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Search for "albumin" in Full Text gives 116 result(s) in Beilstein Journal of Nanotechnology.

Effects of drug concentration and PLGA addition on the properties of electrospun ampicillin trihydrate-loaded PLA nanofibers

  • Tuğba Eren Böncü and
  • Nurten Ozdemir

Beilstein J. Nanotechnol. 2022, 13, 245–254, doi:10.3762/bjnano.13.19

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  • properties values (p < 0.05). This was similar to our previous studies with linezolid-loaded PLGA and PCL/PLGA nanofibers [16][30]. Chew et al. (2006) also showed that an increase in bovine serum albumin caused an increase in nanofiber diameter and a decrease in mechanical properties of poly(caprolactone-co
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Published 21 Feb 2022

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

  • Senuri Kumarage,
  • Imalka Munaweera and
  • Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

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  • work, a mildly hydrolyzed PAN membrane has been modified by fusing bovine serum albumin (BSA) obtained from laboratory wastes, and it has shown a maximum dye removal capacity of 434.78 mg/g, at pH 12 for TBO. The membrane has the ability to be regenerated by eluting the dye completely with 1 M NaCl or
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Published 31 Jan 2022

Bacterial safety study of the production process of hemoglobin-based oxygen carriers

  • Axel Steffen,
  • Yu Xiong,
  • Radostina Georgieva,
  • Ulrich Kalus and
  • Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

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  • modifications [5][6]. Thus, it was possible to immobilize vitamin B2 (riboflavin) in these particles together with human serum albumin (HSA). This resulted in a drug delivery system with good hemocompatibility and release of riboflavin over a prolonged period [7]. In addition, HSA microparticles could be loaded
  • , Bernburg, Germany; aqua ad iniectabilia (Ampuwa) from Fresenius Kabi Deutschland GmbH, Bad Homburg, Germany, and sodium chloride (NaCl) from B. Braun Melsungen AG, Melsungen, Germany. Human serum albumin, 200 g/L, Baxalta was obtained from Takeda Pharma Vertrieb GmbH & Co. KG, Berlin, Germany. EDTA, PBS
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Published 24 Jan 2022

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

  • Rouhollah Khodadust,
  • Ozlem Unal and
  • Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

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  • was recorded using a UV–vis spectrophotometer (Shimadzu UV-3600 UV–vis–NIR spectrophotometer). A calibration curve was prepared with bovine serum albumin (BSA) at concentration values of 0, 1, 2, 4, 6, 8, and 10 µg/mL in PBS to enable a correlation between the measured absorbance and protein
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Published 18 Jan 2022

An overview of microneedle applications, materials, and fabrication methods

  • Zahra Faraji Rad,
  • Philip D. Prewett and
  • Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

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  • incorporated drug. A wide range of molecules including the anthrax vaccine [26], aminolevulinic acid [27], calcein [28], erythropoietin [29], bovine serum albumin [30][31], ovalbumin [32], insulin [33][34], and plasmid DNA [35] have been transdermally delivered using microneedles of various designs, aimed at a
  • microneedles of soluble poly(lactic-co-glycolic acid) (PLGA) and PLGA–polyvinylpyrrolidone (PLGA–PVP) layered combinations have been used to provide controlled drug delivery of bovine serum albumin (BSA), rather than instantaneous release [60]. There are only a few published studies demonstrating the
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Published 13 Sep 2021

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

  • Sepand Tehrani Fateh,
  • Lida Moradi,
  • Elmira Kohan,
  • Michael R. Hamblin and
  • Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

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  • isothiocyanate (FITC)-labeled bovine serum albumin (BSA), FITC-labeled 150, 500, and 2000 kDa dextrans into DU145 prostate cancer cells. They blocked the endocytosis mechanism to assess whether the endocytic pathway was upregulated during US exposure. They showed that all of these fluorescent molecules were
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Published 11 Aug 2021

