Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

BergaCare SmartLipids: commercial lipophilic active concentrates for improved performance of dermal products

• Florence Olechowski,
• Rainer H. Müller and
• Sung Min Pyo

Beilstein J. Nanotechnol. 2019, 10, 2152–2162, doi:10.3762/bjnano.10.208

• irritating/damaging effects) and the often unpleasant application feeling did lead to a market failure. Polymeric nanoparticles, developed by P. P. Speiser for pharmaceutical purposes in the middle of the 1970s [2], found only limited use in consumer care/cosmetics. Problems are often the lack of regulatory

Gold-coated plant virus as computed tomography imaging contrast agent

• Alaa A. A. Aljabali,
• Mazhar S. Al Zoubi,
• Khalid M. Al-Batanyeh,
• Ali Al-Radaideh,
• Mohammad A. Obeid,
• Abeer Al Sharabi,
• Walhan Alshaer,
• Bayan AbuFares,
• Tasnim Al-Zanati,
• Murtaza M. Tambuwala,
• Naveed Akbar and
• David J. Evans

Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195

• ; computed tomography (CT); gold; nanotechnology; viruses; targeting; Introduction Numerous types of nanomaterials are currently under investigation in medicine, including dendrimers, polymeric nanoparticles (NPs), liposomes and protein-based NPs. Each system has advantages and disadvantages in terms of its

• contrast agents including gold nanoparticles (AuNPs) [13], bromine [14], platinum [15], ytterbium [16], gadolinium [4], and tungsten [15]. Many of the systems are made up of a core that is coated with a polymeric material such as liposomes [17], micelles [13], lipoproteins or polymeric nanoparticles [18

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

• Mohammad A. Obeid,
• Ibrahim Khadra,
• Abdullah Albaloushi,
• Margaret Mullin,
• Hanin Alyamani and
• Valerie A. Ferro

Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177

• unwanted side effects [8][9]. Liposomes, solid lipid nanoparticles, dendrimers, micelles, polymeric nanoparticles, gold nanoparticles, and carbon nanotubes are among the most common types of nanoparticle delivery systems [10]. These efforts have been reported in several studies. For example, Guo et al

• . were able to efficiently encapsulate curcumin into polymeric nanoparticles prepared using a fabricated microchannel. The prepared polymeric nanoparticles had an average particle size of 167 nm with a curcumin loading capacities of 15% [11]. Using niosome nanoparticles composed of different non-ionic

Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules

• María Francisca Matus,
• Martín Ludueña,
• Cristian Vilos,
• Iván Palomo and
• Marcelo M. Mariscal

Beilstein J. Nanotechnol. 2018, 9, 1328–1338, doi:10.3762/bjnano.9.126

• ; reactive force field; Introduction In recent years, the use of drug delivery systems based on polymeric nanoparticles (NPs) has generated innovative therapeutic strategies for infection and immune diseases, as well as cancer therapy [1][2][3]. Polymeric NPs have shown significant advantages compared with

Al₂O₃/TiO₂ inverse opals from electrosprayed self-assembled templates

• Arnau Coll,
• Sandra Bermejo,
• David Hernández and
• Luís Castañer

Beilstein J. Nanotechnol. 2018, 9, 216–223, doi:10.3762/bjnano.9.23

• ]. Polymeric nanoparticles can also be used as templates, as they can be deposited in an ordered way and can be either dissolved or burned after the main structural material has been deposited. The technological procedure, however, suffers from limitations of the temperature compatibility of the structural

• material deposition process with the maximum temperature that the polymeric nanoparticles can sustain, which is typically below 90–100 °C. This low temperature reduces the choices of materials that have suitable optical properties for a given application [35][36]. As an example, TiO2 deposited at <150 °C

Advances and challenges in the field of plasma polymer nanoparticles

• Andrei Choukourov,
• Pavel Pleskunov,
• Daniil Nikitin,
• Valerii Titov,
• Artem Shelemin,
• Mykhailo Vaidulych,
• Anna Kuzminova,
• Pavel Solař,
• Jan Hanuš,
• Jaroslav Kousal,
• Ondřej Kylián,
• Danka Slavínská and
• Hynek Biederman

Beilstein J. Nanotechnol. 2017, 8, 2002–2014, doi:10.3762/bjnano.8.200

• to the investigation of the properties of plasma polymer particles themselves, regardless of the effects their presence produces on the plasma. It was recognized that polymeric nanoparticles (NPs) can be highly desired in various fields including photonics [37] and biomedical applications where they

