Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• , magnetite NPs have some serious limitations, such as chemical reactivity, rapid oxidation, particle agglomeration, and high surface energy which may affect their biocompatibility and performance [11]. Moreover, they have low magnetization at a smaller size and the presence of iron has been associated with

• penetration and hemocompatibility which can be useful for biomedical applications [12][17]. Furthermore, in order to be exploited in biomedical applications, NPs need to fulfill certain criteria which include water solubility, excellent colloidal stability, biocompatibility, and high saturation magnetization

• hydrophobic NPs was achieved by the functionalization with an amphiphilic brush copolymer, poly(isobutylene-alt-maleic anhydride) (PMA) implanted with dodecylamine, which provides biocompatibility, colloidal stability, and hydrophilicity [22]. It is composed of hydrophobic side chains and the backbone of

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• , simple modeling, excellent biocompatibility and biodegradability in vivo. In addition, amino acids can be assembled with other components to meet multiple scientific needs. However, using these simple building blocks to design attractive materials remains a challenge due to the simplicity of the amino

• structure and functional reorganization. Peptides and proteins are attractive candidates for functional biomedical materials [10] due to their extensive existence in nature, easy access, and good biocompatibility [11]. Self-assembly refers to the selective and spontaneous formation of one or more well

• nucleotides, can be self-assembled [14]. Proteins are direct functional performers of countless interactions between living organisms and the outside world, and are susceptible to changes in pH value, ionic strength, and temperature [15]. Peptides have similar biocompatibility and diversity as proteins, but

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• deployment in drug delivery is contingent upon controlled drug loading and a desired release profile, with simultaneous biocompatibility and cellular targeting. Iron oxide nanoparticles (IONPs), being biocompatible, are used as drug carriers. However, to prevent aggregation of bare IONPs, they are coated

• biocompatibility and magnetic properties, have found applications in drug delivery, magnetic resonance imaging and treatment of iron deficiencies [3][4][5][6]. The property of hyperthermia has been found to be beneficial in localized drug release, particularly in cancer therapy [7]. In anti-cancer therapy, IONPs

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• nanoparticles (50–1000 nm) [61]. They contain crystallized lipid droplets that are solid at room and body temperatures [62][63], with the drug or the molecule of interest loaded into the solid lipid phase [64]. The advantages of SLN include high drug loading capacity, great stability, good biocompatibility, and

• advantages include high biocompatibility, safety, and flexibility (the latter can be modulated by the concentration of cholesterol in the lipid membrane) [40][73][74]. PEGylated long-circulating liposomes with co-encapsulated CUR–doxorubicin inhibited C26 (murine colon carcinoma) cell proliferation, in

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• or height, and shaft and tip shape. Other parameters including fluid flow rates, biocompatibility, penetration force, fragility, relative simplicity, and cost of fabrication are all key design considerations. The final design will depend on the limitations of the fabrication method and the mechanical

• are currently receiving more interest because of biocompatibility, superior mechanical properties, low material cost, and biodegradability. The low-cost of fabrication is an additional advantage of polymer microneedles over silicon. It is increasingly clear that the favoured fabrication methods used

• (COP) material using this method [5]. Fabrication and use of metal microneedles In addition to silicon and polymers, microneedles are also fabricated from metals including nickel, titanium, stainless steel, and palladium. Metals provide good mechanical properties and biocompatibility for microneedle

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

• Nabojit Das,
• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69

• the reported gold nanostars and nanoflowers [96]. Concerning the biocompatibility of the nanomaterials synthesized using DESs, only a couple of studies has been carried out in vivo and in vitro. Mineral-substituted apatite nanoparticles synthesized using a choline chloride/thiourea mixture for

• , biocompatibility, sustainability, and low cost, achieving the real potential in nanobiotechnology is not far. Carrageenan as green/safe stabilizing agent in nanomaterial synthesis A stabilizing agent, often known as capping agent, is one of the vital components in the synthesis of nanomaterials. The colloidal

• positively charged head group of the surfactants in the solution phase. The importance of using DESs and carrageenan is the fact that the biocompatible molecules already used in designing safe nanomaterials add no further improvement than just biocompatibility. Some are also prone to enzymatic degradation

