum [38][41], and also that these inhibitors are not specific (see Table 1) [39][40]. Intracellular Effects of Accumulation and Degradation of Nanoparticles It has been known for years that even small particles such as QDs

• with receptor/membrane transport in various organelles will have secondary effects on membrane transport in general. Also, if not degradable but ending up in endosomes or lysosomes, one would expect that an accumulation of NPs may disturb membrane trafficking and lysosomal degradation in these cells

Recent progress on field-effect transistor-based biosensors: device perspective

• Billel Smaani,
• Fares Nafa,
• Mohamed Salah Benlatrech,
• Ismahan Mahdi,
• Hamza Akroum,
• Mohamed walid Azizi,
• Khaled Harrar and
• Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

• sensing membrane is accommodated between the contact of the metal gate and the insulator part. The carrier concentration in the body channel might change as a result of an accumulation, depletion, or inversion process when an external voltage is applied [51]. This results in the formation of a band

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• of folic acid did not change the level of the cell signal. F127 also assists in the accumulation of the nanoparticles in the cell via clathrin-mediated endocytosis and caveolae-mediated endocytosis [9][44]. In our study, F127 enhanced the internalization of the nanoparticles in MCF7, HepG2, and HEK

Effects of cutting tool geometry on material removal of a gradient nanograined CoCrNi medium entropy alloy

• Yu-Sheng Lu,
• Yu-Xuan Hung,
• Thi-Xuyen Bui and
• Te-Hua Fang

Beilstein J. Nanotechnol. 2024, 15, 925–940, doi:10.3762/bjnano.15.76

• accumulation, and the chip volume increase significantly with the increase in cutting depth. In contrast to sharp tools, which mainly use shear deformation, blunt tools remove material by plowing, and the cutting force increases with the increase in cutting-edge radius and negative rake angle. Keywords

• al. have shown that, as the grain size changes, the difference in friction coefficient with each cutting length is chaotic and does not follow the law of grain size increase [23]. The grain size affects the coefficient of friction in a rather complex way. Dislocation accumulation, lattice instability

• , and material accumulation may affect the cutting force response [21][24]. Furthermore, tangential forces are generated through work hardening resulting from the accumulation of chips or material pile-up [22]. The average resultant force is highest for the sample with a grain size gradient of 5-7-9 nm

Electron-induced ligand loss from iron tetracarbonyl methyl acrylate

• Hlib Lyshchuk,
• Atul Chaudhary,
• Thomas F. M. Luxford,
• Miloš Ranković,
• Jaroslav Kočišek,
• Juraj Fedor,
• Lisa McElwee-White and
• Pamir Nag

Beilstein J. Nanotechnol. 2024, 15, 797–807, doi:10.3762/bjnano.15.66

• leads to metal–ligand bond cleavage, which is often incomplete and leads to the accumulation of organic contamination in the final deposit. So far, the above interest has focused mainly on the well-established precursors. In this paper, we probe a novel precursor, namely, iron tetracarbonyl methyl

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO₂/graphene quantum dot-modified electrode

• Vu Ngoc Hoang,
• Dang Thi Ngoc Hoa,
• Nguyen Quang Man,
• Le Vu Truong Son,
• Le Van Thanh Son,
• Vo Thang Nguyen,
• Le Thi Hong Phong,
• Ly Hoang Diem,
• Kieu Chan Ly,
• Ho Sy Thang and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 719–732, doi:10.3762/bjnano.15.60

• oxidation of URI generates a bis-imine [35], and the oxidation of HYP forms 6,8-dioxypurine at the N7=C8 double bond [36]. Relevant operational parameters In the present work, the operational parameters accumulation potential (Eacc), accumulation time (tacc), pulse amplitude (ΔE), and potential step (Ustep

• ± 0.25 μA (n = 7), respectively; while the values for HYP are 1.341 ± 0.004 V and 7.204 ± 0.055 μA (n = 7), respectively. This shows that the TiO2/GQDs material interacts well with URI and HYP during the accumulation step. An Eacc value of +0.1 V with low relative standard deviation (RSD) values for IP

• accumulation time increases from 5 to 20 s, the IP values of URI and HYP are not statistically different. However, it is possible that the high concentration of URI and HYP in the solution might saturate on the modified electrode surface. Therefore, an accumulation time of 15 s was chosen for further studies

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

• Theo Fromme,
• Sven Reichenberger,
• Katharine M. Tibbetts and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

• an accumulation of anions in the Helmholtz layer indicated by zeta potential measurements. Scaramuzza et al., in contrast, investigated non-ionic additives and their influence on structure and composition during the ablation of metastable AuFe alloys [20]. They used ethanol and water as solvents and

• /cavitation bubble phase in which the carbon-based solvent is decomposed, followed by an accumulation of the decomposition products on the metal surface and a final carbonization step to form carbon shells on the nanoparticle surface [101][148]. The latter were reported to undergo graphitization to onion-like

• the nanoparticle surface during cooling, (ii) decomposition of the solvent molecules on the (hot) particle surface during the process, or (iii) post-process adsorption and accumulation of formed carbon by-products on the particle surface. Theoretical and conceptual approaches to laser-induced solvent

Comparative analysis of the ultrastructure and adhesive secretion pathways of different smooth attachment pads of the stick insect Medauroidea extradentata (Phasmatodea)

