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Search for "nanomedicine" in Full Text gives 119 result(s) in Beilstein Journal of Nanotechnology.

Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

  • Dimitri Vanhecke,
  • Dagmar A. Kuhn,
  • Dorleta Jimenez de Aberasturi,
  • Sandor Balog,
  • Ana Milosevic,
  • Dominic Urban,
  • Diana Peckys,
  • Niels de Jonge,
  • Wolfgang J. Parak,
  • Alke Petri-Fink and
  • Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2017, 8, 2396–2409, doi:10.3762/bjnano.8.239

Graphical Abstract
  • negative, must be considered for nanotechnology and nanomedicine in particular to develop to its full potential. Keywords: co-exposure; endocytosis; live cell imaging; nanoparticles; quantitative microscopy; Introduction Over the past two decades, improvements in nanomaterial research were followed by a
  • the effects of exposure to each individual NP [26]. Moreover, little is known about how co-exposure of different NPs affects cellular uptake (e.g., whether it enhances or even inhibits selective NP uptake), which is –particularly in nanomedicine– highly relevant to the understanding of their behaviour
  • , the demonstration of interactions between different particle types at the cellular level reveals that synergetic effects, either positive or negative, must be considered for nanotechnology and nanomedicine in particular to develop to its full potential. Experimental Materials HPLC grade acetone
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Published 14 Nov 2017

Advances and challenges in the field of plasma polymer nanoparticles

  • Andrei Choukourov,
  • Pavel Pleskunov,
  • Daniil Nikitin,
  • Valerii Titov,
  • Artem Shelemin,
  • Mykhailo Vaidulych,
  • Anna Kuzminova,
  • Pavel Solař,
  • Jan Hanuš,
  • Jaroslav Kousal,
  • Ondřej Kylián,
  • Danka Slavínská and
  • Hynek Biederman

Beilstein J. Nanotechnol. 2017, 8, 2002–2014, doi:10.3762/bjnano.8.200

Graphical Abstract
  • sources in the production of plasma polymer NPs opens new horizons in precise tuning of their size, shape, chemical composition, surface charge and wettability. There are great potential benefits for the use of plasma polymer NPs in photonics, nanomedicine and other applications, but also significant
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Published 25 Sep 2017

Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics

  • Stefania Lettieri,
  • Marta d’Amora,
  • Adalberto Camisasca,
  • Alberto Diaspro and
  • Silvia Giordani

Beilstein J. Nanotechnol. 2017, 8, 1878–1888, doi:10.3762/bjnano.8.188

Graphical Abstract
  • fluorescent CNOs is fast and reversible both in solution and in vitro, making this nanomaterial suitable as pH-dependent probes for diagnostic applications. Keywords: carbon nanomaterials; fluorescence; imaging; nanomedicine; nano-onion; Introduction Nanomaterial-based probes (nano-probes) that are able to
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Published 07 Sep 2017

Methionine-mediated synthesis of magnetic nanoparticles and functionalization with gold quantum dots for theranostic applications

  • Arūnas Jagminas,
  • Agnė Mikalauskaitė,
  • Vitalijus Karabanovas and
  • Jūrate Vaičiūnienė

Beilstein J. Nanotechnol. 2017, 8, 1734–1741, doi:10.3762/bjnano.8.174

Graphical Abstract
  • nanomedicine, biocompatible iron oxide-based NPs have attracted particular interest due to their size-dependent magnetic, optical and chemical properties that allow for the design of NPs for multimodal imaging and photothermal therapy of cancer cells [1]. Dual-imaging probes, capable to perform simultaneously
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Published 22 Aug 2017

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

  • Gamze Varan,
  • Juan M. Benito,
  • Carmen Ortiz Mellet and
  • Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

