Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• particles were removed by washing with distilled water. The PEGylation PDA/Fe3O4 NPs were then dried in a vacuum oven at 45 °C. The PDA-coated Fe3O4 nanoparticles were modified with SH-PEG to facilitate their accumulation in tumour regions. In similar studies, the conjugation of SH-PEG onto the surface of

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• our NPs. Second, the ligand attached to the nanoparticles would aid in the accumulation of nanoparticles within the cells. Numerous studies have employed different ligands to target overexpressed receptors on cancer cells, including folate receptors [13][37], integrins [36][37], and vascular

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• on Raphanus sativus (R. sativus) concerning its tolerance levels, toxicity, and accumulation. ZnO NPs were synthesized by the wet chemical method and characterized by powder X-ray diffraction (PXRD), Fourier-transform infrared (FTIR) spectroscopy, ultraviolet–visible (UV–vis) spectroscopy, dynamic

• elevated accumulation of Zn [1][3]. Long-term, high-dose Zn supplementation disrupts copper intake, induces brain cell death, contributes to prostate cancer, and also functions as a gliotoxin and a neurotoxin [3][4]. Conversely, the most common micronutrient deficiency of crop plants is Zn deficiency

• at higher doses was investigated against R. sativus to determine its tolerance. Further, this study also attempted to assess the accumulation of Zn in R. sativus seedlings by determining the effect of ZnO NPs on the soluble protein content, indole acetic acid (IAA) content, total carbohydrate content

New application of bimetallic Ag/Pt nanoplates in a colorimetric biosensor for specific detection of E. coli in water

• Azam Bagheri Pebdeni,
• Mohammad N. AL-Baiati and
• Morteza Hosseini

Beilstein J. Nanotechnol. 2024, 15, 95–103, doi:10.3762/bjnano.15.9

• resultant agent is generated by the specific binding of the aptamer to the surface of the bacteria and the accumulation of numerous biosensors around the target leads to an increase in the intensity of the blue color. As a result, we attempted to explain the phenomenon and used it to develop a biosensor for

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• cells. Penetration and accumulation of NPs was not accompanied by a bactericidal or inhibitory effect of growth as demonstrated with the Gram-negative E. coli species and confirmed with a Gram-positive bacterial species (Staphylococcus aureus). Altogether, these results allow us to envisage the use of

• labelled BSA/PDA NPs to track bacteria and carry drugs in the core of bacterial cells. Keywords: accumulation; albumin; antibacterial; Escherichia coli; fluorescence; nanoparticles; penetration; polydopamine; Introduction Organic nanoparticles (ONPs) are used to target and deliver drugs to tissue and

• NPs) but have not been elucidated so far. In contrast to inorganic NPs [23][24], it is unclear whether ONPs can penetrate bacterial cells. Alipour et al. have shown that a 170 nm diameter liposomal nanocarrier increased the accumulation of an antibiotic (polymyxin B) in Gram-negative bacterial cells

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• barriers besides cellular membranes need to be addressed. A few examples of these barriers are penetration in or permeation through mucus, skin penetration, overcoming the blood brain barrier, or extravasation from blood vessels. Another challenge is the accumulation of particulate drug delivery systems in

• . Nanoparticles often show high accumulation in the liver, where particles are cleared by the reticuloendothelial system (RES), and in the spleen due to its filtering function. Softer hydrogel nanoparticles composed of poly(carboxybetaine) [13] as well as poly(ethylene glycol) diacrylate (PEGDA) [28] showed

• enhanced tumor accumulation and deeper penetration of nanolipogels (NLGs) [32]. The particles had a phospholipid double layer and except for the softest formulation, their cores were filled with agarose gels of different gel strength values. With this method they were able to prepare nanoparticles with

Sulfur nanocomposites with insecticidal effect for the control of Bactericera cockerelli

• Lany S. Araujo-Yépez,
• Juan O. Tigrero-Salas,
• Vicente A. Delgado-Rodríguez,
• Vladimir A. Aguirre-Yela and
• Josué N. Villota-Méndez

