Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• , and has gained further importance over the past few decades [1]. This technology also offers promising possibilities for medical applications such as tumor diagnostics and therapy, as drug carriers or in biodegradable implants, e.g., in laser tissue soldering (LTS) [2]. LTS provides a promising

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• ]. Since that discovery, PDA has received extensive attention owing to its extremely attractive properties. Owing to its simplicity, PDA-assisted coating has been intensively applied for various nanoparticles including nanodiamonds [26], polymeric drug carriers [27], AuNRs [28][29][30][31][32][33][34

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• , Spain Dpto. Materiales y Producción Aeroespacial, ETSI Aeronáutica y del Espacio, Universidad Politécnica de Madrid, 28040-Madrid, Spain 10.3762/bjnano.10.16 Abstract The use of nanoparticles as drug carriers has provided a powerful weapon in the fight against cancer. These nanocarriers are able to

• affecting healthy tissue. These nanoparticles are able to load great amounts of drugs, to transport them in the blood stream and finally, to recognize the tumoral tissue and release their cargo inside the tumoral cells. The idea to use nanoparticles as drug carriers in oncology arose in 1986, when two

A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO₂ nanotubes with a hydrophobic layer

• Caihong Liang,
• Jiang Wen and
• Xiaoming Liao

Beilstein J. Nanotechnol. 2018, 9, 1793–1801, doi:10.3762/bjnano.9.170

• exhibit promising application as a localized, prolonged drug delivery platform. Keywords: Ag doping; drug delivery; hydrophobic layer; prolonged drug release; TiO2 nanotubes; visible-light-controlled release; Introduction Titanium dioxide nanotubes (TNTs) are often employed as drug carriers, owing to

Advances and challenges in the field of plasma polymer nanoparticles

• Andrei Choukourov,
• Pavel Pleskunov,
• Daniil Nikitin,
• Valerii Titov,
• Artem Shelemin,
• Mykhailo Vaidulych,
• Anna Kuzminova,
• Pavel Solař,
• Jan Hanuš,
• Jaroslav Kousal,
• Ondřej Kylián,
• Danka Slavínská and
• Hynek Biederman

Beilstein J. Nanotechnol. 2017, 8, 2002–2014, doi:10.3762/bjnano.8.200

• can be used as biomolecule and drug carriers [38][39][40]. Gas aggregation cluster sources (GAS) were considered feasible for the synthesis of plasma polymer NPs with a tuneable size distribution, retention of functional groups and cross-link density. The concept of GAS was originally developed for

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• last decades, various nanoparticles such as carbon nanotubes (CNTs) and carbon nanofibers (CNFs) have been extensively investigated for their utilization as drug carriers and delivery vehicles. They possess great potential for such biomedical applications based on their ability to be loaded with

Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy

• Isabella Tavernaro,
• Christian Cavelius,
• Henrike Peuschel and
• Annette Kraegeloh

Beilstein J. Nanotechnol. 2017, 8, 1283–1296, doi:10.3762/bjnano.8.130

• drug carriers [3][4][5], as transfection agents [6][7], for cancer treatment by local hyperthermia [8][9], for labelling [10][11] and for bioimaging [12][13][14]. The detection of cell-associated and internalised nanoparticles and the analysis of their interactions with extracellular or subcellular

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

• Liga Saulite,
• Dominyka Dapkute,
• Karlis Pleiko,
• Ineta Popena,
• Simona Steponkiene,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2017, 8, 1218–1230, doi:10.3762/bjnano.8.123

• drug carriers [3]. Recent studies have shown that nano-engineered mesenchymal stem cells (MSCs) could be used as tumour-targeted therapeutic carriers, reflecting their tumour-homing capabilities [4][5][6]. MSCs are present in many tissues of the human body, including bone marrow, adipose tissues, skin

Dispersion of single-wall carbon nanotubes with supramolecular Congo red – properties of the complexes and mechanism of the interaction

• Anna Jagusiak,
• Barbara Piekarska,
• Tomasz Pańczyk,
• Małgorzata Jemioła-Rzemińska,
• Elżbieta Bielańska,
• Barbara Stopa,
• Grzegorz Zemanek,
• Janina Rybarska,
• Irena Roterman and
• Leszek Konieczny

