PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• . Intravenous administration of aEGFR-LNPs at 0.4 mg·kg−1 in pregnant mice resulted in a nearly twofold increase in mRNA expression in placentas compared to antibody-free LNPs, without detectable fetal transfer. Flow cytometry also confirmed a twofold increase in aEGFR-LNP uptake in EGFR+ trophoblasts and

Programmable soliton dynamics in all-Josephson-junction logic cells and networks

• Vsevolod I. Ruzhickiy,
• Anastasia A. Maksimovskaya,
• Sergey V. Bakurskiy,
• Andrey E. Schegolev,
• Maxim V. Tereshonok,
• Mikhail Yu. Kupriyanov,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1883–1893, doi:10.3762/bjnano.16.131

• can be achieved through alternative means, such as by creating a local mismatch in the damping parameter, for instance, by increasing α from 1 to 3 for one of the series junctions instead of the critical current. The ability to enforce a specific direction of soliton flow makes the soliton diode an

• mechanism would depend on the incorporation of KICKs into specific segments of these all-JJTLs. By programming each KICK to be in either its Open mode (transmitting) or Close mode (blocking), one could control the flow of solitons through the network and define a unique path from any input to any output. To

• functionality would be predicated on the synergistic action of its core components. First, KICKs integrated into the line segments would act as programmable switches controlling the signal flow. Second, the directionality of soliton propagation would be rigorously enforced by integrated soliton diodes. Thus

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• , which may be due to the fact that the aptamer was not modified and was easily degraded by nucleases. The cytotoxicity of Te4 to TE-1 and HEEC cells showed no potential as a therapeutic agent for EC alone. In addition, Te4 target has been identified as a membrane protein only by flow cytometry, and the

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• Technologies, USA). The column used was a SP®-2560 capillary GC column (100 m × 0.25 mm × 0.20 µm) (Supelco). The injector temperature was maintained at 230 °C, with helium (He) serving as the carrier gas at a flow rate of 1 mL·min−1. The oven temperature was programmed to increase from 150 to 300 °C at a rate

• Thermogravimetric (TG) and differential scanning calorimetry (DSC) analyses of LO (20.5 mg) were performed using a Simultaneous Thermal Analyzer (STA) 449 F3 Jupiter (NETZSCH, Germany). The samples were scanned from 25 to 700 °C at a heating rate of 10 K·min−1 under a nitrogen (N2) atmosphere with a flow rate of 50

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• mode): In a second experiment, 200 µs pulses of C2H4 were introduced into a 10 sccm O2 flow over a polycrystalline Pd catalyst at 365 °C with a repetition rate of 10 Hz and a total pressure of 3.7 × 10−3 mbar (the local pressure at the sample surface is much higher). The resulting APXP spectra shown in

• reaction cell was designed to replicate commercial ALD conditions, including independent pulsing of precursor gases, laminar flow across the sample, and substrate heating. The setup allows for independent control of precursor and co-reactant exposure and supports a variety of chemistries [60]. ALD is a key

• provides unique insight into surface reactions, charge transfer, and interface stability, which are central to the performance and degradation mechanisms of electrochemical systems. Electrochemical interfaces can be studied by APXPS using two primary cell types, namely, membrane-based flow cells and “dip

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• CXCL9/10 expression in Schwann cells [114]. Particle size and stability of the formulation in the patent were characterized using scanning electron microscopy (SEM). The nanoparticles demonstrated enhanced uptake in HepG2 cells, as confirmed by flow cytometry and confocal microscopy, and achieved a

• editing efficiency, MTT assay, and flow cytometry tests were carried out to observe the therapeutic activity of the technology. The results demonstrated that the nanoparticles increased targeting and internalization, had a knockout rate of 80%, and exhibited better inhibition of HepG2 cell proliferation

Bioinspired polypropylene-based functionally graded materials and metamaterials modeling the mistletoe–host interface

• Lina M. Rojas González,
• Naeim Ghavidelnia,
• Christoph Eberl and
• Max D. Mylo