Beilstein J. Nanotechnol. 2023, 14, 1106–1115, doi:10.3762/bjnano.14.91

• 292 nm for nanocomposites with rosemary oil at concentrations of 0.25%, 0.5%, and 0.75%, respectively (Figure 5). The density plots and the statistics (Table 1) show particle sizes without a particular distribution, and the increase in size and accumulation of the nanocomposites may be influenced by

Density functional theory study of Au-fcc/Ge and Au-hcp/Ge interfaces

• Olga Sikora,
• Małgorzata Sternik,
• Benedykt R. Jany,
• Franciszek Krok,
• Przemysław Piekarz and
• Andrzej M. Oleś

Beilstein J. Nanotechnol. 2023, 14, 1093–1105, doi:10.3762/bjnano.14.90

• accumulation (yellow) and charge depletion (light blue) regions with respect to separate Ge and Au slabs terminated with vacuum (see Appendix B for details). One can observe charge accumulation between the interface Ge and Au atoms, as expected for bond formation. Figure 12b presents the charge density map for

•  13 with yellow regions representing charge accumulation and light blue regions indicating charge depletion. For all heterostructures, the charge transfer from Au and Ge interfacial atoms leads to the electron accumulation at approximately half of their distance. At the presented isocharge surface

• e/Å−3) for variants C (a) and D (b) of the Au-fcc(011)/Ge(001) interface compared with the isosurface of the Au-hcp(010)/Ge(111) interface (c). Yellow and cyan regions indicate the electron accumulation and depletion, respectively. Interfacial energies (γint), work of separation values (Wsep

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• when using HbMPs as oxygen carriers [34]. In addition to transporting oxygen, HbMPs can also be used as drug carriers. However, in a pharmacokinetic study with HbMPs, accumulation of the particles in the sinusoids of the liver, where the Kupffer cells are located, was observed [35]. The mechanisms of

• Zhang describes [47]. Lück et al. showed by two-dimensional electrophoresis that upon serum incubation, protein accumulation occurred on latex particles with an average size of 660 nm leading to complement activation [48]. At this time, it is unclear whether this mechanism could also play a role in HbMP

Prediction of cytotoxicity of heavy metals adsorbed on nano-TiO₂ with periodic table descriptors using machine learning approaches

• Joyita Roy,
• Souvik Pore and
• Kunal Roy

Beilstein J. Nanotechnol. 2023, 14, 939–950, doi:10.3762/bjnano.14.77

• increased the accumulation of Cd2+ in the ciliate Tetrahymen thermophila. Further, Tan et al. [12] showed increased uptake and retention of Cd2+ and Zn2+ adsorbed on TiO2 NPs in Daphnia magna. Heavy metal contamination affects plant growth and indirectly affects human health via the food chain. Heavy metals

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• identify new molecular markers for the rapid detection and treatment of various types of cancers. NPs enhance the drug accumulation at the target site due to their advantages, including higher surface-to-volume ratio, ease of surface modification and functionalization, precise control of structure and size

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• , different from most compounds, drugs, and nanomaterials developed in the last decades. During TEM analyses, we observed that intracellular amastigotes were undergoing substantial ultrastructural alterations (Figure 5) when treated with SPIONs. These alterations include (1) accumulation of lipid bodies, (2

Cross-sectional Kelvin probe force microscopy on III–V epitaxial multilayer stacks: challenges and perspectives

• Mattia da Lisca,
• José Alvarez,
• James P. Connolly,
• Nicolas Vaissiere,
• Karim Mekhazni,
• Jean Decobert and
• Jean-Paul Kleider

Beilstein J. Nanotechnol. 2023, 14, 725–737, doi:10.3762/bjnano.14.59

• formation of space charge regions among the different layers along the structure [28]. Specifically, the VCPD progression reflects the band bending present in the presence of depletion and accumulation regions. In particular, undoped InP crystals always contain different unintentional impurities due to the