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core–shell polymeric nanoparticles with positive charge by employing a chitosan coating. Additionally, an implantable formulation for the chemotherapeutic nanoparticles was developed as a bioadhesive film to be applied

• barrier. The size of these fenestrations depends on the type of organ and tumor [51]. For this reason, the nanoparticle particle size is crucial for a targeted organ/tumor. As core–shell polymeric nanoparticles can be prepared using different techniques, the optimal preparation technique was determined to

• when compared with non-coated nanoparticles. Conclusion In this study, the anticancer drug DOC, encapsulated in anionic and cationic polymeric nanoparticles and administered in a bioadhesive film formulation, was successfully developed to apply the chemotherapeutic drug directly to the action site

Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors

• David E. Jones,
• Hamidreza Ghandehari and
• Julio C. Facelli

Beilstein J. Nanotechnol. 2015, 6, 1886–1896, doi:10.3762/bjnano.6.192

• resulting in their well-defined, highly branched structure [12][13]. The generation of the dendrimer is determined by the number of concentric shells that surround the core of the structure. These polymeric nanoparticles can easily be tailored for specific applications. Benefiting from their characteristic

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• interaction in malignant cell lines. Here, we report on the influence of polymeric nanoparticles on human hematopoietic stem cells (hHSCs) and mesenchymal stem cells (hMSCs). In this study we systematically investigated the influence of polymeric nanoparticles on the cell functionality and differentiation

• particles were fluorescently labeled with the fluorescent dye N-(2,6-diisopropylphenyl)perylene-3,4-dicarboximide (PMI). The magnetite was encapsulated for magnetic resonance purposes. The polymeric nanoparticles used in this work were obtained by miniemulsion polymerization (non-functionalized and

• . The nanoparticles were purified from the surfactant excess by dialysis using Amicon Ultra membrane filters with MWCO 100 kDa (Millipore). The main characteristics of the nanoparticles are described in Table 1. Uptake and toxicity of polymeric nanoparticles Before the nanoparticles were used for

Imaging the intracellular degradation of biodegradable polymer nanoparticles

• Anne-Kathrin Barthel,
• Martin Dass,
• Melanie Dröge,
• Jens-Michael Cramer,
• Daniela Baumann,
• Markus Urban,
• Katharina Landfester,
• Volker Mailänder and
• Ingo Lieberwirth

Beilstein J. Nanotechnol. 2014, 5, 1905–1917, doi:10.3762/bjnano.5.201

• ), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany 10.3762/bjnano.5.201 Abstract In recent years, the development of smart drug delivery systems based on biodegradable polymeric nanoparticles has become of great interest. Drug-loaded nanoparticles

• , biodegradable polymeric nanoparticles are a promising vehicle for smart drug delivery systems and to this regard, it is even more important to examine intracellular degradation dynamics of these bio-polymers. The objective of this work is to follow the fate of intracellular PLLA nanoparticles over a long time

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

Ceria/silicon carbide core–shell materials prepared by miniemulsion technique

• Lars Borchardt,
• Martin Oschatz,
• Robert Frind,
• Emanuel Kockrick,
• Martin R. Lohe,
• Christoph P. Hauser,
• Clemens K. Weiss,
• Katharina Landfester,
• Bernd Büchner and
• Stefan Kaskel

Beilstein J. Nanotechnol. 2011, 2, 638–644, doi:10.3762/bjnano.2.67

• ; TPO catalytic; Introduction In recent years miniemulsions have been studied intensively [1][2][3]. Polymeric nanoparticles [1][2] from homo- or copolymers [3] as well as hybrid materials [3][4] such as magnetic [5][6][7][8] or silica/polymer nanoparticles [9][10] have been synthesized by this

Platinum nanoparticles from size adjusted functional colloidal particles generated by a seeded emulsion polymerization process

• Nicolas Vogel,
• Ulrich Ziener,
• Achim Manzke,
• Alfred Plettl,
• Paul Ziemann,
• Johannes Biskupek,
• Clemens K. Weiss and
• Katharina Landfester

Beilstein J. Nanotechnol. 2011, 2, 459–472, doi:10.3762/bjnano.2.50

• incorporation. Quantitative incorporation, for example, to create a precise stoichiometry of several different molecules within a latex particle, is thus impeded by emulsion polymerization [16]. Miniemulsion polymerization on the contrary is a powerful tool for the synthesis of highly functional polymeric

• nanoparticles [17][18][19][20]. Here, the monomer droplets are preformed by ultrasonication and critically stabilized against coagulation by the addition of surfactants. Ostwald ripening, the mechanism that leads to formation of bigger particles at the expense of smaller ones due to the higher Laplace pressure