Graphical Abstract
  • Gamze Varan Juan M. Benito Carmen Ortiz Mellet Erem Bilensoy Department of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering, Hacettepe University, Ankara, 06800, Turkey Institute for Chemical Research, CSIC - University of Sevilla, Av. Américo Vespucio 49, Sevilla, 41092
  • problems. PCX was selected as the target drug in this study also for the fact that it is available on the market in nanomedicine form, known as Abraxane®. Results and Discussion Pre-formulation studies Nanoparticles are promising carriers for drugs due to their tunable dimensions and shape. There are
  • several factors that influence the particle size, particle distribution, surface charge, homogeneity and shape of nanometer-sized drug delivery systems. These factors have a subsequent influence on the biodistribution and the fate of the nanomedicine in the body [27]. In this case, the formulation
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Published 13 Jul 2017

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

  • Cem Varan and
  • Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

Graphical Abstract
  • Cem Varan Erem Bilensoy Department of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering, Hacettepe University, Ankara, 06800, Turkey Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, 06100, Turkey 10.3762/bjnano.8.144 Abstract
  • nanoparticles were administered as a dispersion in the hydroxypropylcellulose (HpC) Klucel™ bioadhesive film. The aim was to develop an implantable, local nanomedicine capable of prolonged release at the tumor site to create a drug reservoir after surgical removal of glioma, avoiding progression and recurrence
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Published 12 Jul 2017

Low uptake of silica nanoparticles in Caco-2 intestinal epithelial barriers

  • Dong Ye,
  • Mattia Bramini,
  • Delyan R. Hristov,
  • Sha Wan,
  • Anna Salvati,
  • Christoffer Åberg and
  • Kenneth A. Dawson

Beilstein J. Nanotechnol. 2017, 8, 1396–1406, doi:10.3762/bjnano.8.141

Graphical Abstract
  • capacity of nanoparticles to enter cells, although promising for nanomedicine [4][5][6][7][8][9], has caused concerns of nanosafety in relation to unintended exposure to nanoparticles used in different technological applications (food additives, paintings, and others) [10][11][12][13]. Along different
  • potential use of nanoparticles for nanomedicine or the potential hazards of nanomaterials, it is fundamental to consider how nanoparticles interact, are processed by and transported across such barriers [14][15][16]. Specialised cellular layers also represent a more complex system compared to single
  • into the Caco-2 barrier. In the context of nanomedicine, the low internalisation could suggest that oral administration routes may lead to poor transport across the intestinal epithelium. For nanosafety, toxic responses measured for single cell cultures (where internalisation is usually substantial
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Published 07 Jul 2017

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs)

  • Michelle Romero-Franco,
  • Hilary A. Godwin,
  • Muhammad Bilal and
  • Yoram Cohen

Beilstein J. Nanotechnol. 2017, 8, 989–1014, doi:10.3762/bjnano.8.101

Graphical Abstract
  • over 1000 nano-enabled consumer products [1], representing an estimated global and US markets of $1 trillion and $800 billion, respectively [2]. Applications of ENMS include, for example, nanomedicine (e.g., drug delivery, early diagnosis and therapy for chronic diseases) [3] and environmental
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Published 05 May 2017

Nanoscale isoindigo-carriers: self-assembly and tunable properties

  • Tatiana N. Pashirova,
  • Andrei V. Bogdanov,
  • Lenar I. Musin,
  • Julia K. Voronina,
  • Irek R. Nizameev,
  • Marsil K. Kadirov,
  • Vladimir F. Mironov,
  • Lucia Ya. Zakharova,
  • Shamil K. Latypov and
  • Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

Graphical Abstract
  • isoindigo scaffold was functionalized with carbohydrate substituents [36][37]. Over the last three decades, extensive research in nanomedicine led to several strategies to improve drug biocompatibility and drug delivery efficacy (e.g., synthesis of polymer–drug conjugates, such as polyethylene glycol
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Published 01 Feb 2017

Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation

  • Roberta D'Agata,
  • Pasquale Palladino and
  • Giuseppe Spoto

Beilstein J. Nanotechnol. 2017, 8, 1–11, doi:10.3762/bjnano.8.1

Graphical Abstract
  • innovative diagnostic approaches we believe that these results will directly impact the ability to produce more reliable and sensitive nanoparticle-based diagnostics assays which could lead to advanced applications in nanomedicine which benefit of the ultrasensitive detection of nucleic acids. In addition
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Published 02 Jan 2017

Intercalation and structural aspects of macroRAFT agents into MgAl layered double hydroxides

  • Dessislava Kostadinova,
  • Ana Cenacchi Pereira,
  • Muriel Lansalot,
  • Franck D’Agosto,
  • Elodie Bourgeat-Lami,
  • Fabrice Leroux,
  • Christine Taviot-Guého,
  • Sylvian Cadars and
  • Vanessa Prevot

Beilstein J. Nanotechnol. 2016, 7, 2000–2012, doi:10.3762/bjnano.7.191

Graphical Abstract
  • interlamellar domain a large variety of negatively charged molecular organic species with different functional properties. This opens the way to a wide range of applications such as anion scavengers, adsorbents, heterogeneous catalysts, supports for species of interest in nanomedicine and fillers in polymer
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Published 15 Dec 2016

Hydrophilic silver nanoparticles with tunable optical properties: application for the detection of heavy metals in water

  • Paolo Prosposito,
  • Federico Mochi,
  • Erica Ciotta,
  • Mauro Casalboni,
  • Fabio De Matteis,
  • Iole Venditti,
  • Laura Fontana,
  • Giovanna Testa and
  • Ilaria Fratoddi

Beilstein J. Nanotechnol. 2016, 7, 1654–1661, doi:10.3762/bjnano.7.157

Graphical Abstract
  • devices, nanobiotechnology and nanomedicine. In particular, from the environmental monitoring perspective, sensors based on silver nanoparticles are in great demand because of their antibacterial and inexpensive synthetic method. In the present study, we synthesized AgNPs in water phase using silver
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Published 09 Nov 2016

Photothermal effect of gold nanostar patterns inkjet-printed on coated paper substrates with different permeability

  • Mykola Borzenkov,
  • Anni Määttänen,
  • Petri Ihalainen,
  • Maddalena Collini,
  • Elisa Cabrini,
  • Giacomo Dacarro,
  • Piersandro Pallavicini and
  • Giuseppe Chirico

Beilstein J. Nanotechnol. 2016, 7, 1480–1485, doi:10.3762/bjnano.7.140

Graphical Abstract
  • Mykola Borzenkov Anni Maattanen Petri Ihalainen Maddalena Collini Elisa Cabrini Giacomo Dacarro Piersandro Pallavicini Giuseppe Chirico Department of Physics “G. Occhialini”, Nanomedicine Center, University of Milano-Bicocca, piazza dell’Ateneo Nuovo, 20126, Milan, Italy Laboratory of Physical
  • of gold nanoparticles in nanomedicine [8][9][10][11][12], and in the fabrication of a broad spectrum of printed diagnostic and analytical tools [13][14][15]. Gold nanoparticles have also large extinction cross-sections in the range of 700–1100 nm (known as the bio-transparent window) because of
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Published 19 Oct 2016

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

  • Yue Zhang and
  • Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

Graphical Abstract
  • considered. Future Perspectives As nanomedicine gradually presents it advantages in medical diagnosis and therapy, the public becomes more and more concerned about their unknown adverse effects on the human body. Many medical researches regard nanoparticles as an extremely suitable material for drug delivery
  • nanomedicine applications. The effects of the phosphorylation process and other processes on the tight junction and its core proteins. For more details see main text. Side effects of NPs. Oxidative stress caused by NPs in different cells and tissues. Acknowledgements The authors are grateful to all members of
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Published 06 May 2016