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

  • Khosro Adibkia,
  • Ali Ehsani,
  • Asma Jodaei,
  • Ezzatollah Fathi,
  • Raheleh Farahzadi and
  • Mohammad Barzegar-Jalali

Beilstein J. Nanotechnol. 2021, 12, 786–797, doi:10.3762/bjnano.12.62

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  • concentration-dependent. More specifically, it was shown that 0.1 µg/mL Ag-NPs caused elevated levels of NK2 homeobox 5 (NKX2.5), myosin heavy chain 6 (MYH6), and islet (ISL) genes expression, of alpha-fetoprotein (AFP), albumin (ALB) proteins expression and of hepatocyte nuclear factor 4 alpha (HNF4A
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Published 02 Aug 2021

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

  • Gabriel M. Misirli,
  • Kishore Sridharan and
  • Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

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  • agents responsible for the toxicity of silver and argyria in our body. When Ag+ enters the bloodstream, it is transported bound to albumin and thiol groups. When it reaches a region close to the skin, in areas affected by light, it can easily be photoreduced to AgNPs, which are then immobilized in the
  • human serum albumin (HSA), fibrinogen and immunoglobulin (IgG), metallothionein (MT), and ceruloplasmin (CP), forming a protein corona (PC) during silver homeostasis [121][122]. The PC is a highly dynamic system and its composition dynamically changes over time, undergoing various transformations until
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Published 14 May 2021

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

  • Nikola Geskovski,
  • Nadica Matevska-Geshkovska,
  • Simona Dimchevska Sazdovska,
  • Marija Glavas Dodov,
  • Kristina Mladenovska and
  • Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

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Published 29 Apr 2021

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

  • Barbora Svitkova,
  • Vlasta Zavisova,
  • Veronika Nemethova,
  • Martina Koneracka,
  • Miroslava Kretova,
  • Filip Razga,
  • Monika Ursinyova and
  • Alena Gabelova

Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22

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  • imaging techniques. The results revealed that the route of MNP entry into cells strongly depends on the surface chemistry of the MNPs. While serum bovine albumin-coated MNPs entered the cells via clathrin-mediated endocytosis (CME), caveolin-mediated endocytosis (CavME) or lipid rafts were preferentially
  • involved in the internalization of polyethylene glycol-coated MNPs. Our data indicate that surface engineering can contribute to an enhanced delivery efficiency of nanoparticles. Keywords: bovine serum albumin; cellular uptake; magnetic iron oxide nanoparticles; polyethylene glycol; surface coating
  • functionalization to increase their accumulation in the tumor mass [3]. Numerous coating moieties have been employed to modify the surface properties of MNPs [16]. Among them, polyethylene glycol (PEG), a non-degradable polyether of the monomer ethylene glycol, and bovine serum albumin (BSA), a versatile protein
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Published 23 Mar 2021

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

  • Sandra Senyo Fometu,
  • Guohua Wu,
  • Lin Ma and
  • Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

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  • the resulting silk fiber with a mechanical strength of 1.07 GPa and a strain of 16.8% [170]. The effects of bovine serum albumin (BSA)-stabilized gold nanoclusters (BSA-Au NCs) at different concentrations (9.38, 1.88, 0.938, and 0.188 µg) inserted via intravascular injection in the silkworm was
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Published 12 Feb 2021

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

  • Cynthia Kembuan,
  • Helena Oliveira and
  • Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3

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  • ionic strength of the cell culture medium (I = 168 mmol/L) reduces the electrostatic stabilization. Besides, the proteins in the DMEM cell culture medium supplemented with 10% FBS contribute to the measured hydrodynamic diameter values [51]. FBS consists mostly of bovine serum albumin. The Z-average
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Published 08 Jan 2021

Electrokinetic characterization of synthetic protein nanoparticles

  • Daniel F. Quevedo,
  • Cody J. Lentz,
  • Adriana Coll de Peña,
  • Yazmin Hernandez,
  • Nahal Habibi,
  • Rikako Miki,
  • Joerg Lahann and
  • Blanca H. Lapizco-Encinas