• the vicinity of the surface [32]; this aspect will be fully addressed in the Discussion section (“Effect of the illumination on the VCPD”). Finally, it is worth mentioning that after illumination the initial conditions are restored, which excludes the presence of long-lived charge accumulation along

Humidity-dependent electrical performance of CuO nanowire networks studied by electrochemical impedance spectroscopy

• Jelena Kosmaca,
• Juris Katkevics,
• Jana Andzane,
• Raitis Sondors,
• Liga Jasulaneca,
• Raimonds Meija,
• Kiryl Niherysh,
• Yelyzaveta Rublova and
• Donats Erts

Beilstein J. Nanotechnol. 2023, 14, 683–691, doi:10.3762/bjnano.14.54

• adsorption sites (S), for example, in a reaction: [30], may contribute to accumulation of holes near the surface (Figure 3c) [12][14][31]. Then, upon exposure to humidity, the conductivity reduces; impedances measured at RH 5–20% (ca. 0.5 GΩ) are lower than impedances of 2–8 GΩ measured in the RH region of

Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review

• Akeem Adeyemi Oladipo,
• Saba Derakhshan Oskouei and
• Mustafa Gazi

Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52

• biomolecules via electrostatic forces, stacking, and/or hydrogen bonding, which lead to high accumulation of the target analyte, are another factor that supports the development of electrochemical sensors. However, because of the high proportion of organic ligands, most MOFs have poor electrical conductivity

Suspension feeding in Copepoda (Crustacea) – a numerical model of setae acting in concert

• Alexander E. Filippov,
• Wencke Krings and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 603–615, doi:10.3762/bjnano.14.50

• correspondingly in Figure 2. For comparison, we also included a curve (line 1 in Figure 2) that depicts the number of eaten particles Neaten(t) in a system without setae. Here, only the flow of water randomly transports particles to the mouth opening and causes a slow accumulation of Neaten(t). It is important to

• appropriate magnification, every large step of the curve has a fine structure with plenty of small steps. Due to the small accumulation window (coinciding with the elementary time interval of the actual calculation), every such step can be resolved down to the independent consumption of sole particles. This

• parameters can be presented in a static form by density distributions projected on the (y,z) plane and histograms of the distributions along the y axis accumulated during long-time simulation runs. Figure 8 and Figure 9 present the results of such an accumulation for four cases with extremely different kinds

SERS performance of GaN/Ag substrates fabricated by Ag coating of GaN platforms

• Magdalena A. Zając,
• Bogusław Budner,
• Malwina Liszewska,
• Bartosz Bartosewicz,
• Łukasz Gutowski,
• Jan L. Weyher and
• Bartłomiej J. Jankiewicz

Beilstein J. Nanotechnol. 2023, 14, 552–564, doi:10.3762/bjnano.14.46

• × objective lens (N.A. = 0.75). The spectrometer was calibrated using an internal silicon wafer, and the spectrum was centered at 520.5 cm−1. The measurement parameters were as follows: acquisition time of 1 s and one accumulation at each point for GaN/Ag substrates, and acquisition time of 5 s and 50

Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35

• in a designed layered structure. As summarized in the review by Akashi and Akagi, LbL assembly is valuable as a pathway to the design and development of innovative biomaterials for tissue engineering [100]. Interfacial phenomena contribute significantly to material accumulation and property

• . Functional exploration through material accumulation and organization has also been widely conducted. The manipulation of precise molecular alignments and photochemical properties through multiple electrostatic interactions with two-dimensional clay mineral nanosheets has been summarized by Ishida [102]. Yue

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

• Santiago Grijalvo and
• Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

• inherent cytotoxicity of PLGA may come from the accumulation of the degraded polymer components leading to changes in osmolality of the culture medium [50]. Other in vitro studies also reported that the size of PLGA nanoparticles had a significant impact on cytotoxicity against BEAS-2B and RAW264.7 cells

Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles

• Magdalena Lasak and
• Karol Ciepluch

Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28

• from the EPR effect and active targeting strategies may increase the efficacy of the therapy. Nevertheless, the accumulation in other, non-targeted organs indicates the existence of a method of NP transport through the endothelium other than EPR [26][28][29][32]. Sindhwani et al. identified an active