Organized films

  • Maurizio Canepa and
  • Helmuth Möhwald

Beilstein J. Nanotechnol. 2016, 7, 406–408, doi:10.3762/bjnano.7.35

Graphical Abstract
  • modifying films, opening the way to patterning and even to nanolithography methods [14]. This was a crucial step in the development of nanosensors and biochips, especially in new and emerging fields such as nanomedicine. Coming back to LB films, irrespective of other technical difficulties in fabrication
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Published 09 Mar 2016

Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection

  • Dinusha N. Udukala,
  • Hongwang Wang,
  • Sebastian O. Wendel,
  • Aruni P. Malalasekera,
  • Thilani N. Samarakoon,
  • Asanka S. Yapa,
  • Gayani Abayaweera,
  • Matthew T. Basel,
  • Pamela Maynez,
  • Raquel Ortega,
  • Yubisela Toledo,
  • Leonie Bossmann,
  • Colette Robinson,
  • Katharine E. Janik,
  • Olga B. Koper,
  • Ping Li,
  • Massoud Motamedi,
  • Daniel A. Higgins,
  • Gary Gadbury,
  • Gaohong Zhu,
  • Deryl L. Troyer and
  • Stefan H. Bossmann

Beilstein J. Nanotechnol. 2016, 7, 364–373, doi:10.3762/bjnano.7.33

Graphical Abstract
  • . Keywords: biophotonics; breast cancer; iron/iron oxide nanoparticle; liquid biopsy; nanodiagnostics detection; nanomedicine; sub-femtomolar limit of detection; Introduction We have detected stage I breast cancer in human patients with statistical significance by means of a simple serum test using highly
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Published 07 Mar 2016

Functional fusion of living systems with synthetic electrode interfaces

  • Oskar Staufer,
  • Sebastian Weber,
  • C. Peter Bengtson,
  • Hilmar Bading,
  • Joachim P. Spatz and
  • Amin Rustom

Beilstein J. Nanotechnol. 2016, 7, 296–301, doi:10.3762/bjnano.7.27

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  • developed into a principal ambition for various scientific disciplines. In particular, emerging fields such as bionics and nanomedicine integrate advanced nanomaterials with biomolecules, cells and organisms in order to develop novel strategies for applications, including energy production or real-time
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Published 26 Feb 2016

Nanoinformatics for environmental health and biomedicine

  • Rong Liu and
  • Yoram Cohen

Beilstein J. Nanotechnol. 2015, 6, 2449–2451, doi:10.3762/bjnano.6.253

Graphical Abstract
  • health risks associated with nanomaterials. As an interdisciplinary field consisting mainly of nanotechnology and data science, nanoinformatics has significantly advanced over the last decade, playing an increasingly important role in research and development in nanomedicine and environmental health
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Editorial
Published 21 Dec 2015

Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials

  • Andrew Williams and
  • Sabina Halappanavar

Beilstein J. Nanotechnol. 2015, 6, 2438–2448, doi:10.3762/bjnano.6.252

Graphical Abstract
  • applications [43]. Current applications of NMs include therapeutic applications (e.g., nanomedicine, drug delivery, diagnostics), agriculture, manufacturing, electronics, cosmetics, textiles, and environmental remediation and protection. Although NMs are synthesized from their corresponding, known, bulk
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Published 21 Dec 2015

Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors

  • David E. Jones,
  • Hamidreza Ghandehari and
  • Julio C. Facelli

Beilstein J. Nanotechnol. 2015, 6, 1886–1896, doi:10.3762/bjnano.6.192

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  • , Salt Lake City, UT 84112, USA, Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84112, USA 10.3762/bjnano.6.192 Abstract The use of data mining techniques in the field of nanomedicine has been very limited. In this paper we demonstrate that data mining
  • techniques can be used for the development of predictive models of the cytotoxicity of poly(amido amine) (PAMAM) dendrimers using their chemical and structural properties. We present predictive models developed using 103 PAMAM dendrimer cytotoxicity values that were extracted from twelve cancer nanomedicine
  • , such as data mining and machine learning, have been very successful in medicinal chemistry and are commonly used to guide the design of small pharmaceutical compounds [1]. In contrast, although nanomedicine is a rapidly growing field [2], there have been only a few attempts to use data mining
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Published 11 Sep 2015