Beilstein J. Nanotechnol. 2020, 11, 1556–1567, doi:10.3762/bjnano.11.138

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  • vaccines [5][6]. Significant advances in self-assembled PNPs via protein engineering techniques have also been observed [7][8]. PNPs have successfully reached the clinic with nab-paclitaxel (Abraxane®), a PNP made of human serum albumin, which is being used for the treatment of metastatic breast cancer
  • variety of different particle and fiber architectures can be made [54][55]. Bovine serum albumin (BSA) SPNPs were synthesized via the EHD co-jetting method, with BSA as the protein and an oligomer composed of poly(ethylene glycol) (PEG, 2 kDa) terminally bifunctionalized with N-hydroxysuccinimide (NHS
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Published 13 Oct 2020

Transient coating of γ-Fe2O3 nanoparticles with glutamate for its delivery to and removal from brain nerve terminals

  • Konstantin Paliienko,
  • Artem Pastukhov,
  • Michal Babič,
  • Daniel Horák,
  • Olga Vasylchenko and
  • Tatiana Borisova

Beilstein J. Nanotechnol. 2020, 11, 1381–1393, doi:10.3762/bjnano.11.122

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  • , that is, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) and NaH2PO4, decreased the ability of γ-Fe2O3 nanoparticles to form a glutamate biocoating by about 50% and 90%, respectively. Only 15% of the amount of glutamate biocoating obtained in water was obtained in blood plasma. Albumin did
  • nanoparticles was measured in the standard salt solution and in its separate components, that is, KCl (10 mM), NaH2PO4 (1 mM), HEPES (20 mM), and also in albumin (0.125 mg/mL) and blood plasma. An amount of 1.5 µL of ʟ-[14C]glutamate (500 nM, 238 mCi/mmol) and non-radiolabeled glutamate at definite
  • concentrations were mixed with abovementioned components along with different amounts of γ-Fe2O3 nanoparticles also added to the probe. The incubation time was 5 min in the salt solutions and 30 min in blood plasma or albumin. After that a magnetic field was applied or the nanoparticles were sedimented in a
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Published 10 Sep 2020

Thermophoretic tweezers for single nanoparticle manipulation

  • Jošt Stergar and
  • Natan Osterman

Beilstein J. Nanotechnol. 2020, 11, 1126–1133, doi:10.3762/bjnano.11.97

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  • with an aqueous solution of bovine serum albumin (Sigma-Aldrich) and washed to prevent nanoparticle adhesion to the glass. A collimated IR laser beam (Compass 1064-2500MN, Coherent, λ = 1064 nm) is deflected with a pair of acousto-optic deflectors (AODs). AODs enable the simultaneous generation of
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Published 30 Jul 2020

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

  • Maria Suciu,
  • Corina M. Ionescu,
  • Alexandra Ciorita,
  • Septimiu C. Tripon,
  • Dragos Nica,
  • Hani Al-Salami and
  • Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

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  • , dendrimers, albumin, silicones, liposomes, poloxamer, poly-ʟ-lysine, sugars, or polyethylene glycol (PEG) [27][28][29][30][31][32][33]. Hyperthermia treatment for cancer therapy is still under scrutiny. It shows great potential due to the property of SPIONs to produce local heat when placed under an
  • be highly toxic [43]. Using Wistar rats, Schlachter et al. [167] tested the release and toxicity of a subcutaneously implanted iron patch made from 15 nm iron oxide particles covered with albumin. Their results also showed that for a period of 6 months there were no toxic effects and no iron overload
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Published 27 Jul 2020

Key for crossing the BBB with nanoparticles: the rational design

  • Sonia M. Lombardo,
  • Marc Schneider,
  • Akif E. Türeli and
  • Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