• and amplified metastatic effect in cancer patients and the accumulation of NPs in unintended organs. Therefore, it is crucial to gain a full understanding of NanoEL and to develop effective and safe inducers, which are NPs that will facilitate access to the target sites and, at the same time, reduce

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• system (RES) or the mononuclear phagocytosis system (MPS) [4]. The subsequent rapid clearance from blood circulation by the liver and kidneys results in insufficient drug accumulation in the target tissue [5]. In addition, NPs can interact with proteins to form a protein corona, which affects the

• tumor-targeting ability of stem cells [12], immune cells [13], and cancer cell membranes [14]. In vitro and in vivo studies have demonstrated that cell membrane-coated nanoparticles exhibit higher potency, longer retention, and more significant accumulation than bare nanoparticles in the tumor

• cancer cell membrane-coated NPs have shown great promise. This strategy could enable the drug to accumulate in target tissues while reducing accumulation in off-target areas. HCC, a common digestive system tumor, presents the sixth leading cancer incidence and the third leading mortality worldwide [61

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• effect, and further accumulation within mitochondria [95]. Barthel et al. developed mixed-layer ABC triblock terpolymer mixed PEO shell nanomicelles of a size below 30 nm, based on poly(ethylene oxide)-b-poly(allyl glycidyl ether)-b-poly(tert-butyl glycidyl ether) (PEO-b-PAGE-b-PtBGE). The PAGE segment

• , and cell internalization of the nanocarriers. Due to the enhanced tumor accumulation, reduced accumulation at the off-site targets, and same-place/same-time delivery of therapeutic concentrations of both drugs at the site of action, an optimal synergistic effect of the active substances and efficient

High–low Kelvin probe force spectroscopy for measuring the interface state density

• Ryo Izumi,
• Masato Miyazaki,
• Yan Jun Li and
• Yasuhiro Sugawara

Beilstein J. Nanotechnol. 2023, 14, 175–189, doi:10.3762/bjnano.14.18

• interface state density inside semiconductors. We derive an analytical expression for the electrostatic forces between a tip and a semiconductor sample in the accumulation, depletion, and inversion regions, taking into account the charge transfer between the bulk and interface states in semiconductors. We

• between a metal tip and a semiconductor surface, a surface potential is generated on the semiconductor surface, resulting in, for example, surface charge accumulation, depletion, and inversion states. The relationship between this surface charge and the electrostatic force between the tip and the sample

• to the surface, forming an accumulation layer of electrons. When a small negative bias voltage is applied to the metal tip (Vdc < 0), electrons (majority carriers) in the semiconductor are depleted from the surface, forming a depletion layer. When a large negative bias voltage is applied to the metal

Characterisation of a micrometer-scale active plasmonic element by means of complementary computational and experimental methods

• Ciarán Barron,
• Giulia Di Fazio,
• Samuel Kenny,
• Silas O’Toole,
• Robin O’Reilly and
• Dominic Zerulla

Beilstein J. Nanotechnol. 2023, 14, 110–122, doi:10.3762/bjnano.14.12

• Figure 7. Directly comparing the simulated and experimental plasmonic resonance positions between the SPR curves in Figure 6, there is a difference of 0.07° in the position of the plasmonic dip. While this is outside the estimated error accumulation of approximately 0.02° on the experimental data, the

The influence of structure and local structural defects on the magnetic properties of cobalt nanofilms

• Alexander Vakhrushev,
• Aleksey Fedotov,
• Olesya Severyukhina and
• Anatolie Sidorenko

Beilstein J. Nanotechnol. 2023, 14, 23–33, doi:10.3762/bjnano.14.3

• materials [7][8], in which heat storage and accumulation occur due to phase transformations. The functioning of such storage media is based on energy fluctuations in the process of crystallization or melting of the media. In contrast to traditional media, thermal storage does not require sealing of the