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• composition. Moreover, their biocompatibility, biodistribution, stability, capacity, and diagnostic efficacy are related to this factor. Lipid- and surfactant-based nanomaterials, polymeric nanomaterials, and metallic and non-metallic nanomaterials, in addition to micro- and nanomotors and some miscellaneous

Silver nanoparticles nucleated in NaOH-treated halloysite: a potential antimicrobial material

• Yuri B. Matos,
• Rodrigo S. Romanus,
• Mattheus Torquato,
• Edgar H. de Souza,
• Rodrigo L. Villanova,
• Marlene Soares and
• Emilson R. Viana

Beilstein J. Nanotechnol. 2021, 12, 798–807, doi:10.3762/bjnano.12.63

• , improving dispersability into polymeric matrices, keeping good biocompatibility with the human body, and immobilizing Ag-NPs on a substrate, which provides better interaction with bacteria and is a more eco-friendly way to obtain antimicrobial agents. Halloysite (HNT) is a natural clay, consisting of an

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• transportation of cargo [22][23], and transmit energy. Compared with other concepts, magnetic MNRs that combine diamagnetic, paramagnetic, and ferromagnetic materials [24] could have a greater driving force and exhibit characteristics such as biocompatibility [25]. Hence, magnetic nanoparticles (MNPs) are widely

• enabled actuation, control, and observation of the FMSM. In most mobile sensing applications, microrobots are driven by chemical fuels such as hydrogen peroxide (H2O2) and surfactants. In contrast, magnetic drives have good biocompatibility and external power supply. For example, a porous microelectrode

• also yielded biocompatibility. At the same time, adding a very thin layer of nickel or iron could improve magnetic properties. In order not to affect the swimming speed and let the flagella oscillate naturally as much as possible, Magdanz and others believed that it is possible to make strongly

Nanogenerator-based self-powered sensors for data collection

• Yicheng Shao,
• Maoliang Shen,
• Yuankai Zhou,
• Xin Cui,
• Lijie Li and
• Yan Zhang

Beilstein J. Nanotechnol. 2021, 12, 680–693, doi:10.3762/bjnano.12.54

• with good biocompatibility can used for implantable self-powered physiological sensors. The sensors can be powered by the mechanical energy from the biological activity of the organism, and provide physiological data. An implantable heart monitoring sensor based on a TENG can work stably for a long

• time, providing a solution for long-term heart monitoring. Zheng et al. proposed an implantable TENG (iTENG) to realize wireless heart monitoring in vivo [28]. The iTENG is not cytotoxic. The packaging material of the iTENG showed good biocompatibility in mouse fibroblasts. The iTENG was implanted

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• properties such as significant absorption or scattering in the visible and near-infrared (NIR) regions, tunable aspect ratio, biocompatibility, fluorescence properties, and the ease of biofunctionalization, which makes them ideal in biomedical applications [13]. Gold-based nanomaterials (i.e., nanospheres

• their biocompatibility and dispersion at physiological pH values. The positive CTAB layer on the GNR surface facilitates electrostatic adsorption of anionic compounds, such as poly(sodium 4-styrenesulfonate) (PSS), which ultimately facilitates electrostatic interaction with cationic anticancerous drugs

• may be responsible for the laser-triggered release of DOX. These findings are consistent with previous studies [23]. PSS-GNRs nanocomplex biocompatibility Dose-dependent biocompatibility and cytotoxicity efficiency of the nanocarriers were measured in vitro. The efficiency of the GNRs in mediating

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

• Barbora Svitkova,
• Vlasta Zavisova,
• Veronika Nemethova,
• Martina Koneracka,
• Miroslava Kretova,
• Filip Razga,
• Monika Ursinyova and
• Alena Gabelova

Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22

• 40–50 nm in diameter [14], or glycosylphosphatidylinositol (GPI)-anchored proteins [15]. Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their biocompatibility, colloidal stability, and bioavailability. Moreover, the coating facilitates their further

