Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

• Liga Saulite,
• Karlis Pleiko,
• Ineta Popena,
• Dominyka Dapkute,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

• to U251 glioma cells and induce cancer cell apoptosis [9]. Moreover, MSCs carrying poly(lactic-co-glycolic acid) (PLGA) NPs linked with paclitaxel selectively accumulate in an orthotopic A549 lung tumour model [2]. It has been reported that IFN-beta secreting MSCs could integrate into A375SM melanoma

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• , Spain Department of Organic Chemistry, University of Sevilla, C/ Prof García Gonzalez 1, Sevilla, 41012, Spain Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, 06100, Turkey 10.3762/bjnano.8.145 Abstract Background: Paclitaxel is a potent anticancer drug that

• is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclitaxel is commercially formulated with co-solvents such as Cremophor EL® that are known to cause serious side effects

• agents for gene delivery in the form of nanoplexes. In this study, the potential of polycationic, amphiphilic cyclodextrin nanoparticles were evaluated in comparison to non-ionic amphiphilic cyclodextrins and core–shell type cyclodextrin nanoparticles for paclitaxel delivery to breast tumors. Pre

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• , facilitating chemotherapy administration to prevent recurrence of the tumor at the time of tumor tissue removal by surgical operation. Among the anticancer drugs that are used in clinics, the taxane family of drugs such as paclitaxel and docetaxel are known to be highly effective against a variety of cancer

• -insoluble drugs from HpC films was examined by different study groups and the release profile was shown to be completed within approximately 10 h [71][72][73]. In another study regarding the release of paclitaxel (which is another member of taxane class, such as docetaxel, released from nanocomposite film

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• have demonstrated that carbon nanomaterials can also act as anti-tumor agents themselves and sensitize cancer cells to cytotoxic drugs such as etoposide [23][24][26], dexamethasone [23], paclitaxel [25] and CDDP [16]. In accordance, we have previously shown that CNFs and multiwalled CNTs could enhance

• –DTX (cell colony formation), CNFs–MMC (cell death rate) and CNFs–CP (cell death rate), respectively (Table 3). Furthermore, other studies have also demonstrated that single-walled CNTs can augment the effectiveness of cytotoxic drugs such as etoposide and paclitaxel via enhanced apoptosis [24][25][26

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• (paclitaxel) on the therapeutic efficacy was also shown [64]. As seen in Figure 2a, the size of SIPs of 2h is ca. 300 nm, which is comparable with that determined by DLS (Figure 2c). The morphology of aggregates resembles branched elongated structures consisting of small particles of 2–3 nm (Figure 2b). The

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• , solvent or tablet excipient. Apart from these applications the PEG has significant effect on the drug release. It has been shown that addition of PEG molecules is an efficient way to modify the release of hydrophobic paclitaxel from poly(lactic acid-co-glycolic acid) matrix [25] or proteins from lipidic

• release of potentially incorporated drug [27][28]. Especially, the addition of PEG has a great impact in systems with hydrophobic drugs (e.g., cyclosporine, paclitaxel) in which it can overcome the complication with homogenous dispersion of drug in the polymer matrix and mainly can facilitate the release

Experiences in supporting the structured collection of cancer nanotechnology data using caNanoLab

• Stephanie A. Morris,
• Sharon Gaheen,
• Michal Lijowski,
• Mervi Heiskanen and
• Juli Klemm

Beilstein J. Nanotechnol. 2015, 6, 1580–1593, doi:10.3762/bjnano.6.161

• triazine dendrimer with paclitaxel. Composition information captures properties inherent to the dendrimer (e.g., generation), as well as properties inherent to several particle types (e.g., chemical name, molecular formula). Bottom diagram highlights high level concepts and properties pertaining to

Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy

• Shanka Walia and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2015, 6, 546–558, doi:10.3762/bjnano.6.57

• after 24 h. Again, Liong et al. [56] reported the synthesis of multifunctional silica nanospheres with magnetic iron oxide NPs, luminescent fluorescein isothiocyanate (FITC) and camptothecin or paclitaxel as anti-cancer drug molecules entrapped inside the core. These nanospheres were finally modified

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• complex that was used as an artificial enzyme against multi-drug-resistant cancer cells was confirmed. A complex of diethylaminoethyl–dextran–methacrylic acid methylester copolymer (DDMC)/paclitaxel (PTX), obtained with PTX as the guest and DDMC as the host, formed a nanoparticle 50–300 nm in size. This

• cancer cells; paclitaxel; supramolecular complex; Review Introduction As a means of delivering a drug to a target effectively, the enhanced permeation and retention (EPR) effect and reticuloendothelial system (RES) were enabled by using a polymer drug delivery system (DDS), and it is thought to

• ligands from an active center. Supramolecules have been suggested for the use as artificial enzymes [9]. The supramolecular diethylaminoethyl (DEAE)–dextran–methacrylic acid methylester (MMA) copolymer (DDMC)/paclitaxel (PTX) complex, which is expected to inhibit drug-induced resistance by allosteric

In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers

• Tianxun Gong,
• Douglas Goh,
• Malini Olivo and
• Ken-Tye Yong

Beilstein J. Nanotechnol. 2014, 5, 546–553, doi:10.3762/bjnano.5.64

• or antigens to be linked to their surface for targeted delivery and imaging [16][17]. More importantly, one is not able to use CTAB-coated AuNRs as a carrier for drug delivery of water insoluble anti-cancer agents (e.g., doxorubicin, paclitaxel) to the cancerous area since their surface is