Beilstein J. Nanotechnol. 2025, 16, 1592–1606, doi:10.3762/bjnano.16.113

• flow rate of 12 g/10 min and an indicated modulus of 1400 MPa and glass fiber-reinforced polypropylene MP2000 (hereafter abbreviated as PPGF) with 25% glass fiber content, a melt flow rate of 16 g/10 min and an indicated modulus of 4000 MPa (both LyondellBasell, Rotterdam, Netherlands). The reported

• produced. It can be seen that unidirectional and bidirectional gradients can be produced with a straight or V-shaped material interface present. However, it is apparent that, as the glass fiber content decreases, the polymer flow increases (Figure 3C, bottom and top part) [40], resulting in less clearly

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• % acetic acid in ultrapure water, with a flow rate set at 1.0 mL·min−1 and an injection volume of 10 μL. Every hour, 0.2 mL of OFL solution was sampled. The photocurrent was tested using a three-electrode system on an electrochemical workstation (CHI600E, Shanghai Chenhua), in which the carbon cloth (2 cm

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• another layer of complexity. Looking ahead, in addition to overcoming the limitations of active degradation materials, innovative encapsulation technologies that can actively control or even electrically manipulate fluid transport, such as through directional flow or on-demand pumping, represent a

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• comprehensive understanding of the process flow, from the laser-induced ejection of material into the gas phase, through its processing and movement in the plume, to its eventual deposition onto a substrate. Figure 1 shows key developments in thin film synthesis and laser-based processing from 1909 to 2025

• used to deposit photoresist films for microelectronic manufacturing, where understanding the interaction between liquid flow and mass transfer during the process became crucial as device sizes decreased. A one-dimensional model of spin coating was developed to describe film thinning due to both

• convective outflow and solvent evaporation, highlighting the formation of a solid “skin” at the surface, which could lead to defects if convective flow ceases too late [101]. By 2009, spin coating had become the dominant technique for producing uniform thin films of photosensitive organic materials, with

Automated collection and categorisation of STM images and STS spectra with and without machine learning

• Dylan Stewart Barker and
• Adam Sweetman

Beilstein J. Nanotechnol. 2025, 16, 1367–1379, doi:10.3762/bjnano.16.99

• would be improved by using the proposed method of classifying the tip based on a spectrum taken over the bare surface, such that the script would only take molecular spectra using probes which have been classified as “good” based on the surface state spectra. An example flow diagram with data taken

• deviation is shown in shaded purple. Example flow of an automated spectroscopy experiment taken over various SnPc molecules on the Au(111) surface. (a) An initial I(z) measurement is taken, where an exponential dependence is observed and so moves onto imaging, (b). The tip is then classified to be “good

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• column with a 0.25 mm thick layer (66DB-5MS, Agilent Technologies, USA) was used as the stationary phase. Helium gas was used as carrier gas at a flow rate of 1.0 mL/min with a split ratio of 1:10. The injector temperature was set to 250 °C. The oven temperature was set to 130 °C for 10 min and then

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• nanogels showed responsiveness to pH and temperature variation. In an ex vivo test performed with rat skin, the nanogel activated by sodium carbonate revealed a significantly higher release of naproxen into the epidermis, with a 2.8-fold increase in the steady flow of the drug. A 50% reduction in the

• the tumor with leakage permeable to blood flow due to disordered endothelial cell layers. This cellular organization of the vasculature with increased permeability allows increased uptake of nanoparticles by endocytosis and, consequently, increased cytotoxic effect of antineoplastic drugs. Thus, with

Crystalline and amorphous structure selectivity of ignoble high-entropy alloy nanoparticles during laser ablation in organic liquids is set by pulse duration

• Robert Stuckert,
• Felix Pohl,
• Oleg Prymak,
• Ulrich Schürmann,
• Christoph Rehbock,
• Lorenz Kienle and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 1141–1159, doi:10.3762/bjnano.16.84

• ± 10 nm after ps-LAL in acetone. As in their work different pulse energies were applied (88 µJ vs 150 µJ in our work) and a different setup was utilized (flow-through chamber vs semi-batch chamber in our work), it is likely that in our case the ablation process happens under harsher conditions. The

• difference in pulse energies possibly leads to stronger spallation [50][83] and thereby result in larger HEA NPs. Further, we cannot exclude that ripening processes occur in the semi-batch chamber utilized in this work, which would be less likely for the flow-through chamber used by Waag et al., as here the