Framework for automatic information extraction from research papers on nanocrystal devices

  • Thaer M. Dieb,
  • Masaharu Yoshioka,
  • Shinjiro Hara and
  • Marcus C. Newton

Beilstein J. Nanotechnol. 2015, 6, 1872–1882, doi:10.3762/bjnano.6.190

Graphical Abstract
  • variety of methods for the extraction of information from research papers [15][16][17]. In the nanoinformatics domain, only a few researchers have attempted to automatically extract information from research papers [18][19][20] and their frameworks are explicitly focused on nanomedicine applications
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Published 07 Sep 2015

The Nanomaterial Data Curation Initiative: A collaborative approach to assessing, evaluating, and advancing the state of the field

  • Christine Ogilvie Hendren,
  • Christina M. Powers,
  • Mark D. Hoover and
  • Stacey L. Harper

Beilstein J. Nanotechnol. 2015, 6, 1752–1762, doi:10.3762/bjnano.6.179

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  • in informatics and computational approaches. This working group includes active membership and input from many communities (e.g., nanoEHS, commercial industry, standards community), but began with a particular emphasis on nanomedicine. From this area of emphasis, the NCIP NanoWG is well-positioned to
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Published 18 Aug 2015

Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer

  • Ying Huang,
  • Jing Ma,
  • Alan L. Porter,
  • Seokbeom Kwon and
  • Donghua Zhu

Beilstein J. Nanotechnol. 2015, 6, 1666–1676, doi:10.3762/bjnano.6.169

Graphical Abstract
  • (language is English and document type is Article), from 1990 to 2014, from the Science Citation Index Expanded (SCI-Expanded) and the Social Sciences Citation Index (SSCI) of the Web of Science (WoS). Nanomedicine research is a multidisciplinary activity, so exploring the disciplinary distribution is
  • , pharmacology & pharmacy, chemistry, neurosciences & neurology, research & experimental medicine and engineering, which indicates that nanomedicine research is a multidisciplinary activity. At the same time, researchers coming from the same institution tend to focus on similar research areas and collaborate on
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Published 31 Jul 2015

Experiences in supporting the structured collection of cancer nanotechnology data using caNanoLab

  • Stephanie A. Morris,
  • Sharon Gaheen,
  • Michal Lijowski,
  • Mervi Heiskanen and
  • Juli Klemm

Beilstein J. Nanotechnol. 2015, 6, 1580–1593, doi:10.3762/bjnano.6.161

Graphical Abstract
  • ; cancer research; databases; nanomaterials; nanomedicine; Introduction The U.S. annual report to the nation on the state of cancer indicates a steady decline in overall mortality rates, with increases in incidence for many cancers [1]. Internationally, cancer incidence paints a more dramatic picture in
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Published 21 Jul 2015

Using natural language processing techniques to inform research on nanotechnology

  • Nastassja A. Lewinski and
  • Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

Graphical Abstract
  • and their associated physico-chemical properties, performance, exposure scenarios, and biological effects. In this paper, we review the different informatics methods that have been applied to patent mining, nanomaterial/device characterization, nanomedicine, and environmental risk assessment. Nine
  • , have also been developed [20][21]. In the following section, we describe our method for identifying the nanoinformatics literature discussed in this paper, and then review the different informatics methods that have been applied such as patent mining, nanomaterial/device characterization, nanomedicine
  • parameter was examined. Nanomedicine Through targeted and activatible delivery, nanomedicine has the potential to greatly improve drug efficacy while reducing side effects. Improved design can also address emerging challenges to disease treatment such as adaptive resistance. Despite the promise, few
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Review
Published 01 Jul 2015
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