Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

• Hannah Onafuye,
• Sebastian Pieper,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Klaus Langer and
• Martin Michaelis

Beilstein J. Nanotechnol. 2019, 10, 1707–1715, doi:10.3762/bjnano.10.166

• level of UKF-NB-3 cells. This suggests that UKF-NB-3rDOX20 cells have developed multiple doxorubicin resistance mechanisms. In contrast, adaptation of UKF-NB-3rVCR1 cells to vincristine, a tubulin-binding agent with an anticancer mechanism of action that is not related to that of the topoisomerase II

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

• Zaid K. Alghrair,
• David G. Fernig and
• Bahram Ebrahimi

Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104

• timely manner. Currently there are two common types of anti-influenza drugs, based on their mechanism of action. The first class are neuraminidase inhibitors such as Oseltamivir (Tamiflu). The second class are virus ion-channel blockers, such as Amantadine (Symetrel). The effectiveness of Tamiflu has

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• may also bind to the “secreted protein, acidic and rich in cysteine” (SPARC) present in the extracellular matrix, facilitating the approximation to tumoral cells. This is the postulated mechanism of action of Abraxane®, one of the most commonly administered nanomedicines based on albumin today (Figure

Cyclodextrin inhibits zinc corrosion by destabilizing point defect formation in the oxide layer

• Abdulrahman Altin,
• Maciej Krzywiecki,
• Adnan Sarfraz,
• Cigdem Toparli,
• Claudius Laska,
• Philipp Kerger,
• Aleksandar Zeradjanin,
• Karl J. J. Mayrhofer,
• Michael Rohwerder and
• Andreas Erbe

Beilstein J. Nanotechnol. 2018, 9, 936–944, doi:10.3762/bjnano.9.86

• , 7491 Trondheim, Norway 10.3762/bjnano.9.86 Abstract Corrosion inhibitors are added in low concentrations to corrosive solutions for reducing the corrosion rate of a metallic material. Their mechanism of action is typically the blocking of free metal surface by adsorption, thus slowing down dissolution

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

• Nagamalai Vasimalai,
• Vânia Vilas-Boas,
• Juan Gallo,
• María de Fátima Cerqueira,
• Mario Menéndez-Miranda,
• José Manuel Costa-Fernández,
• Lorena Diéguez,
• Begoña Espiña and
• María Teresa Fernández-Argüelles

Beilstein J. Nanotechnol. 2018, 9, 530–544, doi:10.3762/bjnano.9.51

• glioblastoma cells, and excellent tolerability by non-cancerous cells, suggest great potential for a biomedical applicability of the spice C-dots as theranostic agents. Further studies would be necessary to achieve a better understanding of the mechanism of action of these C-dots, and to clarify the pathways

• %, respectively, whereas there was no significant growth inhibition to non-cancerous cells. Our preliminary results showed that this effect might be attributed to the presence of active molecules within the C-dot nanostructure, and more studies should be performed to understand the mechanism of action. Although

Phospholipid arrays on porous polymer coatings generated by micro-contact spotting

• Sylwia Sekula-Neuner,
• Monica de Freitas,
• Lea-Marie Tröster,
• Tobias Jochum,
• Pavel A. Levkin,
• Michael Hirtz and
• Harald Fuchs

Beilstein J. Nanotechnol. 2017, 8, 715–722, doi:10.3762/bjnano.8.75

• mechanism of action of this receptor new approaches are needed to facilitate studies with AR. Embedding AR in a lipid layer within HEMA-EDMA mesh might facilitate studies relying not only on fluorescence microscopy techniques but also on spectroscopy, to evaluate coactivators, co-chaperones [22] and even

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• mechanism of action. However, application of MIF is limited by its poor water solubility and low oral bioavailability. In this work, we developed a drug delivery system based on chitosan nanoparticles (CNs) to improve its bioavailability and anticancer activity. The MIF-loaded chitosan nanoparticles (MCNs

NanoE-Tox: New and in-depth database concerning ecotoxicity of nanomaterials

• Katre Juganson,
• Angela Ivask,
• Irina Blinova,
• Monika Mortimer and
• Anne Kahru

Beilstein J. Nanotechnol. 2015, 6, 1788–1804, doi:10.3762/bjnano.6.183

• [116][133][191] and TiO2 [153][154][155][156][192] was usually reported as particle-driven mechanical membrane damage. NanoE-Tox database contains only one study suggesting the mechanism of toxicity of fullerenes (oxidative stress) [193] and there are no data about possible mechanism of action of FeOx

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• superior efficacy and improved drug delivery, it is assumed that DOX has to detach in order to maintain the functionality of its mechanism of action. The mechanism of action for DOX involves the crosslinking of DNA, inhibiting DNA replication. In release studies (not shown), 85% of DOX was retained to the

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• anticancer effect of taxol is mainly attributed to its mechanism of action. It stabilizes microtubules by preventing their depolymerization [19][20]. However, taxol is a hydrophobic drug and less specific to certain tumors due to its low solubility in water. To counter these problems, we carried out the