Influence of ion beam current on the structural, optical, and mechanical properties of TiO₂ coatings: ion beam-assisted vs conventional electron beam evaporation

• Agata Obstarczyk and
• Urszula Wawrzaszek

Beilstein J. Nanotechnol. 2025, 16, 1097–1112, doi:10.3762/bjnano.16.81

• crucible. Diffusion and a rotary backing pumps enabled a base pressure in the vacuum chamber below 1.5·10−5 mbar. The operating pressure in the IBAD process was kept below 1.7·10−3 mbar, and the thin film coatings were deposited with an additional oxygen gas flow of 100 sccm. The ion beam gun (Advanced

• anatase and rutile phases, prepared by magnetron sputtering using continuous and pulsed gas flow processes were 0.17 and 0.24 eV, respectively. It was found that the lower value of Eu was obtained for the anatase thin film, which was directly related to the much more ordered structure of this layer, as

Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

• Sevin Adiguzel,
• Nilay Cicek,
• Zehra Cobandede,
• Feray B. Misirlioglu,
• Hulya Yilmaz and
• Mustafa Culha

Beilstein J. Nanotechnol. 2025, 16, 1068–1081, doi:10.3762/bjnano.16.78

• 45 min. Afterward, fluorescence and absorbance were measured at the 485/535 nm range by a microplate reader (Tecan, Switzerland). Cellular uptake assay According to the logic of the NMs uptake procedure by flow cytometry, an increasing percentage of side scatter (SSC%) shift indicates growth in

• for 24 h. Then, the cells were harvested and centrifuged, and cell pellets were suspended with 200 µL PBS for cellular uptake analysis with flow cytometry (BD LSR Fortessa Flow Cytometer, US) and the FlowJo software was used for interpretation of data. Scratch assay A scratch assay was performed to

• . Although applying US to the environment is a noninvasive mechanical stimulation, it may still cause acoustic streaming, acoustic microstreaming, and cavitation. This mechanical effect may cause fluid flow in the extracellular environment, creating temporary membrane deformation and tension on osteoblasts

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• , and polymer motion via Marangoni flow. It is possible to extend this series of photoresponsive properties to other photochromic molecules and polymers. This methodology will be of interest for a variety of smart molecular system devices and smart applications. Plastic crystals are materials that

Multifunctional properties of bio-poly(butylene succinate) reinforced with multiwalled carbon nanotubes

• Volodymyr Krasinskyi,
• Krzysztof Bajer,
• Ludmila Dulebova,
• Nickolas Polychronopoulos,
• Oksana Krasinska and
• Daniel Kaczor

Beilstein J. Nanotechnol. 2025, 16, 1014–1024, doi:10.3762/bjnano.16.76

• into nanosizes and uniformly distributed within the polymer matrix. To investigate the effect of CNTs on the rheological properties of PBS, specifically its flowability, the melt mass-flow rate (MFR) of pure PBS and the PBS/CNT_0.5 nanocomposite was studied at different temperatures and loads (Figure 2

• important to note that the MFR of the PBS/CNT_10 masterbatch could not be determined under the given conditions, as its melt exhibited minimal flow through the plastometer capillary. Therefore, the MFR of the masterbatch was measured at 230 °C and a load of 21.6 kg, yielding approximately 0.04 g/10 min

• revealed that CNTs decreased the melt flow rate by 5–25% at lower temperatures (180–190 °C), while improving flowability by 5–12% at 200 °C. It is hypothesized that the observed decrease in crystallinity may contribute to enhanced biodegradability. These results suggest promising applications for PBS/MWCNT

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

• formation via direct and near-field forces [24][25][26][27]. Furthermore, the application of TTM is hampered by the relatively high uncertainty of material parameters such as the temperature- or field-dependent interaction cross section or the non-linear heat capacities [28][29][30][31]. Heat flow and phase

• MeV-UED facility of SLAC National Accelerator Laboratory. This setup features a high brightness, femtosecond electron beam operating at 3–4 MeV energies, coupled with a rapid-flow liquid sheet jet system, which ensures that the sample is refreshed before each pump–probe shot sequence. The scattering

Focused ion beam-induced platinum deposition with a low-temperature cesium ion source