The nanomorphology of cell surfaces of adhered osteoblasts

• Christian Voelkner,
• Mirco Wendt,
• Regina Lange,
• Max Ulbrich,
• Martina Gruening,
• Susanne Staehlke,
• Barbara Nebe,
• Ingo Barke and
• Sylvia Speller

Beilstein J. Nanotechnol. 2021, 12, 242–256, doi:10.3762/bjnano.12.20

• surface of the material. Apart from cell biologic parameters, the adhesion interface area and the speed of its formation provide insights concerning the biocompatibility of the surface with regard to osteoblastic cells [11]. Dynamic remodeling of the cytoskeleton is the basis for shape adaptation and

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

• Sina Kaabipour and
• Shohreh Hemmati

Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9

• nanostructures using plants and plant extracts has recently gained more attention. These methods can act as appropriate alternatives for other methods as a result of their simplicity, low-cost, non-toxicity, and simple scale-up capability [186]. In addition, thanks to their non-pathogenic and biocompatibility

ZnO and MXenes as electrode materials for supercapacitor devices

• Ameen Uddin Ammar,
• Ipek Deniz Yildirim,
• Feray Bakan and
• Emre Erdem

Beilstein J. Nanotechnol. 2021, 12, 49–57, doi:10.3762/bjnano.12.4

• biocompatibility, photothermal efficiency, low Seebeck coefficient, as well as good conductivity. They synthesized tantalum carbide MXene sheets from a tantalum aluminum carbide (Ta4AlC3) MAX phase through etching the intermediate aluminium with the aid of hydrofluoric acid (HF). Analysis of the synthesized

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

• Cynthia Kembuan,
• Helena Oliveira and
• Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3

• shells with thickness values of 7 nm or even 21 nm were not sufficient to completely hinder the release of lanthanide ions from UCNPs. According to MTT assays and, more specifically, cell cycle analysis, the UCNPs did not exhibit a biocompatibility level similar to that of silica particles without a

PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation

• Shuoye Yang,
• Zhenwei Wang,
• Yahong Ping,
• Yuying Miao,
• Yongmei Xiao,
• Lingbo Qu,
• Lu Zhang,
• Yuansen Hu and
• Jinshui Wang

Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155

• from PEI make the CNTs much more soluble in aqueous solution and thus improve their biocompatibility [37]. Furthermore, surface modification with PEGylated agents or positively charged groups can protect the nanocarriers by providing a steric barrier from being recognized and captured by the

Out-of-plane surface patterning by subsurface processing of polymer substrates with focused ion beams

• Serguei Chiriaev,
• Luciana Tavares,
• Vadzim Adashkevich,
• Arkadiusz J. Goszczak and
• Horst-Günter Rubahn

Beilstein J. Nanotechnol. 2020, 11, 1693–1703, doi:10.3762/bjnano.11.151

• high transparency, biocompatibility, and low cost, enable the broad use of PDMS for the fabrication of microfluidic, microelectromechanical, and microoptical devices [20]. The effects of ion irradiation on chemical and physical properties and on the surface morphology of PDMS have been extensively

Cardiomyocyte uptake mechanism of a hydroxyapatite nanoparticle mediated gene delivery system

• Hiroaki Komuro,
• Masahiro Yamazoe,
• Kosuke Nozaki,
• Akiko Nagai and
• Tetsuo Sasano

Beilstein J. Nanotechnol. 2020, 11, 1685–1692, doi:10.3762/bjnano.11.150

• regarding safety has attracted significant attention [4][5]. The calcium phosphate (CaP) co-precipitation method has been extensively used for gene delivery due to its excellent biocompatibility and simple preparation [6]. CaP is commonly considered as one of the most important inorganic materials for

Electrokinetic characterization of synthetic protein nanoparticles

• Daniel F. Quevedo,
• Cody J. Lentz,
• Adriana Coll de Peña,
• Yazmin Hernandez,
• Nahal Habibi,
• Rikako Miki,
• Joerg Lahann and
• Blanca H. Lapizco-Encinas