Beilstein J. Nanotechnol. 2017, 8, 636–648, doi:10.3762/bjnano.8.68

• advantage of carbon nanotubes, as compared to other potential drug carriers, is based on their high drug-binding surface (both inner and outer) and the possibility of chemical modification (functionalization) of the nanotube surface and adjustment of their length [8]. Both functionalization and shortening

• to the diseased tissue. Lipophilic SWNTs can easily penetrate through cellular membranes. CNTs are characterized by high mechanical strength and heat conductibility and their magnetic and optical properties may be the basis of their simultaneous use as drug carriers and sensitizers in photodynamic

• (intercalate) many different compounds, provided that at least a part of a molecule is a planar aromatic ring (e.g., Rhodamin B, Titan yellow) [36][37][38]. Since many drugs show such a structural feature, CR-nanotube complexes can be considered as possible drug-carriers. The ability of nanotubes to bind high

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• . Drug nanostructures thus obtained are single-component systems unlike traditional colloidal drug carriers. The design of building blocks allows for the control of physical and chemical properties of self-assembled systems. Self-assembly [41] and nanoprecipitation [42] are the most common approaches to

Hierarchical coassembly of DNA–triptycene hybrid molecular building blocks and zinc protoporphyrin IX

• Rina Kumari,
• Sumit Singh,
• Mohan Monisha,
• Sourav Bhowmick,
• Anindya Roy,
• Neeladri Das and
• Prolay Das

Beilstein J. Nanotechnol. 2016, 7, 697–707, doi:10.3762/bjnano.7.62

• building smart drug carriers, sensors or materials with significant property combinations. Experimental General HPLC-purified single strand 12-mer 5′-(CH2)12-amine-modified DNA, 1,3-dicyclohexylcarbodiimide (DCC), N-hydroxysuccinimide (NHS), hydroxybenzotriazole (HOBt), dimethylformamide (DMF

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• aspect in terms of side effects of the drug. Keywords: daunorubicin (DNR); 1,2-dipalmitoyl-sn-glycero-3-phosphothioethanol (DPPTE); drug carriers; model lipid membranes; single-walled carbon nanotubes (SWCNTs); Introduction Daunorubicin (DNR) is an anthracycline antitumor drug, which finds application

• employed in case of other DDS such as biodegradable polymers, which co-assemble into composite micelles [10]. Another type of common drug carriers includes nanoparticles. Magnetic Fe3O4 nanoparticles are often employed because they give possibility to control the transport by applying external magnetic

• : free and attached to drug carriers. However, due to different solubilities, the experimental procedures are different: free drug is more soluble and, therefore, can be dissolved in the subphase from which it penetrates the lipid monolayer, while drug–carbon nanotube adduct is added to the thiolipid and

Fabrication and characterization of novel multilayered structures by stereocomplexion of poly(D-lactic acid)/poly(L-lactic acid) and self-assembly of polyelectrolytes

• Elena Dellacasa,
• Li Zhao,
• Gesheng Yang,
• Laura Pastorino and
• Gleb B. Sukhorukov

Beilstein J. Nanotechnol. 2016, 7, 81–90, doi:10.3762/bjnano.7.10

• medical materials made from PLA, such as surgical suture, implants, as well as drug carriers, are in high demand. Recently PLA-based polymers have been used for the fabrication of drug carriers by a LBL self-assembly technique [15][17][34]. As an example, the stepwise assembly of poly(L-lactic acid) (PLLA

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

• Manuel Häuser,
• Klaus Langer and
• Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

• taken up by endocytosis. During the process of endocytosis, nanoparticular drug carriers most often end up in endolysosomes with a reduced internal pH value. In order to provide improved accessibility of the drug to the whole cell, membrane destruction of the endolysosomal bilayer would be beneficial

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• findings can be applied to develop nanofibrous drug carriers for the local delivery of hydrophobic pharmacologically active compounds, because the release of auxiliary hydrophilic molecules can effectively control the drug release kinetics. Experimental Reagents PCL (Mw ≈ 80 kDa) and trifluoroacetic acid

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• paramagnetism, super saturation, and having free electrons, magnetic nanoparticles have emerged as promising candidates for various medical and biological applications including magnetic resonance imaging (MRI) (as a contrast agent), smart drug delivery (as drug carriers), gene therapy, hyperthermia and tissue

Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer

• Ying Huang,
• Jing Ma,
• Alan L. Porter,
• Seokbeom Kwon and
• Donghua Zhu

Beilstein J. Nanotechnol. 2015, 6, 1666–1676, doi:10.3762/bjnano.6.169

• exposure of the pharmaceutical through controlled release. Thus, NEDD provides a novel approach to medical therapy, including treatment of chronic diseases and genetic disorders [5]. At the present, various kinds of nanoparticles have been developed as drug carriers, such as liposomes, micelles, polymeric

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• antibacterial properties [12][13], are used in the cosmetics industry [14][15], and are used as nanoscale biosensors [11] and as drug carriers [16][17]. These NPs are being increasingly recognized due to their differential activity against tumor cells while being non-toxic to normal cells [18][19][20][21][22

Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes

• Julia M. Tan,
• Jhi Biau Foo,
• Sharida Fakurazi and
• Mohd Zobir Hussein

Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23

• of the diseased cells. Generally, drug carriers can be categorized into four major groups: inorganic nanoparticles [2][3], recombinant proteins [4], viral or non-viral carriers [5] and organic cationic compounds [6]. Recently, inorganic nanoparticles such as carbon nanotubes (CNTs) were subjected to

• carried out in PC12 cell lines in order to evaluate their possible effects in normal neuronal cells in vitro. The results obtained from this preliminary study are expected to provide a theoretical basis and understanding for preparation of efficient drug carriers in the future. Results and Discussion

• a combination of both traditional medical technology and nanotechnology, with the exploitation of nanosized materials of dimensions less than 100 nm. One such nanomedical approach to drug delivery technology that has made a great impact was the first demonstration utilizing liposomes as drug

Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state

• Florian G. Strobl,
• Florian Seitz,
• Christoph Westerhausen,
• Armin Reller,
• Adriano A. Torrano,
• Christoph Bräuchle,
• Achim Wixforth and
• Matthias F. Schneider

Beilstein J. Nanotechnol. 2014, 5, 2468–2478, doi:10.3762/bjnano.5.256

• field of nanotoxicity [1][2][3][4]. The uptake of nanoparticles by living cells and the related risks play a crucial role in these areas. The high efficiency of this uptake in many cases recommends the application of nanoparticles as drug carriers or contrast agents [5][6]. While it was shown that very

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• cytoplasmic organelles, including mitochondria. Acting as drug carriers, these micelles affect the cellular distribution of the drug, as well as effectively increase the total quantity of the drug delivered to the cell [4]. It has been shown that by conjugating a drug to a copolymer carrier, the medicinal

Biopolymer colloids for controlling and templating inorganic synthesis

• Laura C. Preiss,
• Katharina Landfester and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2014, 5, 2129–2138, doi:10.3762/bjnano.5.222

• ” geometries. In a very recent work, Taheri et al. [63] have presented the formation of potato starch capsules decorated with silver nanoparticles, which could have applications as drug carriers or antibacterial coatings. The capsules are prepared in an inverse (water-in-oil) miniemulsion and the surfactant

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

• Dominic Docter,
• Christoph Bantz,
• Dana Westmeier,
• Hajo J. Galla,
• Qiangbin Wang,
• James C. Kirkpatrick,
• Peter Nielsen,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

• and drug carriers [10][15]. Amorphous silica is registered as a food additive within the EU, named also E551, and therefore it is already widely used in various consumer products [9][10][15]. The assessment of amorphous silica being non-toxic is mostly based on the testing of micrometer-sized bulk

En route to controlled catalytic CVD synthesis of densely packed and vertically aligned nitrogen-doped carbon nanotube arrays

• Slawomir Boncel,
• Sebastian W. Pattinson,
• Valérie Geiser,
• Milo S. P. Shaffer and
• Krzysztof K. K. Koziol

Beilstein J. Nanotechnol. 2014, 5, 219–233, doi:10.3762/bjnano.5.24

• steerable drug carriers for the enhanced penetration of target cells in anticancer therapies [72][73]. Experimental Synthesis. The synthesis setup was composed of a pre-heater, a furnace, a quartz reaction tube, injection pump with a syringe, an inert gas flow-meter and an exhausts purifier. The pre-heater