Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

• Fabian Herzog,
• Kateryna Loza,
• Sandor Balog,
• Martin J. D. Clift,
• Matthias Epple,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1357–1370, doi:10.3762/bjnano.5.149

• (diameter 100 nm; coated with polyvinylpyrrolidone: PVP). Ag NPs were found to be highly aggregated within ALI exposed cells with no impairment of cell morphology. Furthermore, a significant increase in release of cytotoxic (LDH), oxidative stress (SOD-1, HMOX-1) or pro-inflammatory markers (TNF-α, IL-8

• , increased levels of oxidative stress and reactive oxygen species (ROS) were detected over a time period of 48 h [22][25][26]. Environmental stressors trigger the production of intracellular ROS, which can overwhelm the cellular antioxidant defence system. ROS can cause DNA damage, which results in the

• could be observed when simultaneously exposed with Ag NPs. Ag NPs were not found to interfere with the ELISA assay (data not shown). Gene expression of pro-inflammatory and oxidative stress markers As described in [44], the total RNA content of the triple cell co-cultures was collected 4 and 24 h after

Antimicrobial properties of CuO nanorods and multi-armed nanoparticles against B. anthracis vegetative cells and endospores

• Pratibha Pandey,
• Merwyn S. Packiyaraj,
• Himangini Nigam,
• Gauri S. Agarwal,
• Beer Singh and
• Manoj K. Patra

Beilstein J. Nanotechnol. 2014, 5, 789–800, doi:10.3762/bjnano.5.91

• Appelrot et al. have found the antibacterial activity of CuO nanoparticles to be due to the generation of ROS by the NPs attached to the bacterial cells, which in turn enhanced the intracellular oxidative stress [25]. By using electron microscopy they also detected the presence of small nanoparticles of

Manipulation of isolated brain nerve terminals by an external magnetic field using D-mannose-coated γ-Fe₂O₃ nano-sized particles and assessment of their effects on glutamate transport

• Tatiana Borisova,
• Natalia Krisanova,
• Arsenii Borуsov,
• Roman Sivko,
• Ludmila Ostapchenko,
• Michal Babic and
• Daniel Horak

Beilstein J. Nanotechnol. 2014, 5, 778–788, doi:10.3762/bjnano.5.90

• higher Ti contents in the hippocampus region. This lead to oxidative stress in the brain of exposed mice, an increase in the activity of catalase, and the excessive release of glutamic acid and nitric oxide [29]. In this study, neurotoxic effects of D-mannose-coated γ-Fe2O3 nanoparticles have been

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• (STATs) to the HSP70 promoters in vascular smooth muscle cells (VSMCs) [32]. This group exposed VSMCs to H2O2 and found that the cytoplasmic janus tyrosine kinase 2 (JAK2)/STAT pathway can up-regulate HSP70 and minimize oxidative stress effects on the cells. The inhibition of HSP70 expression under laser

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

• Nadine Haberl,
• Stephanie Hirn,
• Alexander Wenk,
• Jörg Diendorf,
• Matthias Epple,
• Blair D. Johnston,
• Fritz Krombach,
• Wolfgang G. Kreyling and
• Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

• times did not cause adverse health effects in rats as measured by lung function, hematology, and body weight chances [25][26]. The mechanisms of toxicity are proposed to be oxidative stress, DNA damage, and the modulation of cytokine production [20]. In addition, Liu et al. showed that AgNP undergo