• Julian Thomas,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 612–630, doi:10.3762/bjnano.15.52

• adhesive secretion reservoir optimizing the substance absorption and discharge [31][65][66][67]. Adjacent to the exocrine cells is the adhesive secretion reservoir serving for the accumulation of the produced adhesive secretion. Both pad types share a similar organisation of the procuticle. The endocuticle

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

• Yanyan Wen,
• Ningning Song,
• Yueyou Peng,
• Weiwei Wu,
• Qixiong Lin,
• Minjie Cui,
• Rongrong Li,
• Qiufeng Yu,
• Sixue Wu,
• Yongkang Liang,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

• through the enhanced permeability and retention (EPR) effect, thereby extending the drug circulation time and improving its accumulation and effective release within tumors [9][22][23]. The newly developed class of nanoparticles with a structure similar to that of plant flowers is called nanoflowers (NFs

Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection

• Le Hong Tho,
• Bui Xuan Khuyen,
• Ngoc Xuan Dat Mai and
• Nhu Hoa Thi Tran

Beilstein J. Nanotechnol. 2024, 15, 426–434, doi:10.3762/bjnano.15.38

• -focus light element from Bruker, UK, were used. Raman spectra were collected with a XploRA ONE spectroscope (HORIBA, Japan), with a laser wavelength of 532 nm, 1 mW power, and an accumulation number of 60. Schematic of the Ag NPs-DES synthesis. (A) UV–vis spectrum of the Ag NPs-DES solution. (B) XRD

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• eliminate ROS, but also up-regulated the Nrf2/HO-1 pathway to maintain redox homeostasis. Depending on the location of the accumulation, nanoantioxidants need to employ different encapsulating or coating strategies. Several studies used neutrophil membranes to increase the specificity of antioxidant

• because most drugs cannot cross the blood–brain barrier (BBB) [115][116]. Besides, the accumulation of drugs at damaged areas of the BBB can lead to an unprotected, disrupted BBB and to disturbances of the brain microenvironment. In contrast, the integrity of the BBB can decrease the accumulation of drugs

• [119]. The main pathogenic mechanisms of Alzheimer’s disease involve not only ROS overproduction but also amyloid beta (Aβ) fibril accumulation. Liu et al. reported a nanosystem employing polydopamine and ruthenium (PDA-Ru) as key elements for ROS scavenging and decomposition of mature Aβ fibrils [120

Investigating ripple pattern formation and damage profiles in Si and Ge induced by 100 keV Ar⁺ ion beam: a comparative study

• Indra Sulania,
• Harpreet Sondhi,
• Tanuj Kumar,
• Sunil Ojha,
• G R Umapathy,
• Ambuj Mishra,
• Ambuj Tripathi,
• Richa Krishna,
• Devesh Kumar Avasthi and
• Yogendra Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 367–375, doi:10.3762/bjnano.15.33

• attributed to the accumulation of defects produced by Ar irradiation. The RBS-c spectra recorded for Si and Ge single-crystal samples pre-damaged with 100 keV Ar+ ions at RT are presented in Figure 5A and Figure 5B, respectively. The RBS spectrum recorded for the pristine sample in random orientation

Modulated critical currents of spin-transfer torque-induced resistance changes in NiCu/Cu multilayered nanowires

• Mengqi Fu,
• Roman Hartmann,
• Julian Braun,
• Sergej Andreev,
• Torsten Pietsch and
• Elke Scheer

Beilstein J. Nanotechnol. 2024, 15, 360–366, doi:10.3762/bjnano.15.32

• structure of the magnetic and spacer layers along the long axis of the nanowires leads to variations of the magnetization in different magnetic layers and to spin accumulation in the spacer layers. Consequently, we expect distinct magnetic and magneto-electrical features compared to the reported nanowires

• macrospin approximation of free layers breaks down to nonuniform excitations, which means the magnetization of the ferromagnet is spatially nonuniform [27][28]. Nonuniform excitations occur in a very thin magnetic layer when the spin accumulation on its two sides is different. Under the critical current

• the spin accumulation at the interfaces between the different layers [7][26][28], more free layers are expected to bring more complex dependencies of the critical currents on the magnetic field, compared to a trilayer system whose Ic+, Ic−, and Imicro values are reported to monotonously change with

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• administered two times a week over three weeks, at 0.4 mg BNZ/kg (2.4 mg/kg TD), increased blood BNZ levels and caused a transient and threefold higher accumulation of BNZ in the liver, which was insufficient to defeat the infection of an acute murine model infected with T. cruzi RA strain. More recently, BNZ

• indicative of the drug’s bioavailability. Because of their huge size, nanomedicines in the blood cannot escape from vascular confinement and are not readily able to extravasate across the endothelium. Moreover, neither their extravasation in areas of high vascular permeability, nor their accumulation in the

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• oxidative damage through free radical accumulation, which could lead to changes in the survival rate of cancerous cells. The developed QSPR and quantitative structure–activity relationship models also give hints regarding safer design and toxicity assessment of MeOx NMs. Keywords: cancer cell treatment

• propensity, whereas Y2O3 NPs with a low zeta potential (−23 mV) cause less damage to cells (−4.5). The increase in zeta potential enhances the accumulation of nanoparticles on the surface of cells. The intensity of accumulation determines the toxicity of the nanoparticles. The concept of zeta potential plays