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  • (e.g., human serum albumin) [28], gold nanoparticles [29] and superparamagnetic iron oxide nanoparticles [30]. This review aims to summarize (i) the different pathways to cross the BBB, (ii) the strategies that can be employed to increase nanoparticle BBB permeation without disrupting the BBB, as well
  • lactoferrin receptor [34][41]. More recently, nicotinic acetylcholine receptors (nAChRS) and diphtheria toxin receptor have also been described [34][42]. However, some receptors usually found on peripheral endothelial cells are not expressed, e.g., the albumin receptor [40][43]. Three major categories of
  • cationic bovine serum albumin (CBSA) allows them to cross the BBB by AMT, as described above [110][111][112][114]. PEG-PLA nanoparticles were labeled with coumarin-6 and conjugated with either CBSA or BSA in a study by Lu and co-workers [110]. Transcytosis assays were performed on a co-culture BBB in vitro
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Published 04 Jun 2020

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

  • Ludovica Soddu,
  • Duong N. Trinh,
  • Eimear Dunne,
  • Dermot Kenny,
  • Giorgia Bernardini,
  • Ida Kokalari,
  • Arianna Marucco,
  • Marco P. Monopoli and
  • Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

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  • , custom parallel plate perfusion chambers were coated overnight with 100 μg/mL VWF, washed with phosphate-buffered saline and blocked with 1% bovine serum albumin for 1 h prior to use. Whole blood was labelled with 1 μM DiOC6 (Sigma-Aldrich, Ireland) for 5 min at 37 °C prior to perfusion through the
  • was found to strongly bind to the CNPs also at higher concentrations of plasma. Similarly, ApoB100 and histidine-rich glycoprotein were enriched at 10% plasma, but they were displaced by other proteins such as vitronectin and ITIH4 at higher concentrations of plasma. Interestingly, albumin (66 kDa
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Published 03 Apr 2020

Luminescent gold nanoclusters for bioimaging applications

  • Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

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  • were observed in N-acetylglutathione (NAGSH) and N-formylglutathione (NFGSH) ligands. Xie and co-workers reported the synthesis of a bovine serum albumin (BSA)-protected water-soluble Au25 nanocluster (Au-BSA) having a red emission at ca. 640 nm with a PL quantum yield of 6% (Figure 1E,F) [63]. More
  • importantly, the Au-BSA NCs are stable under ambient conditions and retain their PL even after drying (Figure 1G,H) allowing for long-term storage [64]. Several other proteins including lysozyme, human serum albumin (HSA) and insulin have been used to prepare inherently luminescent AuNCs [65][66][67][68][69
  • are presented. In each section representative early examples along with the recent examples are discussed. Biosensing and imaging of pathogens Chan et al. reported human serum albumin (HSA)-stabilized gold NCs (Au-HSA) for sensing Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus
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Published 30 Mar 2020

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

  • Varsha Sharma and
  • Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

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  • PE capsules by changing the open and closed state of the capsules. PAH/PMA microcapsules were successfully loaded with fluorescein isothiocyanate-bovine serum albumin (FITC-BSA) at pH < 4 [70]. Confocal microscopy was used to visualize the open and closed state of the capsules at pH 3 and 7
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Published 27 Mar 2020

Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

  • Gennady L. Burygin,
  • Polina I. Abronina,
  • Nikita M. Podvalnyy,
  • Sergey A. Staroverov,
  • Leonid O. Kononov and
  • Lev A. Dykman

Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39

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  • -called weak antigens (haptens), i.e., a pronounced immune response against them is not developed (in general, substances with molecular mass ca. 1 kDa or less are not immunogenic). As a rule, haptens are conjugated with carrier proteins, such as bovine serum albumin, hemocyanin, ovalbumin, or
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Published 19 Mar 2020

Rational design of block copolymer self-assemblies in photodynamic therapy

  • Maxime Demazeau,
  • Laure Gibot,
  • Anne-Françoise Mingotaud,
  • Patricia Vicendo,
  • Clément Roux and
  • Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