• Thomas Henning Loeber,
• Bert Laegel,
• Meltem Sezen,
• Feray Bakan Misirlioglu,
• Edgar J. D. Vredenbregt and
• Yang Li

Beilstein J. Nanotechnol. 2025, 16, 910–920, doi:10.3762/bjnano.16.69

• standard ion columns from ThermoFisher [23]. Both the Cs+ and the Rb+ FIB are equipped with a standard Pt GIS. The same precursor trimethylplatinum, C5H4CH3Pt(CH3)3, was used for all FIBID-Pt experiments. The precursor was heated to 40 °C to create a gas flow through the GIS nozzle, with the exit of the

• limited gas flow, which leads to an overall lower increase in growth rate with increasing current density. This agrees with previous findings for Ga+ FIBID-Pt [25]. Also, for Cs+ at 5 kV, the deposition rate is lower. A possible explanation might be the broader beam diameter, which increases for lower

• average grain diameter grows from 1.9 to 5.8 nm when the beam energy increases from 2 to 16 kV. With larger grain diameters, the Pt-rich particles have larger surface areas in close contact. These larger surface areas help the current to flow more easily between the Pt deposits. Therefore, the deposit

Characterization of ion track-etched conical nanopores in thermal and PECVD SiO₂ using small angle X-ray scattering

• Shankar Dutt,
• Rudradeep Chakraborty,
• Christian Notthoff,
• Pablo Mota-Santiago,
• Christina Trautmann and
• Patrick Kluth

Beilstein J. Nanotechnol. 2025, 16, 899–909, doi:10.3762/bjnano.16.68

• thick) grown on a 300 μm thick, polished ⟨100⟩ Si substrates using an Oxford Plasmalab 100 PECVD system. PECVD deposition was performed at 650 °C with gas flow rates of 16 sccm SiH4, 980 sccm N2, and 14 sccm NH3. Ellipsometry measurements employing a Tauc–Lorentz model revealed a deposition rate of

Heat-induced transformation of nickel-coated polycrystalline diamond film studied in situ by XPS and NEXAFS

• Olga V. Sedelnikova,
• Yuliya V. Fedoseeva,
• Dmitriy V. Gorodetskiy,
• Yuri N. Palyanov,
• Elena V. Shlyakhova,
• Eugene A. Maksimovskiy,
• Anna A. Makarova,
• Lyubov G. Bulusheva and
• Aleksandr V. Okotrub

Beilstein J. Nanotechnol. 2025, 16, 887–898, doi:10.3762/bjnano.16.67

• hydrogen/acetone/air mixture. The deposition parameters were typical of those previously employed for an “Astex” system (2.45 GHz, 4.5 kW): a pressure of 115 Torr, hydrogen, acetone, and air flow rates of 500, 18, and 0.3 sccm, respectively, and substrate temperature in the range of 940–980 °C [28][37

Synchrotron X-ray photoelectron spectroscopy study of sodium adsorption on vertically arranged MoS₂ layers coated with pyrolytic carbon

• Alexander V. Okotrub,
• Anastasiya D. Fedorenko,
• Anna A. Makarova,
• Veronica S. Sulyaeva,
• Yuliya V. Fedoseeva and
• Lyubov G. Bulusheva

Beilstein J. Nanotechnol. 2025, 16, 847–859, doi:10.3762/bjnano.16.64

• , molybdenum was sputtered from a Mo target with a purity of 99.9% for 10 s at a magnetron power of 100 W and an argon partial pressure of 5.4 × 10−1 Pa. The output pressure in the chamber was controlled by the argon flow. The MoS2 films were synthesized by sulfurization of molybdenum layers deposited on SiO2

• /Si substrates in a two-zone quartz reactor. The substrate was placed in the high-temperature zone and annealed there at 423 K for 30 min in an argon flow of 250 sccm. Then, this zone was heated to 873 K. 200 mg of sulfur powder (99.9% purity) were placed in a quartz crucible in the low-temperature

• reactor zone heated to 473 K. A flow of 24 sccm argon was passed through both reactor zones for 30 min at atmospheric pressure. After this time, sulfurization of the Mo layer was complete. Both zones were cooled to room temperature in a flow of 250 sccm argon. To remove polysulfide impurities and form a