Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• superior efficacy and improved drug delivery, it is assumed that DOX has to detach in order to maintain the functionality of its mechanism of action. The mechanism of action for DOX involves the crosslinking of DNA, inhibiting DNA replication. In release studies (not shown), 85% of DOX was retained to the

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• anticancer effect of taxol is mainly attributed to its mechanism of action. It stabilizes microtubules by preventing their depolymerization [19][20]. However, taxol is a hydrophobic drug and less specific to certain tumors due to its low solubility in water. To counter these problems, we carried out the