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  • , the porphyrin photosensitizer was released and the size of the nanoobjects in solution increased (Figure 5d) [77]. For a combined photodynamic therapy/photothermal therapy (PDT/PTT) approach, indocyanine green (ICG) has been encapsulated in a protein, namely human serum albumin. First human serum
  • albumin (HSA) is reduced and encapsulates ICG thanks to electrostatic interactions, then the disulfide links are reconstructed for carrier stabilization. This carrier is then glutathione-sensitive and its reduction under in vivo conditions enhanced the PDT efficiency [78]. The cleavage of ROS-responsive
  • released [91]. The photoactivity of the photosensitizer can also be modulated by conjugation with a quencher molecule different from the photosensitizer itself. IR780 could be used as a quencher of chlorin-e6 fluorescence in albumin-based nanosystems [107]. Upon NIR excitation and IR780 degradation chlorin
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Published 15 Jan 2020

Internalization mechanisms of cell-penetrating peptides

  • Ivana Ruseska and
  • Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

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  • in numerous functions, having important roles in cell signaling, lipid regulation and endocytosis [91]. The most famous ligand for this pathway seems to be albumin. The binding to its receptor, gp60, provokes internalization of the protein. In addition, there is a growing number of receptors, other
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Published 09 Jan 2020

Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions

  • Anna V. Epanchintseva,
  • Julia E. Poletaeva,
  • Dmitrii V. Pyshnyi,
  • Elena I. Ryabchikova and
  • Inna A. Pyshnaya

Beilstein J. Nanotechnol. 2019, 10, 2568–2578, doi:10.3762/bjnano.10.248

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  • suspension at 4 °C for different times resulted in the formation of particle clusters of high colloidal stability as demonstrated by conventional methods. These clusters completely disintegrated when albumin was added, indicating that they are agglomerates (and not aggregates) of AuNP-siRNA. The AuNPs-siRNA
  • of the clumping of AuNP-siRNA, we used the known property of albumin to increase the dispersion of AuNP suspensions [29]. We added 3% human serum albumin (HSA) (corresponding to 10% serum commonly used in the cell cultivation) to samples ×1 and ×10 (freshly prepared and stored for one or eight days
  • disappearance of the AuNP-siRNA clusters (Figure 4D,E,F) even after the addition of 3% albumin to the samples in the DMEM medium, which promoted aggregation of AuNP-siRNA as shown in Figure 2. The hydrodynamic parameters of the AuNP-siRNA particles after the addition of albumin were impossible to evaluate
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Published 23 Dec 2019

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

  • Camila A. Proença,
  • Tayane A. Freitas,
  • Thaísa A. Baldo,
  • Elsa M. Materón,
  • Flávio M. Shimizu,
  • Gabriella R. Ferreira,
  • Frederico L. F. Soares,
  • Ronaldo C. Faria and
  • Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

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  • . Reduced ʟ-glutathione (GSH, 99%), bovine serum albumin (BSA), HAuCl4·3H2O (99.9%), sodium borohydride (99%), horseradish peroxidase (HRP, MW = 44000; 250–330 u·mg−1), poly(diallydimethylammonium chloride) (PDDA, 20 wt % in H20), 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (EDC), N
  • PBS and incubated with 5 μL of bovine serum albumin (BSA) (2% w/w) diluted in PBS to avoid non-specific binding (NBS). Each step of the modification was monitored with polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS, see Figure S1F in Supporting Information File 1). The
  • incubated with 5 μL of bovine serum albumin (BSA) (2% w/w) diluted in phosphate-buffered saline (PBS), to avoid non-specific binding. Preparation of the bioconjugate complex of Ab2 and HRP (Ab2-MNP-HRP). Illustration of the PSA capturing step. Comparison of various sandwich-type immunosensors and
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Published 06 Nov 2019
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