Beilstein J. Nanotechnol. 2020, 11, 1556–1567, doi:10.3762/bjnano.11.138

• treatment of a wide variety of diseases. However, the slow progress in the field has resulted in relatively few therapies being translated into the clinic. Anisotropic synthetic protein nanoparticles (ASPNPs) show potential as a next-generation drug-delivery technology, due to their biocompatibility

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

• Matías Guerrero Correa,
• Fernanda B. Martínez,
• Cristian Patiño Vidal,
• Camilo Streitt,
• Juan Escrig and
• Carol Lopez de Dicastillo

Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129

• antimicrobial studies revealed good antimicrobial activity against E. coli, S. flexneri, and S. aureus cells [123]. Superparamagnetic iron-oxide nanoparticles Superparamagnetic iron oxide nanoparticles are a special class of metal-oxide NPs with magnetic properties and excellent biocompatibility. Their shape

• stability and good biocompatibility [20]. The Si NPs enhance the bactericidal effects of some compounds, mainly metallic systems, against a broad range of microorganisms due to their easy delivery [20][140]. In addition, their surfaces can be easily modified by relatively inexpensive precursors which can

Structure and electrochemical performance of electrospun-ordered porous carbon/graphene composite nanofibers

• Yi Wang,
• Yanhua Song,
• Chengwei Ye and
• Lan Xu

Beilstein J. Nanotechnol. 2020, 11, 1280–1290, doi:10.3762/bjnano.11.112

• electrical conductivity and good biocompatibility [28][29][30]. Studies have indicated that graphene still maintains an excellent charge/discharge performance at an electrochemical scan rate of almost 250 mV·s−1 [31] and has an excellent cycle performance and fast charge/discharge characteristics [32

Influence of the magnetic nanoparticle coating on the magnetic relaxation time

• Mihaela Osaci and
• Matteo Cacciola

Beilstein J. Nanotechnol. 2020, 11, 1207–1216, doi:10.3762/bjnano.11.105

• nanoparticle coating plays an important role in the nanoparticle dispersion stability and biocompatibility. However, theoretical studies in this field are lacking. In addition, the ways in which the nanoparticle coating influences the magnetic properties of the nanoparticles are not yet understood. In order to

• other hand, organic coating (particularly polymers) has a number of advantages over inorganic coating, such as better particle dispersion, good colloidal stability, biocompatibility, good nanoparticle circulation in the blood, reduced toxicity and low risk of blood capillary obstruction. In the last

• biocompatibility or to enable specific hydrophilic properties, nanoparticles were coated with poly(ethylene glycol) (PEG) [16]. Experimental data concerning how different coatings influence nanoparticle magnetic properties are quite controversial. A few studies indicate that a thin polymer coating layer enhances

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• have advantages over other NPs, such as controlled and sustained release, enhanced solubility and biocompatibility [30][31][32]. Within the wide variety of existing nanomaterials with antibacterial properties, photothermally active nanoparticles, with absorption in the visible–near-infrared (NIR

• NIR irradiation. Among other examples of photothermally active nanoparticles applied for bacteria eradication it is worth mentioning the MoS2 nanoparticles. These nanoparticles have a good biocompatibility and a high photothermal conversion efficiency over a broad NIR range [95]. PEG-MoS2 nanoflowers

Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

• Mohammad Jaber,
• Asim Mushtaq,
• Kebiao Zhang,
• Jindan Wu,
• Dandan Luo,
• Zihan Yi,
• M. Zubair Iqbal and
• Xiangdong Kong

Beilstein J. Nanotechnol. 2020, 11, 1119–1125, doi:10.3762/bjnano.11.96

• antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag

• (NCs) have been considered as an alternative since they contain a small amount of Ag in a highly biocompatible material. Along these lines, TiO2 NPs have been used worldwide in biomedical applications due to their biocompatibility and cost-effectiveness [15]. Moreover, TiO2 NPs are inorganic materials

• incubated with NPs was higher than 80% even at high NP concentrations. The cytotoxicity results demonstrate that the NCs have a good biocompatibility which is needed for biomedical applications. A number of intrinsic factors such as shape, size and surface chemistry of the nanostructures strongly influence